Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis

British Journal of Anaesthesia

Volumn 114, Issue 1, 2015, Pages 10-31

  Mishriky, B M ^a   Waldron, N H ^a   Habib, A S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

meta analysis; postoperative pain; pregabalin

Indexed keywords

4 AMINOBUTYRIC ACID; ANALGESIC AGENT; PREGABALIN;

ACUTE PAIN; ANALOGS AND DERIVATIVES; CHRONIC PAIN; HUMAN; META ANALYSIS; PAIN, POSTOPERATIVE;

ACUTE PAIN; ANALGESICS; CHRONIC PAIN; GAMMA-AMINOBUTYRIC ACID; HUMANS; PAIN, POSTOPERATIVE;

EID: 84922422878     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aeu293     Document Type: Review

References (72)

1. Ha, KY, Carragee, E, Cheng, I, Kwon, SE, Kim, YH, Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells. J Korean Med Sci 26 (2011), 404–411.
2. Dahl, JB, Mathiesen, O, Moiniche, S, ‘Protective premedication': an option with gabapentin and related drugs? A review of gabapentin and pregabalin in the treatment of post-operative pain. Acta Anaesthesiol Scand 48 (2004), 1130–1136.
3. Clarke, H, Bonin, RP, Orser, BA, Englesakis, M, Wijeysundera, DN, Katz, J, The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis. Anesth Analg 115 (2012), 428–442.
4. Engelman, E, Cateloy, F, Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. Acta Anaesthesiol Scand 55 (2011), 927–943.
5. Zhang, J, Ho, KY, Wang, Y, Efficacy of pregabalin in acute postoperative pain: a meta-analysis. Br J Anaesth 106 (2011), 454–462.
6. Buvanendran, A, Kroin, JS, Della Valle, CJ, Kari, M, Moric, M, Tuman, KJ, Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial. Anesth Analg 110 (2010), 199–207.
7. Burke, SM, Shorten, GD, Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. Anesth Analg 110 (2010), 1180–1185.
8. Pesonen, A, Suojaranta-Ylinen, R, Hammaren, E, et al. Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. Br J Anaesth 106 (2011), 873–881.
9. Joshi, SS, Jagadeesh, AM, Efficacy of perioperative pregabalin in acute and chronic post-operative pain after off-pump coronary artery bypass surgery: a randomized, double-blind placebo controlled trial. Ann Card Anaesth 16 (2013), 180–185.
10. Kim, SY, Song, JW, Park, B, Park, S, An, YJ, Shim, YH, Pregabalin reduces post-operative pain after mastectomy: a double-blind, randomized, placebo-controlled study. Acta Anaesthesiol Scand 55 (2011), 290–296.
11. Jo, HR, Chae, YK, Kim, YH, et al. Remifentanil-induced pronociceptive effect and its prevention with pregabalin. Korean J Anesthesiol 60 (2011), 198–204.
12. Acin, MP, Bono, MC, Rodrigo, MD, Martinez, R, Faci, A, Escartin, R, Preventive analgesia with pregabalin in mesh hernia repair. Review at 1 year. Rev Soc Esp Dolor 16 (2009), 215–221.
13. Fassoulaki, A, Melemeni, A, Tsaroucha, A, Paraskeva, A, Perioperative pregabalin for acute and chronic pain after abdominal hysterectomy or myomectomy: a randomised controlled trial. Eur J Anaesthesiol 29 (2012), 531–536.
14. Gianesello, L, Pavoni, V, Barboni, E, Galeotti, I, Nella, A, Perioperative pregabalin for postoperative pain control and quality of life after major spinal surgery. J Neurosurg Anesthesiol 24 (2012), 121–126.
15. Kim, SY, Jeong, JJ, Chung, WY, Kim, HJ, Nam, KH, Shim, YH, Perioperative administration of pregabalin for pain after robot-assisted endoscopic thyroidectomy: a randomized clinical trial. Surg Endosc 24 (2010), 2776–2781.
16. Liberati, A, Altman, DG, Tetzlaff, J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med, 6, 2009, e1000100.
17. Higgins, J, Green, S, Cochrane Handbook for Systematic Reviews of Interventions, 2011, The Cochrance Collaboration version 5.1.0 [updated March 2011] Available from www.cochrane-handbook.org.
18. Gammaitoni, AR, Fine, P, Alvarez, N, McPherson, ML, Bergmark, S, Clinical application of opioid equianalgesic data. Clin J Pain 19 (2003), 286–297.
19. Ohqvist, G, Hallin, R, Gelinder, S, Lang, H, Samuelson, S, A comparison between morphine, meperidine and ketobemidone in continuous intravenous infusion for postoperative relief. Acta Anaesthesiol Scand 35 (1991), 44–48.
20. Dopfmer, UR, Schenk, MR, Kuscic, S, Beck, DH, Dopfmer, S, Kox, WJ, A randomized controlled double-blind trial comparing piritramide and morphine for analgesia after hysterectomy. Eur J Anaesthesiol 18 (2001), 389–393.
21. Rice, AS, Lloyd, J, Miller, CG, Bullingham, RE, O'Sullivan, GM, A double-blind study of the speed of onset of analgesia following intramuscular administration of ketorolac tromethamine in comparison to intramuscular morphine and placebo. Anaesthesia 46 (1991), 541–544.
22. Egger, M, Davey Smith, G, Schneider, M, Minder, C, Bias in meta-analysis detected by a simple, graphical test. Br Med J 315 (1997), 629–634.
23. Agarwal, A, Gautam, S, Gupta, D, Agarwal, S, Singh, PK, Singh, U, Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy. Br J Anaesth 101 (2008), 700–704.
24. Balaban, F, Yagar, S, Ozgok, A, Koc, M, Gullapoglu, H, A randomized, placebo-controlled study of pregabalin for postoperative pain intensity after laparoscopic cholecystectomy. J Clin Anesth 24 (2012), 175–178.
25. Bornemann-Cimenti, H, Lederer, AJ, Wejbora, M, et al. Preoperative pregabalin administration significantly reduces postoperative opioid consumption and mechanical hyperalgesia after transperitoneal nephrectomy. Br J Anaesth 108 (2012), 845–849.
26. Buvanendran, A, Kroin, JS, Della Valle, CJ, Moric, M, Tuman, KJ, Cerebrospinal fluid neurotransmitter changes during the perioperative period in patients undergoing total knee replacement: a randomized trial. Anesth Analg 114 (2012), 434–441.
27. Cabrera Schulmeyer, MC, de la Maza, J, Ovalle, C, Farias, C, Vives, I, Analgesic effects of a single preoperative dose of pregabalin after laparoscopic sleeve gastrectomy. Obes Surg 20 (2010), 1678–1681.
28. Chang, SH, Lee, HW, Kim, HK, Kim, SH, Kim, DK, An evaluation of perioperative pregabalin for prevention and attenuation of postoperative shoulder pain after laparoscopic cholecystectomy. Anesth Analg 109 (2009), 1284–1286.
29. Chaparro, LE, Clarke, H, Valdes, PA, Mira, M, Duque, L, Mitsakakis, N, Adding pregabalin to a multimodal analgesic regimen does not reduce pain scores following cosmetic surgery: a randomized trial. J Anesth 26 (2012), 829–835.
30. Cheung, CW, Choi, WS, Leung, YY, et al. A double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia. J Oral Maxillofac Surg 70 (2012), 25–30.
31. Choi, YS, Shim, JK, Song, JW, Kim, JC, Yoo, YC, Kwak, YL, Combination of pregabalin and dexamethasone for postoperative pain and functional outcome in patients undergoing lumbar spinal surgery: a randomized placebo-controlled trial. Clin J Pain 29 (2013), 9–14.
32. Clendenen, SR, Rajendran, S, Kopacz, DJ, et al. Pregabalin as an adjunct to a multimodal analgesic regimen to achieve opioid sparing in arthroscopic rotator cuff repair. Jurnalul Roman de Anestezie Terapie Intensiva/Romanian J Anaesth Intensive Care 17 (2010), 5–10.
33. Ghai, A, Gupta, M, Hooda, S, Singla, D, Wadhera, R, A randomized controlled trial to compare pregabalin with gabapentin for postoperative pain in abdominal hysterectomy. Saudi J Anaesth 5 (2011), 252–257.
34. Gonano, C, Latzke, D, Sabeti-Aschraf, M, Kettner, SC, Chiari, A, Gustorff, B, The anxiolytic effect of pregabalin in outpatients undergoing minor orthopaedic surgery. J Psychopharmacol 25 (2011), 249–253.
35. Ittichaikulthol, W, Virankabutra, T, Kunopart, M, Khamhom, W, Putarawuthichai, P, Rungphet, S, Effects of pregabalin on post operative morphine consumption and pain after abdominal hysterectomy with/without salphingo-oophorectomy: a randomized, double-blind trial. J Med Assoc Thai 92 (2009), 1318–1323.
36. Jokela, R, Ahonen, J, Tallgren, M, Haanpaa, M, Korttila, K, Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Br J Anaesth 100 (2008), 834–840.
37. Jokela, R, Ahonen, J, Tallgren, M, Haanpaa, M, Korttila, K, A randomized controlled trial of perioperative administration of pregabalin for pain after laparoscopic hysterectomy. Pain 134 (2008), 106–112.
38. Kim, JC, Choi, YS, Kim, KN, Shim, JK, Lee, JY, Kwak, YL, Effective dose of peri-operative oral pregabalin as an adjunct to multimodal analgesic regimen in lumbar spinal fusion surgery. Spine (Phila Pa 1976) 36 (2011), 428–433.
39. Kohli, M, Murali, T, Gupta, R, Khan, P, Bogra, J, Optimization of subarachanoid block by oral pregabalin for hysterectomy. J Anaesthesiol Clin Pharmacol 27 (2011), 101–105.
40. Mathiesen, O, Jacobsen, LS, Holm, HE, et al. Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty. Br J Anaesth 101 (2008), 535–541.
41. Mathiesen, O, Jorgensen, DG, Hilsted, KL, et al. Pregabalin and dexamethasone improves post-operative pain treatment after tonsillectomy. Acta Anaesthesiol Scand 55 (2011), 297–305.
42. Mathiesen, O, Rasmussen, ML, Dierking, G, et al. Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy. A randomized clinical trial. Acta Anaesthesiol Scand 53 (2009), 227–235.
43. Ozgencil, E, Yalcin, S, Tuna, H, Yorukoglu, D, Kecik, Y, Perioperative administration of gabapentin 1,200 mg day-1 and pregabalin 300 mg day-1 for pain following lumbar laminectomy and discectomy: a randomised, double-blinded, placebo-controlled study. Singapore Med J 52 (2011), 883–889.
44. Peng, PW, Li, C, Farcas, E, et al. Use of low-dose pregabalin in patients undergoing laparoscopic cholecystectomy. Br J Anaesth 105 (2010), 155–161.
45. Sahu, S, Sachan, S, Verma, A, Pandey, HD, Chitra, Evaluation of pregabalin for attenuation of postoperative pain in below umbilical surgeries under spinal anaesthesia. J Anaesthesiol Clin Pharmacol 26 (2010), 167–171.
46. Spreng, UJ, Dahl, V, Raeder, J, Effect of a single dose of pregabalin on post-operative pain and pre-operative anxiety in patients undergoing discectomy. Acta Anaesthesiol Scand 55 (2011), 571–576.
47. Sundar, AS, Kodali, R, Sulaiman, S, Ravullapalli, H, Karthekeyan, R, Vakamudi, M, The effects of preemptive pregabalin on attenuation of stress response to endotracheal intubation and opioid-sparing effect in patients undergoing off-pump coronary artery bypass grafting. Ann Card Anaesth 15 (2012), 18–25.
48. Wang, H, Gargano, C, Lukac, S, et al. An enhanced bunionectomy model as a potential tool for early decision-making in the development of new analgesics. Adv Ther 27 (2010), 963–980.
49. White, PF, Tufanogullari, B, Taylor, J, Klein, K, The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. Anesth Analg 108 (2009), 1140–1145.
50. Yadeau, JT, Paroli, L, Kahn, RL, et al. Addition of pregabalin to multimodal analgesic therapy following ankle surgery: a randomized double-blind, placebo-controlled trial. Reg Anesth Pain Med 37 (2012), 302–307.
51. Yucel, A, Ozturk, E, Aydoan, MS, Durmus, M, Colak, C, Ersoy, MO, Effects of 2 different doses of pregabalin on morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind clinical trial. Curr Ther Res Clin Exp 72 (2011), 174–175.
52. Alimian, M, Imani, F, Hassani, V, Rahimzadeh, P, Sharifian, M, Safari, S, Effects of single-dose pregabalin on postoperative pain in dacryocystorhinostomy surgery. Anesth Pain Med 2 (2012), 72–76.
53. Bekawi, MS, El Wakeel, LM, Al Taher, WM, Abdel Mageed, WM, Clinical study evaluating pregabalin efficacy and tolerability for pain management in patients undergoing laparoscopic cholecystectomy. Clin J Pain, 2014 (Epub ahead of print).
54. Koyuncu, T, Oguz, G, Akben, S, Nas, S, Unver, S, The effects of pregabaline on postoperative pain and opioid consumption used perioperatively in patients undergoing modified radical mastectomy. Agri 25 (2013), 169–178.
55. Demirhan, A, Tekelioglu, UY, Akkaya, A, et al. Effect of pregabalin and dexamethasone addition to multimodal analgesia on postoperative analgesia following rhinoplasty surgery. Aesthetic Plast Surg 37 (2013), 1100–1106.
56. Eskandar, AM, Ebeid, AM, Effect of pregabalin on postoperative pain after shoulder arthroscopy. Egypt J Anaesth 29 (2013), 363–367.
57. George, RB, McKeen, DM, Andreou, P, Habib, AS, A randomized placebo-controlled trial of two doses of pregabalin for postoperative analgesia in patients undergoing abdominal hysterectomy. Can J Anaesth 61 (2014), 551–557.
58. Ghoneim, AH, Hegazy, MM, The analgesic effect of preoperative pregabalin in radical cystectomy for cancer bladder patients. Chinese-German J Clin Oncol 12 (2013), 113–117.
59. Jain, P, Jolly, A, Bholla, V, Adatia, S, Sood, J, Evaluation of efficacy of oral pregabalin in reducing postoperative pain in patients undergoing total knee arthroplasty. Indian J Orthop 46 (2012), 646–652.
60. Khurana, G, Jindal, P, Sharma, JP, Bansal, KK, Postoperative pain and long-term functional outcome after administration of gabapentin and pregabalin in patients undergoing spinal surgery. Spine (Phila Pa 1976) 39 (2014), E363–E368.
61. Kumar, KP, Kulkarni, DK, Gurajala, I, Gopinath, R, Pregabalin versus tramadol for postoperative pain management in patients undergoing lumbar laminectomy: a randomized, double-blinded, placebo-controlled study. J Pain Res 6 (2013), 471–478.
62. Lee, C, Lee, HW, Kim, JN, Effect of oral pregabalin on opioid-induced hyperalgesia in patients undergoing laparo-endoscopic single-site urologic surgery. Korean J Anesthesiol 64 (2013), 19–24.
63. Martinez, V, Cymerman, A, Ben Ammar, S, et al. The analgesic efficiency of combined pregabalin and ketamine for total hip arthroplasty: a randomised, double-blind, controlled study. Anaesthesia 69 (2014), 46–52.
64. Nutthachote, P, Sirayapiwat, P, Wisawasukmongchol, W, Charuluxananan, S, A randomized, double blind, placebo-controlled trial of oral pregabalin for the relief of shoulder pain following laparoscopic gynecologic surgery. J Minim Invasive Gynecol 21 (2014), 669–673.
65. El Rahmawy, G, Doaa Rashwan, D, Mohamed, N, The efficacy of preoperative pregabalin on reduction of the incidence and severity of postdural puncture headache after spinal anesthesia. Egypt J Anaesth 29 (2013), 357–361.
66. Sagit, M, Yalcin, S, Polat, H, Korkmaz, F, Cetinkaya, S, Somdas, MA, Efficacy of a single preoperative dose of pregabalin for postoperative pain after septoplasty. J Craniofac Surg 24 (2013), 373–375.
67. Sarakatsianou, C, Theodorou, E, Georgopoulou, S, Stamatiou, G, Tzovaras, G, Effect of pre-emptive pregabalin on pain intensity and postoperative morphine consumption after laparoscopic cholecystectomy. Surg Endosc 27 (2013), 2504–2511.
68. Paech, MJ, Goy, R, Chua, S, Scott, K, Christmas, T, Doherty, DA, A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery. Anesth Analg 105 (2007), 1449–1453.
69. Gajraj, NM, Pregabalin: its pharmacology and use in pain management. Anesth Analg 105 (2007), 1805–1815.
70. Chaparro, LE, Smith, SA, Moore, RA, Wiffen, PJ, Gilron, I, Pharmacotherapy for the prevention of chronic pain after surgery in adults. Cochrane Database Syst Rev, 7, 2013 CD008307.
71. Ip, HY, Abrishami, A, Peng, PW, Wong, J, Chung, F, Predictors of postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology 111 (2009), 657–677.
72. Higgins, JP, Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified. Int J Epidemiol 37 (2008), 1158–1160.