메뉴 건너뛰기




Volumn 21, Issue 1, 2016, Pages

Spontaneous and induced tolerance for liver transplant recipients

Author keywords

Cellular therapy; Immunosuppression withdrawal; Liver transplantation; Tolerance

Indexed keywords

ALLOGRAFT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBIOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LIVER GRAFT; LONG TERM SURVIVAL; MULTICENTER STUDY; RECIPIENT; REGULATORY T LYMPHOCYTE; ALLOTRANSPLANTATION; ANIMAL; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; TRANSPLANTATION TOLERANCE;

EID: 84953637289     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0000000000000268     Document Type: Review
Times cited : (17)

References (51)
  • 1
    • 0034035178 scopus 로고    scopus 로고
    • Immunological tolerance: The liver effect
    • Calne RY. Immunological tolerance: the liver effect. Immunol Rev 2000; 174:280-282.
    • (2000) Immunol Rev , vol.174 , pp. 280-282
    • Calne, R.Y.1
  • 2
    • 0014661390 scopus 로고
    • Induction of immunological tolerance by porcine liver allografts
    • Epub 1969/08/02
    • Calne RY, Sells RA, Pena JR, et al. Induction of immunological tolerance by porcine liver allografts. Nature 1969; 223:472-476; Epub 1969/08/02.
    • (1969) Nature , vol.223 , pp. 472-476
    • Calne, R.Y.1    Sells, R.A.2    Pena, J.R.3
  • 3
    • 0014208896 scopus 로고
    • Prolonged survival of liver transplants in the pig
    • Calne RY, White HJ, Yoffa DE, et al. Prolonged survival of liver transplants in the pig. Br Med J 1967; 4:645-648.
    • (1967) Br Med J , vol.4 , pp. 645-648
    • Calne, R.Y.1    White, H.J.2    Yoffa, D.E.3
  • 4
    • 84877633176 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Sachs DH, Sykes M, Cosimi AB. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2013; 368:1850-1852.
    • (2013) N Engl J Med , vol.368 , pp. 1850-1852
    • Kawai, T.1    Sachs, D.H.2    Sykes, M.3    Cosimi, A.B.4
  • 5
    • 38549088096 scopus 로고    scopus 로고
    • HLA-mismatched renal transplantation without maintenance immunosuppression
    • Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008; 358:353-361.
    • (2008) N Engl J Med , vol.358 , pp. 353-361
    • Kawai, T.1    Cosimi, A.B.2    Spitzer, T.R.3
  • 6
    • 84863229939 scopus 로고    scopus 로고
    • Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation
    • Leventhal J, Abecassis M, Miller J, et al. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci Transl Med 2012; 4:124ra28.
    • (2012) Sci Transl Med , vol.4 , pp. 124ra28
    • Leventhal, J.1    Abecassis, M.2    Miller, J.3
  • 7
    • 80053480657 scopus 로고    scopus 로고
    • Induced immune tolerance for kidney transplantation
    • Scandling JD, Busque S, Shizuru JA, et al. Induced immune tolerance for kidney transplantation. N Engl J Med 2011; 365:1359-1360.
    • (2011) N Engl J Med , vol.365 , pp. 1359-1360
    • Scandling, J.D.1    Busque, S.2    Shizuru, J.A.3
  • 8
    • 38549134052 scopus 로고    scopus 로고
    • Tolerance and chimerism after renal and hematopoietic-cell transplantation
    • Scandling JD, Busque S, Dejbakhsh-Jones S, et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008; 358:362-368.
    • (2008) N Engl J Med , vol.358 , pp. 362-368
    • Scandling, J.D.1    Busque, S.2    Dejbakhsh-Jones, S.3
  • 9
    • 84856110514 scopus 로고    scopus 로고
    • Mixed chimerism through donor bone marrow transplantation: A tolerogenic cell therapy for application in organ transplantation
    • Pilat N, Hock K, Wekerle T. Mixed chimerism through donor bone marrow transplantation: a tolerogenic cell therapy for application in organ transplantation. Curr Opin Organ Transplant 2012; 17:63-70.
    • (2012) Curr Opin Organ Transplant , vol.17 , pp. 63-70
    • Pilat, N.1    Hock, K.2    Wekerle, T.3
  • 10
    • 78751576088 scopus 로고    scopus 로고
    • Liver antigen-presenting cells
    • Crispe IN. Liver antigen-presenting cells. J Hepatol 2011; 54:357-365.
    • (2011) J Hepatol , vol.54 , pp. 357-365
    • Crispe, I.N.1
  • 11
    • 84911887407 scopus 로고    scopus 로고
    • Immune tolerance in liver disease
    • Epub 2014/06/11
    • Crispe IN. Immune tolerance in liver disease. Hepatology 2014; 60:2109-2117; Epub 2014/06/11.
    • (2014) Hepatology , vol.60 , pp. 2109-2117
    • Crispe, I.N.1
  • 12
    • 75149196666 scopus 로고    scopus 로고
    • Immune tolerance: What is unique about the liver
    • Tiegs G, Lohse AW. Immune tolerance: what is unique about the liver. J Autoimmunity 2010; 34:1-6.
    • (2010) J Autoimmunity , vol.34 , pp. 1-6
    • Tiegs, G.1    Lohse, A.W.2
  • 13
    • 84937837169 scopus 로고    scopus 로고
    • Molecular and cellular insights into T cell exhaustion
    • Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol 2015; 15:486-499.
    • (2015) Nat Rev Immunol , vol.15 , pp. 486-499
    • Wherry, E.J.1    Kurachi, M.2
  • 14
    • 34250845839 scopus 로고    scopus 로고
    • Randomized controlled trial of total immunosuppression withdrawal in liver transplant recipients: Role of urso-deoxycholic acid
    • Assy N, Adams PC, Myers P, et al. Randomized controlled trial of total immunosuppression withdrawal in liver transplant recipients: role of urso-deoxycholic acid. Transplantation 2007; 83:1571-1576.
    • (2007) Transplantation , vol.83 , pp. 1571-1576
    • Assy, N.1    Adams, P.C.2    Myers, P.3
  • 15
    • 84887020345 scopus 로고    scopus 로고
    • Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients
    • Benitez C, Londono MC, Miquel R, et al. Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients. Hepatology 2013; 58:1824-1835.
    • (2013) Hepatology , vol.58 , pp. 1824-1835
    • Benitez, C.1    Londono, M.C.2    Miquel, R.3
  • 16
    • 84883224473 scopus 로고    scopus 로고
    • Trial of complete weaning from immunosuppression for liver transplant recipients: Factors predictive of tolerance
    • de la Garza RG, Sarobe P, Merino J, et al. Trial of complete weaning from immunosuppression for liver transplant recipients: factors predictive of tolerance. Liver Transplant 2013; 19:937-944.
    • (2013) Liver Transplant , vol.19 , pp. 937-944
    • De La Garza, R.G.1    Sarobe, P.2    Merino, J.3
  • 17
    • 0031899420 scopus 로고    scopus 로고
    • Defining the outcome of immuno-suppression withdrawal after liver transplantation
    • Devlin J, Doherty D, Thomson L, et al. Defining the outcome of immuno-suppression withdrawal after liver transplantation. Hepatology 1998; 27:926-933.
    • (1998) Hepatology , vol.27 , pp. 926-933
    • Devlin, J.1    Doherty, D.2    Thomson, L.3
  • 18
    • 18644364703 scopus 로고    scopus 로고
    • Tolerance: Is it worth the risk?
    • Eason JD, Cohen AJ, Nair S, et al. Tolerance: is it worth the risk? Transplantation 2005; 79:1157-1159.
    • (2005) Transplantation , vol.79 , pp. 1157-1159
    • Eason, J.D.1    Cohen, A.J.2    Nair, S.3
  • 19
    • 33846910502 scopus 로고    scopus 로고
    • Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
    • Koshiba T, Li Y, Takemura M, et al. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transplant Immunol 2007; 17:94-97.
    • (2007) Transplant Immunol , vol.17 , pp. 94-97
    • Koshiba, T.1    Li, Y.2    Takemura, M.3
  • 20
    • 74549148889 scopus 로고    scopus 로고
    • Withdrawal of immunosuppression in pediatric liver transplant recipients in Korea
    • Lee JH, Lee SK, Lee HJ, et al. Withdrawal of immunosuppression in pediatric liver transplant recipients in Korea. Yonsei Med J 2009; 50:784-788.
    • (2009) Yonsei Med J , vol.50 , pp. 784-788
    • Lee, J.H.1    Lee, S.K.2    Lee, H.J.3
  • 21
    • 33846940520 scopus 로고    scopus 로고
    • Clinical tolerance following liver transplantation: Long term results and future prospects
    • Mazariegos GV, Sindhi R, Thomson AW, Marcos A. Clinical tolerance following liver transplantation: long term results and future prospects. Transplant Immunol 2007; 17:114-119.
    • (2007) Transplant Immunol , vol.17 , pp. 114-119
    • Mazariegos, G.V.1    Sindhi, R.2    Thomson, A.W.3    Marcos, A.4
  • 22
    • 56049120306 scopus 로고    scopus 로고
    • The Tor Vergata weaning off immuno-suppression protocol in stable HCV liver transplant patients: The updated follow up at 78 months
    • Orlando G, Manzia T, Baiocchi L, et al. The Tor Vergata weaning off immuno-suppression protocol in stable HCV liver transplant patients: the updated follow up at 78 months. Transplant Immunol 2008; 20 (1-2):43-47.
    • (2008) Transplant Immunol , vol.20 , Issue.1-2 , pp. 43-47
    • Orlando, G.1    Manzia, T.2    Baiocchi, L.3
  • 23
    • 20844449097 scopus 로고    scopus 로고
    • Endothelial cell chimerism does not influence allograft tolerance in liver transplant patients after withdrawal of immunosuppression
    • Pons JA, Yelamos J, Ramirez P, et al. Endothelial cell chimerism does not influence allograft tolerance in liver transplant patients after withdrawal of immunosuppression. Transplantation 2003; 75:1045-1047.
    • (2003) Transplantation , vol.75 , pp. 1045-1047
    • Pons, J.A.1    Yelamos, J.2    Ramirez, P.3
  • 24
    • 0028799575 scopus 로고
    • Weaning of immunosuppression in long-term liver transplant recipients
    • Ramos HC, Reyes J, Abu-Elmagd K, et al. Weaning of immunosuppression in long-term liver transplant recipients. Transplantation 1995; 59:212-217.
    • (1995) Transplantation , vol.59 , pp. 212-217
    • Ramos, H.C.1    Reyes, J.2    Abu-Elmagd, K.3
  • 25
    • 33644923002 scopus 로고    scopus 로고
    • Complete weaning off immunosup-pression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence
    • Tisone G, Orlando G, Cardillo A, et al. Complete weaning off immunosup-pression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence. J Hepatol 2006; 44:702-709.
    • (2006) J Hepatol , vol.44 , pp. 702-709
    • Tisone, G.1    Orlando, G.2    Cardillo, A.3
  • 26
    • 20044361820 scopus 로고    scopus 로고
    • The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotrans-plantation
    • Tryphonopoulos P, Tzakis AG, Weppler D, et al. The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotrans-plantation. Am J Transplant 2005; 5:608-613.
    • (2005) Am J Transplant , vol.5 , pp. 608-613
    • Tryphonopoulos, P.1    Tzakis, A.G.2    Weppler, D.3
  • 27
    • 84855993116 scopus 로고    scopus 로고
    • Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants
    • Feng S, Ekong UD, Lobritto SJ, et al. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants. JAMA 2012; 307:283-293.
    • (2012) JAMA , vol.307 , pp. 283-293
    • Feng, S.1    Ekong, U.D.2    Lobritto, S.J.3
  • 28
    • 33846252277 scopus 로고    scopus 로고
    • Multiparameter immune profiling of operational tolerance in liver transplantation
    • Martinez-Llordella M, Puig-Pey I, Orlando G, et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant 2007; 7:309-319.
    • (2007) Am J Transplant , vol.7 , pp. 309-319
    • Martinez-Llordella, M.1    Puig-Pey, I.2    Orlando, G.3
  • 29
    • 48749084927 scopus 로고    scopus 로고
    • Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients
    • Martinez-Llordella M, Lozano JJ, Puig-Pey I, et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest 2008; 118:2845-2857.
    • (2008) J Clin Invest , vol.118 , pp. 2845-2857
    • Martinez-Llordella, M.1    Lozano, J.J.2    Puig-Pey, I.3
  • 30
    • 84855467970 scopus 로고    scopus 로고
    • Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation
    • Bohne F, Martinez-Llordella M, Lozano JJ, et al. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest 2012; 122:368-382.
    • (2012) J Clin Invest , vol.122 , pp. 368-382
    • Bohne, F.1    Martinez-Llordella, M.2    Lozano, J.J.3
  • 31
    • 84942683893 scopus 로고    scopus 로고
    • Iron deficiency impairs intra-hepatic lymphocyte mediated immune response
    • Bonaccorsi-Riani E, Danger R, Lozano JJ, et al. Iron deficiency impairs intra-hepatic lymphocyte mediated immune response. PLoS One 2015; 10:e0136106.
    • (2015) PLoS One , vol.10 , pp. e0136106
    • Bonaccorsi-Riani, E.1    Danger, R.2    Lozano, J.J.3
  • 32
    • 0344553377 scopus 로고    scopus 로고
    • Heterologous immunity: An overlooked barrier to tolerance
    • Epub 2003/11/18
    • Adams AB, Pearson TC, Larsen CP. Heterologous immunity: an overlooked barrier to tolerance. Immunol Rev 2003; 196:147-160; Epub 2003/11/18.
    • (2003) Immunol Rev , vol.196 , pp. 147-160
    • Adams, A.B.1    Pearson, T.C.2    Larsen, C.P.3
  • 33
    • 79956345084 scopus 로고    scopus 로고
    • Inflammation and transplantation tolerance
    • Goldstein DR. Inflammation and transplantation tolerance. Semin Immuno-pathol 2011; 33:111-115.
    • (2011) Semin Immuno-pathol , vol.33 , pp. 111-115
    • Goldstein, D.R.1
  • 34
    • 34047172640 scopus 로고    scopus 로고
    • IL-10, T cell exhaustion and viral persistence
    • Blackburn SD, Wherry EJ. IL-10, T cell exhaustion and viral persistence. Trends Microbiol 2007; 15:143-146.
    • (2007) Trends Microbiol , vol.15 , pp. 143-146
    • Blackburn, S.D.1    Wherry, E.J.2
  • 35
    • 84898936752 scopus 로고    scopus 로고
    • Hepatic immune regulation and its involvement in viral hepatitis infection
    • Knolle PA, Thimme R. Hepatic immune regulation and its involvement in viral hepatitis infection. Gastroenterology 2014; 146:1193-1207.
    • (2014) Gastroenterology , vol.146 , pp. 1193-1207
    • Knolle, P.A.1    Thimme, R.2
  • 36
    • 84903767450 scopus 로고    scopus 로고
    • HCV-induced immune responses influence the development of operational tolerance after liver transplantation in humans
    • Bohne F, Londono MC, Benitez C, et al. HCV-induced immune responses influence the development of operational tolerance after liver transplantation in humans. Sci Transl Med 2014; 6:242ra81.
    • (2014) Sci Transl Med , vol.6 , pp. 242ra81
    • Bohne, F.1    Londono, M.C.2    Benitez, C.3
  • 38
    • 33750131777 scopus 로고    scopus 로고
    • Early immunosuppression withdrawal after living donor liver transplantation and donor stem cell infusion
    • Donckier V, Troisi R, Le Moine A, et al. Early immunosuppression withdrawal after living donor liver transplantation and donor stem cell infusion. Liver Transplant 2006; 12:1523-1528.
    • (2006) Liver Transplant , vol.12 , pp. 1523-1528
    • Donckier, V.1    Troisi, R.2    Le Moine, A.3
  • 39
    • 4544223677 scopus 로고    scopus 로고
    • Donor stem cell infusion after nonmyeloablative conditioning for tolerance induction to HLA mismatched adult living-donor liver graft
    • Donckier V, Troisi R, Toungouz M, et al. Donor stem cell infusion after nonmyeloablative conditioning for tolerance induction to HLA mismatched adult living-donor liver graft. Transplant Immunol 2004; 13:139-146.
    • (2004) Transplant Immunol , vol.13 , pp. 139-146
    • Donckier, V.1    Troisi, R.2    Toungouz, M.3
  • 40
    • 0032490341 scopus 로고    scopus 로고
    • Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients
    • Calne R, Friend P, Moffatt S, et al. Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet 1998; 351:1701-1702.
    • (1998) Lancet , vol.351 , pp. 1701-1702
    • Calne, R.1    Friend, P.2    Moffatt, S.3
  • 41
    • 0033933267 scopus 로고    scopus 로고
    • Prope tolerance: A step in the search for tolerance in the clinic
    • Calne RY. Prope tolerance: a step in the search for tolerance in the clinic. World J Surg 2000; 24:793-796.
    • (2000) World J Surg , vol.24 , pp. 793-796
    • Calne, R.Y.1
  • 42
    • 0038298787 scopus 로고    scopus 로고
    • Tolerogenic immunosuppression for organ transplantation
    • Starzl TE, Murase N, Abu-Elmagd K, et al. Tolerogenic immunosuppression for organ transplantation. Lancet 2003; 361:1502-1510.
    • (2003) Lancet , vol.361 , pp. 1502-1510
    • Starzl, T.E.1    Murase, N.2    Abu-Elmagd, K.3
  • 43
    • 77957191625 scopus 로고    scopus 로고
    • ATG-Fresenius treatment and low-dose tacrolimus: Results of a randomized controlled trial in liver transplantation
    • Benitez CE, Puig-Pey I, Lopez M, et al. ATG-Fresenius treatment and low-dose tacrolimus: results of a randomized controlled trial in liver transplantation. Am J Transplant 2010; 10:2296-2304.
    • (2010) Am J Transplant , vol.10 , pp. 2296-2304
    • Benitez, C.E.1    Puig-Pey, I.2    Lopez, M.3
  • 44
    • 84881610502 scopus 로고    scopus 로고
    • Expansion of memory-type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and rapamycin
    • Donckier V, Craciun L, Miqueu P, et al. Expansion of memory-type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and rapamycin. Transplantation 2013; 96:306-315.
    • (2013) Transplantation , vol.96 , pp. 306-315
    • Donckier, V.1    Craciun, L.2    Miqueu, P.3
  • 45
    • 64649104649 scopus 로고    scopus 로고
    • Acute liver transplant rejection upon immunosuppression withdrawal in a tolerance induction trial: Potential role of IFN-gamma-secreting CD8+ T cells
    • Donckier V, Craciun L, Lucidi V, et al. Acute liver transplant rejection upon immunosuppression withdrawal in a tolerance induction trial: potential role of IFN-gamma-secreting CD8+ T cells. Transplantation 2009; 87 (9 Suppl):S91-S95.
    • (2009) Transplantation , vol.87 , Issue.9 , pp. S91-S95
    • Donckier, V.1    Craciun, L.2    Lucidi, V.3
  • 46
    • 22144481995 scopus 로고    scopus 로고
    • Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates
    • Bashuda H, Kimikawa M, Seino K, et al. Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates. J Clin Invest 2005; 115:1896-1902.
    • (2005) J Clin Invest , vol.115 , pp. 1896-1902
    • Bashuda, H.1    Kimikawa, M.2    Seino, K.3
  • 47
    • 84869758998 scopus 로고    scopus 로고
    • Ex vivo alloanergization with belatacept: A strategy to selectively modulate alloresponses after transplantation
    • Davies JK, Barbon CM, Voskertchian A, et al. Ex vivo alloanergization with belatacept: a strategy to selectively modulate alloresponses after transplantation. Cell Transplant 2012; 21:2047-2061.
    • (2012) Cell Transplant , vol.21 , pp. 2047-2061
    • Davies, J.K.1    Barbon, C.M.2    Voskertchian, A.3
  • 48
    • 56049106841 scopus 로고    scopus 로고
    • Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity
    • Davies JK, Yuk D, Nadler LM, Guinan EC. Induction of alloanergy in human donor T cells without loss of pathogen or tumor immunity. Transplantation 2008; 86:854-864.
    • (2008) Transplantation , vol.86 , pp. 854-864
    • Davies, J.K.1    Yuk, D.2    Nadler, L.M.3    Guinan, E.C.4
  • 49
    • 0033519661 scopus 로고    scopus 로고
    • Transplantation of anergic histoincompatible bone marrow allografts
    • Guinan EC, Boussiotis VA, Neuberg D, et al. Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med 1999; 340:1704-1714.
    • (1999) N Engl J Med , vol.340 , pp. 1704-1714
    • Guinan, E.C.1    Boussiotis, V.A.2    Neuberg, D.3
  • 50
    • 84886786872 scopus 로고    scopus 로고
    • Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation
    • Putnam AL, Safinia N, Medvec A, et al. Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation. Am J Transplant 2013; 13:3010-3020.
    • (2013) Am J Transplant , vol.13 , pp. 3010-3020
    • Putnam, A.L.1    Safinia, N.2    Medvec, A.3
  • 51
    • 84887194102 scopus 로고    scopus 로고
    • Regulatory T-cell therapy in transplantation: Moving to the clinic
    • a015552
    • Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harbor Perspect Med 2013; 3:; pii: a015552.
    • (2013) Cold Spring Harbor Perspect Med , vol.3
    • Tang, Q.1    Bluestone, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.