Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong

Journal of Infection

Volumn 69, Issue 1, 2014, Pages 60-68

  To, Kelvin Kai Wang ^a,b,c   Song, Wenjun ^b   Lau, Siu Ying ^b   Que, Tak Lun ^d   Lung, David Christopher ^d   Hung, Ivan Fan Ngai ^b   Chen, Honglin ^a,b,c   Yuen, Kwok Yung ^a,b,c  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c Research Centre of Infection and Immunology   (Hong Kong)

^d TUEN MUN HOSPITAL   (Hong Kong)

Author keywords

Avian influenza; Evolution; H7N9; L336M; PA; Phylogenetic tree

Indexed keywords

ALANINE AMINOTRANSFERASE; AMOXICILLIN PLUS CLAVULANIC ACID; ANTINUCLEAR ANTIBODY; AZITHROMYCIN; COMPLEMENT; DNA ANTIBODY; OSELTAMIVIR; ZANAMIVIR; PA PROTEIN, INFLUENZA VIRUSES; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN; VIRUS RNA;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINO ACID SEQUENCE; ANTIBIOTIC THERAPY; ANTIBODY TITER; ARTICLE; BLOOD CELL COUNT; BLOOD CLOTTING DISORDER; CASE REPORT; COMPLEMENT BLOOD LEVEL; CYTOPENIA; EXTRACORPOREAL OXYGENATION; FEMALE; GENE CLUSTER; GENE MUTATION; GENE SEQUENCE; HA GENE; HONG KONG; HUMAN; INFLUENZA A; INFLUENZA VIRUS A H7N9; LIVER FUNCTION; MP GENE; MYOGLOBINURIA; NA GENE; NS GENE; NUCLEOTIDE SEQUENCE; PARTIAL THROMBOPLASTIN TIME; PB1 GENE; PB2 GENE; PHYLOGENY; PROTHROMBIN TIME; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOLYSIS; SALVAGE THERAPY; SEQUENCE HOMOLOGY; SINGLE DRUG DOSE; THORAX RADIOGRAPHY; TRACHEAL ASPIRATION PROCEDURE; VIRUS CULTURE; VIRUS GENE; VIRUS GENOME; VIRUS IDENTIFICATION; VIRUS ISOLATION; VIRUS STRAIN; CLASSIFICATION; CLUSTER ANALYSIS; COMMUNICABLE DISEASES, EMERGING; DNA SEQUENCE; GENETIC REASSORTMENT; GENETICS; INFLUENZA, HUMAN; ISOLATION AND PURIFICATION; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION; TRACHEA; VIROLOGY;

ADULT; CLUSTER ANALYSIS; COMMUNICABLE DISEASES, EMERGING; EVOLUTION, MOLECULAR; FEMALE; HONG KONG; HUMANS; INFLUENZA A VIRUS, H7N9 SUBTYPE; INFLUENZA, HUMAN; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; REASSORTANT VIRUSES; RNA REPLICASE; RNA, VIRAL; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY; TRACHEA; VIRAL PROTEINS;

EID: 84901997984     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2014.02.012     Document Type: Article

References (29)

1. Chan J.F., To K.K., Tse H., Jin D.Y., Yuen K.Y. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiol 2013 Jun 13, 10.1016/j.tim.2013.05.005.
2. Yuan J., Zhang L., Kan X., Jiang L., Yang J., Guo Z., et al. Origin and molecular characteristics of a novel 2013 avian influenza A(H6N1) virus causing human infection in Taiwan. Clin Infect Dis 2013 Nov, 57(9):1367-1368.
3. Chen Y., Liang W., Yang S., Wu N., Gao H., Sheng J., et al. Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet 2013 Jun 1, 381(9881):1916-1925.
4. To K.K., Chan J.F., Chen H., Li L., Yuen K.Y. The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities. Lancet Infect Dis 2013, 13:809-821.
5. Cheng V.C., To K.K., Tse H., Hung I.F., Yuen K.Y. Two years after pandemic influenza A/2009/H1N1: what have we learned?. Clin Microbiol Rev 2012 Apr, 25(2):223-263.
6. Cheng V.C., Lau S.K., Woo P.C., Yuen K.Y. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev 2007 Oct, 20(4):660-694.
7. World Health Organization. Number of confirmed human cases of avian influenza A(H7N9) reported to WHO. Available at: [accessed 10.12.13]. http://www.who.int/influenza/human_animal_interface/influenza_h7n9/Data_Reports/en/index.html.
8. Yu L., Wang Z., Chen Y., Ding W., Jia H., Chan J.F., et al. Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus. Clin Infect Dis 2013 Nov, 57(10):1449-1457.
9. Yang S., Chen Y., Cui D., Yao H., Lou J., Huo Z., et al. Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: a serological study. J Infect Dis 2014 Jan 15, 209(2):265-269.
10. Gao H.N., Lu H.Z., Cao B., Du B., Shang H., Gan J.H., et al. Clinical findings in 111 cases of influenza A (H7N9) virus infection. N Engl J Med 2013 Jun 13, 368(24):2277-2285.
11. Qi X., Qian Y.H., Bao C.J., Guo X.L., Cui L.B., Tang F.Y., et al. Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation. BMJ 2013, 347:f4752.
12. Cowling B.J., Jin L., Lau E.H., Liao Q., Wu P., Jiang H., et al. Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases. Lancet 2013 Jul 13, 382(9887):129-137.
13. To K.K., Ng K.H., Que T.L., Chan J.M., Tsang K.Y., Tsang A.K., et al. Avian influenza A H5N1 virus: a continuous threat to humans. Emerg Microbes Infect 2012, 1:e25.
14. Chen E., Chen Y., Fu L., Chen Z., Gong Z., Mao H., et al. Human infection with avian influenza A(H7N9) virus re-emerges in China in winter 2013. Euro Surveill 2013, 18(43).
15. The Government of the Hong Kong Special Administrative Region. SFH on confirmed human case of avian influenza A(H7N9). Available at: [accessed on 03.10.13]. http://www.info.gov.hk/gia/general/201312/03/P201312030033.htm.
16. Bernard G.R., Artigas A., Brigham K.L., Carlet J., Falke K., Hudson L., et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994 Mar, 149(3 Pt 1):818-824.
17. Chan K.H., To K.K., Chan B.W., Li C.P., Chiu S.S., Yuen K.Y., et al. Comparison of pyrosequencing, Sanger sequencing, and melting curve analysis for detection of low-frequency macrolide-resistant mycoplasma pneumoniae quasispecies in respiratory specimens. J Clin Microbiol 2013 Aug, 51(8):2592-2598.
18. Herfst S., Schrauwen E.J., Linster M., Chutinimitkul S., de Wit E., Munster V.J., et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science 2012 Jun 22, 336(6088):1534-1541.
19. Bussey K.A., Desmet E.A., Mattiacio J.L., Hamilton A., Bradel-Tretheway B., Bussey H.E., et al. PA residues in the 2009 H1N1 pandemic influenza virus enhance avian influenza virus polymerase activity in mammalian cells. J Virol 2011 Jul, 85(14):7020-7028.
20. Yuen K.Y., Chan P.K., Peiris M., Tsang D.N., Que T.L., Shortridge K.F., et al. Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet 1998 Feb 14, 351(9101):467-471.
21. Gao R., Cao B., Hu Y., Feng Z., Wang D., Hu W., et al. Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 2013 May 16, 368(20):1888-1897.
22. Lam T.T., Wang J., Shen Y., Zhou B., Duan L., Cheung C.L., et al. The genesis and source of the H7N9 influenza viruses causing human infections in China. Nature 2013 Oct 10, 502(7470):241-244.
23. Liu D., Shi W., Shi Y., Wang D., Xiao H., Li W., et al. Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. Lancet 2013 Jun 1, 381(9881):1926-1932.
24. Zhang L., Zhang Z., Weng Z. Rapid reassortment of internal genes in avian influenza A(H7N9) virus. Clin Infect Dis 2013 Oct, 57(7):1059-1061.
25. Manz B., Schwemmle M., Brunotte L. Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier. J Virol 2013 Jul, 87(13):7200-7209.
26. Jonges M., Bataille A., Enserink R., Meijer A., Fouchier R.A., Stegeman A., et al. Comparative analysis of avian influenza virus diversity in poultry and humans during a highly pathogenic avian influenza A (H7N7) virus outbreak. J Virol 2011 Oct, 85(20):10598-10604.
27. Hu Y., Lu S., Song Z., Wang W., Hao P., Li J., et al. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet 2013 Jun 29, 381(9885):2273-2279.
28. Lin P.H., Chao T.L., Kuo S.W., Wang J.T., Hung C.C., Lin H.C., et al. Virological, serological, and antiviral studies in an imported human case of avian influenza A(H7N9) virus in Taiwan. Clin Infect Dis 2014 Jan, 58(2):242-246.
29. Ren X., Yang F., Hu Y., Zhang T., Liu L., Dong J., et al. Full genome of influenza A (H7N9) virus derived by direct sequencing without culture. Emerg Infect Dis 2013 Nov, 19(11).