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Volumn 61, Issue 6, 2016, Pages 1561-1571

IL-6/STAT3 Plays a Regulatory Role in the Interaction Between Pancreatic Stellate Cells and Cancer Cells

Author keywords

Desmoplastic reaction; Epithelial mesenchymal transition; Fibrosis; Pancreatic cancer; Pancreatitis; Stroma

Indexed keywords

4 [[(4 METHYLPHENYL)SULFONYLOXY]ACETAMIDO]SALICYLIC ACID; ALPHA SMOOTH MUSCLE ACTIN; ALPHA TUBULIN; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CADHERIN; COLLAGEN TYPE 1; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 6; LIPOCALIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STAT3 PROTEIN; TRANSCRIPTION FACTOR SNAIL; AMINOSALICYLIC ACID DERIVATIVE; BENZENESULFONIC ACID DERIVATIVE; IL6 PROTEIN, HUMAN; NEUTRALIZING ANTIBODY; STAT3 PROTEIN, HUMAN;

EID: 84953245938     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-015-4001-5     Document Type: Article
Times cited : (61)

References (40)
  • 1
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • COI: 1:CAS:528:DC%2BC3cXlsV2ns7o%3D, PID: 20427809
    • Hidalgo M. Pancreatic cancer. N Engl J Med. 2010;362:1605–1617.
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 2
    • 79955828776 scopus 로고    scopus 로고
    • Stromal biology and therapy in pancreatic cancer
    • PID: 20966025
    • Neesse A, Michl P, Frese KK, et al. Stromal biology and therapy in pancreatic cancer. Gut. 2011;60:861–868.
    • (2011) Gut , vol.60 , pp. 861-868
    • Neesse, A.1    Michl, P.2    Frese, K.K.3
  • 3
    • 0031842971 scopus 로고    scopus 로고
    • Periacinar stellate shaped cells in rat pancreas: identification, isolation and culture
    • COI: 1:STN:280:DyaK1cvksVemtA%3D%3D, PID: 9771417
    • Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation and culture. Gut. 1998;43:128–133.
    • (1998) Gut , vol.43 , pp. 128-133
    • Apte, M.V.1    Haber, P.S.2    Applegate, T.L.3
  • 4
    • 84855201311 scopus 로고    scopus 로고
    • StellaTUM: current consensus and discussion on pancreatic stellate cell research
    • COI: 1:CAS:528:DC%2BC38Xis1ejsb4%3D, PID: 22115911
    • Erkan M, Adler G, Apte MV, et al. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 2012;61:172–178.
    • (2012) Gut , vol.61 , pp. 172-178
    • Erkan, M.1    Adler, G.2    Apte, M.V.3
  • 5
    • 65049091645 scopus 로고    scopus 로고
    • Signal transduction in pancreatic stellate cells
    • PID: 19271115
    • Masamune A, Shimosegawa T. Signal transduction in pancreatic stellate cells. J Gastroenterol. 2009;44:249–260.
    • (2009) J Gastroenterol , vol.44 , pp. 249-260
    • Masamune, A.1    Shimosegawa, T.2
  • 6
    • 84876786403 scopus 로고    scopus 로고
    • A starring role for stellate cells in the pancreatic cancer microenvironment
    • PID: 23622130
    • Apte MV, Wilson JS, Lugea A, Pandol SJ. A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology. 2013;144:1210–1219.
    • (2013) Gastroenterology , vol.144 , pp. 1210-1219
    • Apte, M.V.1    Wilson, J.S.2    Lugea, A.3    Pandol, S.J.4
  • 7
    • 84877984622 scopus 로고    scopus 로고
    • Pancreatic stellate cells-multi-functional cells in the pancreas
    • COI: 1:CAS:528:DC%2BC3sXltFClsrg%3D, PID: 23561965
    • Masamune A, Shimosegawa T. Pancreatic stellate cells-multi-functional cells in the pancreas. Pancreatology. 2013;13:102–105.
    • (2013) Pancreatology , vol.13 , pp. 102-105
    • Masamune, A.1    Shimosegawa, T.2
  • 8
    • 17144404527 scopus 로고    scopus 로고
    • Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    • COI: 1:CAS:528:DC%2BD2MXjvV2qt7w%3D, PID: 15825074
    • Bachem MG, Schünemann M, Ramadani M, et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology. 2005;128:907–921.
    • (2005) Gastroenterology , vol.128 , pp. 907-921
    • Bachem, M.G.1    Schünemann, M.2    Ramadani, M.3
  • 9
    • 38849141696 scopus 로고    scopus 로고
    • Cancer-associated stromal fibroblasts promote pancreatic tumor progression
    • COI: 1:CAS:528:DC%2BD1cXhtlygtbs%3D, PID: 18245495
    • Hwang RF, Moore T, Arumugam T, et al. Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 2008;68:918–926.
    • (2008) Cancer Res , vol.68 , pp. 918-926
    • Hwang, R.F.1    Moore, T.2    Arumugam, T.3
  • 10
    • 42049097658 scopus 로고    scopus 로고
    • Pancreatic stellate cells: partners in crime with pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BD1cXktVyqtbs%3D, PID: 18381413
    • Vonlaufen A, Joshi S, Qu C, et al. Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res. 2008;68:2085–2093.
    • (2008) Cancer Res , vol.68 , pp. 2085-2093
    • Vonlaufen, A.1    Joshi, S.2    Qu, C.3
  • 11
    • 78650175637 scopus 로고    scopus 로고
    • Pancreatic stellate cells promote epithelial–mesenchymal transition in pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BC3cXhsF2mtLzM, PID: 21081113
    • Kikuta K, Masamune A, Watanabe T, et al. Pancreatic stellate cells promote epithelial–mesenchymal transition in pancreatic cancer cells. Biochem Biophys Res Commun. 2010;403:380–384.
    • (2010) Biochem Biophys Res Commun , vol.403 , pp. 380-384
    • Kikuta, K.1    Masamune, A.2    Watanabe, T.3
  • 12
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial–mesenchymal transitions in development and disease
    • COI: 1:CAS:528:DC%2BC3cXksFWltA%3D%3D, PID: 19945376
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial–mesenchymal transitions in development and disease. Cell. 2009;139:871–890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 13
    • 84917690504 scopus 로고    scopus 로고
    • IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival
    • PID: 25415223
    • Lunardi S, Jamieson NB, Lim SY, et al. IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival. Oncotarget. 2014;5:11064–11080.
    • (2014) Oncotarget , vol.5 , pp. 11064-11080
    • Lunardi, S.1    Jamieson, N.B.2    Lim, S.Y.3
  • 14
    • 84877848590 scopus 로고    scopus 로고
    • Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner
    • COI: 1:CAS:528:DC%2BC3sXnsFejsL0%3D, PID: 23514705
    • Mace TA, Ameen Z, Collins A, et al. Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Res. 2013;73:3007–3018.
    • (2013) Cancer Res , vol.73 , pp. 3007-3018
    • Mace, T.A.1    Ameen, Z.2    Collins, A.3
  • 15
    • 84860431671 scopus 로고    scopus 로고
    • Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BC38XmtFamsr0%3D, PID: 22510406
    • Hamada S, Masamune A, Takikawa T, et al. Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells. Biochem Biophys Res Commun. 2012;421:349–354.
    • (2012) Biochem Biophys Res Commun , vol.421 , pp. 349-354
    • Hamada, S.1    Masamune, A.2    Takikawa, T.3
  • 16
    • 63849290925 scopus 로고    scopus 로고
    • Fibrinogen induces cytokine and collagen production in pancreatic stellate cells
    • COI: 1:CAS:528:DC%2BC3cXivFWlsbs%3D, PID: 19052021
    • Masamune A, Kikuta K, Watanabe T, et al. Fibrinogen induces cytokine and collagen production in pancreatic stellate cells. Gut. 2009;58:550–559.
    • (2009) Gut , vol.58 , pp. 550-559
    • Masamune, A.1    Kikuta, K.2    Watanabe, T.3
  • 17
    • 34250658084 scopus 로고    scopus 로고
    • Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
    • COI: 1:CAS:528:DC%2BD2sXlslWqsbY%3D, PID: 17463090
    • Siddiquee K, Zhang S, Guida WC, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci USA. 2007;104:7391–7396.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7391-7396
    • Siddiquee, K.1    Zhang, S.2    Guida, W.C.3
  • 18
    • 77957367120 scopus 로고    scopus 로고
    • Nuclear expression of interleukin-33 in pancreatic stellate cells
    • COI: 1:CAS:528:DC%2BC3cXhtlKlu77I, PID: 20689058
    • Masamune A, Watanabe T, Kikuta K, et al. Nuclear expression of interleukin-33 in pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2010;299:G821–G832.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.299 , pp. G821-G832
    • Masamune, A.1    Watanabe, T.2    Kikuta, K.3
  • 19
    • 84888426235 scopus 로고    scopus 로고
    • MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX
    • COI: 1:CAS:528:DC%2BC2cXivVKhuw%3D%3D, PID: 24216611
    • Hamada S, Masamune A, Miura S, Satoh K, Shimosegawa T. MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX. Cell Signal. 2014;26:179–185.
    • (2014) Cell Signal , vol.26 , pp. 179-185
    • Hamada, S.1    Masamune, A.2    Miura, S.3    Satoh, K.4    Shimosegawa, T.5
  • 20
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • COI: 1:CAS:528:DC%2BD3sXitlCnsL4%3D, PID: 12538238
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 2003;19:185–193.
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 21
    • 0036898577 scopus 로고    scopus 로고
    • Microarray data normalization and transformation
    • COI: 1:CAS:528:DC%2BD38XovFyqs70%3D, PID: 12454644
    • Quackenbush J. Microarray data normalization and transformation. Nat Genet. 2002;32(Suppl):496–501.
    • (2002) Nat Genet , vol.32 , pp. 496-501
    • Quackenbush, J.1
  • 22
    • 84880956327 scopus 로고    scopus 로고
    • miR-210 regulates the interaction between pancreatic cancer cells and stellate cells
    • COI: 1:CAS:528:DC%2BC3sXhtFCqsb%2FK, PID: 23831622
    • Takikawa T, Masamune A, Hamada S, et al. miR-210 regulates the interaction between pancreatic cancer cells and stellate cells. Biochem Biophys Res Commun. 2013;437:433–439.
    • (2013) Biochem Biophys Res Commun , vol.437 , pp. 433-439
    • Takikawa, T.1    Masamune, A.2    Hamada, S.3
  • 23
    • 84924560120 scopus 로고    scopus 로고
    • The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition
    • COI: 1:CAS:528:DC%2BC2MXjt1Slu74%3D, PID: 25749511
    • Garbers C, Aparicio-Siegmund S, Rose-John S. The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition. Curr Opin Immunol. 2015;34:75–82.
    • (2015) Curr Opin Immunol , vol.34 , pp. 75-82
    • Garbers, C.1    Aparicio-Siegmund, S.2    Rose-John, S.3
  • 24
    • 84908890879 scopus 로고    scopus 로고
    • Identification of human complement factor B as a novel biomarker candidate for pancreatic ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BC2cXht1SmtL7N, PID: 25057901
    • Lee MJ, Na K, Jeong SK, et al. Identification of human complement factor B as a novel biomarker candidate for pancreatic ductal adenocarcinoma. J Proteome Res. 2014;13:4878–4888.
    • (2014) J Proteome Res , vol.13 , pp. 4878-4888
    • Lee, M.J.1    Na, K.2    Jeong, S.K.3
  • 25
    • 84899476213 scopus 로고    scopus 로고
    • Expression profiles for 14-3-3 zeta and CCL20 in pancreatic cancer and chronic pancreatitis
    • COI: 1:CAS:528:DC%2BC2cXksFWmurw%3D, PID: 24629487
    • Klemm C, Dommisch H, Göke F, et al. Expression profiles for 14-3-3 zeta and CCL20 in pancreatic cancer and chronic pancreatitis. Pathol Res Pract. 2014;210:335–341.
    • (2014) Pathol Res Pract , vol.210 , pp. 335-341
    • Klemm, C.1    Dommisch, H.2    Göke, F.3
  • 26
    • 84867131966 scopus 로고    scopus 로고
    • Lipocalin2 promotes invasion, tumorigenicity and gemcitabine resistance in pancreatic ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BC38XhsFalu7nE, PID: 23056397
    • Leung L, Radulovich N, Zhu CQ, et al. Lipocalin2 promotes invasion, tumorigenicity and gemcitabine resistance in pancreatic ductal adenocarcinoma. PLoS One. 2012;7:e46677.
    • (2012) PLoS One , vol.7 , pp. 46677
    • Leung, L.1    Radulovich, N.2    Zhu, C.Q.3
  • 27
    • 84899412960 scopus 로고    scopus 로고
    • Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members
    • PID: 24710357
    • Beigel F, Friedrich M, Probst C, et al. Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. PLoS One. 2014;9:e93498.
    • (2014) PLoS One , vol.9 , pp. 93498
    • Beigel, F.1    Friedrich, M.2    Probst, C.3
  • 28
    • 0035865517 scopus 로고    scopus 로고
    • STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma
    • COI: 1:CAS:528:DC%2BD3MXht1Gisr0%3D, PID: 11159537
    • Brender C, Nielsen M, Kaltoft K, et al. STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma. Blood. 2001;97:1056–1062.
    • (2001) Blood , vol.97 , pp. 1056-1062
    • Brender, C.1    Nielsen, M.2    Kaltoft, K.3
  • 29
    • 84905966696 scopus 로고    scopus 로고
    • Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells
    • COI: 1:CAS:528:DC%2BC2cXhtlClsbfL, PID: 24903147
    • Chen J, Xu H, Zou X, et al. Snail recruits Ring1B to mediate transcriptional repression and cell migration in pancreatic cancer cells. Cancer Res. 2014;74:4353–4363.
    • (2014) Cancer Res , vol.74 , pp. 4353-4363
    • Chen, J.1    Xu, H.2    Zou, X.3
  • 30
    • 33846263431 scopus 로고    scopus 로고
    • Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression
    • COI: 1:CAS:528:DC%2BD28Xhtlagu7%2FO, PID: 17178870
    • Shintani Y, Hollingsworth MA, Wheelock MJ, Johnson KR. Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression. Cancer Res. 2006;66:11745–11753.
    • (2006) Cancer Res , vol.66 , pp. 11745-11753
    • Shintani, Y.1    Hollingsworth, M.A.2    Wheelock, M.J.3    Johnson, K.R.4
  • 31
    • 84924700441 scopus 로고    scopus 로고
    • Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines
    • COI: 1:CAS:528:DC%2BC2MXmt12ks7g%3D, PID: 25732306
    • Wu HH, Hwang-Verslues WW, Lee WH, et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. J Exp Med. 2015;212:333–349.
    • (2015) J Exp Med , vol.212 , pp. 333-349
    • Wu, H.H.1    Hwang-Verslues, W.W.2    Lee, W.H.3
  • 32
    • 84855590868 scopus 로고    scopus 로고
    • The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma
    • PID: 22190968
    • Tjomsland V, Niklasson L, Sandström P, et al. The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma. Clin Dev Immunol. 2011;2011:212810.
    • (2011) Clin Dev Immunol , vol.2011 , pp. 212810
    • Tjomsland, V.1    Niklasson, L.2    Sandström, P.3
  • 33
    • 84873992685 scopus 로고    scopus 로고
    • Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: a multicenter retrospective analysis
    • PID: 22989892
    • Ueda J, Tanaka M, Ohtsuka T, et al. Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: a multicenter retrospective analysis. Surgery. 2013;153:357–364.
    • (2013) Surgery , vol.153 , pp. 357-364
    • Ueda, J.1    Tanaka, M.2    Ohtsuka, T.3
  • 34
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • COI: 1:CAS:528:DC%2BC3MXks1WqsLY%3D, PID: 21481787
    • Fukuda A, Wang SC, Morris JP 4th, et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell. 2011;19:441–455.
    • (2011) Cancer Cell , vol.19 , pp. 441-455
    • Fukuda, A.1    Wang, S.C.2    Morris, J.P.3
  • 35
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • COI: 1:CAS:528:DC%2BC3MXks1WqsLc%3D, PID: 21481788
    • Lesina M, Kurkowski MU, Ludes K, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell. 2011;19:456–469.
    • (2011) Cancer Cell , vol.19 , pp. 456-469
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3
  • 36
    • 84930910883 scopus 로고    scopus 로고
    • A comprehensive analysis of candidate genes and pathways in pancreatic cancer
    • COI: 1:CAS:528:DC%2BC2cXitVSgtrrP, PID: 25409614
    • Liu J, Li J, Li H, et al. A comprehensive analysis of candidate genes and pathways in pancreatic cancer. Tumour Biol. 2015;36:1849–1857.
    • (2015) Tumour Biol , vol.36 , pp. 1849-1857
    • Liu, J.1    Li, J.2    Li, H.3
  • 37
    • 84886002334 scopus 로고    scopus 로고
    • Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance
    • COI: 1:CAS:528:DC%2BC3sXhs1ahur%2FF, PID: 24097820
    • Zhang Y, Yan W, Collins MA, et al. Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res. 2013;73:6359–6374.
    • (2013) Cancer Res , vol.73 , pp. 6359-6374
    • Zhang, Y.1    Yan, W.2    Collins, M.A.3
  • 38
    • 84902469661 scopus 로고    scopus 로고
    • Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
    • COI: 1:CAS:528:DC%2BC2cXosl2hsr0%3D, PID: 24856586
    • Ozdemir BC, Pentcheva-Hoang T, Carstens JL, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014;25:719–734.
    • (2014) Cancer Cell , vol.25 , pp. 719-734
    • Ozdemir, B.C.1    Pentcheva-Hoang, T.2    Carstens, J.L.3
  • 39
    • 84902435628 scopus 로고    scopus 로고
    • Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
    • COI: 1:CAS:528:DC%2BC2cXoslyisbc%3D, PID: 24856585
    • Rhim AD, Oberstein PE, Thomas DH, et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 2014;25:735–747.
    • (2014) Cancer Cell , vol.25 , pp. 735-747
    • Rhim, A.D.1    Oberstein, P.E.2    Thomas, D.H.3
  • 40
    • 84907485104 scopus 로고    scopus 로고
    • Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
    • COI: 1:CAS:528:DC%2BC2cXhs1GmtLfO, PID: 25259922
    • Sherman MH, Yu RT, Engle DD, et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014;159:80–93.
    • (2014) Cell , vol.159 , pp. 80-93
    • Sherman, M.H.1    Yu, R.T.2    Engle, D.D.3


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