Clinical tolerance following liver transplantation: Long term results and future prospects

Transplant Immunology

Volumn 17, Issue 2, 2007, Pages 114-119

  Mazariegos, George V ^a,b   Sindhi, Rakesh ^a,b   Thomson, Angus W ^a,b   Marcos, Amadeo ^a,b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Drug weaning; Immunosuppression withdrawal; Liver transplantation; Tolerance; Tolerance assays

Indexed keywords

STEROID; TACROLIMUS;

BILE DUCT INJURY; CD4+ T LYMPHOCYTE; CLINICAL RESEARCH; COHORT ANALYSIS; DENDRITIC CELL; DNA POLYMORPHISM; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; EPSTEIN BARR VIRUS; FOLLOW UP; GENE EXPRESSION; GRAFT FAILURE; GRAFT INFECTION; GRAFT SURVIVAL; HUMAN; KIDNEY FAILURE; KIDNEY GRAFT; LIVER BIOPSY; LIVER FAILURE; LIVER FUNCTION TEST; LIVER GRAFT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LONG TERM CARE; LYMPHOPROLIFERATIVE DISEASE; PATIENT ASSESSMENT; PATIENT CODING; PATIENT COMPLIANCE; PHYSICIAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; TRANSPLANTATION TOLERANCE; TREATMENT REFUSAL;

CLINICAL TRIALS; HUMANS; IMMUNOSUPPRESSION; LIVER TRANSPLANTATION; MONITORING, IMMUNOLOGIC; TRANSPLANTATION TOLERANCE; WITHHOLDING TREATMENT;

EID: 33846940520     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2006.09.033     Document Type: Review

References (46)

1. Fridell J.A., Jain A., Reyes J., Beiderman R., Green M., Sindhi R., et al. Causes of mortality beyond 1 year after primary pediatric liver transplant under tacrolimus. Transplantation 74 12 (2002) 1721-1724
2. McDiarmid S.V. Management of the pediatric liver transplant patient. Liver Transpl 7 11 Suppl 1 (2001) S77-S86
3. Wallot M.A., Mathot M., Janssen M., Holter T., Paul K., Paul Buts J., et al. Long-term survival and late graft loss in pediatric liver transplant recipients-a 15-year single-center experience. Liver Transpl 8 7 (2002) 615-622
4. Starzl T.E., Demetris A.J., Murase N., Ildstad S., Ricordi C., and Trucco M. Cell migration, chimerism, and graft acceptance. Lancet 339 8809 (1992) 1579-1582
5. Starzl T.E., Demetris A.J., Trucco M., Murase N., Ricordi C., Ildstad S., et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology 17 6 (1993) 1127-1152
6. Starzl T.E., and Zinkernagel R.M. Transplantation tolerance from a historical perspective. Nat Rev Immunol 1 3 (2001) 233-239
7. Starzl T.E., Murase N., Abu-Elmagd K., Gray E.A., Shapiro R., Eghtesad B., et al. Tolerogenic immunosuppression for organ transplantation. Lancet 361 9368 (2003) 1502-1510
8. Auchincloss Jr. H. In search of the elusive Holy Grail: the mechanisms and prospects for achieving clinical transplantation tolerance. Am J Transplant 1 1 (2001) 6-12
9. Calne R.Y. Prope tolerance: a step in the search for tolerance in the clinic. World J Surg 24 7 (2000) 793-796
10. Reding R., Gras J., Bourdeaux C., Wieers G., Truong Q.D., Latinne D., et al. Stepwise minimization of the immunosuppressive therapy in pediatric liver transplantation. A conceptual approach towards operational tolerance. Acta Gastroenterol Belg 68 3 (2005) 320-322
11. Varela-Fascinetto G., Treacy S.J., and Vacanti J.P. Approaching operational tolerance in long-term pediatric liver transplant recipients receiving minimal immunosuppression. Transplant Proc 29 1-2 (1997) 449-451
12. Manez R., Kusne S., Linden P., Gonzalez-Pinto I., Bonet H., Kramer D., et al. Temporary withdrawal of immunosuppression for life-threatening infections after liver transplantation. Transplantation 57 1 (1994) 149-151
13. Reyes J., Zeevi A., Ramos H., Tzakis A., Todo S., Demetris A.J., et al. Frequent achievement of a drug-free state after orthotopic liver transplantation. Transplant Proc 25 6 (1993) 3315-3319
14. Mazariegos G.V., Reyes J., Marino I.R., Demetris A.J., Flynn B., Irish W., et al. Weaning of immunosuppression in liver transplant recipients. Transplantation 63 2 (1997) 243-249
15. Ramos H.C., Reyes J., Abu-Elmagd K., Zeevi A., Reinsmoen N., Tzakis A., et al. Weaning of immunosuppression in long-term liver transplant recipients. Transplantation 59 2 (1995) 212-217
16. Mazariegos G.V. Withdrawal of immunosuppression in liver transplantation: lessons learned from PTLD. Pediatr Transplant 8 3 (2004) 210-213
17. Kirk A.D. Meteorology and tolerance. Am J Transplant 6 4 (2006) 645-646
18. Devlin J., Doherty D., Thomson L., Wong T., Donaldson P., Portmann B., et al. Defining the outcome of immunosuppression withdrawal after liver transplantation. Hepatology 27 4 (1998) 926-933
19. Girlanda R., Rela M., Williams R., O'Grady J.G., and Heaton N.D. Long-term outcome of immunosuppression withdrawal after liver transplantation. Transplant Proc 37 4 (2005) 1708-1709
20. Lerut J., and Sanchez-Fueyo A. An appraisal of tolerance in liver transplantation. Am J Transplant 6 8 (2006) 1774-1780
21. Oike F., Yokoi A., Nishimura E., Ogura Y., Fujimoto Y., Kasahara M., et al. Complete withdrawal of immunosuppression in living donor liver transplantation. Transplant Proc 34 5 (2002) 1521
22. Takatsuki M., Uemoto S., Inomata Y., Egawa H., Kiuchi T., Fujita S., et al. Weaning of immunosuppression in living donor liver transplant recipients. Transplantation 72 3 (2001) 449-454
23. Tryphonopoulos P., Tzakis A.G., Weppler D., Garcia-Morales R., Kato T., Madariaga Jr., et al. The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotransplantation. Am J Transplant 5 3 (2005) 608-613
24. Yoshida E.M., and Chung S.W. Outcomes after complete immunosuppression withdrawal in liver transplant recipients: rejection-free graft tolerance or late acute rejection?. Can J Gastroenterol 12 6 (1998) 387-389
25. Padbury R.T., Toogood G.J., and McMaster P. Withdrawal of immunosuppression in liver allograft recipients. Liver Transpl Surg 4 3 (1998) 242-248
26. Green M. Management of Epstein-Barr virus-induced post-transplant lymphoproliferative disease in recipients of solid organ transplantation. Am J Transplant 1 2 (2001) 103-108
27. Hurwitz M., Desai D.M., Cox K.L., Berquist W.E., Esquivel C.O., and Millan M.T. Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation. Pediatr Transplant 8 3 (2004) 267-272
28. Randhawa P., Blakolmer K., Kashyap R., Raikow R., Nalesnik M., Demetris A.J., et al. Allograft liver biopsy in patients with Epstein-Barr virus-associated posttransplant lymphoproliferative disease. Am J Surg Pathol 25 3 (2001) 324-330
29. Demetris A.J., Adeyi O., Bellamy C.O., Clouston A., Charlotte F., Czaja A., et al. Liver biopsy interpretation for causes of late liver allograft dysfunction. Hepatology 44 2 (2006) 489-501
30. Pappo O., Ramos H., Starzl T.E., Fung J.J., and Demetris A.J. Structural integrity and identification of causes of liver allograft dysfunction occurring more than 5 years after transplantation. Am J Surg Pathol 19 2 (1995) 192-206
31. Tisone G., Orlando G., Cardillo A., Palmieri G., Manzia T.M., Baiocchi L., et al. Complete weaning off immunosuppression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence. J Hepatol 44 4 (2006) 702-709
32. Demetris A.J., Eghtesad B., Marcos A., Ruppert K., Nalesnik M.A., Randhawa P., et al. Recurrent hepatitis C in liver allografts: prospective assessment of diagnostic accuracy, identification of pitfalls, and observations about pathogenesis. Am J Surg Pathol 28 5 (2004) 658-669
33. Eghtesad B., Fung J.J., Demetris A.J., Murase N., Ness R., Bass D.C., et al. Immunosuppression for liver transplantation in HCV-infected patients: mechanism-based principles. Liver Transpl 11 11 (2005) 1343-1352
34. Marcos A., Eghtesad B., Fung J.J., Fontes P., Patel K., deVera M., et al. Use of alemtuzumab and tacrolimus monotherapy for cadaveric liver transplantation: with particular reference to hepatitis C virus. Transplantation 78 7 (2004) 966-971
35. Reding R., Gras J., Truong D.Q., Wieers G., and Latinne D. The immunological monitoring of alloreactive responses in liver transplant recipients: a review. Liver Transpl 12 3 (2006) 373-383
36. Thomson A.W., Mazariegos G.V., Reyes J., Donnenberg V.S., Donnenberg A.D., Bentlejewski C., et al. Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients. Transplantation 72 8 Suppl (2001) S13-S22
37. Yoshizawa A., Ito A., Li Y., Koshiba T., Sakaguchi S., Wood K.J., et al. The roles of CD25+CD4+ regulatory T cells in operational tolerance after living donor liver transplantation. Transplant Proc 37 1 (2005) 37-39
38. Morelli A.E., and Thomson A.W. Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol Rev 196 (2003) 125-146
39. Kuwana M., Kaburaki J., Wright T.M., Kawakami Y., and Ikeda Y. Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors. Eur J Immunol 31 9 (2001) 2547-2557
40. Mazariegos G.V., Zahorchak A.F., Reyes J., Chapman H., Zeevi A., and Thomson A.W. Dendritic cell subset ratio in tolerant, weaning and non-tolerant liver recipients is not affected by extent of immunosuppression. Am J Transplant 5 2 (2005) 314-322
41. Holweg C.T., Weimar W., Uitterlinden A.G., and Baan C.C. Clinical impact of cytokine gene polymorphisms in heart and lung transplantation. J Heart Lung Transplant 23 9 (2004) 1017-1026
42. Marder B., Schroppel B., and Murphy B. Genetic variability and transplantation. Curr Opin Urol 13 2 (2003) 81-89
43. Marshall S.E., and Welsh K.I. The role of cytokine polymorphisms in rejection after solid organ transplantation. Genes Immun 2 6 (2001) 297-303
44. Awad M.R., Webber S., Boyle G., Sturchio C., Ahmed M., Martell J., et al. The effect of cytokine gene polymorphisms on pediatric heart allograft outcome. J Heart Lung Transplant 20 6 (2001) 625-630
45. Ternstrom L., Jeppsson A., Ricksten A., and Nilsson F. Tumor necrosis factor gene polymorphism and cardiac allograft vasculopathy. J Heart Lung Transplant 24 4 (2005) 433-438
46. Mazariegos G.V., Reyes J., Webber S.A., Thomson A.W., Ostrowski L., Abmed M., et al. Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation. Transplantation 73 8 (2002) 1342-1345