메뉴 건너뛰기




Volumn 45, Issue 2, 2015, Pages 234-242

Prospect for Pharmacological Therapies to Treat Skeletal Muscle Dysfunction

Author keywords

Atrophy; Cachexia; Muscle wasting; Muscular dystrophies; Sarcopenia

Indexed keywords

MUSCLE RELAXANT AGENT;

EID: 84952720471     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s00223-014-9926-8     Document Type: Review
Times cited : (18)

References (59)
  • 1
    • 78651379305 scopus 로고    scopus 로고
    • Muscles and their myokines
    • COI: 1:CAS:528:DC%2BC3MXjtFCnsb0%3D, PID: 21177953
    • Pedersen BK (2011) Muscles and their myokines. J Exp Biol 214:337–346
    • (2011) J Exp Biol , vol.214 , pp. 337-346
    • Pedersen, B.K.1
  • 2
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
    • COI: 1:CAS:528:DC%2BC3cXjtFWjtw%3D%3D, PID: 19918075
    • Wenz T, Rossi SG, Rotundo RL, Speigelman BM, Moraes CT (2009) Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging. Proc Nat Acad Sci USA 106:20405–20410
    • (2009) Proc Nat Acad Sci USA , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3    Speigelman, B.M.4    Moraes, C.T.5
  • 3
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • COI: 1:CAS:528:DC%2BD3cXhs1yisA%3D%3D, PID: 10600804
    • Kelley DE, Goodpaster B, Wing RR, Simoneau JA (1999) Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277:E1130–E1141
    • (1999) Am J Physiol , vol.277 , pp. 1130-1141
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 4
    • 0030593939 scopus 로고    scopus 로고
    • Mechanisms of muscle wasting: the role of the ubiquitin-proteasome pathway
    • COI: 1:CAS:528:DyaK2sXjt1OjtA%3D%3D, PID: 8948566
    • Mitch WE, Goldberg AL (1996) Mechanisms of muscle wasting: the role of the ubiquitin-proteasome pathway. N Engl J Med 335:1897–1905
    • (1996) N Engl J Med , vol.335 , pp. 1897-1905
    • Mitch, W.E.1    Goldberg, A.L.2
  • 5
    • 84893142272 scopus 로고    scopus 로고
    • Signaling pathways controlling skeletal muscle mass
    • COI: 1:CAS:528:DC%2BC2cXhtlCrs7Y%3D, PID: 24237131
    • Egerman MA, Glass DJ (2014) Signaling pathways controlling skeletal muscle mass. Crit Rev Biochem Mol Biol 49:59–68
    • (2014) Crit Rev Biochem Mol Biol , vol.49 , pp. 59-68
    • Egerman, M.A.1    Glass, D.J.2
  • 6
    • 79953063911 scopus 로고    scopus 로고
    • Exercise and Duchenne muscular dystrophy: toward evidence-based exercise prescription
    • COI: 1:CAS:528:DC%2BC3MXlvFWrtrc%3D, PID: 21404285
    • Markert CD, Ambrosio F, Call JA, Grange RW (2011) Exercise and Duchenne muscular dystrophy: toward evidence-based exercise prescription. Muscle Nerve 43:464–478
    • (2011) Muscle Nerve , vol.43 , pp. 464-478
    • Markert, C.D.1    Ambrosio, F.2    Call, J.A.3    Grange, R.W.4
  • 7
    • 0037160782 scopus 로고    scopus 로고
    • The muscular dystrophies
    • COI: 1:CAS:528:DC%2BD38Xhs1yntbw%3D, PID: 11879882
    • Emery AEH (2002) The muscular dystrophies. Lancet 359:687–695
    • (2002) Lancet , vol.359 , pp. 687-695
    • Emery, A.E.H.1
  • 8
    • 84868239216 scopus 로고    scopus 로고
    • The muscular dystrophies
    • PID: 23117950
    • Flanigan KM (2012) The muscular dystrophies. Semin Neurol 32:255–263
    • (2012) Semin Neurol , vol.32 , pp. 255-263
    • Flanigan, K.M.1
  • 9
    • 0027460658 scopus 로고
    • Dystrophin protects the sarcolemma from stresses developed during muscle contraction
    • COI: 1:CAS:528:DyaK3sXktVKnsb4%3D, PID: 8475120
    • Petrof BJ, Shrager JB, Stedman HH, Kelly AM, Sweeney HL (1993) Dystrophin protects the sarcolemma from stresses developed during muscle contraction. Proc Natl Acad Sci USA 90:3710–3714
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3710-3714
    • Petrof, B.J.1    Shrager, J.B.2    Stedman, H.H.3    Kelly, A.M.4    Sweeney, H.L.5
  • 10
    • 0033695935 scopus 로고    scopus 로고
    • Contraction-induced injury to single permeabilized muscle fibers from mdx, transgenic mdx, and control mice
    • COI: 1:CAS:528:DC%2BD3cXnsFOrt7k%3D, PID: 11003610
    • Lynch GS, Rafael JA, Chamberlain JS, Faulkner JA (2000) Contraction-induced injury to single permeabilized muscle fibers from mdx, transgenic mdx, and control mice. Am J Physiol Cell Physiol 279:C1290–C1294
    • (2000) Am J Physiol Cell Physiol , vol.279 , pp. 1290-1294
    • Lynch, G.S.1    Rafael, J.A.2    Chamberlain, J.S.3    Faulkner, J.A.4
  • 11
    • 0023739851 scopus 로고
    • Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice
    • COI: 1:CAS:528:DyaL1MXlslWm, PID: 3173492
    • Turner PR, Westwood T, Regen CM, Steinhardt RA (1988) Increased protein degradation results from elevated free calcium levels found in muscle from mdx mice. Nature 335:735–738
    • (1988) Nature , vol.335 , pp. 735-738
    • Turner, P.R.1    Westwood, T.2    Regen, C.M.3    Steinhardt, R.A.4
  • 12
    • 67149122523 scopus 로고    scopus 로고
    • Mechanisms of muscle degeneration, regeneration, and repair in muscular dystrophies
    • COI: 1:CAS:528:DC%2BD1MXjsValsLo%3D, PID: 18808326
    • Wallace GQ, McNally EM (2009) Mechanisms of muscle degeneration, regeneration, and repair in muscular dystrophies. Annu Rev Physiol 71:37–57
    • (2009) Annu Rev Physiol , vol.71 , pp. 37-57
    • Wallace, G.Q.1    McNally, E.M.2
  • 13
    • 84872374881 scopus 로고    scopus 로고
    • The medical genetics of dystrophinopathies: molecular genetic diagnosis and its impact on clinical practice
    • PID: 23116935
    • Ferlini A, Neri M, Gualandi F (2013) The medical genetics of dystrophinopathies: molecular genetic diagnosis and its impact on clinical practice. Neuromusc Disord 23:4–14
    • (2013) Neuromusc Disord , vol.23 , pp. 4-14
    • Ferlini, A.1    Neri, M.2    Gualandi, F.3
  • 14
    • 0024466501 scopus 로고
    • The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion
    • COI: 1:STN:280:DyaK3Mzjs1amtg%3D%3D, PID: 2491009
    • Koenig M, Beggs AH, Moyer M et al (1989) The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion. Am J Hum Genet 45:498–506
    • (1989) Am J Hum Genet , vol.45 , pp. 498-506
    • Koenig, M.1    Beggs, A.H.2    Moyer, M.3
  • 15
    • 0036895736 scopus 로고    scopus 로고
    • Loss of myostatin attenuates severity of muscular dystrophy in mdx mice
    • COI: 1:CAS:528:DC%2BD38Xps1OqsL0%3D, PID: 12447939
    • Wagner KR, Mcpherron AC, Winik N, Lee SJ (2002) Loss of myostatin attenuates severity of muscular dystrophy in mdx mice. Ann Neurol 52:832–836
    • (2002) Ann Neurol , vol.52 , pp. 832-836
    • Wagner, K.R.1    Mcpherron, A.C.2    Winik, N.3    Lee, S.J.4
  • 16
    • 77949453616 scopus 로고    scopus 로고
    • Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice
    • Morine KJ, Bish LT, Pendrak K, Sleeper MM, Barton ER, Sweeney HL (2010) Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice. PLoSOne 5:e9176
    • (2010) PLoSOne , vol.5 , pp. 9176
    • Morine, K.J.1    Bish, L.T.2    Pendrak, K.3    Sleeper, M.M.4    Barton, E.R.5    Sweeney, H.L.6
  • 18
    • 79952764909 scopus 로고    scopus 로고
    • Targeting the activin type IIB receptor to improve muscle mass and function in the mdx mouse model of Duchenne muscular dystrophy
    • PID: 21356379
    • Pistilli EE, Bogdanovich S, Goncalves MD, Ahima RS, Lachey J, Seehra J, Khurana T (2011) Targeting the activin type IIB receptor to improve muscle mass and function in the mdx mouse model of Duchenne muscular dystrophy. Am J Pathol 178:1287–1297
    • (2011) Am J Pathol , vol.178 , pp. 1287-1297
    • Pistilli, E.E.1    Bogdanovich, S.2    Goncalves, M.D.3    Ahima, R.S.4    Lachey, J.5    Seehra, J.6    Khurana, T.7
  • 19
    • 38949123031 scopus 로고    scopus 로고
    • Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice
    • COI: 1:CAS:528:DC%2BD1cXhvVSqsbc%3D, PID: 17893249
    • Nakatani M, Takehara Y, Sugino H, Hashimoto O, Hasegawa Y, Murakami T, Uezumi A, Takeda S, Noji S, Sunada Y, Tsuchida K (2008) Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice. FASEB J 22:477–487
    • (2008) FASEB J , vol.22 , pp. 477-487
    • Nakatani, M.1    Takehara, Y.2    Sugino, H.3    Hashimoto, O.4    Hasegawa, Y.5    Murakami, T.6    Uezumi, A.7    Takeda, S.8    Noji, S.9    Sunada, Y.10    Tsuchida, K.11
  • 21
    • 84867004601 scopus 로고    scopus 로고
    • TGFβ signaling: its role in fibrosis formation and myopathies
    • COI: 1:CAS:528:DC%2BC38XhsVenu73L, PID: 22918531
    • MacDonald EM, Cohn RD (2012) TGFβ signaling: its role in fibrosis formation and myopathies. Curr Opin Rheumatol 24:628–634
    • (2012) Curr Opin Rheumatol , vol.24 , pp. 628-634
    • MacDonald, E.M.1    Cohn, R.D.2
  • 23
    • 0025765844 scopus 로고
    • A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beat 1
    • COI: 1:CAS:528:DyaK3MXisVWgt70%3D, PID: 2022183
    • Miyazono K, Olofsson A, Colosetti P, Heldin CH (1991) A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beat 1. EMBO J 10:1091–1101
    • (1991) EMBO J , vol.10 , pp. 1091-1101
    • Miyazono, K.1    Olofsson, A.2    Colosetti, P.3    Heldin, C.H.4
  • 26
    • 53949118974 scopus 로고    scopus 로고
    • Insulin-like growth factor-I growth factor analogue protects muscle of dystrophic mdx mice from contraction-mediated damage
    • COI: 1:CAS:528:DC%2BD1MXmtVGjsg%3D%3D, PID: 18567600
    • Gehrig SM, Ryall JG, SChertzer JD, Lynch GS (2008) Insulin-like growth factor-I growth factor analogue protects muscle of dystrophic mdx mice from contraction-mediated damage. Exp Physiol 93:1190–1198
    • (2008) Exp Physiol , vol.93 , pp. 1190-1198
    • Gehrig, S.M.1    Ryall, J.G.2    SChertzer, J.D.3    Lynch, G.S.4
  • 27
    • 35348909483 scopus 로고    scopus 로고
    • Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice
    • COI: 1:CAS:528:DC%2BD2sXht1Smtr7N, PID: 17823291
    • Schertzer JD, Gehrig SM, Ryall JG, Lynch GS (2007) Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. Am J Pathol 171:1180–1188
    • (2007) Am J Pathol , vol.171 , pp. 1180-1188
    • Schertzer, J.D.1    Gehrig, S.M.2    Ryall, J.G.3    Lynch, G.S.4
  • 28
    • 84900524773 scopus 로고    scopus 로고
    • Genetic basis of limb-girdle muscular dystrophies: the 2014 update
    • COI: 1:CAS:528:DC%2BC2cXhslKlsbnF, PID: 24843229
    • Nigro V, Savarese M (2014) Genetic basis of limb-girdle muscular dystrophies: the 2014 update. Acta Myol 33:1–12
    • (2014) Acta Myol , vol.33 , pp. 1-12
    • Nigro, V.1    Savarese, M.2
  • 29
    • 39749114099 scopus 로고    scopus 로고
    • Myostatin blockade improves function but not histopathology in a murine model of limb-girdle muscular dystrophy 2C
    • COI: 1:CAS:528:DC%2BD1cXjs1eqtLY%3D, PID: 18041051
    • Bogdanovich S, McNally EM, Khurana TS (2008) Myostatin blockade improves function but not histopathology in a murine model of limb-girdle muscular dystrophy 2C. Muscle Nerve 37:308–316
    • (2008) Muscle Nerve , vol.37 , pp. 308-316
    • Bogdanovich, S.1    McNally, E.M.2    Khurana, T.S.3
  • 30
    • 33744720767 scopus 로고    scopus 로고
    • Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy
    • COI: 1:CAS:528:DC%2BD28XlvVOhsb8%3D, PID: 16723712
    • Parsons SA, Millay DP, Sargent MA, McNally EM, Molkentin JD (2006) Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. Am J Pathol 168:1975–1985
    • (2006) Am J Pathol , vol.168 , pp. 1975-1985
    • Parsons, S.A.1    Millay, D.P.2    Sargent, M.A.3    McNally, E.M.4    Molkentin, J.D.5
  • 34
    • 67650314502 scopus 로고    scopus 로고
    • FSHD region gene 1 (FRG1) is crucial for angiogenesis linking FRG1 to facioscapulohumeral muscular dystrophy-associated vasculopathy
    • COI: 1:CAS:528:DC%2BD1MXotFOltbs%3D, PID: 19383939
    • Wuebbles RD, Hanel ML, Jones PL (2009) FSHD region gene 1 (FRG1) is crucial for angiogenesis linking FRG1 to facioscapulohumeral muscular dystrophy-associated vasculopathy. Dis Model Mech 2:267–274
    • (2009) Dis Model Mech , vol.2 , pp. 267-274
    • Wuebbles, R.D.1    Hanel, M.L.2    Jones, P.L.3
  • 35
    • 84860186068 scopus 로고    scopus 로고
    • Losartan, a therapeutic candidate in congenital muscular dystrophy: studies in the dy(2J)/dy(2J) mouse
    • COI: 1:CAS:528:DC%2BC38XlvVKhtLk%3D, PID: 22522482
    • Elbaz M, Yanay N, Aga-Mizrachi S, Brunschwig Z, Kassis I, Ettinger K, Barak V, Nevo Y (2012) Losartan, a therapeutic candidate in congenital muscular dystrophy: studies in the dy(2J)/dy(2J) mouse. Ann Neurol 71:699–708
    • (2012) Ann Neurol , vol.71 , pp. 699-708
    • Elbaz, M.1    Yanay, N.2    Aga-Mizrachi, S.3    Brunschwig, Z.4    Kassis, I.5    Ettinger, K.6    Barak, V.7    Nevo, Y.8
  • 36
    • 0024430754 scopus 로고
    • Summary comments
    • Rosenberg IH (1989) Summary comments. Am J Clin Nutr 50:1231–1233
    • (1989) Am J Clin Nutr , vol.50 , pp. 1231-1233
    • Rosenberg, I.H.1
  • 37
    • 0028898029 scopus 로고
    • Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
    • COI: 1:STN:280:DyaK2M7ktVSlsw%3D%3D, PID: 7838189
    • Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB (1995) Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. New Engl J Med 332:556–561
    • (1995) New Engl J Med , vol.332 , pp. 556-561
    • Guralnik, J.M.1    Ferrucci, L.2    Simonsick, E.M.3    Salive, M.E.4    Wallace, R.B.5
  • 40
    • 84901065506 scopus 로고    scopus 로고
    • Molecular and cell-based therapies for muscle degenerations: a road under construction
    • Berardi E, Annibali D, Cassano M, Crippa S, Sampaolesi M (2014) Molecular and cell-based therapies for muscle degenerations: a road under construction. Front Physiol 5:1–13
    • (2014) Front Physiol , vol.5 , pp. 1-13
    • Berardi, E.1    Annibali, D.2    Cassano, M.3    Crippa, S.4    Sampaolesi, M.5
  • 43
    • 0036544519 scopus 로고    scopus 로고
    • Muscle specific expression of insulin-like growth factor I counters muscle decline in mdx mice
    • COI: 1:CAS:528:DC%2BD38Xis1Knsb8%3D, PID: 11927606
    • Barton ER, Morris L, Musaro A, Rosenthal N, Sweeney HL (2002) Muscle specific expression of insulin-like growth factor I counters muscle decline in mdx mice. J Cell Biol 157:137–148
    • (2002) J Cell Biol , vol.157 , pp. 137-148
    • Barton, E.R.1    Morris, L.2    Musaro, A.3    Rosenthal, N.4    Sweeney, H.L.5
  • 44
    • 38349180111 scopus 로고    scopus 로고
    • Muscle-specific overexpression of IGF-1 improves E–C coupling in skeletal muscle fibers from dystrophic mdx mice
    • COI: 1:CAS:528:DC%2BD1cXhtVWkur4%3D, PID: 17989207
    • Schertzer JD, Van Der Poel C, Shavlakadze T, Grounds MD, Lynch GS (2008) Muscle-specific overexpression of IGF-1 improves E–C coupling in skeletal muscle fibers from dystrophic mdx mice. Am J Physiol Cell Physiol 294:C161–C168
    • (2008) Am J Physiol Cell Physiol , vol.294 , pp. 161-168
    • Schertzer, J.D.1    Van Der Poel, C.2    Shavlakadze, T.3    Grounds, M.D.4    Lynch, G.S.5
  • 45
    • 23844515285 scopus 로고    scopus 로고
    • Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by IGF1 codelivery
    • COI: 1:CAS:528:DC%2BD2MXos1agsrw%3D, PID: 16099410
    • Abmayr S, Gregorevic P, Allen JM, Chamberlain JS (2005) Phenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by IGF1 codelivery. Mol Ther 12:441–450
    • (2005) Mol Ther , vol.12 , pp. 441-450
    • Abmayr, S.1    Gregorevic, P.2    Allen, J.M.3    Chamberlain, J.S.4
  • 46
    • 35348909483 scopus 로고    scopus 로고
    • Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice
    • COI: 1:CAS:528:DC%2BD2sXht1Smtr7N, PID: 17823291
    • Schertzer JD, Gehrig SM, Ryall JG, Lynch GS (2007) Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice. Am J Pathol 171:1180–1188
    • (2007) Am J Pathol , vol.171 , pp. 1180-1188
    • Schertzer, J.D.1    Gehrig, S.M.2    Ryall, J.G.3    Lynch, G.S.4
  • 47
    • 84857460345 scopus 로고    scopus 로고
    • Role of TGF-β signaling in inherited and acquired myopathies
    • COI: 1:CAS:528:DC%2BC3MXmtVKrsLw%3D, PID: 21798096
    • Burks TN, Cohn RD (2011) Role of TGF-β signaling in inherited and acquired myopathies. Skelet Muscle 1:19
    • (2011) Skelet Muscle , vol.1 , pp. 19
    • Burks, T.N.1    Cohn, R.D.2
  • 48
    • 0028359187 scopus 로고
    • Expression of transforming growth factor-beta 1 and its relation to endomysial fibrosis in progressive muscular dystrophy
    • COI: 1:STN:280:DyaK2c7ksVKksA%3D%3D, PID: 8311110
    • Yamazaki M, Minota S, Sakurai H, Miyazono K, Yamada A, Kanazawa I, Kawai M (1994) Expression of transforming growth factor-beta 1 and its relation to endomysial fibrosis in progressive muscular dystrophy. Am J Pathol 144:221–226
    • (1994) Am J Pathol , vol.144 , pp. 221-226
    • Yamazaki, M.1    Minota, S.2    Sakurai, H.3    Miyazono, K.4    Yamada, A.5    Kanazawa, I.6    Kawai, M.7
  • 49
    • 0029153067 scopus 로고
    • Expression of transforming growth factor-beta 1 in dystrophic patient muscles correlates with fibrosis. Pathogenetic role of a fibrogenic cytokine
    • COI: 1:CAS:528:DyaK2MXnsVansL0%3D, PID: 7635950
    • Bernasconi P, Torchiana E, Confalonieri P, Brugnoni R, Barresi R, Mora M, Cornelio F, Morandi L, Mantegazza R (1995) Expression of transforming growth factor-beta 1 in dystrophic patient muscles correlates with fibrosis. Pathogenetic role of a fibrogenic cytokine. J Clin Invest 96:1137–1144
    • (1995) J Clin Invest , vol.96 , pp. 1137-1144
    • Bernasconi, P.1    Torchiana, E.2    Confalonieri, P.3    Brugnoni, R.4    Barresi, R.5    Mora, M.6    Cornelio, F.7    Morandi, L.8    Mantegazza, R.9
  • 52
    • 84874716506 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor anatagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A)
    • COI: 1:CAS:528:DC%2BC3sXktlWjtb8%3D, PID: 22943509
    • Meinen S, Lin S, Ruegg MA (2012) Angiotensin II type 1 receptor anatagonists alleviate muscle pathology in the mouse model for laminin-α2-deficient congenital muscular dystrophy (MDC1A). Skelet Muscle 2:18
    • (2012) Skelet Muscle , vol.2 , pp. 18
    • Meinen, S.1    Lin, S.2    Ruegg, M.A.3
  • 55
    • 0141841602 scopus 로고    scopus 로고
    • Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart
    • COI: 1:CAS:528:DC%2BD3sXnsVKrs7o%3D, PID: 12952841
    • Yue Y, Li Z, Harper SQ, Davisson RL, Chamberlain JS, Duan D (2003) Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart. Circulation 108(13):1626–1632
    • (2003) Circulation , vol.108 , Issue.13 , pp. 1626-1632
    • Yue, Y.1    Li, Z.2    Harper, S.Q.3    Davisson, R.L.4    Chamberlain, J.S.5    Duan, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.