The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotransplantation

American Journal of Transplantation

Volumn 5, Issue 3, 2005, Pages 608-613

  Tryphonopoulos, Panagiotis ^a   Tzakis, Andreas G ^a   Weppler, Debbie ^a   Garcia Morales, Rolando ^a   Kato, Tomoaki ^a   Madariaga, Juan R ^a   Levi, David M ^a   Nishida, Seigo ^a   Moon, Jang ^a   Selvaggi, Gennaro ^a   Regev, Arie ^a   Nery, Caio ^a   Bejarano, Pablo ^b   Khaled, Amr ^b   Kleiner, Gary ^a   Esquenazi, Violet ^a   Miller, Joshua ^a   Ruiz, Philip ^a,b   Ricordi, Camillo ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b JACKSON MEMORIAL HOSPITAL   (United States)

Author keywords

Donor bone narrow infusion; Immunosuppression withdrawal; Liver transplantation; Tolerance

Indexed keywords

ANTIVIRUS AGENT; CYCLOSPORIN A; METHYLPREDNISOLONE SODIUM SUCCINATE; OKT 3; RAPAMYCIN; TACROLIMUS;

ADULT; ARTICLE; BASAL CELL CARCINOMA; BONE MARROW TRANSPLANTATION; CHIMERA; CONTROLLED STUDY; FEMALE; GRAFT SURVIVAL; HERPES ZOSTER; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

BONE MARROW TRANSPLANTATION; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; LIVER TRANSPLANTATION; MALE; TIME FACTORS; TISSUE DONORS;

EID: 20044361820     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2004.00743.x     Document Type: Article

References (20)

1. Ojo AO, Held PJ, Port FK et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 2003; 349: 931-940.
2. Wekerle T, Blaha P, Koporc Z et al. Mechanisms of tolerance induction through the transplantation of donor hematopoietic stem cells: central versus peripheral tolerance. Transplantation 2003; 75: 21S-25S.
3. Starzl TE, Demetris AJ, Murase N et al. Cell migration, chimerism and graft acceptance. Lancet 1992; 339: 1579-1582.
4. Rugeles MT, Aitouche A, Zeevi A et al. Evidence for the presence of multilineage chimerism and progenitors of donor dendritic cells in the peripheral blood of bone-marrow augmented organ transplant recipients. Transplantation 1997; 64: 735-741.
5. Fontes P, Rao AS, Demetris AJ et al. Bone marrow augmentation of donor cell chimerism in kidney, liver, heart and pancreas islet transplantation. Lancet 1994; 344: 151-155.
6. Garcia-Morales R, Mathew JM, Carreno M et al. Continuing observations on the regulatory effects of donor-specific bone marrow cell infusions and chimerism in kidney transplant recipients. Transplantation 1997; 65: 956-965.
7. Ricordi C, Karatzas T, Nery J et al. High dose donor bone marrow infusions to enhance allograft survival. Transplantation 2001; 63: 7-11.
8. Barber WH, Mankin JA, Laskow DA et al. Long term results of a controlled prospective study with transfusion of donor-specific bone marrow in 57 cadaveric renal allograft recipients. Transplantation 1991; 51: 70-75.
9. Ciancio G, Miller J, Garcia-Morales R et al. Six year clinical effect of donor bone marrow infusions in renal transplant patients. Transplantation 2001; 71: 827-835.
10. Monaco AP, Medawar P. Chimerism in organ transplantation: conflicting experiments and clinical observations. Transplantation 2003; 75: 13S-16S.
11. Ramos HC, Reyes J, Abu-Elmagd K et al. Weaning of immunosuppression in long-term liver transplant patients. Transplantation 1995; 59: 212-217.
12. Mazariegos GV, Reyes J, Marino IR et al. Weaning of immunosuppression in liver transplant patients. Transplantation 1997; 63: 243-249.
13. Taniguchi H, Toyoshima T, Fukao K, Nakauchi H. Presence of hematopoietic stem cells in the adult liver. Nat Med 1996; 2: 198-203.
14. Strober SLR, Shizuru JA, Scandling JD, Millan MT et al. Approaches to transplantation tolerance in humans. Transplantation 2004; 77: 932-936.
15. Umemura AMH, Li XC, Tahan S, Monaco AP, Maki T. Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation. J Immunol 2001; 167: 3043-3048.
16. Higuchi MZD, Shizuru J, Gworek J, Dejbakhsh-Jones S, Taniguchi M, Strober S. Immune tolerance to combined organ and bone marrow transplants after fractionated lymphoid irradiation involves regulatory NK T cells and clonal deletion. J Immunol 2002; 169: 5564-5570.
17. Elwood ETLC, Maurer DH, Routenberg KL et al. Microchimerism and rejection in clinical transplantation. Lancet 1997; 349: 1358-1360.
18. Hisanaga MHJ, Boker K, Uthoff K et al. Development, stability, and clinical correlations of allogeneic microchimerism after solid organ transplantation. Transplantation 1996; 61: 40-45.
19. Buhler LHST, Sykes M, Sachs DH et al. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation 2002; 74: 1405-1409.
20. Xu HCP, Huang Y, Schanie CL, Ildstad ST. Production of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism. J Immunol 2004; 172: 1463-1471.