메뉴 건너뛰기




Volumn 81, Issue 1, 2016, Pages 41-51

The mass action equation in pharmacology

Author keywords

Dose response; Mass action; Pharmacology; Receptor

Indexed keywords

ADSORPTION; AGONIST POTENCY; ALLOSTERISM; ANTAGONIST POTENCY; ARTICLE; CONFORMATION; DISSOCIATION CONSTANT; DRUG MECHANISM; DRUG MIXTURE; DRUG POTENCY; EC50; INTRACELLULAR SIGNALING; LIGAND BINDING; MASS ACTION; MASS ACTION EQUATION; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEIN CONFORMATION; STOICHIOMETRY; ANIMAL; CHEMISTRY; DOSE RESPONSE; HUMAN; PHARMACOLOGY; PROBABILITY;

EID: 84953245929     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/bcp.12810     Document Type: Article
Times cited : (35)

References (38)
  • 3
    • 0000282255 scopus 로고
    • Imprecision in presentation of binding studies
    • Colquhoun D. Imprecision in presentation of binding studies. Trends Pharmacol Sci 1985; 6: 197.
    • (1985) Trends Pharmacol Sci , vol.6 , pp. 197
    • Colquhoun, D.1
  • 4
    • 0026440948 scopus 로고
    • Atypical molecular pharmacology of a new long acting β2-adrenoceptor agonist TA 2005
    • Voss H-P, Donnell D, Bast A. Atypical molecular pharmacology of a new long acting β2-adrenoceptor agonist TA 2005. Eur J Pharmacol 1992; 227: 403-9.
    • (1992) Eur J Pharmacol , vol.227 , pp. 403-409
    • Voss, H.-P.1    Donnell, D.2    Bast, A.3
  • 5
    • 0019790028 scopus 로고
    • Conformational changes and drug action
    • Burgen ASV. Conformational changes and drug action. Fed Proc 1981; 40: 2723-8.
    • (1981) Fed Proc , vol.40 , pp. 2723-2728
    • Burgen, A.S.V.1
  • 7
    • 0026320866 scopus 로고
    • The energy landscapes and motions of proteins
    • Fraunfelder H, Sligar SG, Wolynes PG. The energy landscapes and motions of proteins. Science 1991; 254: 1598-603.
    • (1991) Science , vol.254 , pp. 1598-1603
    • Fraunfelder, H.1    Sligar, S.G.2    Wolynes, P.G.3
  • 8
    • 0032544060 scopus 로고    scopus 로고
    • The structural distribution of cooperative interactions in proteins: Analysis of the native state ensemble
    • Hilser J, Dowdy D, Oas TG, Freire E. The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. Proc Natl Acad Sci U S A 1998; 95: 9903-8.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 9903-9908
    • Hilser, J.1    Dowdy, D.2    Oas, T.G.3    Freire, E.4
  • 10
    • 0001870572 scopus 로고    scopus 로고
    • Agonist efficacy and allosteric models of receptor action
    • Onaran HO, Costa T. Agonist efficacy and allosteric models of receptor action. Ann N Y Acad Sci 1997; 812: 98-115.
    • (1997) Ann N y Acad Sci , vol.812 , pp. 98-115
    • Onaran, H.O.1    Costa, T.2
  • 12
    • 0036591660 scopus 로고    scopus 로고
    • The ligand paradox between affinity and efficacy: Can you be there and not make a difference?
    • Kenakin TP, Onaran O. The ligand paradox between affinity and efficacy: can you be there and not make a difference? Trends Pharmacol Sci 2002; 23: 275-80.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 275-280
    • Kenakin, T.P.1    Onaran, O.2
  • 13
    • 0000870544 scopus 로고
    • Die kinetic der invertinwirkung
    • Michaelis L, Menten ML. Die kinetic der invertinwirkung. Biochem Z 1913; 49: 333-69.
    • (1913) Biochem Z , vol.49 , pp. 333-369
    • Michaelis, L.1    Menten, M.L.2
  • 14
    • 0021058380 scopus 로고
    • Operational models of pharmacological agonist
    • Black JW, Leff P. Operational models of pharmacological agonist. Proc R Soc Lond [Biol] 1983; 220: 141-62.
    • (1983) Proc R Soc Lond [Biol] , vol.220 , pp. 141-162
    • Black, J.W.1    Leff, P.2
  • 15
    • 0021990306 scopus 로고
    • An operational model of pharmacological agonism: The effect of E/[A] curve shape on agonist dissociation constant estimation
    • Black JW, Leff P, Shankley NP. (Appendix J. Wood) An operational model of pharmacological agonism: the effect of E/[A] curve shape on agonist dissociation constant estimation. Br J Pharmacol 1985; 84: 561-71.
    • (1985) Br J Pharmacol , vol.84 , pp. 561-571
    • Black, J.W.1    Leff, P.2    Shankley, N.P.3
  • 16
    • 33751162165 scopus 로고    scopus 로고
    • Distinct signaling profiles of β1 and β2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy
    • Galandrin S, Bouvier M. Distinct signaling profiles of β1 and β2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol 2006; 70: 1575-84.
    • (2006) Mol Pharmacol , vol.70 , pp. 1575-1584
    • Galandrin, S.1    Bouvier, M.2
  • 17
    • 8444238556 scopus 로고    scopus 로고
    • Betablockers in heart failure: Are pharmacological differences clinically important?
    • Metra M, Dei Cas L, di Lenarda A, Poole-Wilson P. Betablockers in heart failure: are pharmacological differences clinically important? Heart Fail Rev 2004; 9: 123-30.
    • (2004) Heart Fail Rev , vol.9 , pp. 123-130
    • Metra, M.1    Dei Cas, L.2    Di Lenarda, A.3    Poole-Wilson, P.4
  • 18
    • 0029054965 scopus 로고
    • Agonist-receptor efficacy II: Agonist-trafficking of receptor signals
    • Kenakin TP. Agonist-receptor efficacy II: agonist-trafficking of receptor signals. Trends Pharmacol Sci 1995; 16: 232-8.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 232-238
    • Kenakin, T.P.1
  • 19
    • 84872048999 scopus 로고    scopus 로고
    • The potential for selective pharmacological therapies through biased receptor signaling
    • Kenakin T. The potential for selective pharmacological therapies through biased receptor signaling. BMC Pharmacol Toxicol 2012; 13: 3.
    • (2012) BMC Pharmacol Toxicol , vol.13 , pp. 3
    • Kenakin, T.1
  • 20
    • 84857497773 scopus 로고    scopus 로고
    • Biased signalling and allosteric machines: New vistas and challenges for drug discovery
    • Kenakin TP. Biased signalling and allosteric machines: new vistas and challenges for drug discovery. Br J Pharmacol 2012; 165: 1659-69.
    • (2012) Br J Pharmacol , vol.165 , pp. 1659-1669
    • Kenakin, T.P.1
  • 21
    • 84856343982 scopus 로고    scopus 로고
    • Cardiorenal actions of TRV120027, a novel β- Arrestin-biased ligand at the angiotensin II type one receptor, in healthy and heart failure canines: A novel therapeutic strategy for acute heart failure
    • Boerrigter G, Lark MW, Whalen EJ, Soergel DG, Violin JD, Burnett JC Jr. Cardiorenal actions of TRV120027, a novel β- arrestin-biased ligand at the angiotensin II type one receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure. Circ Heart Fail 2011; 4: 770-8.
    • (2011) Circ Heart Fail , vol.4 , pp. 770-778
    • Boerrigter, G.1    Lark, M.W.2    Whalen, E.J.3    Soergel, D.G.4    Violin, J.D.5    Burnett, J.C.6
  • 22
    • 84868668210 scopus 로고    scopus 로고
    • TRV120027, a novel β-arrestin biased ligand at the angiotensin II type i receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure
    • Boerrigter G, Soergel DG, Violin JD, Lark MW, Burnett JC Jr. TRV120027, a novel β-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. Circ Heart Fail 2012; 5: 627-34.
    • (2012) Circ Heart Fail , vol.5 , pp. 627-634
    • Boerrigter, G.1    Soergel, D.G.2    Violin, J.D.3    Lark, M.W.4    Burnett, J.C.5
  • 23
    • 0003043542 scopus 로고
    • The possible effects of the aggregation of the molecules of hæmoglobin on its dissociation curves
    • Hill AV. The possible effects of the aggregation of the molecules of hæmoglobin on its dissociation curves. J Physiol 1910; 40 (Suppl.): iv-vii.
    • (1910) J Physiol , vol.40 , pp. iv-vii
    • Hill, A.V.1
  • 24
    • 4043158815 scopus 로고
    • The constitution and fundamental properties of solids and liquids. Part i Solids
    • Langmuir I. The constitution and fundamental properties of solids and liquids. Part I Solids. J Am Chem Soc 1916; 38: 2221-95.
    • (1916) J Am Chem Soc , vol.38 , pp. 2221-2295
    • Langmuir, I.1
  • 25
    • 30444460582 scopus 로고    scopus 로고
    • The quantitative analysis of drug-receptor interactions: A short history
    • Colquhoun D. The quantitative analysis of drug-receptor interactions: a short history. Trends Pharmacol Sci 2006; 27: 149-57.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 149-157
    • Colquhoun, D.1
  • 26
    • 77952354490 scopus 로고    scopus 로고
    • Seven transmembrane receptors as shapeshifting proteins: The impact of allosteric modulation and functional selectivity on new drug discovery
    • Kenakin T, Miller LJ. Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev 2010; 62: 265-304.
    • (2010) Pharmacol Rev , vol.62 , pp. 265-304
    • Kenakin, T.1    Miller, L.J.2
  • 27
    • 0020533362 scopus 로고
    • Modification of the binding properties of muscarinic receptors by gallamine
    • Stockton JM, Birdsall NJM, Burgen ASV, Hulme EC. Modification of the binding properties of muscarinic receptors by gallamine. Mol Pharmacol 1983; 23: 551-7.
    • (1983) Mol Pharmacol , vol.23 , pp. 551-557
    • Stockton, J.M.1    Birdsall, N.J.M.2    Burgen, A.S.V.3    Hulme, E.C.4
  • 28
    • 0023958554 scopus 로고
    • Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods
    • Ehlert EJ. Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. Mol Pharmacol 1988; 33: 187-94.
    • (1988) Mol Pharmacol , vol.33 , pp. 187-194
    • Ehlert, E.J.1
  • 32
    • 38949112855 scopus 로고    scopus 로고
    • Galphasubunits differentially alter the conformation and agonist affinity of k-opioid receptors
    • Yan F, Mosier PD, Westkaemper RB, Roth BL. Galphasubunits differentially alter the conformation and agonist affinity of k-opioid receptors. Biochem 2008; 47: 1567-78.
    • (2008) Biochem , vol.47 , pp. 1567-1578
    • Yan, F.1    Mosier, P.D.2    Westkaemper, R.B.3    Roth, B.L.4
  • 33
    • 0025281924 scopus 로고
    • Interpretation of agonist affinity estimations: The question of distributed receptor states
    • Black JW, Shankley NP. Interpretation of agonist affinity estimations: the question of distributed receptor states. Proc Roy Soc Lond B Biol Sci 1990; 240: 503-18.
    • (1990) Proc Roy Soc Lond B Biol Sci , vol.240 , pp. 503-518
    • Black, J.W.1    Shankley, N.P.2
  • 35
    • 0023227107 scopus 로고
    • Multiple mechanisms of serotonergic signal transduction
    • Roth BL, Chuang DM. Multiple mechanisms of serotonergic signal transduction. Life Sci 1987; 41: 1051-64.
    • (1987) Life Sci , vol.41 , pp. 1051-1064
    • Roth, B.L.1    Chuang, D.M.2
  • 37
    • 0036177114 scopus 로고    scopus 로고
    • Efficacy at G protein coupled receptors
    • Kenakin TP. Efficacy at G protein coupled receptors. Annu Rev Pharmacol Toxicol 2002; 42: 349-79.
    • (2002) Annu Rev Pharmacol Toxicol , vol.42 , pp. 349-379
    • Kenakin, T.P.1
  • 38
    • 34447636845 scopus 로고    scopus 로고
    • Collateral efficacy as pharmacological problem applied to new drug discovery
    • Kenakin TP. Collateral efficacy as pharmacological problem applied to new drug discovery. Expert Opin Drug Disc 2006; 1: 635-52.
    • (2006) Expert Opin Drug Disc , vol.1 , pp. 635-652
    • Kenakin, T.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.