Microvascular Dysfunction as Opposed to Conduit Artery Disease Explains Sex-specific Chest Pain in Emergency Department Patients with Low to Moderate Cardiac Risk

Clinical Therapeutics

Volumn 38, Issue 2, 2016, Pages 240-255.e1

  Safdar, Basmah ^a,d   Ali, Asad ^b   D'Onofrio, Gail ^a   Katz, Stuart D ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Department of Emergency Medicine ^*  (United States)

Author keywords

brachial artery reactivity; chest pain; emergency department; reactive hyperemia; sex difference

Indexed keywords

ACUTE CORONARY SYNDROME; ARTERY DIAMETER; ARTICLE; BLOOD FLOW VELOCITY; BRACHIAL ARTERY; CARDIOVASCULAR RISK; COHORT ANALYSIS; CONDUIT ARTERY DISEASE; CONTROLLED STUDY; EMERGENCY WARD; FEMALE; HUMAN; HYPEREMIA; MAJOR CLINICAL STUDY; MALE; MICROANGIOPATHY; PROSPECTIVE STUDY; SEX DIFFERENCE; THORAX PAIN; VASODILATATION; ADULT; BLOOD PRESSURE; CASE CONTROL STUDY; CHEST PAIN; CORONARY ARTERY DISEASE; HOSPITAL EMERGENCY SERVICE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; RISK FACTOR; VASCULAR ENDOTHELIUM;

ADULT; BLOOD PRESSURE; BRACHIAL ARTERY; CASE-CONTROL STUDIES; CHEST PAIN; COHORT STUDIES; CORONARY ARTERY DISEASE; EMERGENCY SERVICE, HOSPITAL; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPEREMIA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; VASODILATION;

EID: 84953432687     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2015.12.010     Document Type: Article

References (50)

1. D. Lloyd-Jones, R.J. Adams, T.M. Brown, and et al. Executive summary: heart disease and stroke statistics - 2010 update: a report from the American Heart Association Circulation 121 2010 948 954
2. S.E. Reis, R. Holubkov, A.J. Conrad Smith, and et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study Am Heart J 141 2001 735 741
3. J.C. Dumville, H. MacPherson, K. Griffith, and et al. Non-cardiac chest pain: a retrospective cohort study of patients who attended a Rapid Access Chest Pain Clinic Fam Pract 24 2007 152 157
4. G.H. Eifert, S.E. Hodson, D.R. Tracey, and et al. Heart-focused anxiety, illness beliefs, and behavioral impairment: comparing healthy heart-anxious patients with cardiac and surgical inpatients J Behav Med 19 1996 385 399
5. A.J. Fagring, K.I. Kjellgren, A. Rosengren, and et al. Depression, anxiety, stress, social interaction and health-related quality of life in men and women with unexplained chest pain BMC Public Health 8 2008 165
6. B. Safdar, J. Dziura, H. Bathulapalli, and et al. Chest pain syndromes are associated with high rates of recidivism and costs in young United States Veterans BMC Fam Pract 16 2015 88
7. D.S. Celermajer, K.E. Sorensen, V.M. Gooch, and et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis Lancet 340 1992 1111 1115
8. E.J. Benjamin, M.G. Larson, M.J. Keyes, and et al. Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study Circulation 109 2004 613 619
9. J.A. Vita, C.B. Treasure, E.G. Nabel, and et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease Circulation 81 1990 491 497
10. I.J. Kullo, A.R. Malik, S. Santos, and et al. Association of cardiovascular risk factors with microvascular and conduit artery function in hypertensive subjects Am J Hypertens 20 2007 735 742
11. J. Yeboah, J.R. Crouse, F.C. Hsu, and et al. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study Circulation 115 2007 2390 2397
12. Y. Matsuzawa, T.G. Kwon, R.J. Lennon, and et al. Prognostic value of flow-mediated vasodilation in brachial artery and fingertip artery for cardiovascular events: a systematic review and meta-analysis J Am Heart Assoc 4 2015 11
13. B. Takase, A. Uehata, T. Akima, and et al. Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease Am J Cardiol 82 1535-1539 1998 A1537 A1538
14. T.J. Anderson, A. Uehata, M.D. Gerhard, and et al. Close relation of endothelial function in the human coronary and peripheral circulations J Am Coll Cardiol 26 1995 1235 1241
15. J.A. Suwaidi, S. Hamasaki, S.T. Higano, and et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction Circulation 101 2000 948 954
16. V. Schachinger, M.B. Britten, and A.M. Zeiher Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease Circulation 101 2000 1899 1906
17. J. Dupuis, J.C. Tardif, P. Cernacek, and P. Theroux Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial Circulation 99 1999 3227 3233
18. L.M. Title, P.M. Cummings, K. Giddens, and et al. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease J Am Coll Cardiol 36 2000 758 765
19. H. Korkmaz, and O. Onalan Evaluation of endothelial dysfunction: flow-mediated dilation Endothellium 15 2008 157 163
20. D. Tousoulis, C. Simopoulou, N. Papageorgiou, and et al. Endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches Pharmacol Ther 144 2014 253 267
21. B.D. Johnson, L.J. Shaw, C.J. Pepine, and et al. Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study Eur Heart J 27 2006 1408 1415
22. L.J. Shaw, C.N. Merz, C.J. Pepine, and et al. The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health - National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation Circulation 114 2006 894 904
23. R.A. Harris, S.K. Nishiyama, D.W. Wray, and R.S. Richardson Ultrasound assessment of flow-mediated dilation Hypertension 55 2010 1075 1085
24. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) JAMA 285 2001 2486 2497
25. G.F. Mitchell, J.A. Vita, M.G. Larson, and et al. Cross-sectional relations of peripheral microvascular function, cardiovascular disease risk factors, and aortic stiffness: the Framingham Heart Study Circulation 112 2005 3722 3728
26. D.S. Celermajer, K.E. Sorensen, D.J. Spiegelhalter, and et al. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women J Am Coll Cardiol 24 1994 471 476
27. Y. Iwamoto, T. Maruhashi, Y. Fujii, and et al. Intima-media thickness of brachial artery, vascular function, and cardiovascular risk factors Arterioscler Thromb Vasc Biol 32 2012 2295 2303
28. M. Sarabi, J. Millgard, and L. Lind Effects of age, gender and metabolic factors on endothelium-dependent vasodilation: a population-based study J Intern Med 246 1999 265 274
29. G.F. Mitchell, H. Parise, E.J. Benjamin, and et al. Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study [see comment] Hypertension 43 2004 1239 1245
30. R.C. Webb, N.J. Rusch, and P.M. Vanhoutte Influence of sex difference and oral contraceptives on forearm reactive hyperemia Blood Vessels 18 1981 161 170
31. M.C. McCue, K.L. Marlatt, A.S. Kelly, and et al. Evaluation of gender differences in endothelium-independent dilation using peripheral arterial tonometry Clin Physiol Funct Imaging 32 2012 94 98
32. G.F. Mitchell, H. Parise, J.A. Vita, and et al. Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study Hypertension 44 2004 134 139
33. S.S. Segal Regulation of blood flow in the microcirculation Microcirculation 12 2005 33 45
34. C.K. Kim, S.P. McGorray, B.A. Bartholomew, and et al. Depressive symptoms and heart rate variability in postmenopausal women Arch Intern Med 165 2005 1239 1244
35. AHRQ Women Dominate Hospitalizations for Chest Pain With No Known Cause November 20, 2008 Agency for Healthcare Research and Quality Rockville
36. A. Phan, C. Shufelt, and C.N. Merz Persistent chest pain and no obstructive coronary artery disease JAMA 301 2009 1468 1474
37. O. Wexler, M.A. Morgan, M.S. Gough, and et al. Brachial artery reactivity in patients with severe sepsis: an observational study Crit Care 16 2012 R38
38. L. Lind Endothelium-dependent vasodilation, insulin resistance and the metabolic syndrome in an elderly cohort: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study Atherosclerosis 196 2008 795 802
39. A.L. Huang, A.E. Silver, E. Shvenke, and et al. Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery Arterioscler Thromb Vasc Biol 27 2007 2113 2119
40. T.J. Anderson, A.C. Roberts, K. Hildebrand, and et al. The fate of endothelial function testing: rationale and design of the Firefighters And Their Endothelium (FATE) study Can J Cardiol 19 2003 61 66
41. M. Dhindsa, S.M. Sommerlad, A.E. DeVan, and et al. Interrelationships among noninvasive measures of postischemic macro- and microvascular reactivity J Appl Physiol 105 2008 427 432
42. J.A. Vita, J.F. Keaney Jr., M.G. Larson, and et al. Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study Circulation 110 2004 3604 3609
43. P.G. Camici, G. d'Amati, and O. Rimoldi Coronary microvascular dysfunction: mechanisms and functional assessment Nat Rev Cardiol 12 2015 48 62
44. G.O. von Mering, C.B. Arant, T.R. Wessel, and et al. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Circulation 109 2004 722 725
45. C.J. Pepine, R.D. Anderson, B.L. Sharaf, and et al. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) study J Am Coll Cardiol 55 2010 2825 2832
46. M. Gulati, R.M. Cooper-DeHoff, C. McClure, and et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women's Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project Arch Intern Med 169 2009 843 850
47. L. Jespersen, A. Hvelplund, S.Z. Abildstrom, and et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events Eur Heart J 33 2012 734 744
48. T.L. Sedlak, M. Lee, M. Izadnegahdar, and et al. Sex differences in clinical outcomes in patients with stable angina and no obstructive coronary artery disease Am Heart J 166 2013 38 44
49. G. Guarini, A. Huqi, D. Morrone, and et al. Pharmacological approaches to coronary microvascular dysfunction Pharmacol Ther 144 2014 283 302
50. M.A. Marinescu, A.I. Loffler, M. Ouellette, and et al. Coronary microvascular dysfunction, microvascular angina, and treatment strategies JACC. Cardiovascular imaging 8 2015 210 220