Antimicrobial surfaces to prevent healthcare-associated infections: A systematic review

Journal of Hospital Infection

Volumn 92, Issue 1, 2016, Pages 7-13

  Muller, M P ^a,b   MacDougall, C ^c   Lim, M ^c   Armstrong, I ^d   Bialachowski, A ^d   Callery, S ^d   Ciccotelli, W ^d   Cividino, M ^d   Dennis, J ^d   Hota, S ^d   Garber, G ^d   Johnstone, J ^d   Katz, K ^d   McGeer, A ^d   Nankoosingh, V ^d   Richard, C ^d   Vearncombe, M ^d  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b PIDAC IPC   (Canada)

^c PUBLIC HEALTH ONTARIO   (Canada)

^d NONE

Author keywords

Antimicrobial surfaces; Copper surfaces; Environmental contamination; Healthcare associated infection

Indexed keywords

ALLOY; COPPER; CORTICOSTEROID; SILANE; SILVER; DISINFECTANT AGENT;

ANTIMICROBIAL SURFACE; ANTIMICROBIAL THERAPY; BACTERIUM CONTAMINATION; BLOODSTREAM INFECTION; COLONY FORMING UNIT; DESCRIPTIVE RESEARCH; DISEASE TRANSMISSION; HEALTH CARE FACILITY; HEALTHCARE ASSOCIATED INFECTION; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; INTERVENTION STUDY; MICROBIAL CONTAMINATION; REVIEW; RISK ASSESSMENT; RISK REDUCTION; SILVER IMPREGNATION; SURFACE AREA; SYSTEMATIC REVIEW; TEXTILE; URINARY CATHETER; VANCOMYCIN RESISTANT ENTEROCOCCUS; WARD; CROSS INFECTION; DISINFECTION; MICROBIOLOGY; PREVENTION AND CONTROL; PROCEDURES; SURFACE PROPERTY;

CROSS INFECTION; DISEASE TRANSMISSION, INFECTIOUS; DISINFECTANTS; DISINFECTION; ENVIRONMENTAL MICROBIOLOGY; HUMANS; SURFACE PROPERTIES;

EID: 84952978064     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2015.09.008     Document Type: Review

References (35)

1. Klevens R.M., Edwards J.R., Richards C.L., et al. Estimating health care-associated infections and deaths in U.S. hospitals, 2002. Public Health Rep 2007, 122:160-166.
2. Magill S.S., Edwards J.R., Bamberg W., et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med 2014, 370:1198-1208.
3. Cosgrove S.E., Sakoulas G., Perencevich E.N., Schwaber M.J., Karchmer A.W., Carmeli Y. Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003, 36:53-59.
4. Maragakis L.L., Perencevich E.N., Cosgrove S.E. Clinical and economic burden of antimicrobial resistance. Expert Rev Antiinfect Ther 2008, 6:751-763.
5. Boyce J.M. Environmental contamination makes an important contribution to hospital infection. J Hosp Infect 2007, 65:S50-S54.
6. Otter J.A., Yezli S., French G.L. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol 2011, 32:687-699.
7. Otter J.A., Yezli S., Salkeld J.A., French G.L. Evidence that contaminated surfaces contribute to the transmission of hospital pathogens and an overview of strategies to address contaminated surfaces in hospital settings. Am J Infect Control 2013, 41:S1-S11.
8. Weber D.J., Rutala W.A., Miller M.B., Huslage K., Sickbert-Bennett E. Role of hospital surfaces in the transmission of emerging health care-associated pathogens: norovirus, Clostridium difficile, and Acinetobacter species. Am J Infect Control 2010, 38:S25-S33.
9. Weber D.J., Anderson D.J., Sexton D.J., Rutala W.A. Role of the environment in the transmission of Clostridium difficile in health care facilities. Am J Infect Control 2013, 41:S105-S110.
10. Kramer A., Schwebke I., Kampf G. How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis 2006, 6:130.
11. Boyce J.M., Havill N.L., Otter J.A., et al. Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in a healthcare setting. Infect Control Hosp Epidemiol 2008, 29:723-729.
12. Byers K.E., Durbin L.J., Simonton B.M., Anglim A.M., Adal K.A., Farr B.M. Disinfection of hospital rooms contaminated with vancomycin-resistant Enterococcus faecium. Infect Control Hosp Epidemiol 1998, 19:261-264.
13. French G.L., Otter J.A., Shannon K.P., Adams N.M., Watling D., Parks M.J. Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus (MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontamination. J Hosp Infect 2004, 57:31-37.
14. Morter S., Bennet G., Fish J., et al. Norovirus in the hospital setting: virus introduction and spread within the hospital environment. J Hosp Infect 2011, 77:106-112.
15. Otter J.A., Cummins M., Ahmad F., van T.C., Drabu Y.J. Assessing the biological efficacy and rate of recontamination following hydrogen peroxide vapour decontamination. J Hosp Infect 2007, 67:182-188.
16. Verity P., Wilcox M.H., Fawley W., Parnell P. Prospective evaluation of environmental contamination by Clostridium difficile in isolation side rooms. J Hosp Infect 2001, 49:204-209.
17. Page K., Wilson M., Parkin I.P. Antimicrobial surfaces and their potential in reducing the role of the inanimate environment in the incidence of hospital-acquired infections. J Material Chem 2009, 19:3819-3831.
18. Abreu A.C., Tavares R.R., Borges A., Mergulhao F., Simoes M. Current and emergent strategies for disinfection of hospital environments. J Antimicrob Chemother 2013, 68:2718-2732.
19. Salgado C.D., Sepkowitz K.A., John J.F., et al. Copper surfaces reduce the rate of healthcare-acquired infections in the intensive care unit. Infect Control Hosp Epidemiol 2013, 34:479-486.
20. Moher D., Liberati A., Tetzlaff J., Altman D.G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009, 6:e1000097. PRISMA Group.
21. Cochrane Effective Practice and Organisation of Care Review Group Risk of bias criteria 2013, Available at:, [last accessed May 2015]. http://bmg.cochrane.org/research-projectscochrane-risk-bias-tool.
22. Harris A.D., Bradham D.D., Baumgarten M., Zuckerman I.H., Fink J.C., Perencevich E.N. The use and interpretation of quasi-experimental studies in infectious diseases. Clin Infect Dis 2004, 38:1586-1591.
23. Guyatt G.H., Oxman A.D., Vist G.E., et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008, 336:924-926.
24. Balshem H., Helfand M., Schunemann H.J., et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol 2011, 64:401-406.
25. Mays N., Pope C., Popay J. Systematically reviewing qualitative and quantitative evidence to inform management and policy-making in the health field. J Health Serv Res Policy 2005, 10:S6-S20.
26. Boyce J.M., Havill N.L., Guercia K.A., Schweon S.J., Moore B.A. Evaluation of two organosilane products for sustained antimicrobial activity on high-touch surfaces in patient rooms. Am J Infect Control 2014, 42:326-328.
27. Casey A.L., Adams D., Karpanen T.J., et al. Role of copper in reducing hospital environment contamination. J Hosp Infect 2010, 74:72-77.
28. Karpanen T.J., Casey A.L., Lambert P.A., et al. The antimicrobial efficacy of copper alloy furnishing in the clinical environment: a crossover study. Infect Control Hosp Epidemiol 2012, 33:3-9.
29. Lazary A., Weinberg I., Vatine J.J., et al. Reduction of healthcare-associated infections in a long-term care brain injury ward by replacing regular linens with biocidal copper oxide impregnated linens. Int J Infect Dis 2014, 24:23-29.
30. Mikolay A., Huggett S., Tikana L., Grass G., Braun J., Nies D.H. Survival of bacteria on metallic copper surfaces in a hospital trial. Appl Microbiol Biotechnol 2010, 87:1875-1879.
31. Phillips P, Taylor L, Hastings R. Silver ion antimicrobial technology: decontamination in a nursing home. Br J Community Nurs 14(S3):S25-S29.
32. Schmidt M.G., Attaway H.H., Sharpe P.A., et al. Sustained reduction of microbial burden on common hospital surfaces through introduction of copper. J Clin Microbiol 2012, 50:2217-2223.
33. Schmidt M.G., Attaway H.H., Fairey S.E., Steed L.L., Michels H.T., Salgado C.D. Copper continuously limits the concentration of bacteria resident on bed rails within the intensive care unit. Infect Control Hosp Epidemiol 2013, 34:530-533.
34. Schweizer M., Graham M., Ohl M., Heilmann K., Boyken L., Diekema D. Novel hospital curtains with antimicrobial properties: a randomized, controlled trial. Infect Control Hosp Epidemiol 2012, 33:1081-1085.
35. Tamimi A.H., Carlino S., Gerba C.P. Long-term efficacy of a self-disinfecting coating in an intensive care unit. Am J Infect Control 2014, 42:1178-1181.