Human bone marrow-derived stem cell proliferation is inhibited by hepatocyte growth factor via increasing the cell cycle inhibitors p53, p21 and p27

Bone

Volumn 49, Issue 6, 2011, Pages 1194-1204

  Chen, Ketian ^a,b   Perez Stable, Carlos ^a,b   D'Ippolito, Gianluca ^a,b   Schiller, Paul C ^a,b   Roos, Bernard A ^a,b   Howard, Guy A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

1,25 dihydroxyvitamin D; Hepatocyte growth factor; Mesenchymal stem cell; Osteoprogenitors; Stem cell

Indexed keywords

CALCITRIOL; PROTEIN P21; PROTEIN P27; PROTEIN P53; SCATTER FACTOR; SMALL INTERFERING RNA;

ADULT; APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL MATURATION; CELL PROLIFERATION; CHILD; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MALE; NONHUMAN; OSTEOBLAST; PHENOTYPE; PRESCHOOL CHILD; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AGED; APOPTOSIS; BONE MARROW CELLS; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD; CHILD, PRESCHOOL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; HEPATOCYTE GROWTH FACTOR; HUMANS; MALE; MIDDLE AGED; OSTEOGENESIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MET; RETINOBLASTOMA PROTEIN; STEM CELLS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; VITAMIN D; YOUNG ADULT;

EID: 81355127653     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.08.023     Document Type: Article

References (41)

1. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
2. Kratchmarova I., Blagoev B., Haack-Sorensen M., Kassem M., Mann M. Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation. Science 2005, 308:1472-1477.
3. Kramperaa M., Marconib S., Pasinia A., Galièc M., Rigottid G., Mosnaa F., et al. Induction of neural-like differentiation in human mesenchymal stem cells derived from bone marrow, fat, spleen and thymus. Bone 2007, 40:382-390.
4. Stuart K.A., Riordan S.M., Lidder S., Crostella L., Williams R., Skouteris G.G. Hepatocyte growth factor/scatter factor-induced intracellular signalling. Int J Exp Pathol 2000, 81:17-30.
5. Takai K., Hara J., Matsumoto K., Hosoi G., Osugi Y., Tawa A., et al. Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis. Blood 1997, 89:1560-1565.
6. Grano M., Galimi F., Zambonin G., Colucci S., Cottone E., Zallone A.Z., et al. Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro. Proc Natl Acad Sci USA 1996, 93:7644-7648.
7. Hammond D.E., Carter S., Clague M.J. Met receptor dynamics and signaling. Curr Top Microbiol Immunol 2004, 286:21-44.
8. Forte G., Minieri M., Cossa P., Antenucci D., Sala M., Gnocchi V., et al. Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells 2006, 24:23-33.
9. D'Ippolito G., Schiller P.C., Perez-Stable C., Balkan W., Roos B.A., Howard G.A. Cooperative action of hepatocyte growth factor and 1,25-dihydroxyvitamin D3 in osteoblastic differentiation of human vertebral bone marrow stromal cells. Bone 2002, 31:269-275.
10. Qadan L.R., Perez-Stable C.M., Schwall R.H., Burnstein K.L., Ostenson R.C., Howard G.A., et al. Hepatocyte growth factor and vitamin D cooperatively inhibit androgen-unresponsive prostate cancer cell lines. Endocrinology 2000, 141:2567-2573.
11. Grumbles R.M., Howell D.S., Wenger L., Altman R.D., Howard G.A., Roos B.A. Hepatocyte growth factor and its actions in growth plate chondrocytes. Bone 1996, 19:255-261.
12. Liu M.L., Mars W.M., Michalopoulos G.K. Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine. Carcinogenesis 1995, 16:841-843.
13. Han J., Tsukada Y., Hara E., Kitamura N., Tanaka T. Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem 2005, 280:31548-31556.
14. Shirako E., Hirayama N., Tsukada Y., Tanaka T., Kitamura N. Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation. J Cell Biochem 2008, 104:176-188.
15. Blanquaert F., Delany A.M., Canalis E. Fibroblast growth factor-2 induces hepatocyte growth factor/scatter factor expression in osteoblasts. Endocrinology 1999, 140:1069-1074.
16. Schwartz R.E., Reyes M., Koodie L., Jiang Y., Blackstad M., Lund T., et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002, 109:1291-1302.
17. Oh S.-H., Miyazaki M., Kouchi H., Inoue Y., Sakaguchi M., Tsuji T., et al. Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. Biochem Biophys Res Commun 2000, 279:500-504.
18. Okumoto K., Saito T., Hattori E., Ito J.-I., Adachi T., Takeda T., et al. Differentiation of bone marrow cells into cells that express liver-specific genes in vitro: implication of the Notch signals in differentiation. Biochem Biophys Res Commun 2003, 304:691-695.
19. Schuldiner M., Yanuka O., Itskovitz-Eldor J., Melton D.A., Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci, USA 2000, 97:11307-11312.
20. Neuss S., Becher E., Wöltje M., Tietze L., Jahnen-Dechent W. Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells 2004, 22:405-414.
21. 3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. Am J Physiol Endocrinol Metab 2003, 284:E219-E227.
22. D'Ippolito G., Schiller P.C., Ricordi C., Roos B.A., Howard G.A. Age-related osteogenic potential of mesenchymal stromal stem cells from human vertebral bone marrow. J Bone Miner Res 1999, 14:1115-1122.
23. Gillies R.J., Didier N., Denton M. Determination of cell number in monolayer cultures. Anal Biochem 1986, 159:109-113.
24. Krishan A. Rapid DNA content analysis by the propidium iodide-hypotonic citrate method. Methods Cell Biol 1990, 33:121-125.
25. Schiller P.C., D'Ippolito G., Balkan W., Roos B.A., Howard G.A. Gap-junctional communication is required for the maturation process of osteoblastic cells in culture. Bone 2001, 28:362-369.
26. Schiller P.C., D'Ippolito G., Brambilla R., Roos B.A., Howard G.A. Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to adipocytes in vitro. J Biol Chem 2001, 276:14133-14138.
27. Brambilla R., Neary J.T., Cattabeni F., Cottini L., D'Ippolito G., Schiller P.C., et al. Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical ostrocytes is dependent on REK1/2 but independent of calcium signaling. J Neurochem 2002, 83:1285-1296.
28. Yang H., Magilnick N., Noureddin M., Mato M.J., Lu C.S. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. J Cellular Physiology 2007, 210:773-776.
29. Itahana K., Campisi J., Dimri G.P. Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol 2007, 371:21-31.
30. Nevins J.R. Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth Differ 1998, 9:585-593.
31. Harbour J.W., Dean D.C. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 2000, 14:2393-2409.
32. Resnick-Silverman L., St Clair S., Maurer M., Zhao K., Manfredi J.J. Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53. Genes Dev 1998, 12:2102-2107.
33. Fausto N., Laird A.D., Webber E.M. Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration. FASEB J 1995, 9:1527-1536.
34. Matsumoto K., Nakamura T. Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions. Crit Rev Oncog 1992, 3:27-54.
35. Verlinden L., Verstuyf A., Convents R., Marcelis S., Van Camp M., Bouillon R. Action of 1,25(OH)2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells. Mol Cell Endocrinol 1998, 142:57-65.
36. Tulasne D., Foveau B. The shadow of death on the MET tyrosine kinase receptor. Cell Death Differ 2008, 15:427-434.
37. 3 on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1α-hydroxylase. J Bone Miner Res 2011, 26:1145-1153.
38. 3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev 1996, 10:142-152.
39. Valtieri M., Sorrentino A. The mesenchymal stromal cell contribution to homeostasis. J Cell Physiol 2008, 217:296-300.
40. Baksh D., Song L., Tuan R.S. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 2004, 8:301-316.
41. Puetzer J.L., Petitte J.N., Loboa E.G. Comparative review of growth factors for induction of three-dimensional in vitro chondrogenesis in human mesenchymal stem cells isolated from bone marrow and adipose tissue. Tissue Eng Part B Rev 2010, 16:435-444.