Proteomic analysis of integrin-associated complexes from mesenchymal stem cells

Proteomics - Clinical Applications

Volumn 10, Issue 1, 2016, Pages 51-57

  Ajeian, Jila N ^a   Horton, Edward R ^a   Astudillo, Pablo ^a   Byron, Adam ^a,c   Askari, Janet A ^a   Millon Frémillon, Angélique ^a   Knight, David ^b   Kimber, Susan J ^b   Humphries, Martin J ^a   Humphries, Jonathan D ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Extracellular matrix; Integrin; LIM domain; Mechanotransduction; Mesenchymal stem cell

Indexed keywords

ALPHA5 INTEGRIN; BETA1 INTEGRIN; FIBRONECTIN; INTEGRIN; INTEGRIN LINKED KINASE; LIM PROTEIN; TALIN; VINCULIN;

CELL FATE; CELL SPREADING; COMPLEX FORMATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MECHANOTRANSDUCTION; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEOMICS; REVIEW; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; PROTEIN DATABASE;

DATABASES, PROTEIN; HUMANS; INTEGRINS; MESENCHYMAL STROMAL CELLS; PROTEOMICS;

EID: 84953366095     PISSN: 18628346     EISSN: 18628354     Source Type: Journal    
DOI: 10.1002/prca.201500033     Document Type: Review

References (37)

1. Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K. et al., Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284, 143-147.
2. Caplan, A. P. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J. Cell. Physiol. 2007, 213, 341-347.
3. Keating, A. Mesenchymal stromal cells: new directions. Cell Stem Cell 2012, 10, 709716.
4. Tschumperlin, D. J., Liu, F., Tager, A. M. Biomechanical regulation of mesenchymal cell function. Curr. Opin. Rheumatol. 2013, 25, 92-100.
5. Mammoto, T., Mammoto, A., Ingber, D. E. Mechanobiology and developmental control. Annu. Rev. Cell Dev. Biol. 2013, 29, 27-61.
6. Engler, A. J., Sen, S., Sweeney, H. L., Discher D. E. Matrix elasticity directs stem cell lineage specification Cell 2006, 126, 677-689.
7. Reilly, G. C., Engler, A. J. Intrinsic extracellular matrix properties regulate stem cell differentiation. J. Biomech. 2010, 43, 55-62.
8. Bellas, E., Chen, C. S. Forms, forces, and stem cell fate. Curr. Opin. Cell Biol. 2014, 31, 92-97.
9. Dupont, S., Morsut, L., Aragona, M., Enzo, E. et al., Role of YAP/TAZ in mechanotransduction. Nature 2011, 474, 179-183.
10. Halder, G., Dupont, S., Piccolo, S. Transduction of mechanical and cytoskeletal cues by YAP and TAZ. Nat. Rev. Mol. Cell Biol. 2012, 13, 591-600.
11. Wolfenson, H., Lavelin, I., Geiger, B. Dynamic regulation of the structure and functions of integrin adhesions. Dev. Cell 2013, 24, 447-458.
12. Winograd-Katz, S. E., Fässler, R., Geiger, B., Legate, K. R. The integrin adhesome: from genes and proteins to human disease. Nat. Rev. Mol. Cell Biol. 2014, 15, 273-288.
13. Maartens, A. P., Brown, N. H. Anchors and signals: the diverse roles of integrins in development. Curr. Top. Dev. Biol. 2015, 112, 233-272.
14. Mathieu, P. S., Loboa, E. G. Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic, and chondrogenic pathways. Tissue Eng. Part B Rev. 2012, 18, 436-444.
15. Kuo, J-C., Han, X., Hsiao, C-T., Yates III, J. R., Waterman C. M. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 2011, 13, 383-393.
16. Schiller, H. B., Friedel, C. C., Boulegue, C., Fässler, R. Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins. EMBO Rep. 2011, 12, 259-266.
17. Byron, A., Askari, J. A., Humphries, J. D., Jacquemet, G. et al., A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting. Nat. Commun. 2015, 6, 6135.
18. Jones, M. C., Humphries, J. D., Byron, A., Millon-Frémillon, A. et al., Isolation of integrin-based adhesion complexes. Curr. Protoc. Cell Biol. 2015, 66, 9.8.1-9.8.15.
19. Zaidel-Bar, R., Itzkovitz, S., Ma'ayan, A., Iyengar, R., Geiger, B. Functional atlas of the integrin adhesome. Nat. Cell Biol. 2007, 9, 858-867.
20. Geiger, T., Zaidel-Bar, R. Opening the floodgates: proteomics and the integrin adhesome. Curr. Opin. Cell Biol. 2012, 24, 562-568.
21. Humphries, J. D., Paul, N. R., Humphries, M. J., Morgan, M. R. Emerging properties of adhesion complexes: what are they and what do they do? Trends Cell Biol. 2015, 25, 388-397.
22. Huang, D. W., Sherman, B. T., Lempicki, R. A. Systematic and integrative analysis of large gene list using DAVID Bioinformatics. Nat. Protoc. 2009, 4, 44-57.
23. Frith, J. E., Mills, R. J., Hudson, J. E., Cooper-White J. J. Tailored integrin-extracellular matrix interactions to direct human mesenchymal stem cell differentiation. Stem Cells Dev. 2012, 21, 2442-2456.
24. Humphries, J. D., Byron, A., Humphries, M. J. Integrin ligands at a glance. J. Cell Sci. 2006, 119, 3901-3903.
25. Schiller, H. B., Fässler, R. Mechanosensitivity and compositional dynamics of cell-matrix adhesions. EMBO Rep. 2013, 14, 509-519.
26. Smith, M. A., Hoffman, L. M., Beckerle, M. C. LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol. 2014, 24, 575-583.
27. Wang, Y-K., Chen, C. S. Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation. J. Cell. Mol. Med. 2013, 17, 823-832.
28. Bara, J. J., Richards, R. G., Alini, M., Stoddart, M. J. Bone marrow-derived mesenchymal stem cells change phenotype following in vitro culture: implications for basic research and the clinic. Stem Cells 2014, 32, 1713-1723.
29. Kaneko, K., Ito, M., Naoe, Y Lacy-Hulbert, A., Ikeda, K. Integrin αv in the mechanical response of osteoblast lineage cells. Biochem. Biophys. Res. Commun. 2014, 447, 352-357.
30. Marie, P. J. Targeting integrins to promote bone formation and repair. Nat. Rev. Endocrinol. 2013, 9, 288-295.
31. Huang, I. H., Hsiao, C. T., Wu, J. C., Shen, R. F. et al., GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment. 2014 J. Cell Sci. 127, 4186-4200.
32. Adams, J. C., Watt, F. M. Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature 1989, 340, 307-309.
33. Baxter, M. A., Camarasa, M. V., Bates, N., Small, F. et al., Analysis of the distinct functions of growth factors and tissue culture substrates necessary for the long-term self-renewal of human embryonic stem cell lines. Stem Cell Res. 2009, 3, 28-38.
34. Singh, P., Schwarzbauer, J. E. Fibronectin and stem cell differentiation - lessons from chondrogenesis. J. Cell Sci. 2012, 125, 3703-3712.
35. Martino, M. M., Mochizuki, M., Rothenfluh, D. A., Rempel, S. A. et al., Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials 2009, 30, 1089-1097.
36. Vizcaíno, J. A., Deutsch, E. W., Wang, R., Csordas, A. et al., ProteomeXchange provides globally co-ordinated proteomics data submission and dissemination. Nature Biotechnol. 2014, 30, 223-226.
37. Choi, H., Fermin, D. Nesvizhskii, A. I. Significance analysis of spectral count data in label-free shotgun proteomics. Mol. Cell. Proteomics 2008, 7, 2373-2385.