Elevated myeloid: Plasmacytoid dendritic cell ratio associates with late, but not early, liver rejection in children induced with rabbit anti-human thymocyte globulin

Transplantation

Volumn 88, Issue 4, 2009, Pages 589-594

  Gupta, Ankit ^a   Kumar, Chethan Ashok ^a   Ningappa, Mylarappa ^a   Sun, Qing ^a   Higgs, Brandon W ^a   Snyder, Sara ^a   Zeevi, Adriana ^b   Thomson, Angus W ^b   Mazariegos, George V ^a   Sindhi, Rakesh ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Anti thymocyte globulin; Dendritic cell subsets; Liver transplantation; Pediatric

Indexed keywords

TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRAFT REJECTION; ANTIGEN EXPRESSION; ARTICLE; CADAVER DONOR; CHILD; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; GRAFT SURVIVAL; HUMAN; INFLAMMATION; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; PRESCHOOL CHILD; PRIORITY JOURNAL;

ANIMALS; ANTILYMPHOCYTE SERUM; CHILD; CHILD, PRESCHOOL; CROSS-SECTIONAL STUDIES; DENDRITIC CELLS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; LONGITUDINAL STUDIES; MALE; MYELOID CELLS; RABBITS; RISK FACTORS; SURVIVAL RATE; TACROLIMUS; TIME FACTORS;

EID: 70349100457     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181b11f12     Document Type: Article

References (23)

1. Fridell JA, Jain A, Reyes J, et al. Causes of mortality beyond 1 year after primary pediatric liver transplant under tacrolimus. Transplantation 2002; 27: 74: 1721.
2. Soltys KA, Mazariegos GV, Squires RH, et al. Late graft loss or death in pediatric liver transplantation: An analysis of the SPLIT database. Am J Transplant 2007; 7: 2165.
3. Balistreri WF, Bucuvalas JC, Ryckman FC. The effect of immunosup-pression on growth and development. Liver Transpl Surg 1995; 1(5 suppl 1): 64.
4. Jain A, Nalesnik M, Reyes J, et al. Post-transplant lymphoproliferative disorders in liver transplantation (LTx): A twenty year experience. Ann Surg 2002; 236: 429.
5. Calne R. Prope tolerance: A step in the search for tolerance in the clinic. Transplant Proc 2000; 32: 2058.
6. Hale SJ, Mannon DA, Kleiner RB, et al. Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapy. Lancet 2002; 360: 1662.
7. Starzl TE, Murase N, Abu-Elmagd K, et al. Tolerogenic immunosup-pression for organ transplantation. Lancet 2000; 361: 1502.
8. Eason JD, Nair S, Cohen AJ, et al. Steroid-free liver transplantation using rabbit antithymocyte globulin and early tacrolimus mono-therapy. Transplantation 2003; 75: 1396.
9. Suchin EJ, Langmuir PB, Palmer E, et al. Quantifying the frequency of alloreactive T cells in vivo: New answers to an old question. J Immunol 2001; 166: 973.
10. Karlsson AC, Martin JN, Younger SR, et al. Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells. J Immunol Methods 2003; 283: 141.
11. Newell KA, Larsen CP. Tolerance assays: Measuring the unknown. Transplantation 2006; 81: 1503.
12. Olweus J, BitMansour A, Warnke R, et al. Dendritic cell ontogeny: A human dendritic cell lineage of myeloid origin. Proc Natl Acad Sci USA 1997; 94: 12551.
13. Solari MG, Thomson AW. Human dendritic cells and transplant outcome. Transplantation 2008; 85: 1513.
14. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245.
15. Morelli AE, Thomson AW. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 2007; 7: 610.
16. Ochando JC, Homma C, Yang Y, et al. Alloantigen presenting plasma-cytoid dendritic cells mediate tolerance to vascularized grafts. Nat Im-munol 2006; 7: 652.
17. Grouard G, Rissoan MC, Filgueira L, et al. The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand. J Exp Med 1997; 185: 1101.
18. Mazariegos GV, Zahorchak AF, Reyes J, et al. Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients. Am J Transplant 2003; 3: 689.
19. Womer KL, Peng R, Patton PR, et al. The effects of renal transplantation on peripheral dendritic cells. Clin Transplant 2005; 19: 659.
20. Athanassopoulos P, Vaessen LM, Maat AP, et al. Preferential depletion of blood myeloid dendritic cells during acute cardiac allograft rejection under controlled immunosuppression. Am J Transplant 2005; 5(4 Part 1):810.
21. Sindhi R, Magill A, Abdullah AM, et al. Enhanced donor-specific alloreactivity occurs independent of immunosuppression in children with early liver allograft rejection. Am J Transplant 2005; 5: 96.
22. Bourdage JS, Hamlin DM. Comparative polyclonal antithymo-cyte globulin and antilymphocyte/antilymphoblast globulin anti-CD antigen analysis by flow cytometry. Transplantation 1995; 59: 1194.
23. Merion RM, Howell T, Bromberg JS. Partial T-cell activation and an-ergy induction by polyclonal antithymocyte globulin. Transplantation 1998; 65: 1481.