Gabapentin does not improve multimodal analgesia outcomes for total knee arthroplasty: A randomized controlled trial

Canadian Journal of Anesthesia

Volumn 60, Issue 5, 2013, Pages 423-431

  Paul, James E ^a   Nantha Aree, Manyat ^a   Buckley, Norman ^a   Cheng, Ji ^a   Thabane, Lehana ^a   Tidy, Antonella ^a   DeBeer, Justin ^a   Winemaker, Mitchell ^a   Wismer, David ^a   Punthakee, Dinshaw ^a   Avram, Victoria ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; FENTANYL; GABAPENTIN; KETOROLAC; MIDAZOLAM; MORPHINE; PARACETAMOL; PLACEBO; PROPOFOL; 4 AMINOBUTYRIC ACID; AMINE; ANALGESIC AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE;

ADULT; AGED; ANALGESIA; ARTICLE; BRADYCARDIA; BRADYPNEA; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; HYPERTENSION; HYPOTENSION; HYPOXIA; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NAUSEA; NEUROTOXICITY; PAIN; PASSIVE MOVEMENT; PATIENT CONTROLLED ANALGESIA; PATIENT SATISFACTION; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; REST; SCORING SYSTEM; SEDATION; SURGICAL PATIENT; TACHYCARDIA; TOTAL KNEE REPLACEMENT; TREATMENT OUTCOME; VERY ELDERLY; VISUAL DISORDER; VOMITING; WEIGHT BEARING; CONTROLLED CLINICAL TRIAL; DRUG COMBINATION; FOLLOW UP; KNEE ARTHROPLASTY; METHODOLOGY; MIDDLE AGED; PAIN ASSESSMENT; TIME;

ACETAMINOPHEN; AGED; AMINES; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS; ARTHROPLASTY, REPLACEMENT, KNEE; CYCLOHEXANECARBOXYLIC ACIDS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; GAMMA-AMINOBUTYRIC ACID; HUMANS; KETOROLAC; LENGTH OF STAY; MALE; MIDDLE AGED; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84886601922     PISSN: 0832610X     EISSN: 14968975     Source Type: Journal    
DOI: 10.1007/s12630-013-9902-1     Document Type: Article

References (23)

1. Felson DT. Epidemiology of hip and knee osteoarthritis. Epidemiol Rev 1988; 10: 1-28.
2. Lawrence RC, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 2008; 58: 26-35.
3. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001; 60: 91-7.
4. Mancuso CA, Ranawat CS, Esdaile JM, Johanson NA, Charlson ME. Indications for total hip and total knee arthroplasties. Results of orthopaedic surveys. J Arthroplasty 1996; 11: 34-46.
5. Mahomed NN, Barrett J, Katz JN, Baron JA, Wright J, Losina E. Epidemiology of total knee replacement in the United States Medicare population. J Bone Joint Surg Am 2005; 87: 1222-8.
6. Singh JA, Vessely MB, Harmsen WS, et al. A population-based study of trends in the use of total hip and total knee arthroplasty, 1969-2008. Mayo Clin Proc 2010; 85: 898-904.
7. Pang WW, Hsu TC, Tung CC, Hung CP, Chang DP, Huang MH. Is total knee replacement more painful than total hip replacement? Acta Anaesthesiol Sin 2000; 38: 143-8.
8. Horlocker TT. Pain management in total joint arthroplasty: a historical review. Orthopedics 2010; 33(9 Suppl): 14-9.
9. Singelyn FJ, Deyaert M, Joris D, Pendeville E, Gouverneur JM. Effects of intravenous patient-controlled analgesia with morphine, continuous epidural analgesia, and continuous three-in-one block on postoperative pain and knee rehabilitation after unilateral total knee arthroplasty. Anesth Analg 1998; 87: 88-92.
10. Paul JE, Arya A, Hurlburt L, et al. Femoral nerve block improves analgesia outcomes after total knee arthroplasty: a meta-analysis of randomized controlled trials. Anesthesiology 2010; 113: 1144-62.
11. Horlocker TT, Hebl JR, Kinney MA, Cabanela ME. Opioid-free analgesia following total knee arthroplasty - a multimodal approach using continuous lumbar plexus (psoas compartment) block, acetaminophen, and ketorolac. Reg Anesth Pain Med 2002; 27: 105-8.
12. Etches RC, Warriner CB, Badner N, et al. Continuous intravenous administration of ketorolac reduces pain and morphine consumption after total hip or knee arthroplasty. Anesth Analg 1995; 81: 1175-80.
13. Sinatra RS, Jahr JS, Reynolds LW, Viscusi ER, Groudine SB, Payen-Champenois C. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Anesthesiology 2005; 102: 822-31.
14. Kong VK, Irwin MG. Gabapentin: a multimodal perioperative drug? Br J Anaesth 2007; 99: 775-86.
15. Taylor CP. Mechanisms of analgesia by gabapentin and pregabalin - calcium channel alpha2-delta [Cavalpha2-delta] ligands. Pain 2009; 142: 13-6.
16. Ho KY, Gan TJ, Habib AS. Gabapentin and postoperative pain - a systematic review of randomized controlled trials. Pain 2006; 126: 91-101.
17. Peng PW, Wijeysundera DN, Li CC. Use of gabapentin for perioperative pain control - a meta-analysis. Pain Res Manag 2007; 12: 85-92.
18. Seib RK, Paul JE. Preoperative gabapentin for postoperative analgesia: a meta-analysis. Can J Anesth 2006; 53: 461-9.
19. Gandhi R, Petruccelli D, Devereaux PJ, Adili A, Hubmann M, de Beer J. Incidence and timing of myocardial infarction after total joint arthroplasty. J Arthroplasty 2006; 21: 874-7.
20. Shapiro A, Zohar E, Zaslansky R, Hoppenstein D, Shabat S, Fredman B. The frequency and timing of respiratory depression in 1524 postoperative patients treated with systemic or neuraxial morphine. J Clin Anesth 2005; 17: 537-42.
21. De Kock M. Expanding our horizons: transition of acute postoperative pain to persistent pain and establishment of chronic postsurgical pain services. Anesthesiology 2009; 111: 461-3.
22. Clarke H, Pereira S, Kennedy D, et al. Gabapentin decreases morphine consumption and improves functional recovery following total knee arthroplasty. Pain Res Manag 2009; 14: 217-22.
23. Psaty BM, Prentice RL. Minimizing bias in randomized trials: the importance of blinding. JAMA 2010; 304: 793-4.