메뉴 건너뛰기




Volumn 6, Issue 6, 2015, Pages

Dual RNA-seq of nontypeable haemophilus influenzae and host cell transcriptomes reveals novel insights into host-pathogen cross talk

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; MESSENGER RNA; MICRORNA; RNA; SMALL CAJAL BODY SPECIFIC RNA; SMALL NUCLEOLAR RNA; TRANSCRIPTOME; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

EID: 84952803151     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01765-15     Document Type: Article
Times cited : (93)

References (58)
  • 1
    • 80355141578 scopus 로고    scopus 로고
    • Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era
    • Agrawal A, Murphy TF. 2011. Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era. J Clin Microbiol 49: 3728-3732. http://dx.doi.org/10.1128/JCM.05476-11.
    • (2011) J Clin Microbiol , vol.49 , pp. 3728-3732
    • Agrawal, A.1    Murphy, T.F.2
  • 2
    • 0028875290 scopus 로고
    • Paracytosis of Haemophilus influenzae through cell layers of NCI-H292 lung epithelial cells
    • Van Schilfgaarde M, van Alphen L, Eijk P, Everts V, Dankert J. 1995. Paracytosis of Haemophilus influenzae through cell layers of NCI-H292 lung epithelial cells. Infect Immun 63:4729-4737.
    • (1995) Infect Immun , vol.63 , pp. 4729-4737
    • Van Schilfgaarde, M.1    van Alphen, L.2    Eijk, P.3    Everts, V.4    Dankert, J.5
  • 3
    • 84862004172 scopus 로고    scopus 로고
    • Characterization of extended co-culture of non-typeable Haemophilus influenzae with primary human respiratory tissues
    • Ren D, Nelson KL, Uchakin PN, Smith AL, Gu X, Daines DA. 2012. Characterization of extended co-culture of non-typeable Haemophilus influenzae with primary human respiratory tissues. Exp Biol Med 237: 540-547. http://dx.doi.org/10.1258/ebm.2012.011377.
    • (2012) Exp Biol Med , vol.237 , pp. 540-547
    • Ren, D.1    Nelson, K.L.2    Uchakin, P.N.3    Smith, A.L.4    Gu, X.5    Daines, D.A.6
  • 4
    • 0025613827 scopus 로고
    • Haemophilus influenzae adheres to and enters cultured human epithelial cells
    • St. Geme JW, III, Falkow S. 1990. Haemophilus influenzae adheres to and enters cultured human epithelial cells. Infect Immun 58:4036-4044.
    • (1990) Infect Immun , vol.58 , pp. 4036-4044
    • St Geme, J.W.1    Falkow, S.2
  • 5
    • 0032768538 scopus 로고    scopus 로고
    • Infection of primary human bronchial epithelial cells by Haemophilus influenzae: Macropinocytosis as a mechanism of airway epithelial cell entry
    • Ketterer MR, Shao JQ, Hornick DB, Buscher B, Bandi VK, Apicella MA. 1999. Infection of primary human bronchial epithelial cells by Haemophilus influenzae: macropinocytosis as a mechanism of airway epithelial cell entry. Infect Immun 67:4161-4170.
    • (1999) Infect Immun , vol.67 , pp. 4161-4170
    • Ketterer, M.R.1    Shao, J.Q.2    Hornick, D.B.3    Buscher, B.4    Bandi, V.K.5    Apicella, M.A.6
  • 6
    • 0028008790 scopus 로고
    • Haemophilus influenzae resides and multiplies intracellularly in human adenoid tissue as demonstrated by in situ hybridization and bacterial viability assay
    • Forsgren J, Samuelson A, Ahlin A, Jonasson J, Rynnel-Dagoo B, Lindberg A. 1994. Haemophilus influenzae resides and multiplies intracellularly in human adenoid tissue as demonstrated by in situ hybridization and bacterial viability assay. Infect Immun 62:673-679.
    • (1994) Infect Immun , vol.62 , pp. 673-679
    • Forsgren, J.1    Samuelson, A.2    Ahlin, A.3    Jonasson, J.4    Rynnel-Dagoo, B.5    Lindberg, A.6
  • 7
    • 0035662726 scopus 로고    scopus 로고
    • Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis
    • Bandi V, Apicella M, Mason E, Murphy T, Siddiqi A, Atmar R, Greenberg S. 2001. Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis. Am J Respir Crit Care Med 164:2114-2119. http://dx.doi.org/10.1164/ajrccm.164.11.2104093.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 2114-2119
    • Bandi, V.1    Apicella, M.2    Mason, E.3    Murphy, T.4    Siddiqi, A.5    Atmar, R.6    Greenberg, S.7
  • 8
    • 15944395145 scopus 로고    scopus 로고
    • Insights into host responses against pathogens from transcriptional profiling
    • Jenner RG, Young RA. 2005. Insights into host responses against pathogens from transcriptional profiling. Nat Rev Microbiol 3:281-294. http:// dx.doi.org/10.1038/nrmicro1126.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 281-294
    • Jenner, R.G.1    Young, R.A.2
  • 9
    • 0034610270 scopus 로고    scopus 로고
    • Pushing the limits of cellular microbiology: Microarrays to study bacteria-host cell intimate contacts
    • Rappuoli R. 2000. Pushing the limits of cellular microbiology: microarrays to study bacteria-host cell intimate contacts. Proc Natl Acad SciUSA 97:13467-13469. http://dx.doi.org/10.1073/pnas.010505497.
    • (2000) Proc Natl Acad SciUSA , vol.97 , pp. 13467-13469
    • Rappuoli, R.1
  • 10
    • 84867600073 scopus 로고    scopus 로고
    • Identification of genes that contribute to the pathogenesis of invasive pneumococcal disease by in vivo transcriptomic analysis
    • Ogunniyi AD, Mahdi LK, Trappetti C, Verhoeven N, Mermans D, Van der Hoek MB, Plumptre CD, Paton JC. 2012. Identification of genes that contribute to the pathogenesis of invasive pneumococcal disease by in vivo transcriptomic analysis. Infect Immun 80:3268-3278. http://dx.doi.org/ 10.1128/IAI.00295-12.
    • (2012) Infect Immun , vol.80 , pp. 3268-3278
    • Ogunniyi, A.D.1    Mahdi, L.K.2    Trappetti, C.3    Verhoeven, N.4    Mermans, D.5    Van der Hoek, M.B.6    Plumptre, C.D.7    Paton, J.C.8
  • 11
    • 84881171701 scopus 로고    scopus 로고
    • Characterization of the molecular interplay between Moraxella catarrhalis and human respiratory tract epithelial cells
    • De Vries SPW, Eleveld MJ, Hermans PWM, Bootsma HJ. 2013. Characterization of the molecular interplay between Moraxella catarrhalis and human respiratory tract epithelial cells. PLoS One 8:e72193. http:// dx.doi.org/10.1371/journal.pone.0072193.
    • (2013) PLoS One , vol.8
    • De Vries, S.P.W.1    Eleveld, M.J.2    Hermans, P.W.M.3    Bootsma, H.J.4
  • 12
    • 0034610257 scopus 로고    scopus 로고
    • The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies
    • Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, Relman DA. 2000. The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Proc Natl Acad Sci U S A 97: 13847-13852. http://dx.doi.org/10.1073/pnas.230262797.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13847-13852
    • Belcher, C.E.1    Drenkow, J.2    Kehoe, B.3    Gingeras, T.R.4    McNamara, N.5    Lemjabbar, H.6    Basbaum, C.7    Relman, D.A.8
  • 15
    • 19744370931 scopus 로고    scopus 로고
    • Bordetella bronchiseptica adherence to cilia is mediated by multiple adhesin factors and blocked by surfactant protein A
    • Edwards JA, Groathouse NA, Boitano S. 2005. Bordetella bronchiseptica adherence to cilia is mediated by multiple adhesin factors and blocked by surfactant protein A. Infect Immun 73:3618-3626. http://dx.doi.org/ 10.1128/IAI.73.6.3618-3626.2005.
    • (2005) Infect Immun , vol.73 , pp. 3618-3626
    • Edwards, J.A.1    Groathouse, N.A.2    Boitano, S.3
  • 16
    • 1842585032 scopus 로고    scopus 로고
    • Human and avian influenza viruses target different cell types in cultures of human airway epithelium
    • Matrosovich MN, Matrosovich TY, Gray T, Roberts NA, Klenk H-. 2004. Human and avian influenza viruses target different cell types in cultures of human airway epithelium. Proc Natl Acad Sci U S A 101: 4620-4624. http://dx.doi.org/10.1073/pnas.0308001101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4620-4624
    • Matrosovich, M.N.1    Matrosovich, T.Y.2    Gray, T.3    Roberts, N.A.4    Klenk, H-.5
  • 17
    • 84865155546 scopus 로고    scopus 로고
    • Dual RNA-seq of pathogen and host
    • Westermann AJ, Gorski SA, Vogel J. 2012. Dual RNA-seq of pathogen and host. Nat Rev Microbiol 10:618-630. http://dx.doi.org/10.1038/ nrmicro2852.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 618-630
    • Westermann, A.J.1    Gorski, S.A.2    Vogel, J.3
  • 18
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang DW, Sherman BT, Lempicki RA. 2008. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4:44-57. http://dx.doi.org/10.1038/nprot.2008.211.
    • (2008) Nat Protoc , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 19
    • 84898002993 scopus 로고    scopus 로고
    • The ToxAvapA toxin-antitoxin locus contributes to the survival of nontypeable Haemophilus influenzae during infection
    • Ren D, Kordis AA, Sonenshine DE, Daines DA. 2014. The ToxAvapA toxin-antitoxin locus contributes to the survival of nontypeable Haemophilus influenzae during infection. PLoS One 9:e91523. http://dx.doi.org/ 10.1371/journal.pone.0091523.
    • (2014) PLoS One , vol.9
    • Ren, D.1    Kordis, A.A.2    Sonenshine, D.E.3    Daines, D.A.4
  • 20
    • 84869108435 scopus 로고    scopus 로고
    • Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae
    • Ren D, Walker AN, Daines DA. 2012. Toxin-antitoxin loci vapBC-1 and vapXD contribute to survival and virulence in nontypeable Haemophilus influenzae. BMC Microbiol 12:263. http://dx.doi.org/10.1186/1471-2180-12-263.
    • (2012) BMC Microbiol , vol.12 , pp. 263
    • Ren, D.1    Walker, A.N.2    Daines, D.A.3
  • 21
    • 84868113986 scopus 로고    scopus 로고
    • Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli
    • Norton JP, Mulvey MA. 2012. Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli. PLoS Pathog 8:e1002954. http://dx.doi.org/10.1371/ journal.ppat.1002954.
    • (2012) PLoS Pathog , vol.8
    • Norton, J.P.1    Mulvey, M.A.2
  • 22
    • 0032502743 scopus 로고    scopus 로고
    • ThiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium
    • Webb E, Claas K, Downs D. 1998. thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium. J Biol Chem 273:8946-8950. http://dx.doi.org/ 10.1074/jbc.273.15.8946.
    • (1998) J Biol Chem , vol.273 , pp. 8946-8950
    • Webb, E.1    Claas, K.2    Downs, D.3
  • 24
    • 77955828073 scopus 로고    scopus 로고
    • Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA
    • Vergauwen B, Elegheert J, Dansercoer A, Devreese B, Savvides SN. 2010. Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA. Proc Natl Acad Sci U S A 107: 13270-13275. http://dx.doi.org/10.1073/pnas.1005198107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13270-13275
    • Vergauwen, B.1    Elegheert, J.2    Dansercoer, A.3    Devreese, B.4    Savvides, S.N.5
  • 26
    • 84919499237 scopus 로고    scopus 로고
    • Peroxiredoxin/glutaredoxin (pdgX) and catalase (htkE) promote resistance of nontypeable Haemophilus influenzae 86-028NP to oxidant and survival within neutrophil extracellular traps
    • Juneau RA, Pang B, Armbruster CE, Murrah KA, Perez AC, Swords WE. 2014. Peroxiredoxin/glutaredoxin (pdgX) and catalase (htkE) promote resistance of nontypeable Haemophilus influenzae 86-028NP to oxidant and survival within neutrophil extracellular traps. Infect Immun 83:239-246. http://dx.doi.org/10.1128/iai.02390-14.
    • (2014) Infect Immun , vol.83 , pp. 239-246
    • Juneau, R.A.1    Pang, B.2    Armbruster, C.E.3    Murrah, K.A.4    Perez, A.C.5    Swords, W.E.6
  • 27
    • 80051639367 scopus 로고    scopus 로고
    • Expression of urease by Haemophilus influenzae during human respiratory tract infection and role in survival in an acid environment
    • Murphy TF, Brauer AL. 2011. Expression of urease by Haemophilus influenzae during human respiratory tract infection and role in survival in an acid environment. BMC Microbiol 11:183. http://dx.doi.org/10.1186/ 1471-2180-11-183.
    • (2011) BMC Microbiol , vol.11 , pp. 183
    • Murphy, T.F.1    Brauer, A.L.2
  • 29
    • 84555179609 scopus 로고    scopus 로고
    • Extracellular matrix degradation and remodeling in development and disease
    • Lu P, Takai K, Weaver VM, Werb Z. 2011. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol 3:a005058. http://dx.doi.org/10.1101/cshperspect.a005058.
    • (2011) Cold Spring Harb Perspect Biol , vol.3
    • Lu, P.1    Takai, K.2    Weaver, V.M.3    Werb, Z.4
  • 32
    • 35948970194 scopus 로고    scopus 로고
    • A small RNA regulates multiple ABC transporter mRNAs by targeting C/A-rich elements inside and upstream of ribosome-binding sites
    • Sharma CM, Darfeuille F, Plantinga TH, Vogel J. 2007. A small RNA regulates multiple ABC transporter mRNAs by targeting C/A-rich elements inside and upstream of ribosome-binding sites. Genes Dev 21: 2804-2817. http://dx.doi.org/10.1101/gad.447207.
    • (2007) Genes Dev , vol.21 , pp. 2804-2817
    • Sharma, C.M.1    Darfeuille, F.2    Plantinga, T.H.3    Vogel, J.4
  • 37
    • 0346496019 scopus 로고    scopus 로고
    • The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
    • He Y, Li H, Zhang J, Hsu C, Lin E, Zhang N, Guo J, Forbush KA, Bevan MJ. 2004. The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol 5:88-97. http:// dx.doi.org/10.1038/ni1021.
    • (2004) Nat Immunol , vol.5 , pp. 88-97
    • He, Y.1    Li, H.2    Zhang, J.3    Hsu, C.4    Lin, E.5    Zhang, N.6    Guo, J.7    Forbush, K.A.8    Bevan, M.J.9
  • 38
    • 84883236781 scopus 로고    scopus 로고
    • Carcinoembryonic antigen (CEA)-related cell adhesion molecules are coexpressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons
    • Klaile E, Klassert TE, Scheffrahn I, Müller MM, Heinrich A, Heyl KA, Dienemann H, Grünewald C, Bals R, Singer BB, Slevogt H. 2013. Carcinoembryonic antigen (CEA)-related cell adhesion molecules are coexpressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II interferons. Respir Res 14:85. http://dx.doi.org/10.1186/1465-9921-14-85.
    • (2013) Respir Res , vol.14 , pp. 85
    • Klaile, E.1    Klassert, T.E.2    Scheffrahn, I.3    Müller, M.M.4    Heinrich, A.5    Heyl, K.A.6    Dienemann, H.7    Grünewald, C.8    Bals, R.9    Singer, B.B.10    Slevogt, H.11
  • 39
    • 79956139648 scopus 로고    scopus 로고
    • Invasive bacterial pathogens exploit TLR-mediated downregulation of tight junction components to facilitate translocation across the epithelium
    • Clarke T, Francella N, Huegel A, Weiser J. 2011. Invasive bacterial pathogens exploit TLR-mediated downregulation of tight junction components to facilitate translocation across the epithelium. Cell Host Microbe 9:404-414. http://dx.doi.org/10.1016/j.chom.2011.04.012.
    • (2011) Cell Host Microbe , vol.9 , pp. 404-414
    • Clarke, T.1    Francella, N.2    Huegel, A.3    Weiser, J.4
  • 40
    • 58949103284 scopus 로고    scopus 로고
    • Host alphaadducin is redistributed and localized to the inclusion membrane in chlamydia-and Chlamydophila-infected cells
    • Chu HG, Weeks SK, Gilligan DM, Rockey DD. 2008. Host alphaadducin is redistributed and localized to the inclusion membrane in chlamydia-and Chlamydophila-infected cells. Microbiology 154: 3848-3855. http://dx.doi.org/10.1099/mic.0.2008/020941-0.
    • (2008) Microbiology , vol.154 , pp. 3848-3855
    • Chu, H.G.1    Weeks, S.K.2    Gilligan, D.M.3    Rockey, D.D.4
  • 41
    • 23944507593 scopus 로고    scopus 로고
    • Neisseria meningitidis lactate permease is required for nasopharyngeal colonization
    • Exley RM, Goodwin L, Mowe E, Shaw J, Smith H, Read RC, Tang CM. 2005. Neisseria meningitidis lactate permease is required for nasopharyngeal colonization. Infect Immun 73:5762-5766. http://dx.doi.org/ 10.1128/IAI.73.9.5762-5766.2005.
    • (2005) Infect Immun , vol.73 , pp. 5762-5766
    • Exley, R.M.1    Goodwin, L.2    Mowe, E.3    Shaw, J.4    Smith, H.5    Read, R.C.6    Tang, C.M.7
  • 42
    • 33847761136 scopus 로고    scopus 로고
    • Lactate acquisition promotes successful colonization of the murine genital tract by Neisseria gonorrhoeae
    • Exley RM, Wu H, Shaw J, Schneider MC, Smith H, Jerse AE, Tang CM. 2007. Lactate acquisition promotes successful colonization of the murine genital tract by Neisseria gonorrhoeae. Infect Immun 75:1318-1324. http://dx.doi.org/10.1128/IAI.01530-06.
    • (2007) Infect Immun , vol.75 , pp. 1318-1324
    • Exley, R.M.1    Wu, H.2    Shaw, J.3    Schneider, M.C.4    Smith, H.5    Jerse, A.E.6    Tang, C.M.7
  • 44
    • 84875979030 scopus 로고    scopus 로고
    • Depolymerization of cytokeratin intermediate filaments facilitates intracellular infection of HeLa cells by Bartonella henselae
    • Zhu C, Bai Y, Liu Q, Li D, Hong J, Yang Z, Cui L, Hua X, Yuan C. 2013. Depolymerization of cytokeratin intermediate filaments facilitates intracellular infection of HeLa cells by Bartonella henselae. J Infect Dis 207: 1397-1405. http://dx.doi.org/10.1093/infdis/jit040.
    • (2013) J Infect Dis , vol.207 , pp. 1397-1405
    • Zhu, C.1    Bai, Y.2    Liu, Q.3    Li, D.4    Hong, J.5    Yang, Z.6    Cui, L.7    Hua, X.8    Yuan, C.9
  • 46
    • 84883364264 scopus 로고    scopus 로고
    • Count-based differential expression analysis of RNA sequencing data using R and Bioconductor
    • Anders S, McCarthy DJ, Chen Y, Okoniewski M, Smyth GK, Huber W, RobinsonMD. 2013. Count-based differential expression analysis of RNA sequencing data using R and Bioconductor. Nat Protoc 8:1765-1786. http://dx.doi.org/10.1038/nprot.2013.099.
    • (2013) Nat Protoc , vol.8 , pp. 1765-1786
    • Anders, S.1    McCarthy, D.J.2    Chen, Y.3    Okoniewski, M.4    Smyth, G.K.5    Huber, W.6    Robinson, M.D.7
  • 47
    • 84878580738 scopus 로고    scopus 로고
    • The Subread aligner: Fast, accurate and scalable read mapping by seed-and-vote
    • Liao Y, Smyth GK, Shi W. 2013. The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote. Nucleic Acids Res 41:e108. http://dx.doi.org/10.1093/nar/gkt214.
    • (2013) Nucleic Acids Res , vol.41
    • Liao, Y.1    Smyth, G.K.2    Shi, W.3
  • 48
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. 2015. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43: http://dx.doi.org/10.1093/nar/ gkv007.
    • (2015) Nucleic Acids Res , vol.43
    • Ritchie, M.E.1    Phipson, B.2    Wu, D.3    Hu, Y.4    Law, C.W.5    Shi, W.6    Smyth, G.K.7
  • 49
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical Bayes methods for assessing differential expression in microarray experiments
    • Smyth GK. 2004. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3:1-25. http://dx.doi.org/10.2202/1544-6115.1027.
    • (2004) Stat Appl Genet Mol Biol , vol.3 , pp. 1-25
    • Smyth, G.K.1
  • 53
    • 34147132825 scopus 로고    scopus 로고
    • Identifying bacterial genes and endosymbiont DNA with Glimmer
    • Delcher AL, Bratke KA, Powers EC, Salzberg SL. 2007. Identifying bacterial genes and endosymbiont DNA with Glimmer. Bioinformatics 23:673-679. http://dx.doi.org/10.1093/bioinformatics/btm009.
    • (2007) Bioinformatics , vol.23 , pp. 673-679
    • Delcher, A.L.1    Bratke, K.A.2    Powers, E.C.3    Salzberg, S.L.4
  • 54
    • 84891760956 scopus 로고    scopus 로고
    • Data, information, knowledge and principle: Back to metabolism in KEGG
    • Kanehisa M, Goto S, Sato Y, Kawashima M, Furumichi M, Tanabe M. 2014. Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res 42:D199-D205. http://dx.doi.org/10.1093/nar/ gkt1076.
    • (2014) Nucleic Acids Res , vol.42 , pp. D199-D205
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3    Kawashima, M.4    Furumichi, M.5    Tanabe, M.6
  • 56
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang DW, Sherman BT, Lempicki RA. 2009. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37:1-13. http://dx.doi.org/10.1093/nar/ gkn923.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.