Theoretical Considerations of the Prigogine-Defay Ratio with Regard to the Glass-Forming Ability of Drugs from Undercooled Melts

Molecular Pharmaceutics

Volumn 13, Issue 1, 2016, Pages 241-250

  Wyttenbach, Nicole ^a   Kirchmeyer, Wiebke ^b,c   Alsenz, Jochem ^a   Kuentz, Martin ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

amorphous drug; crystallization tendency; glass forming ability; in silico prediction; undercooled melt

Indexed keywords

ANTHRANILIC ACID; ATENOLOL; ATOVAQUONE; BENZAMIDE; BENZOCAINE; BIFONAZOLE; CAFFEINE; CELECOXIB; CHLORZOXAZONE; CINNARIZINE; CLOFIBRIC ACID; DIFLUNISAL; FENOFIBRATE; FLUFENAMIC ACID; FLURBIPROFEN; GLASS; INDOPROFEN; MEFENAMIC ACID; NAPROXEN; NEPAFENAC; NIFEDIPINE; NIMESULIDE; PARACETAMOL; PHENACETIN; PIROXICAM; PROBENECID; SACCHARIN; SALICYLIC ACID; THEOPHYLLINE; TOLFENAMIC ACID;

ARTICLE; CHEMICAL REACTION; COMPUTER MODEL; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG FORMULATION; ENTHALPY; ENTROPY; EVAPORATION; GLASS FORMING ABILITY; GLASS TRANSITION TEMPERATURE; HYDROGEN BOND; MELTING POINT; MOLECULAR DYNAMICS; MOLECULAR SIZE; MOLECULAR WEIGHT; PRIGOGINE DEFAY RATIO; PRIORITY JOURNAL; THERMOGRAVIMETRY; CHEMISTRY; COMPUTER SIMULATION; DRUG STABILITY; MEDICINAL CHEMISTRY; PROCEDURES; TRANSITION TEMPERATURE;

CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; CRYSTALLIZATION; DRUG STABILITY; GLASS; HYDROGEN BONDING; TRANSITION TEMPERATURE;

EID: 84953410937     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00688     Document Type: Article

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