Prevalence and characteristics of hypoxic hepatitis in the largest single-centre cohort of avian influenza A(H7N9) virus-infected patients with severe liver impairment in the intensive care unit

Emerging Microbes and Infections

Volumn 5, Issue , 2016, Pages

  Zhang, YiMin ^a   Liu, JiMin ^b,c   Yu, Liang ^a   Zhou, Ning ^a   Ding, Wei ^c   Zheng, ShuFa ^a   Shi, Ding ^a   Li, LanJuan ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b MCMASTER UNIVERSITY   (Canada)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

avian influenza A(H7N9); hypoxic hepatitis; liver impairment; prevalence

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE;

ADOLESCENT; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPSY; AVIAN INFLUENZA; AVIAN INFLUENZA A (H7N9); CLINICAL FEATURE; CRITICALLY ILL PATIENT; DEATH; DISEASE EXACERBATION; FEMALE; HEPATITIS; HUMAN; HUMAN TISSUE; HYPOXIC HEPATITIS; INFLUENZA A VIRUS (H7N9); LIVER ISCHEMIA; LIVER NECROSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; SEVERE HEPATIC IMPAIRMENT; BLOOD; CASE REPORT; CELL HYPOXIA; COMPLICATION; INFLUENZA, HUMAN; INTENSIVE CARE UNIT; LIVER; MORTALITY; ORGAN DYSFUNCTION SCORE; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; CELL HYPOXIA; FEMALE; HEPATITIS; HUMANS; INFLUENZA A VIRUS, H7N9 SUBTYPE; INFLUENZA, HUMAN; INTENSIVE CARE UNITS; LIVER; MALE; MIDDLE AGED; ORGAN DYSFUNCTION SCORES; PREVALENCE; REAL-TIME POLYMERASE CHAIN REACTION; YOUNG ADULT;

EID: 84953258348     PISSN: None     EISSN: 22221751     Source Type: Journal    
DOI: 10.1038/emi.2016.3     Document Type: Article

References (26)

1. Gao R, Cao B, Hu Y et al. Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 2013; 368: 1888-1897.
2. World Health Organization. WHO risk assessment of human infection with avian influenza A(H7N9) virus as of 23 February 2015. Geneva: WHO, 2015. Available at http://www.who.int/influenza/human-animal-interface/influenza-h7n9/RiskAssessment-H7N9-23Feb20115.pdf; 2015. (accessed 8 August 2015).
3. Li Q, Zhou L, Zhou M et al. Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med 2014; 370: 520-532.
4. Wiwanitkit V. H7N9 influenza-the laboratory presentations: a letter to editor. Asian Pac J Trop Biomed 2013; 3: 584-585.
5. Zhang J, Zhao Y, Chen Y. Laboratory findings in patients with avian-origin influenza A (H7N9) virus infections. J Med Virol 2014; 86: 895-898.
6. To KK, Song W, Lau SY et al. Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong. J Infect 2014; 69: 60-68.
7. Henrion J. Hypoxic hepatitis. Liver Int 2012; 32: 1039-1052.
8. Trilok G, Qing YC, Li-Jun X. Hypoxic hepatitis: a challenging diagnosis. Hepatol Int 2012; 6: 663-669.
9. Gao HN, Lu HZ, Cao B et al. Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med 2013; 368: 2277-2285.
10. Henrion J, Schapira M, Luwaert R et al. Hypoxic hepatitis: clinical and hemodynamic study in 142 consecutive cases. Medicine (Baltimore) 2003; 82: 392-406.
11. Fuhrmann V, Kneidinger N, Herkner H et al. Hypoxic hepatitis: underlying conditions and risk factors for mortality in critically ill patients. Intensive Care Med 2009; 35: 1397-1405.
12. Raurich JM, Llompart-Pou JA, Ferreruela M et al. Hypoxic hepatitis in critically ill patients: incidence, etiology and risk factors for mortality. J Anesth 2010; 25: 50-56.
13. Birrer R, Takuda Y, Takara T. Hypoxic hepatopathy: pathophysiology and prognosis. Intern Med 2007; 46: 1063-1070.
14. Chen Y, Liang W, Yang S et al. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet 2013; 381: 1916-1925.
15. Lu S, Zheng Y, Li T et al. Clinical findings for early human cases of influenza A(H7N9) virus infection, Shanghai, China. Emerg Infect Dis 2013; 19: 1142-1146.
16. Fries LF, Smith GE, Glenn GM. A recombinant viruslike particle influenza A (H7N9) vaccine. N Engl J Med 2013; 369: 2564-2566.
17. Chau T-N, Lee K-C, Yao H et al. SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases. Hepatology 2004; 39: 302-310.
18. Kleiner DE, Chalasani NP, Lee WM et al. Hepatic histological findings in suspected drug-induced liver injury: systematic evaluation and clinical associations. Hepatology 2014; 59: 661-670.
19. Li B, Wang Z, Fang JJ, Xu CY, Chen WX. Evaluation of prognostic markers in severe drug-induced liver disease. World J Gastroenterol 2007; 13: 628-632.
20. Wikipedia. Oseltamivir. Available at https://en.wikipedia.org/wiki/Oseltamivir#cite-note-rossi-2006-32; 2015.en/ (accessed 18 August 2015).
21. Fuhrmann V, Jager B, Zubkova A, Drolz A. Hypoxic hepatitis - epidemiology, pathophysiology and clinical management. Wien Klin Wochenschr 2010; 122: 129-139.
22. Johnson RD, O'Connor ML, Kerr RM. Extreme serum elevations of aspartate aminotransferase. Am J Gastroenterol 1995; 90: 1244-1245.
23. Dellinger RP, Levy MM, Rhodes A et al. Surviving Sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013; 39: 165-228.
24. de Jong MD, Simmons CP, Thanh TT et al. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 2006; 12: 1203-1207.
25. Chi Y, Zhu Y, Wen T et al. Cytokine and chemokine levels in patients infected with the novel avian influenza A (H7N9) virus in China. J Infect Dis 2013; 208: 1962-1967.
26. Lefer AM, Galvin MJ. Comparison of the cytotoxic actions of hypoxia and endotoxin in the perfused cat liver. Circ Shock 1978; 5: 145-155.