Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways

Oncotarget

Volumn 6, Issue 42, 2015, Pages 44422-44436

  Wang, Lu Qian ^a   Wong, Kwan Yeung ^a   Rosèn, Anders ^b   Chim, Chor Sang ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Chronic lymphocytic leukemia; DNA methylation; microRNA; MiR 3151; Tumor suppressor

Indexed keywords

MAP KINASE ACTIVATING DEATH DOMAIN; MESSENGER RNA; MICRORNA 3151; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOINOSITIDE 3 KINASE REGULATORY SUBUNIT 2; PROTEIN KINASE B; PROTEIN MCL 1; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; AZACITIDINE; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DECITABINE; DNA METHYLTRANSFERASE; ENZYME INHIBITOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MADD PROTEIN, HUMAN; MCL1 PROTEIN, HUMAN; MICRORNA; MIRN203 MICRORNA, HUMAN; MIRN3151 MICRORNA, HUMAN; MIRN34 MICRORNA, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITOL-3 KINASE REGULATORY SUBUNIT 2, HUMAN;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHINESE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; FEMALE; GENE LOCUS; GENE SILENCING; GENE TARGETING; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MADD GENE; MAJOR CLINICAL STUDY; MALE; PIK3R2 GENE; PROMOTER REGION; SIGNAL TRANSDUCTION; TUMOR GENE; 3' UNTRANSLATED REGION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; ASIAN CONTINENTAL ANCESTRY GROUP; BINDING SITE; CHINA; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC TRANSFECTION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; RNA INTERFERENCE; TUMOR CELL LINE; VERY ELDERLY;

3' UNTRANSLATED REGIONS; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; ASIAN CONTINENTAL ANCESTRY GROUP; AZACITIDINE; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; CHINA; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DNA METHYLATION; DNA MODIFICATION METHYLASES; ENZYME ACTIVATION; ENZYME INHIBITORS; EPIGENESIS, GENETIC; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MICRORNAS; MIDDLE AGED; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84953385928     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6251     Document Type: Article

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