Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants

Cell Reports

Volumn 13, Issue 8, 2015, Pages 1683-1691

  Zhu, Xueyong ^a   Viswanathan, Karthik ^b   Raman, Rahul ^b   Yu, Wenli ^a   Sasisekharan, Ram ^b   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Crystal structure; Glycan complex; H5N1 influenza virus; Hemagglutinin; Receptor binding specificity; Transmission

Indexed keywords

GLYCAN; INFLUENZA VIRUS HEMAGGLUTININ; CELL SURFACE RECEPTOR; HEMAGGLUTININ; POLYSACCHARIDE; PROTEIN BINDING;

ARTICLE; AVIAN INFLUENZA VIRUS; BACULOVIRUS EXPRESSION SYSTEM; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISEASE TRANSMISSION; FERRET; HYDROGEN BOND; INFLUENZA A VIRUS (H5N1); MOLECULAR CLONING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; RECEPTOR BINDING; ZOONOSIS; ANIMAL; BIRD; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MUTATION; PHYSIOLOGY; PROCEDURES; X RAY CRYSTALLOGRAPHY;

ANIMALS; BIRDS; CRYSTALLOGRAPHY, X-RAY; HEMAGGLUTININS; HUMANS; INFLUENZA A VIRUS, H5N1 SUBTYPE; MUTATION; POLYSACCHARIDES; PROTEIN BINDING; RECEPTORS, CELL SURFACE;

EID: 84952871165     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.10.027     Document Type: Article

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