OCT4 activity during conversion of human intermediately reprogrammed stem cells to iPSCs through mesenchymalepithelial transition

Development (Cambridge)

Volumn 143, Issue 1, 2016, Pages 15-23

  Teshigawara, Rika ^a   Hirano, Kunio ^a   Nagata, Shogo ^a   Ainscough, Justin ^b   Tada, Takashi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF YORK   (United Kingdom)

Author keywords

CRISPR; Human; IPS; MET; OCT4; Reprogramming

Indexed keywords

KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR FOXC1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; KRUPPEL LIKE FACTOR; MYC PROTEIN, HUMAN; NANOG PROTEIN, HUMAN; POU5F1 PROTEIN, HUMAN; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX;

ARTICLE; CELL DIVISION; CELL STRUCTURE; CONTROLLED STUDY; CRISPR CAS SYSTEM; EPITHELIAL MESENCHYMAL TRANSITION; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; CELL LINE; CELL TRANSDIFFERENTIATION; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CYTOLOGY; ENZYME ACTIVATION; EPITHELIUM CELL; GENETICS; INDUCED PLURIPOTENT STEM CELL; MESENCHYMAL STROMA CELL; METABOLISM; PHYSIOLOGY;

CELL DIVISION; CELL LINE; CELL TRANSDIFFERENTIATION; CELLULAR REPROGRAMMING; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; ENZYME ACTIVATION; EPITHELIAL CELLS; GREEN FLUORESCENT PROTEINS; HOMEODOMAIN PROTEINS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MESENCHYMAL STROMAL CELLS; OCTAMER TRANSCRIPTION FACTOR-3; PROTO-ONCOGENE PROTEINS C-MYC; SOXB1 TRANSCRIPTION FACTORS;

EID: 84953379368     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.130344     Document Type: Article

References (33)

1. Brambrink, T., Foreman, R.,Welstead, G. G., Lengner, C. J.,Wernig, M., Suh, H. and Jaenisch, R. (2008). Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2, 151-159.
2. Buecker, C., Chen, H.-H., Polo, J. M., Daheron, L., Bu, L., Barakat, T. S., Okwieka, P., Porter, A., Gribnau, J., Hochedlinger, K. et al. (2010). A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells. Cell Stem Cell 6, 535-546.
3. Buganim, Y., Faddah, D. A., Cheng, A. W., Itskovich, E., Markoulaki, S., Ganz, K., Klemm, S. L., van Oudenaarden, A. and Jaenisch, R. (2012). Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 150, 1209-1222.
4. Chen, J., Liu, H., Liu, J., Qi, J., Wei, B., Yang, J., Liang, H., Chen, Y., Chen, J., Wu, Y., et al. (2013). H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat. Genet. 45, 34-42.
5. Cheng, L.-T., Sun, L.-T. and Tada, T. (2012). Genome editing in induced pluripotent stem cells. Genes Cells 17, 431-438.
6. Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A. et al. (2013). Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823.
7. Greder, L. V., Gupta, S., Li, S., Abedin, M. J., Sajini, A., Segal, Y., Slack, J. M.W. and Dutton, J. R. (2012). Analysis of endogenous Oct4 activation during induced pluripotent stem cell reprogramming using an inducible Oct4 lineage label. Stem Cells 30, 2596-2601.
8. Hecker, K. H. and Roux, H. (1996). High and low annealing temperatures increase both specificity and yield in touchdown and stepdown PCR. Biotechniques 20, 478-485.
9. Hirano, K., Nagata, S., Yamaguchi, S., Nakagawa, M., Okita, K., Kotera, H., Ainscough, J. and Tada, T. (2012). Human and mouse induced pluripotent stem cells are differentially reprogrammed in response to kinase inhibitors. Stem Cells Dev. 21, 1287-1298.
10. Hochedlinger, K. and Plath, K. (2009). Epigenetic reprogramming and induced pluripotency. Development 136, 509-523.
11. Hockemeyer, D., Wang, H., Kiani, S., Lai, C. S., Gao, Q., Cassady, J. P., Cost, G. J., Zhang, L., Santiago, Y., Miller, J. C. et al. (2011). Genetic engineering of human pluripotent cells using TALE nucleases. Nat. Biotechnol. 29, 731-734.
12. Hotta, A. and Ellis, J. (2008). Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states. J. Cell Biochem. 105, 940-948.
13. Hu, G., Kim, J., Xu, Q., Leng, Y., Orkin, S. H. and Elledge, S. J. (2009). A genomewide RNAi screen identifies a new transcriptional module required for selfrenewal. Genes Dev. 23, 837-848.
14. Kuroda, T., Tada, M., Kubota, H., Kimura, H., Hatano, S.-y., Suemori, H., Nakatsuji, N. and Tada, T. (2005). Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol. Cell. Biol. 25, 2475-2485.
15. Li, R., Liang, J., Ni, S., Zhou, T., Qing, X., Li, H., He, W., Chen, J., Li, F., Zhuang, Q. et al. (2010). A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 7, 51-63.
16. Nagata, S., Hirano, K., Kanemori, M., Sun, L.-T. and Tada, T. (2012). Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells. PLoS ONE 7, e48699.
17. Nishimura, K., Kato, T., Chen, C., Oinam, L., Shiomitsu, E., Ayakawa, D., Ohtaka, M., Fukuda, A., Nakanishi, M. and Hisatake, K. (2014). Manipulation of KLF4 expression generates iPSCs paused at successive stages of reprogramming. Stem Cell Rep. 3, 915-929.
18. Ohgushi, M. and Sasai, Y. (2011). Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states. Trends Cell Biol. 21, 274-282.
19. Polo, J. M. and Hochedlinger, K. (2010). When fibroblasts MET iPSCs. Cell Stem Cell 7, 5-6.
20. Polo, J. M., Anderssen, E., Walsh, R. M., Schwarz, B. A., Nefzger, C. M., Lim, S. M., Borkent, M., Apostolou, E., Alaei, S., Cloutier, J. et al. (2012). A molecular roadmap of reprogramming somatic cells into iPS cells. Cell 151, 1617-1632.
21. Saitou, M., Barton, S. C. and Surani, M. A. (2002). A molecular programme for the specification of germ cell fate in mice. Nature 418, 293-300.
22. Samavarchi-Tehrani, P., Golipour, A., David, L., Sung, H.-k., Beyer, T. A., Datti, A.,Woltjen, K., Nagy, A. andWrana, J. L. (2010). Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell 7, 64-77.
23. Silva, J., Barrandon, O., Nichols, J., Kawaguchi, J., Theunissen, T. W. and Smith, A. (2008). Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol. 6, e253.
24. Stadtfeld, M. and Hochedlinger, K. (2010). Induced pluripotency: history, mechanisms, and applications. Genes Dev. 24, 2239-2263.
25. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861-872.
26. Tanaka, Y., Hysolli, E., Su, J., Xiang, Y., Kim, K.-Y., Zhong, M., Li, Y., Heydari, K., Euskirchen, G., Snyder, M. P. et al. (2015). Transcriptome signature and regulation in human somatic cell reprogramming. Stem Cell Rep. 4, 1125-1139.
27. Theunissen, T.W., van Oosten, A. L., Castelo-Branco, G., Hall, J., Smith, A. and Silva, J. C. R. (2011). Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr. Biol. 21, 65-71.
28. Tonge, P. D., Corso, A. J., Monetti, C., Hussein, S. M. I., Puri, M. C., Michael, I. P., Li, M., Lee, D.-S., Mar, J. C., Cloonan, N. et al. (2014). Divergent reprogramming routes lead to alternative stem-cell states. Nature 516, 192-197.
29. Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J. B., Nishikawa, S., Nishikawa, S.-i., Muguruma, K. et al. (2007). A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat. Biotechnol. 25, 681-686.
30. Wernig, M., Lengner, C. J., Hanna, J., Lodato, M. A., Steine, E., Foreman, R., Staerk, J., Markoulaki, S. and Jaenisch, R. (2008). A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat. Biotechnol. 26, 916-924.
31. Wolf, D. and Goff, S. P. (2007). TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells. Cell 131, 46-57.
32. Yamanaka, S. (2009). Elite and stochastic models for induced pluripotent stem cell generation. Nature 460, 49-52.
33. Yang, J., Gao, C., Chai, L. and Ma, Y. (2010). A novel SALL4/OCT4 transcriptional feedback network for pluripotency of embryonic stem cells. PLoS ONE 5, e10766.