Diagnostic accuracy of the Xpert® MTB/RIF assay for extrapulmonary tuberculosis: A meta-analysis

International Journal of Tuberculosis and Lung Disease

Volumn 19, Issue 3, 2015, Pages 278-284

  Penz, E ^a   Boffa, J ^b   Roberts, D J ^c   Fisher, D ^b   Cooper, R ^d   Ronksley, P E ^e   James, M T ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c FOOTHILLS HOSPITAL   (Canada)

^d ROYAL ALEXANDRA HOSPITAL   (Canada)

^e OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Extra pulmonary tuberculosis; Metaanalysis; Sensitivity; Specificity; Systematic review; Xpert MTB RIF

Indexed keywords

ARTICLE; BACTERIUM CULTURE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC EQUIPMENT; DIAGNOSTIC TEST ACCURACY STUDY; EXTRAPULMONARY TUBERCULOSIS; GASTROINTESTINAL TRACT EXAMINATION; HUMAN; LYMPH ANALYSIS; MAJOR CLINICAL STUDY; META ANALYSIS; NUCLEIC ACID AMPLIFICATION; PLEURA FLUID; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SYSTEMATIC REVIEW; URINALYSIS; ISOLATION AND PURIFICATION; MOLECULAR DIAGNOSIS; MYCOBACTERIUM TUBERCULOSIS; PROCEDURES; TUBERCULOSIS, PULMONARY;

TUBERCULOSTATIC AGENT;

ANTIBIOTICS, ANTITUBERCULAR; HUMANS; MOLECULAR DIAGNOSTIC TECHNIQUES; MYCOBACTERIUM TUBERCULOSIS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS, PULMONARY;

EID: 84953343025     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: 10.5588/ijtld.14.0262     Document Type: Article

References (38)

1. Johannes B, Reitsma J B, Glas A S, et al. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol 2005; 58: 982-990.
2. Ablanedo-Terrazas Y, Alvarado-de la Barrera C, Hernández- Juan R, Ruiz-Cruz M, Reyes-Terán G. Xpertw MTB/RIF for diagnosis of tuberculous cervical lymphadenitis in HIV-infected patients. Laryngoscope 2014; 124: 1382-1385.
3. Al-Ateah S M, Al-Dowaidi M M, El-Khizzi N A. Evaluation of direct detection of Mycobacterium tuberculosis complex in respiratory and non-respiratory clinical specimens using the Cepheid Gene Xpert system. SaudiMed J 2012; 33: 1100-1105.
4. Armand S, Vanhuls P, Delcroix G, Courcol R, Lemâitre N. Comparison of the Xpertw MTB/RIF test with an IS6110- TaqMan real-time PCR assay for direct detection of Mycobacterium tuberculosis in respiratory and nonrespiratory specimens. J Clin Microbiol 2011; 49: 1772-1776.
5. Blaich A, Frei F. Performance of the Xpertw MTB/RIF assay on non-respiratory specimens and accuracy of this assay for detection of rifampin resistance in a low-prevalence setting. J Clin Microbiol 2014; 52: 706.
6. Bunsow E, Ruiz-Serrano M J, López Roa P, Kestler M, Viedma D G, Bouza E. Evaluation of GeneXpertw MTB/RIF for the detection of Mycobacterium tuberculosis and resistance to rifampin in clinical specimens. J Infect 2014; 68: 338-343.
7. CausseM, Ruiz P, Gutiérrez-Aroca J B, CasalM. Comparison of two molecular methods for rapid diagnosis of extrapulmonary tuberculosis. J Clin Microbiol 2011; 49: 3065-3067.
8. ChristopherDJ, Schumacher S G, Michael J S, et al. Performance of Xpertw MTB/RIF on pleural tissue for the diagnosis of pleural tuberculosis. Eur Respir J 2013; 42: 1427-1429.
9. Clemente M G, Palacios J J, Penedo A, et al. Evaluation of the Xpertw MTB/RIF test for rapid detection of Mycobacterium tuberculosis. American Thoracic Society International Conference; Denver, CO, USA; 13-18 May 2011. Am J Respir Crit Care Med 2011; 183 (MeetingAbstracts): A1207.
10. Deforges L, Le Glaunec JM, Launay N, et al. Application of the rapid detection system for M. tuberculosis complex and rifampicin resistance Xpertw MTB/RIF in decontaminated respiratory specimens, non-respiratory specimens and cultures. Clin Microbiol Infect 2010; 16: S53 [Abstract O235].
11. Deggim V, Somoskovi A, Voit A, Böttger E C, Bloemberg G V. Integrating the Xpertw MTB/RIF assay into a diagnostic workflow for rapid detection of Mycobacterium tuberculosis in a low-prevalence area. J Clin Microbiol 2013; 51: 2396-2399.
12. Dhasmana D J, Ross C, Bradley C J, et al. Performance of Xpertw MTB/RIF in the diagnosis of tuberculous mediastinal lymphadenopathy by endobronchial ultrasound. Ann Am Thorac Soc 2014; 11: 392-396.
13. Friedrich S O, von Groote-Bidlingmaier F, Diacon A H. Xpertw MTB/RIF assay for diagnosis of pleural tuberculosis. J Clin Microbiol 2011; 49: 4341-4342.
14. Guna M R, Tormo N, Villamayor L, et al. Detection of Mycobacterium tuberculosis complex by RT-PCR in nonrespiratory clinical specimens in Health Department 9, Valencia (Spain). Clin Microbiol Infect 2010; 17: S591 [Abstract P2008].
15. Hillemann D, Rüsch-Gerdes S, Boehme C, Richter E. Rapid molecular detection of extrapulmonary tuberculosis by the automated GeneXpertw MTB/RIF system. J Clin Microbiol 2011; 49: 1202-1205.
16. Ioannidis P, Papaventsis D, Karabela S, et al. Cepheid GeneXpertw MTB/RIF assay for Mycobacterium tuberculosis detection and rifampin resistance identification in patients with substantial clinical indications of tuberculosis and smear-negative microscopy results. J Clin Microbiol 2011; 49: 3068-3070.
17. Kim C H, Woo H, Hyun I G, et al. A comparison between the efficiency of the Xpertw MTB/RIF assay and nested PCR in identifying Mycobacterium tuberculosis during routine clinical practice. J Thorac Dis 2014; 6: 625-631.
18. Ligthelm L J, NicolMP, Hoek K G, et al. Xpertw MTB/RIF for rapid diagnosis of tuberculous lymphadenitis from fine-needleaspiration biopsy specimens. J Clin Microbiol 2011; 49: 3967-3970.
19. Malbruny B, Le Marrec G, Courageux K, Leclercq R, Cattoir V. Rapid and efficient detection of Mycobacterium tuberculosis in respiratory and non-respiratory samples. Int J Tuberc Lung Dis 2011; 15: 553-555.
20. Meldau R, Peter J, Theron G, et al. Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-c for the evaluation of pleural tuberculosis: a prospective cohort study. BMC Pulm Med 2014; 14: 58.
21. Miller M B, Popowitch E B, Backlund M G, Ager E P. Performance of Xpertw MTB/RIF RUO assay and IS6110 realtime PCR for Mycobacterium tuberculosis detection in clinical samples. J Clin Microbiol 2011; 49: 3458-3462.
22. Mokaddas E, Ahmad S, SaadEldeen H. Comparison of two nucleic acid amplification assays, the ProbeTec ET assay and Xpertw MTB/RIF assay, for detection of Mycobacterium tuberculosis in pulmonary and extrapulmonary specimens. Clin Microbiol Infect 2012; 18: 547.
23. Moure R, Martin R, Alcaide F. Effectiveness of an integrated real-time PCR method for detection of the Mycobacterium tuberculosis complex in smear-negative extra-pulmonary samples in an area of low tuberculosis prevalence. J Clin Microbiol 2012; 50: 513-515.
24. Naidoo S. Evaluation of GeneXpertw MTB/RIF assay on pulmonary and extra-pulmonary samples in a high-throughput laboratory. Clin Microbiol Infect 2010; 16 (Suppl): S604-S605 [Abstract P2032].
25. Nazli A, Cavusoglu C. Evaluation of GeneXpertw MTB/RIF assay for the diagnosis of tuberculosis and rapid detection of rifampin resistance in clinical specimens. Clin Microbiol Infect 2011; 17 (Suppl): S592-S593 [Abstract 1291].
26. Nhu N T, Heemskerk D, Thu do D A, et al. Evaluation of GeneXpertw MTB/RIF for diagnosis of tuberculous meningitis. J Clin Microbiol 2014; 52: 226-233.
27. Ozkutuk N, Suruc üoglu S. [Evaluation of the Xpertw MTB/RIF assay for the diagnosis of pulmonary and extra-pulmonary tuberculosis in an intermediate-prevalence setting]. Mikrobiyol Bul 2014; 48: 223-232. [Turkish]
28. Patel V B, Connolly C, Singh R, et al. Comparison of amplicor and GeneXpertw MTB/RIF tests for diagnosis of tuberculous meningitis. J Clin Microbiol 2014; 52: 3777-3780.
29. Porcel JM, Palma R, Valdés L, Bielsa S, San-José E, Esquerda A. Xpertw MTB/RIF in pleural fluid for the diagnosis of tuberculosis. Int J Tuberc Lung Dis 2013; 17: 1217-1219.
30. Safianowska A, Walkiewicz R, Nejman-Gryz P, Grubek- Jaworska H. [Two selected commercially based nucleic acid amplification tests for the diagnosis of tuberculosis]. Pneumonol Alergol Pol 2012; 80: 6-12. [Polish]
31. Scott L E, Gous N, Cunningham B E, et al. Dried culture spots for Xpertw MTB/RIF external quality assessment: Results of a phase 1 pilot study in South Africa. J Clin Microbiol 2011; 49: 4356-4360.
32. Teo J, Jureen R, Chiang D, Chan D, Lin R. Comparison of two nucleic acid amplification assays, the Xpertw MTB/RIF assay and the amplified mycobacterium tuberculosis direct assay, for detection of Mycobacterium tuberculosis in respiratory and nonrespiratory specimens. J Clin Microbiol 2011; 49: 3659-3662.
33. Theron G D V, Peter J G, Lenders L, et al. Evaluation of the GeneXpert MTB/RIF assay for the diagnosis of tuberculosis (TB) using sputum and extra-pulmonary samples. Am J Crit Care Med 2011; 183 (Meeting abstracts): AS312.
34. Tortoli E, Russo C, Piersimoni C, et al. Clinical validation of Xpertw MTB/RIF for the diagnosis of extra-pulmonary tuberculosis. Eur Respir J 2012; 40: 442-447.
35. Vadwai V, Boehme C, Nabeta P, Shetty A, Alland D, Rodrigues C. Xpertw MTB/RIF: a new pillar in diagnosis of extrapulmonary tuberculosis? J Clin Microbiol 2011; 49: 2540-2545.
36. van Rie A, Page-Shipp L, Mellet K, et al. Diagnostic accuracy and effectiveness of the Xpertw MTB/RIF assay for the diagnosis of HIV-associated lymph node tuberculosis. Eur J Clin Microbiol Infect Dis 2013; 32: 1409-1415.
37. Zeka A N, Tasbakan S, Cavusoglu C. Evaluation of the GeneXpertw MTB/RIF assay for rapid diagnosis of tuberculosis and detection of rifampin resistance in pulmonary and extrapulmonary specimens. J Clin Microbiol 2011; 49: 4138-4141.
38. Zmak L, Jankovic M, Jankovic V K. Evaluation of Xpert MTB/RIF assay for rapid molecular diagnosis of tuberculosis in a two-year period in Croatia. Int J Mycobacteriol 2013; 2: 179-182.