The diverging roles of dendritic cells in kidney allotransplantation

Transplantation Reviews

Volumn 29, Issue 3, 2015, Pages 114-120

  Podestà, Manuel Alfredo ^a   Cucchiari, David ^a   Ponticelli, Claudio ^a  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD11B ANTIGEN; CD4 ANTIGEN; CD45RA ANTIGEN; CD64 ANTIGEN; CHEMOKINE RECEPTOR CX3CR1; GLYCOPROTEIN P 15095; INTERLEUKIN 2 RECEPTOR ALPHA; PATTERN RECOGNITION RECEPTOR; TRANSCRIPTION FACTOR FOXP3; ALLOANTIGEN;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL MIGRATION; CELLULAR DISTRIBUTION; DENDRITIC CELL; DISEASE ASSOCIATION; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INFLAMMATORY CELL; INNATE IMMUNITY; INTRACELLULAR SIGNALING; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LYMPHOCYTE DIFFERENTIATION; MOLECULAR DYNAMICS; MONOCYTE DERIVED DENDRITIC CELL; NONHUMAN; ONTOGENY; PLASMACYTOID DENDRITIC CELL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REPERFUSION INJURY; REVIEW; TH1 CELL; TH17 CELL; ADVERSE EFFECTS; ALLOGRAFT; ANIMAL; CYTOLOGY; DISEASE MODEL; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; IMMUNOLOGY; MOUSE; PHYSIOLOGY; PROCEDURES;

ADAPTIVE IMMUNITY; ALLOGRAFTS; ANIMALS; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNE TOLERANCE; IMMUNITY, INNATE; ISOANTIGENS; KIDNEY TRANSPLANTATION; MICE; TRANSPLANTATION IMMUNOLOGY;

EID: 84952877269     PISSN: 0955470X     EISSN: 15579816     Source Type: Journal    
DOI: 10.1016/j.trre.2015.04.001     Document Type: Review

References (86)

1. Langerhans P. Ueber die Nerven der menschlichen haut. Arch Für Pathol Anat Physiol Für Klin Med 1868, 44:325-337. 10.1007/BF01959006.
2. Steinman R.M., Cohn Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973, 137:1142-1162.
3. Steinman R.M., Cohn Z.A. Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional properties in vitro. J Exp Med 1974, 139:380-397.
4. Steinman R.M., Witmer M.D. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc Natl Acad Sci U S A 1978, 75:5132-5136.
5. Dudziak D., Kamphorst A.O., Heidkamp G.F., et al. Differential antigen processing by dendritic cell subsets in vivo. Science 2007, 315:107-111. 10.1126/science.1136080.
6. Manz M.G., Traver D., Miyamoto T., Weissman I.L., Akashi K. Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 2001, 97:3333-3341.
7. Anjuère F., Martínez del Hoyo G., Martín P., Ardavín C. Langerhans cells acquire a CD8+ dendritic cell phenotype on maturation by CD40 ligation. J Leukoc Biol 2000, 67:206-209.
8. Mildner A., Yona S., Jung S. A close encounter of the third kind: monocyte-derived cells. Adv Immunol 2013, 120:69-103. 10.1016/B978-0-12-417028-5.00003-X.
9. Guilliams M., Henri S., Tamoutounour S., et al. From skin dendritic cells to a simplified classification of human and mouse dendritic cell subsets. Eur J Immunol 2010, 40:2089-2094. 10.1002/eji.201040498.
10. Kool M., Soullié T., van Nimwegen M., et al. Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells. J Exp Med 2008, 205:869-882. 10.1084/jem.20071087.
11. Haniffa M., Collin M., Ginhoux F. Ontogeny and functional specialization of dendritic cells in human and mouse. Adv Immunol 2013, 120:1-49. 10.1016/B978-0-12-417028-5.00001-6.
12. Siegal F.P., Kadowaki N., Shodell M., et al. The nature of the principal type 1 interferon-producing cells in human blood. Science 1999, 284:1835-1837.
13. Lindenmeyer M., Noessner E., Nelson P.J., Segerer S. Dendritic cells in experimental renal inflammation-part I. Nephron Exp Nephrol 2011, 119:e83-e90. 10.1159/000332029.
14. Blasius A.L., Giurisato E., Cella M., Schreiber R.D., Shaw A.S., Colonna M. Bone marrow stromal cell antigen 2 is a specific marker of type I IFN-producing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol 2006, 177:3260-3265.
15. Krüger T., Benke D., Eitner F., et al. Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol 2004, 15:613-621.
16. Rogers N.M., Ferenbach D.A., Isenberg J.S., Thomson A.W., Hughes J. Dendritic cells and macrophages in the kidney: a spectrum of good and evil. Nat Rev Nephrol 2014, 10:625-643. 10.1038/nrneph.2014.170.
17. Ginhoux F., Liu K., Helft J., et al. The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med 2009, 206:3115-3130. 10.1084/jem.20091756.
18. Klechevsky E., Morita R., Liu M., et al. Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. Immunity 2008, 29:497-510. 10.1016/j.immuni.2008.07.013.
19. Crozat K., Guiton R., Guilliams M., et al. Comparative genomics as a tool to reveal functional equivalences between human and mouse dendritic cell subsets. Immunol Rev 2010, 234:177-198. 10.1111/j.0105-2896.2009.00868.x.
20. Robbins S.H., Walzer T., Dembélé D., et al. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol 2008, 9:R17. 10.1186/gb-2008-9-1-r17.
21. Dzionek A., Fuchs A., Schmidt P., et al. BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol 2000, 165:6037-6046.
22. Segura E., Touzot M., Bohineust A., et al. Human inflammatory dendritic cells induce Th17 cell differentiation. Immunity 2013, 38:336-348. 10.1016/j.immuni.2012.10.018.
23. Hänsel A., Günther C., Ingwersen J., et al. Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong TH17/TH1 T-cell responses. J Allergy Clin Immunol 2011, 127:787-794.e1-9. 10.1016/j.jaci.2010.12.009.
24. Woltman A.M., de Fijter J.W., Zuidwijk K., et al. Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions. Kidney Int 2007, 71:1001-1008. 10.1038/sj.ki.5002187.
25. Noessner E., Lindenmeyer M., Nelson P.J., Segerer S. Dendritic cells in human renal inflammation-part II. Nephron Exp Nephrol 2011, 119:e91-e98. 10.1159/000332032.
26. Fiore N., Castellano G., Blasi A., et al. Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritis. Mol Immunol 2008, 45:259-265. 10.1016/j.molimm.2007.04.029.
27. Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010, 11:373-384. 10.1038/ni.1863.
28. Mildner A., Jung S. Development and function of dendritic cell subsets. Immunity 2014, 40:642-656. 10.1016/j.immuni.2014.04.016.
29. Steinman R.M., Hawiger D., Nussenzweig M.C. Tolerogenic dendritic cells. Annu Rev Immunol 2003, 21:685-711. 10.1146/annurev.immunol.21.120601.141040.
30. Mahnke K., Schmitt E., Bonifaz L., Enk A.H., Jonuleit H. Immature, but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol 2002, 80:477-483. 10.1046/j.1440-1711.2002.01115.x.
31. Chung C.Y.J., Ysebaert D., Berneman Z.N., Cools N. Dendritic cells: cellular mediators for immunological tolerance. Clin Dev Immunol 2013, 2013:972865. 10.1155/2013/972865.
32. Waldner H. The role of innate immune responses in autoimmune disease development. Autoimmun Rev 2009, 8:400-404. 10.1016/j.autrev.2008.12.019.
33. Banchereau J., Palucka A.K. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 2005, 5:296-306. 10.1038/nri1592.
34. Ponticelli CE The impact of cold ischemia time on renal transplant outcome. Kidney Int 2015, 87(2):272-275. 10.1038/ki.2014.359.
35. Cavaillé-Coll M., Bala S., Velidedeoglu E., et al. Summary of FDA workshop on ischemia reperfusion injury in kidney transplantation. Am J Transplant 2013, 13:1134-1148. 10.1111/ajt.12210.
36. Ponticelli C. Ischaemia-reperfusion injury: a major protagonist in kidney transplantation. Nephrol Dial Transplant 2014, 29:1134-1140. 10.1093/ndt/gft488.
37. Land W.G. Emerging role of innate immunity in organ transplantation part II: potential of damage-associated molecular patterns to generate immunostimulatory dendritic cells. Transplant Rev (Orlando) 2012, 26:73-87. 10.1016/j.trre.2011.02.003.
38. Cella M., Jarrossay D., Facchetti F., et al. Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med 1999, 5:919-923. 10.1038/11360.
39. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003, 3:133-146. 10.1038/nri1001.
40. Cyster J.G. Leukocyte migration: scent of the T zone. Curr Biol 2000, 10:R30-R33.
41. Dunkelberger J.R., Song W.-C. Role and mechanism of action of complement in regulating T cell immunity. Mol Immunol 2010, 47:2176-2186. 10.1016/j.molimm.2010.05.008.
42. Carroll M.C., Isenman D.E. Regulation of humoral immunity by complement. Immunity 2012, 37:199-207. 10.1016/j.immuni.2012.08.002.
43. Peng Q., Li K., Wang N., et al. Dendritic cell function in allostimulation is modulated by C5aR signaling. J Immunol 2009, 183:6058-6068. 10.4049/jimmunol.0804186.
44. Zhou W., Farrar C.A., Abe K., et al. Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest 2000, 105:1363-1371. 10.1172/JCI8621.
45. Li L., Okusa M.D. Macrophages, dendritic cells, and kidney ischemia-reperfusion injury. Semin Nephrol 2010, 30:268-277. 10.1016/j.semnephrol.2010.03.005.
46. Schwartz R.H. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 1992, 71:1065-1068.
47. McLellan A.D., Sorg R.V., Williams L.A., Hart D.N. Human dendritic cells activate T lymphocytes via a CD40: CD40 ligand-dependent pathway. Eur J Immunol 1996, 26:1204-1210. 10.1002/eji.1830260603.
48. Game D.S., Rogers N.J., Lechler R.I. Acquisition of HLA-DR and costimulatory molecules by T cells from allogeneic antigen presenting cells. Am J Transplant 2005, 5:1614-1625. 10.1111/j.1600-6143.2005.00916.x.
49. Wood K.J., Zaitsu M., Goto R. Cell mediated rejection. Methods Mol Biol 2013, 1034:71-83. 10.1007/978-1-62703-493-7_3.
50. Bajwa A., Huang L., Ye H., et al. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol 2012, 189:2584-2596. 10.4049/jimmunol.1200999.
51. Girlanda R., Kleiner D.E., Duan Z., et al. Monocyte infiltration and kidney allograft dysfunction during acute rejection. Am J Transplant 2008, 8:600-607. 10.1111/j.1600-6143.2007.02109.x.
52. Matheson P.J., Dittmer I.D., Beaumont B.W., Merrilees M.J., Pilmore H.L. The macrophage is the predominant inflammatory cell in renal allograft intimal arteritis. Transplantation 2005, 79:1658-1662.
53. Zuidwijk K., de Fijter J.W., Mallat M.J.K., et al. Increased influx of myeloid dendritic cells during acute rejection is associated with interstitial fibrosis and tubular atrophy and predicts poor outcome. Kidney Int 2012, 81:64-75. 10.1038/ki.2011.289.
54. Colonna M., Trinchieri G., Liu Y.-J. Plasmacytoid dendritic cells in immunity. Nat Immunol 2004, 5:1219-1226. 10.1038/ni1141.
55. Martín-Gayo E., Sierra-Filardi E., Corbí A.L., Toribio M.L. Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development. Blood 2010, 115:5366-5375. 10.1182/blood-2009-10-248260.
56. Ozaki K.S., Kimura S., Nalesnik M.A., et al. The loss of renal dendritic cells and activation of host adaptive immunity are long-term effects of ischemia/reperfusion injury following syngeneic kidney transplantation. Kidney Int 2012, 81:1015-1025. 10.1038/ki.2011.458.
57. Morello S., Ito K., Yamamura S., et al. IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter. J Immunol 2006, 177:7173-7183.
58. Elliott M.R., Chekeni F.B., Trampont P.C., et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature 2009, 461:282-286. 10.1038/nature08296.
59. Sitkovsky M.V., Lukashev D., Apasov S., et al. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol 2004, 22:657-682. 10.1146/annurev.immunol.22.012703.104731.
60. Sevigny C.P., Li L., Awad A.S., et al. Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition. J Immunol 2007, 178:4240-4249.
61. Crikis S., Lu B., Murray-Segal L.M., et al. Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury. Am J Transplant 2010, 10:2586-2595. 10.1111/j.1600-6143.2010.03257.x.
62. 2AR agonist attenuate acute kidney injury. J Clin Invest 2012, 122:3931-3942. 10.1172/JCI63170.
63. Wu W., Shan J., Li Y., et al. Adoptive transfusion of tolerance dendritic cells prolongs the survival of cardiac allograft: a systematic review of 44 basic studies in mice. J Evid-Based Med 2012, 5:139-153. 10.1111/j.1756-5391.2012.01191.x.
64. Zhou Y., Shan J., Li Y., et al. Adoptive transfusion of tolerance dendritic cells prolongs the survival of skin allografts in mice: a systematic review. J Evid-Based Med 2013, 6:90-103. 10.1111/jebm.12035.
65. Xia M.J., Shan J., Li Y.P., et al. Adoptive transfusion of tolerogenic dendritic cells prolongs the survival of liver allograft: a systematic review. J Evid-Based Med 2014, 7:135-146. 10.1111/jebm.12094.
66. Gabrilovich D.I., Chen H.L., Girgis K.R., et al. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med 1996, 2:1096-1103.
67. Steinbrink K., Wölfl M., Jonuleit H., Knop J., Enk A.H. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997, 159:4772-4780.
68. Jolivel V., Luessi F., Masri J., et al. Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis. Brain J Neurol 2013, 136:1048-1066. 10.1093/brain/awt023.
69. Lee C.-C., Wang C.-N., Lai Y.-T., et al. Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma. Br J Pharmacol 2010, 161:1496-1511. 10.1111/j.1476-5381.2010.00972.x.
70. Li C.-Y., Chao L.K., Wang S.-C., et al. Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells. J Cell Physiol 2011, 226:2338-2349. 10.1002/jcp.22576.
71. Bayry J., Lacroix-Desmazes S., Carbonneil C., et al. Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin. Blood 2003, 101:758-765. 10.1182/blood-2002-05-1447.
72. Heystek H.C., Thierry A.-C., Soulard P., Moulon C. Phosphodiesterase 4 inhibitors reduce human dendritic cell inflammatory cytokine production and Th1-polarizing capacity. Int Immunol 2003, 15:827-835.
73. Taner T., Hackstein H., Wang Z., Morelli A.E., Thomson A.W. Rapamycin-treated, alloantigen-pulsed host dendritic cells induce ag-specific T cell regulation and prolong graft survival. Am J Transplant 2005, 5:228-236. 10.1046/j.1600-6143.2004.00673.x.
74. Horibe E.K., Sacks J., Unadkat J., et al. Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion. Transpl Immunol 2008, 18:307-318. 10.1016/j.trim.2007.10.007.
75. Ezzelarab M.B., Zahorchak A.F., Lu L., et al. Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates. Am J Transplant 2013, 13:1989-2005. 10.1111/ajt.12310.
76. Penna G., Adorini L. 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 2000, 164:2405-2411.
77. Afzali B., Edozie F.C., Fazekasova H., et al. Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation. Clin J Am Soc Nephrol 2013, 8:1396-1405. 10.2215/CJN.12931212.
78. Stallone G., Pontrelli P., Infante B., et al. Rapamycin induces ILT3(high)ILT4(high) dendritic cells promoting a new immunoregulatory pathway. Kidney Int 2014, 85:888-897. 10.1038/ki.2013.337.
79. Hadeiba H., Sato T., Habtezion A., Oderup C., Pan J., Butcher E.C. CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol 2008, 9:1253-1260. 10.1038/ni.1658.
80. Gupta A., Kumar C.A., Ningappa M., et al. Elevated myeloid: plasmacytoid dendritic cell ratio associates with late, but not early, liver rejection in children induced with rabbit anti-human thymocyte globulin. Transplantation 2009, 88:589-594. 10.1097/TP.0b013e3181b11f12.
81. Tokita D., Mazariegos G.V., Zahorchak A.F., et al. High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. Transplantation 2008, 85:369-377. 10.1097/TP.0b013e3181612ded.
82. Pallotta M.T., Orabona C., Volpi C., et al. Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol 2011, 12:870-878. 10.1038/ni.2077.
83. Reizis B., Bunin A., Ghosh H.S., Lewis K.L., Sisirak V. Plasmacytoid dendritic cells: recent progress and open questions. Annu Rev Immunol 2011, 29:163-183. 10.1146/annurev-immunol-031210-101345.
84. Rogers N.M., Isenberg J.S., Thomson A.W. Plasmacytoid dendritic cells: no longer an enigma and now key to transplant tolerance?. Am J Transplant 2013, 13:1125-1133. 10.1111/ajt.12229.
85. Ezzelarab M., Thomson A.W. Tolerogenic dendritic cells and their role in transplantation. Semin Immunol 2011, 23:252-263. 10.1016/j.smim.2011.06.007.
86. Moreau A., Varey E., Bériou G., et al. Tolerogenic dendritic cells and negative vaccination in transplantation: from rodents to clinical trials. Front Immunol 2012, 3:218. 10.3389/fimmu.2012.00218.