-
1
-
-
77950565188
-
Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
-
Theravance, Inc. EP 1735304, JP 2007535546, JP 2008174569, US 2005228014, US 2007281970, US 7375114, US 7728006, WO 2005100350
-
Marquess, D., Fatheree, P.R., Turner, D.S., Long, D.D., Choi, S.-K., Goldblum, A.A., Genov, D. (Theravance, Inc.). Quinolinone-carboxamide compounds as 5-HT4 receptor agonists. EP 1735304, JP 2007535546, JP 2008174569, US 2005228014, US 2007281970, US 7375114, US 7728006, WO 2005100350.
-
-
-
Marquess, D.1
Fatheree, P.R.2
Turner, D.S.3
Long, D.D.4
Choi, S.-K.5
Goldblum, A.A.6
Genov, D.7
-
2
-
-
77950565188
-
Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
-
Theravance, Inc. US 2007270457, US 7592355
-
Marquess, D., Fatheree, P.R., Turner, S.D., Long, D.D., Choi, S., Goldblum, A.A., Genov, D. (Theravance, Inc.). Quinolinone-carboxamide compounds as 5-HT4 receptor agonists. US 2007270457, US 7592355.
-
-
-
Marquess, D.1
Fatheree, P.R.2
Turner, S.D.3
Long, D.D.4
Choi, S.5
Goldblum, A.A.6
Genov, D.7
-
3
-
-
77950565188
-
Quinolinone-carboxamide compounds as 5-HT4, receptor agonists
-
Theravance, Inc. US 2008176895, US 7763637
-
Marquess, D., Fatheree, P.R., Turner, S.D., Long, D.D., Choi, S., Goldblum, A.A., Genov, D. (Theravance, Inc.). Quinolinone-carboxamide compounds as 5-HT4, receptor agonists. US 2008176895, US 7763637.
-
-
-
Marquess, D.1
Fatheree, P.R.2
Turner, S.D.3
Long, D.D.4
Choi, S.5
Goldblum, A.A.6
Genov, D.7
-
4
-
-
84952979736
-
5-HT4 receptor agonist compounds
-
Theravance, Inc. US 2008255187, US 7534889
-
Choi, S.-K., Fatheree, P., Goldblum, A.A., Jiang, L., Long, D.D., Marquess, D., Turner, S.D. (Theravance, Inc.). 5-HT4 receptor agonist compounds. US 2008255187, US 7534889.
-
-
-
Choi, S.-K.1
Fatheree, P.2
Goldblum, A.A.3
Jiang, L.4
Long, D.D.5
Marquess, D.6
Turner, S.D.7
-
5
-
-
77950565188
-
Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
-
Theravance, Inc. US 2010285519
-
Marquess, D., Fatheree, P.R., Turner, S.D., Long, D.D., Choi, S.-K., Goldblum, A.A., Genov, D. (Theravance, Inc.). Quinolinone-carboxamide compounds as 5-HT4 receptor agonists. US 2010285519.
-
-
-
Marquess, D.1
Fatheree, P.R.2
Turner, S.D.3
Long, D.D.4
Choi, S.-K.5
Goldblum, A.A.6
Genov, D.7
-
6
-
-
77950565188
-
Quinolone-carboxamide compounds as 5-HT4 receptor agonists
-
Theravance, Inc. US 2010311979
-
Marquess, D., Fatheree, P.R., Turner, S.D., Long, D.D., Choi, S.-K., Goldblum, A.A., Genov, D. (Theravance, Inc.). Quinolone-carboxamide compounds as 5-HT4 receptor agonists. US 2010311979.
-
-
-
Marquess, D.1
Fatheree, P.R.2
Turner, S.D.3
Long, D.D.4
Choi, S.-K.5
Goldblum, A.A.6
Genov, D.7
-
7
-
-
84952979736
-
5-HT4 receptor agonist compounds
-
Theravance, Inc. EP 1807422, JP 2008518965, US 2006100236, US 7399862, WO 2006052640
-
Choi, S.-K., Fatheree, P., Goldblum, A.A., Jiang, L., Long, D.D., Marquess, D., Turner, S.D. (Theravance, Inc.). 5-HT4 receptor agonist compounds. EP 1807422, JP 2008518965, US 2006100236, US 7399862, WO 2006052640.
-
-
-
Choi, S.-K.1
Fatheree, P.2
Goldblum, A.A.3
Jiang, L.4
Long, D.D.5
Marquess, D.6
Turner, S.D.7
-
8
-
-
85061202970
-
Crystalline form of a quinolinone-carboxamide compound
-
Theravance, Inc. EP 1874766, JP 2008535848, US 2006229332, US 7728004, WO 2006108127
-
Fatheree, P.R., Turner, S.D., Goldblum, A., Chao, R., Genov, D. (Theravance, Inc.). Crystalline form of a quinolinone-carboxamide compound. EP 1874766, JP 2008535848, US 2006229332, US 7728004, WO 2006108127.
-
-
-
Fatheree, P.R.1
Turner, S.D.2
Goldblum, A.3
Chao, R.4
Genov, D.5
-
9
-
-
69949089934
-
A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists
-
McKinnell, R.M., Armstrong, S.R., Beattie, D.T. et al. A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists. J Med Chem 2009, 52(17): 5330-43.
-
(2009)
J Med Chem
, vol.52
, Issue.17
, pp. 5330-5343
-
-
McKinnell, R.M.1
Armstrong, S.R.2
Beattie, D.T.3
-
10
-
-
84952982211
-
Process for preparing intermediates to 5-HT4 receptor agonist compounds
-
Theravance, Inc. EP 1984362, JP 2009526852, US 2007191355, WO 2007097976
-
Genov, D., Lee, J., Liu, J. (Theravance, Inc.). Process for preparing intermediates to 5-HT4 receptor agonist compounds. EP 1984362, JP 2009526852, US 2007191355, WO 2007097976.
-
-
-
Genov, D.1
Lee, J.2
Liu, J.3
-
11
-
-
2442629629
-
Epidemiology of Constipation in North America: A Systematic Review
-
DOI 10.1111/j.1572-0241.2004.04114.x
-
Higgins, P.D., Johanson, J.F. Epidemiology of constipation in North America: A systematic review. Am J Gastroenterol 2004, 99(4): 750-9. (Pubitemid 38612817)
-
(2004)
American Journal of Gastroenterology
, vol.99
, Issue.4
, pp. 750-759
-
-
Higgins, P.D.R.1
Johanson, J.F.2
-
12
-
-
0141653832
-
Chronic constipation
-
Lembo, A., Camilleri, M. Chronic constipation. N Engl J Med 2003, 349(14): 1360-8.
-
(2003)
N Engl J Med
, vol.349
, Issue.14
, pp. 1360-1368
-
-
Lembo, A.1
Camilleri, M.2
-
13
-
-
50649111199
-
Ambulatory care for constipation in the United States, 1993-2004
-
Shah, N.D., Chitkara, D.K., Locke, G.R., Meek, P.D., Talley, N.J. Ambulatory care for constipation in the United States, 1993-2004. Am J Gastroenterol 2008, 103(7): 1746-53.
-
(2008)
Am J Gastroenterol
, vol.103
, Issue.7
, pp. 1746-1753
-
-
Shah, N.D.1
Chitkara, D.K.2
Locke, G.R.3
Meek, P.D.4
Talley, N.J.5
-
14
-
-
78650268288
-
Longitudinal direct medical costs associated with constipation in women
-
rd, Talley, N.J. Longitudinal direct medical costs associated with constipation in women. Aliment Pharmacol Ther 2011, 33(2): 251-60.
-
(2011)
Aliment Pharmacol Ther
, vol.33
, Issue.2
, pp. 251-260
-
-
Choung, R.S.1
Branda, M.E.2
Chitkara, D.3
Shah, N.D.4
Katusic, S.K.5
Locke III, G.R.6
Talley, N.J.7
-
15
-
-
0024478044
-
Physician visits in the Unites States for constipation: 1958 to 1986
-
DOI 10.1007/BF01536339
-
Sonnenberg, A., Koch, T.R. Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci 1989, 34(4): 606-11. (Pubitemid 19122000)
-
(1989)
Digestive Diseases and Sciences
, vol.34
, Issue.4
, pp. 606-611
-
-
Sonnenberg, A.1
Koch, T.R.2
-
16
-
-
64049099100
-
Health-related quality of life in young adults with symptoms of constipation continuing from childhood into adulthood
-
Bongers, M.E., Benninga, M.A., Maurice-Stam, H., Grootenhuis, M.A. Health-related quality of life in young adults with symptoms of constipation continuing from childhood into adulthood. Health Qual Life Outcomes 2009, 7: 20.
-
(2009)
Health Qual Life Outcomes
, vol.7
, pp. 20
-
-
Bongers, M.E.1
Benninga, M.A.2
Maurice-Stam, H.3
Grootenhuis, M.A.4
-
17
-
-
6044278151
-
SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents
-
DOI 10.1152/ajpcell.00528.2003
-
Cuppoletti, J., Malinowska, D.H., Tewari, K.P., Li, Q.J., Sherry, A.M., Patchen, M.L., Ueno, R. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol 2004, 287(5): C1173-83. (Pubitemid 39382875)
-
(2004)
American Journal of Physiology - Cell Physiology
, vol.287
, Issue.5
-
-
Cuppoletti, J.1
Malinowska, D.H.2
Tewari, K.P.3
Li, Q.-J.4
Sherry, A.M.5
Patchen, M.L.6
Ueno, R.7
-
18
-
-
79952438594
-
Lubiprostone activates Cl(-) secretion via cAMPsignaling and increases membrane CFTR in the human colon carcinoma cell line, T84
-
Ao, M., Venkatasubramanian, J., Boonkaewwan, C., Ganesan, N., Syed, A., Benya, R.V., Rao, M.C. Lubiprostone activates Cl(-) secretion via cAMPsignaling and increases membrane CFTR in the human colon carcinoma cell line, T84. Dig Dis Sci 2011, 56(2): 339-51.
-
(2011)
Dig Dis Sci
, vol.56
, Issue.2
, pp. 339-351
-
-
Ao, M.1
Venkatasubramanian, J.2
Boonkaewwan, C.3
Ganesan, N.4
Syed, A.5
Benya, R.V.6
Rao, M.C.7
-
19
-
-
69249105681
-
Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator
-
Bijvelds, M.J., Bot, A.G., Escher, J.C., De Jonge, H.R. Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology 2009, 137(3): 976-85.
-
(2009)
Gastroenterology
, vol.137
, Issue.3
, pp. 976-985
-
-
Bijvelds, M.J.1
Bot, A.G.2
Escher, J.C.3
De Jonge, H.R.4
-
20
-
-
40949131857
-
Clinical trial: Phase 2 study of lubiprostone for irritable bowel syndrome with constipation
-
DOI 10.1111/j.1365-2036.2008.03629.x
-
Johanson, J.F., Drossman, D.A., Panas, R., Wahle, A., Ueno, R. Clinical trial: Phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2008, 27(8): 685-96. (Pubitemid 351406304)
-
(2008)
Alimentary Pharmacology and Therapeutics
, vol.27
, Issue.8
, pp. 685-696
-
-
Johanson, J.F.1
Drossman, D.A.2
Panas, R.3
Wahle, A.4
Ueno, R.5
-
21
-
-
58149103805
-
Clinical trial: Lubiprostone in patients with constipation-associated irritable bowel syndrome - Results of two randomized, placebo-controlled studies
-
Drossman, D.A., Chey, W.D., Johanson, J.F., Fass, R., Scott, C., Panas, R., Ueno, R. Clinical trial: Lubiprostone in patients with constipation- associated irritable bowel syndrome - Results of two randomized, placebo-controlled studies. Aliment Pharmacol Ther 2009, 29(3): 329-41.
-
(2009)
Aliment Pharmacol Ther
, vol.29
, Issue.3
, pp. 329-341
-
-
Drossman, D.A.1
Chey, W.D.2
Johanson, J.F.3
Fass, R.4
Scott, C.5
Panas, R.6
Ueno, R.7
-
22
-
-
37849024665
-
Multicenter, 4-week, doubleblind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation
-
Johanson, J.F., Morton, D., Geenen, J., Ueno, R. Multicenter, 4-week, doubleblind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation. Am J Gastroenterol 2008, 103(1): 170-7.
-
(2008)
Am J Gastroenterol
, vol.103
, Issue.1
, pp. 170-177
-
-
Johanson, J.F.1
Morton, D.2
Geenen, J.3
Ueno, R.4
-
23
-
-
33846347644
-
The Serotonin Signaling System: From Basic Understanding To Drug Development for Functional GI Disorders
-
DOI 10.1053/j.gastro.2006.11.002, PII S001650850602436X
-
Gershon, M.D., Tack, J. The serotonin signaling system: From basic understanding to drug development for functional GI disorders. Gastroenterology 2007, 132(1): 397-414. (Pubitemid 46127672)
-
(2007)
Gastroenterology
, vol.132
, Issue.1
, pp. 397-414
-
-
Gershon, M.D.1
Tack, J.2
-
24
-
-
0031876343
-
The influence of cisapride on gastric tone and the perception of gastric distension
-
DOI 10.1046/j.1365-2036.1998.00366.x
-
Tack, J., Broeckaert, D., Coulie, B., Janssens, J. The influence of cisapride on gastric tone and the perception of gastric distension. Aliment Pharmacol Ther 1998, 12(8): 761-6. (Pubitemid 28369883)
-
(1998)
Alimentary Pharmacology and Therapeutics
, vol.12
, Issue.8
, pp. 761-766
-
-
Tack, J.1
Broeckaert, D.2
Coulie, B.3
Janssens, J.4
-
25
-
-
0034089045
-
Tegaserod accelerates orocecal transit in patients with constipation- predominant irritable bowel syndrome
-
Prather, C.M., Camilleri, M., Zinsmeister, A.R., McKinzie, S., Thomforde, G. Tegaserod accelerates orocecal transit in patients with constipation- predominant irritable bowel syndrome. Gastroenterology 2000, 118(3): 463-8. (Pubitemid 30140843)
-
(2000)
Gastroenterology
, vol.118
, Issue.3
, pp. 463-468
-
-
Prather, C.M.1
Camilleri, M.2
Zinsmeister, A.R.3
McKinzie, S.4
Thomforde, G.5
-
26
-
-
33646153533
-
Safety and tolerability of tegaserod in patients with chronic constipation: Pooled data from two phase III studies
-
Quigley, E.M., Wald, A., Fidelholtz, J., Boivin, M., Pecher, E., Earnest, D. Safety and tolerability of tegaserod in patients with chronic constipation: Pooled data from two phase III studies. Clin Gastroenterol Hepatol 2006, 4(5): 605-13.
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, Issue.5
, pp. 605-613
-
-
Quigley, E.M.1
Wald, A.2
Fidelholtz, J.3
Boivin, M.4
Pecher, E.5
Earnest, D.6
-
27
-
-
44949106525
-
Tegaserod for the treatment of irritable bowel syndrome and chronic constipation
-
CD003960
-
Evans, B.W., Clark, W.K., Moore, D.J. et al. Tegaserod for the treatment of irritable bowel syndrome and chronic constipation. Cochrane Database Syst Rev 2007: CD003960.
-
(2007)
Cochrane Database Syst Rev
-
-
Evans, B.W.1
Clark, W.K.2
Moore, D.J.3
-
28
-
-
8744318249
-
2B receptor antagonist in vitro and in vivo
-
DOI 10.1038/sj.bjp.0705929
-
Beattie, D.T., Smith, J.A., Marquess, D. et al. The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo. Br J Pharmacol 2004, 143(5): 549-60. (Pubitemid 39524272)
-
(2004)
British Journal of Pharmacology
, vol.143
, Issue.5
, pp. 549-560
-
-
Beattie, D.T.1
Smith, J.A.M.2
Marquess, D.3
Vickery, R.G.4
Armstrong, S.R.5
Pulido-Rios, T.6
McCullough, J.L.7
Sandlund, C.8
Richardson, C.9
Mai, N.10
Humphrey, P.P.A.11
-
29
-
-
4444245748
-
Effect of tegaserod in chronic constipation: A randomized, double-blind, controlled trial
-
DOI 10.1016/S1542-3565(04)00356-8, PII S1542356504003568
-
Johanson, J.F., Wald, A., Tougas, G. et al. Effect of tegaserod in chronic constipation: A randomized, double-blind, controlled trial. Clin Gastroenterol Hepatol 2004, 2(9): 796-805. (Pubitemid 39200718)
-
(2004)
Clinical Gastroenterology and Hepatology
, vol.2
, Issue.9
, pp. 796-805
-
-
Johanson, J.F.1
Wald, A.2
Tougas, G.3
Chey, W.D.4
Novick, J.S.5
Lembo, A.J.6
Fordham, F.7
Guella, M.8
Nault, B.9
-
30
-
-
20044386871
-
Tegaserod for the treatment of chronic constipation: A randomized, double-blind, placebo-controlled multinational study
-
DOI 10.1111/j.1572-0241.2005.40749.x
-
Kamm, M.A., Muller-Lissner, S., Talley, N.J, et al. Tegaserod for the treatment of chronic constipation: A randomized, double-blind, placebo-controlled multinational study. Am J Gastroenterol 2005, 100(2): 362-72. (Pubitemid 40314521)
-
(2005)
American Journal of Gastroenterology
, vol.100
, Issue.2
, pp. 362-372
-
-
Kamm, M.A.1
Muller-Lissner, S.2
Talley, N.J.3
Tack, J.4
Boeckxstaens, G.5
Minushkin, O.N.6
Kalinin, A.7
Dzieniszewski, J.8
Haeck, P.9
Fordham, F.10
Hugot-Cournez, S.11
Nault, B.12
-
31
-
-
72049098520
-
Prucalopride
-
Frampton, J.E. Prucalopride. Drugs 2009, 69(17): 2463-76.
-
(2009)
Drugs
, vol.69
, Issue.17
, pp. 2463-2476
-
-
Frampton, J.E.1
-
32
-
-
44349130441
-
A placebo-controlled trial of prucalopride for severe chronic constipation
-
DOI 10.1056/NEJMoa0800670
-
Camilleri, M., Kerstens, R., Rykx, A., Vandeplassche, L. A placebo-controlled trial of prucalopride for severe chronic constipation. N Engl J Med 2008, 358(22): 2344-54. (Pubitemid 351749158)
-
(2008)
New England Journal of Medicine
, vol.358
, Issue.22
, pp. 2344-2354
-
-
Camilleri, M.1
Kerstens, R.2
Rykx, A.3
Vandeplassche, L.4
-
33
-
-
0035121508
-
Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder
-
Bouras, E.P., Camilleri, M., Burton, D.D., Thomforde, G., McKinzie, S., Zinsmeister, A.R. Prucalopride accelerates gastrointestinal and colonic transit in patients with constipation without a rectal evacuation disorder. Gastroenterology 2001, 120(2): 354-60. (Pubitemid 32147632)
-
(2001)
Gastroenterology
, vol.120
, Issue.2
, pp. 354-360
-
-
Bouras, E.P.1
Camilleri, M.2
Burton, D.D.3
Thomforde, G.4
McKinzie, S.5
Zinsmeister, A.R.6
-
34
-
-
0036024222
-
Prucalopride, a systemic enterokinetic, for the treatment of constipation
-
Emmanuel, A.V., Roy, A.J., Nicholls, T.J., Kamm, M.A. Prucalopride, a systemic enterokinetic, for the treatment of constipation. Aliment Pharmacol Ther 2002, 16(7): 1347-56.
-
(2002)
Aliment Pharmacol Ther
, vol.16
, Issue.7
, pp. 1347-1356
-
-
Emmanuel, A.V.1
Roy, A.J.2
Nicholls, T.J.3
Kamm, M.A.4
-
35
-
-
58149084950
-
Clinical trial: The efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - A 12-week, randomized, double-blind, placebocontrolled study
-
Quigley, E.M., Vandeplassche, L., Kerstens, R., Ausma, J. Clinical trial: The efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - A 12-week, randomized, double-blind, placebocontrolled study. Aliment Pharmacol Ther 2009, 29(3): 315-28.
-
(2009)
Aliment Pharmacol Ther
, vol.29
, Issue.3
, pp. 315-328
-
-
Quigley, E.M.1
Vandeplassche, L.2
Kerstens, R.3
Ausma, J.4
-
36
-
-
33845656047
-
4 receptor agonist, ATI-7505, in humans
-
DOI 10.1111/j.1365-2982.2006.00865.x
-
Camilleri, M., Vazquez-Roque, M.I., Burton, D., Ford, T., McKinzie, S., Zinsmeister, A.R., Druzgala, P. Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans. Neurogastroenterol Motil 2007, 19(1): 30-8. (Pubitemid 44952776)
-
(2007)
Neurogastroenterology and Motility
, vol.19
, Issue.1
, pp. 30-38
-
-
Camilleri, M.1
Vazquez-Roque, M.I.2
Burton, D.3
Ford, T.4
McKinzie, S.5
Zinsmeister, A.R.6
Druzgala, P.7
-
37
-
-
79957604521
-
A novel gastrointestinal prokinetic, ATI-7505, increased spontaneous bowel movements (SBMS) in a phase II, randomized, placebo-controlled study of patients with chronic idiopathic constipation
-
Palme, M., Milner, P.G., Ellis, D.J., Marmon, T., Canafax, D.M. A novel gastrointestinal prokinetic, ATI-7505, increased spontaneous bowel movements (SBMS) in a phase II, randomized, placebo-controlled study of patients with chronic idiopathic constipation. Gastroenterology 2010, 138(5, Suppl. 1): S128-9.
-
(2010)
Gastroenterology
, vol.138
, Issue.5 SUPPL. 1
-
-
Palme, M.1
Milner, P.G.2
Ellis, D.J.3
Marmon, T.4
Canafax, D.M.5
-
38
-
-
79959462765
-
Results of a thorough QT study (ICH E14) testing a novel gastrointestinal prokinetic, ATI-7505, show no ECG effects at therapeutic and supratherapeutic doses
-
Milner, P.G., Canafax, D.M., Palme, M., Morganroth, J. Results of a thorough QT study (ICH E14) testing a novel gastrointestinal prokinetic, ATI-7505, show no ECG effects at therapeutic and supratherapeutic doses. Gastroenterology 2010, 138(5, Suppl. 1): S164-5.
-
(2010)
Gastroenterology
, vol.138
, Issue.5 SUPPL. 1
-
-
Milner, P.G.1
Canafax, D.M.2
Palme, M.3
Morganroth, J.4
-
39
-
-
72449143707
-
Effects of velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipation
-
Manini, M.L., Camilleri, M., Goldberg, M. et al. Effects of velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipation. Neurogastroenterol Motil 2010, 22(1): 42-9, e7-8.
-
(2010)
Neurogastroenterol Motil
, vol.22
, Issue.1
-
-
Manini, M.L.1
Camilleri, M.2
Goldberg, M.3
-
40
-
-
0034297908
-
Serotonin: A mediator of the brain-gut connection
-
Kim, D.Y., Camilleri, M. Serotonin: A mediator of the brain-gut connection. Am J Gastroenterol 2000, 95(10): 2698-709.
-
(2000)
Am J Gastroenterol
, vol.95
, Issue.10
, pp. 2698-2709
-
-
Kim, D.Y.1
Camilleri, M.2
-
41
-
-
0036119338
-
Molecular, pharmacological and functional diversity of 5-HT receptors
-
DOI 10.1016/S0091-3057(01)00746-8, PII S0091305701007468
-
Hoyer, D., Hannon, J.P., Martin, G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 2002, 71(4): 533-54. (Pubitemid 34219205)
-
(2002)
Pharmacology Biochemistry and Behavior
, vol.71
, Issue.4
, pp. 533-554
-
-
Hoyer, D.1
Hannon, J.P.2
Martin, G.R.3
-
42
-
-
0030265544
-
Peripheral 5-HT4 receptors
-
Hegde, S.S., Eglen, R.M. Peripheral 5-HT4 receptors. FASEB J 1996, 10(12): 1398-407.
-
(1996)
FASEB J
, vol.10
, Issue.12
, pp. 1398-1407
-
-
Hegde, S.S.1
Eglen, R.M.2
-
43
-
-
45849108757
-
The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity
-
Smith, J.A., Beattie, D.T., Marquess, D., Shaw, J.P., Vickery, R.G., Humphrey, P.P. The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity. Naunyn Schmiedebergs Arch Pharmacol 2008, 378(1): 125-37.
-
(2008)
Naunyn Schmiedebergs Arch Pharmacol
, vol.378
, Issue.1
, pp. 125-137
-
-
Smith, J.A.1
Beattie, D.T.2
Marquess, D.3
Shaw, J.P.4
Vickery, R.G.5
Humphrey, P.P.6
-
44
-
-
72449154733
-
TD-5108, a selective, high intrinsic activity 5-HT4 receptor agonist - In vitro profile at human recombinant 5-HT4 receptor splice variant and human isolated colon
-
Dig Dis Week (May 19-24, Washington, D.C.) 2007 Abst W1222
-
Smith, J., Beattie, D.T., Cuthbert, A.W. et al. TD-5108, a selective, high intrinsic activity 5-HT4 receptor agonist - In vitro profile at human recombinant 5-HT4 receptor splice variant and human isolated colon. Gastroenterology [Dig Dis Week (May 19-24, Washington, D.C.) 2007] 2007, 132(4, Suppl. 2): Abst W1222.
-
(2007)
Gastroenterology
, vol.132
, Issue.4 SUPPL. 2
-
-
Smith, J.1
Beattie, D.T.2
Cuthbert, A.W.3
-
45
-
-
72449158039
-
The in vivo preclinical profile of TD-5108, a selective, high intrinsic activity 5HT-4 receptor agonist
-
Dig Dis Week (May 19-24, Washington, D.C.) 2007 Abst W1228
-
Beattie, D.T., Armstrong, S.R., Marquess, D., Shaw, J.-P., Smith, J.A., Humphrey, P.P. The in vivo preclinical profile of TD-5108, a selective, high intrinsic activity 5HT-4 receptor agonist. Gastroenterology [Dig Dis Week (May 19-24, Washington, D.C.) 2007] 2007, 132(4, Suppl. 2): Abst W1228.
-
(2007)
Gastroenterology
, vol.132
, Issue.4 SUPPL. 2
-
-
Beattie, D.T.1
Armstrong, S.R.2
Marquess, D.3
Shaw, J.-P.4
Smith, J.A.5
Humphrey, P.P.6
-
46
-
-
72449205222
-
In healthy subjects TD-5108, a selective high intrinsic activity 5-HT4 receptor agonist, shows dose-proportional pharmacokinetics and exhibits a profile consistent with once-caily dosing
-
Dig Dis Week (May 19-24, Washington, D.C.) 2007
-
Wong, S.L., Goldberg, M.R., Shaw, J.-P., Lanni, C., Ganju, J., Ballow, C.H., Kitt, M.M. In healthy subjects TD-5108, a selective high intrinsic activity 5-HT4 receptor agonist, shows dose-proportional pharmacokinetics and exhibits a profile consistent with once-caily dosing. Gastroenterology [Dig Dis Week (May 19-24, Washington, D.C.) 2007] 2007, 132(4, Suppl. 2): M-1156.
-
(2007)
Gastroenterology
, vol.132
, Issue.4 SUPPL. 2
-
-
Wong, S.L.1
Goldberg, M.R.2
Shaw, J.-P.3
Lanni, C.4
Ganju, J.5
Ballow, C.H.6
Kitt, M.M.7
-
47
-
-
84952984557
-
TD-5108 pharmacokinetics and bowel function in health and constipation
-
Dig Dis Week (May 30-June 4, Chicago) 2009 Abst T1255
-
Manini, M.L., Wong, S.L., Goldberg, M.R. et al. TD-5108 pharmacokinetics and bowel function in health and constipation. Gastroenterology [Dig Dis Week (May 30-June 4, Chicago) 2009] 2009, Abst T1255.
-
(2009)
Gastroenterology
-
-
Manini, M.L.1
Wong, S.L.2
Goldberg, M.R.3
-
48
-
-
78649489728
-
Clinical trial: The efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation - A 4-week, randomized, doubleblind, placebo-controlled, dose-response study
-
Goldberg, M., Li, Y.P., Johanson, J.F, et al. Clinical trial: The efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation - A 4-week, randomized, doubleblind, placebo-controlled, dose-response study. Aliment Pharmacol Ther 2010, 32(9): 1102-12.
-
(2010)
Aliment Pharmacol Ther
, vol.32
, Issue.9
, pp. 1102-1112
-
-
Goldberg, M.1
Li, Y.P.2
Johanson, J.F.3
-
49
-
-
72449201670
-
TD-5108, a selective 5-HT4 agonist with high intrinsic activity, shows immediate and sustained prokinetic activity in healthy subjects
-
Dig Dis Week (May 19-24, Washington, D.C.) 2007 Abst 322
-
Goldberg, M.R., Wong, S.L., Ganju, J., Li, Y.P., Ballow, C.H., Kitt, M.M. TD-5108, a selective 5-HT4 agonist with high intrinsic activity, shows immediate and sustained prokinetic activity in healthy subjects. Gastroenterology [Dig Dis Week (May 19-24, Washington, D.C.) 2007] 2007, 132(4, Suppl. 2): Abst 322.
-
(2007)
Gastroenterology
, vol.132
, Issue.4 SUPPL. 2
-
-
Goldberg, M.R.1
Wong, S.L.2
Ganju, J.3
Li, Y.P.4
Ballow, C.H.5
Kitt, M.M.6
-
50
-
-
79953174333
-
Genomics and drug response
-
Wang, L., McLeod, H.L., Weinshilboum, R.M. Genomics and drug response. N Engl J Med 2011, 364(12): 1144-53.
-
(2011)
N Engl J Med
, vol.364
, Issue.12
, pp. 1144-1153
-
-
Wang, L.1
McLeod, H.L.2
Weinshilboum, R.M.3
|