Effects of ginsenoside Rg1 on the expression of toll-like receptor 3, 4 and their signalling transduction factors in the NG108-15 murine neuroglial cell line

Molecules

Volumn 19, Issue 10, 2014, Pages 16925-16936

  Zhao, Bao Sheng ^a   Liu, Yang ^a   Gao, Xiao Yan ^a   Zhai, Hua Qiang ^a   Guo, Jian You ^b   Wang, Xue Yong ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b INSTITUTE OF PSYCHOLOGY   (China)

Author keywords

Alzheimer's disease; Ginsenoside Rg1; Nuclear factor kappa B; Toll like receptor; Tumor necrosis factor receptor associated factor 6

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (25-35); AUTACOID; GINSENOSIDE; GINSENOSIDE RG 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON; MESSENGER RNA; NOS2 PROTEIN, HUMAN; PEPTIDE FRAGMENT; TLR3 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; GLIA; METABOLISM; MOUSE; PANAX; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GINSENOSIDES; INFLAMMATION MEDIATORS; INTERFERONS; MICE; NEUROGLIA; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PANAX; PEPTIDE FRAGMENTS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84952715250     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules191016925     Document Type: Article

References (39)

1. Daniilidou, M.; Koutroumani, M.; Tsolaki, M. Epigenetic mechanisms in Alzheimer's disease. Curr. Med. Chem. 2011, 18, 1751-1756.
2. Burns, A.; O'Brien, J. Clinical practice with anti-dementia drugs: A consensus statement from British Association for Psychopharmacology. J. Psychopharmacol. 2006, 20, 732-755.
3. + current. Neurobiol. Aging 2006, 27, 1673-1683.
4. Schwab, C.; McGeer, P.L. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. J. Alzheimer's Dis. 2008, 13, 359-369.
5. McGeer, P.L.; Rogers, J.; McGeer, E.G. Inflammation, anti-inflammatory agents and Alzheimer disease: The last 12 years. J. Alzheimer's Dis. 2006, 9, 271-276.
6. Akama, K.T.; van Eldik, L.J. Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha TNFalpha-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism. J. Biol. Chem. 2000, 275, 7918-7924.
7. Weggen, S.L.; Eriksen, J.L.; Das, P.; Sagi, S.A.; Wang, R.; Pietrzik, C.U.; Findlay, K.A.; Smith, T.E.; Murphy, M.P.; Bulter, T.; et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 2001, 414, 212-216.
8. Trinchieri, G.; Sher, A. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 2007, 7, 179-190.
9. Tahara, K.; Kim, H.D.; Jin, J.J.; Maxwell, J.A.; Li, L.; Fukuchi, K. Role of toll-like receptor signalling in Abeta uptake and clearance. Brain 2006, 129, 3006-3019.
10. Walter, S.; Letiembre, M.; Liu, Y.; Heine, H.; Penke, B.; Hao, W.; Bode, B.; Manietta, N.; Walter, J.; Schulz-Schuffer, W.; et al. Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease. Cell. Physiol. Biochem. 2007, 20, 947-956.
11. Bsibsi, M.; Ravid, R.; Gveric, D.; van Noort, J.M. Broad expression of Toll-like receptors in the human central nervous system. J. Neuropathol. Exp. Neurol. 2002, 61, 1013-1021.
12. Letiembre, M.; Hao, W.; Liu, Y.; Walter, S.; Mihaljevic, I.; Rivest, S.; Hartmann, T.; Fassbender, K. Innate immune receptor expression in normal brain aging. Neuroscience 2007, 146, 248-254.
13. Frank, S.; Copanaki, E.; Burbach, G.J.; Müller, U.C.; Deller, T. Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice. Neurosci. Lett. 2009, 453, 41-44.
14. Letiembre, M.; Liu, Y.; Walter, S.; Hao, W.; Pfander, T.; Wrede, A.; Schulz-Schaeffer, W.; Fassbender, K. Screening of innate immune receptors in neurodegenerative diseases: A similar pattern. Neurobiol. Aging 2009, 30, 759-768.
15. Howes, M.J.; Perry, N.S.; Houghton, P.J. Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother. Res. 2003, 17, 1-18.
16. Wollen, K.A. Alzheimer's disease: The pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. Altern. Med. Rev. 2010, 15, 223-244.
17. Yu, L.C.; Chen, S.C.; Chang, W.C.; Huang, Y.C.; Lin, K.M.; Lai, P.H.; Sung, H.W. Stability of angiogenic agents, ginsenoside Rg1 and Re, isolated from Panax ginseng: In vitro and in vivo studies. Int. J. Pharm. 2007, 328, 168-176.
18. Zhang, J.T. Pathogensis and therapeutic strategies of senior dementia. Acta Pharmacol. Sin. 2000, 35, 635-640.
19. Cheng, Y.; Shen, L.H.; Zhang, J.T. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol. Sin. 2005, 26, 143-149.
20. 2+ channels in NG108-15 cells. Toxicon 2005, 45, 53-60.
21. Hu, Q.; Shi, Y.L. Characterization of an inward-rectifying potassium current in NG108-15 neuroblastoma x glioma cells. Pflug. Arch.-Eur. J. Physiol. 1997, 433, 617-625.
22. Cho, S.O.; Ban, J.Y.; Kim, J.Y.; Jeong, H.Y.; Lee, I.S.; Song, K.S.; Bae, K.; Seong, Y.H. Aralia cordata protects against amyloid beta protein 25-35-induced neurotoxicity in cultured neurons and has antidementia activities in mice. J. Pharmacol. Sci. 2009, 111, 22-32.
23. Orellana, J.A.; Shoji, K.F.; Abudara, V.; Ezan, P.; Amigou, E.; Sáez, P.J.; Jiang, J.X.; Naus, C.C.; Sáez, J.C.; Giaume, C. Amyloid beta-induced death in neurons involves glial and neuronal hemichannels. J. Neurosci. 2011, 31, 4962-4977.
24. Zhang, H.Y.; Liang, Y.Q.; Tang, X.C.; He, X.C.; Bai, D.L. Stereoselectivities of enantiomers of huperzine A in protection against beta-amyloid25-35-induced injury in PC12 and NG108-15 cells and cholinesterase inhibition in mice. Neurosci. Lett. 2002, 317, 143-146.
25. Hoozemans, J.J.; Rozemuller, J.M.; van Haastert, E.S.; Veerhuis, R.; Eikelenboom, P. Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology. Curr. Pharm. Des. 2008, 14, 1419-1427.
26. Kaisho, T.; Akira, S. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 2006, 117, 979-987.
27. Iwamura, C.; Nakayama, T. Toll-like receptors in the respiratory system: Their roles in inflammation. Curr. Allergy Asthma Rep. 2008, 8, 7-13.
28. Bowman, C.C.; Rasley, A.; Tranguch, S.L.; Marriott, I. Cultured astrocytes express toll-like receptors for bacterial products. Glia 2003, 43, 281-291.
29. Olson, J.K.; Miller, S.D. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 2004, 173, 3916-3924.
30. Tang, S.C.; Arumugam, T.V.; Xu, X.; Cheng, A.; Mughal, M.R.; Jo, D.G.; Lathia, J.D.; Siler, D.A.; Chigurupati, S.; Ouyang, X.; et al. Pivotal role for neuronal toll-like receptors in ischemic brain injury and functional deficits. Proc. Natl. Acad. Sci. USA 2007, 104, 13798-13803.
31. Takeda, K.; Akira, S. Toll-like receptors in innate immunity. Int. Immunol. 2005, 17, 1-14.
32. Honda, K.; Taniguchi, T. IRFs: Master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 2006, 6, 644-658.
33. Akira, S.; Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4, 499-511.
34. Jackson, A.C.; Rossiter, J.P.; Lafon, M. Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases. J. Neurovirol. 2006, 12, 229-234.
35. Arbour, N.C.; Lorenz, E.; Schutte, B.C.; Zabner, J.; Kline, J.N.; Jones, M.; Frees, K.; Watt, J.L.; Schwartz, D.A. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 2000, 25, 187-191.
36. Guo, J.Y.; Huo, H.R.; Li, L.F.; Guo, S.Y.; Jiang, T.L. Sini tang prevents depression-like behavior in rats exposed to chronic unpredictable stress. Am. J. Chin. Med. 2009, 37, 261-272.
37. Guo, J.Y.; Li, C.Y.; Ruan, Y.P.; Sun, M.; Qi, X.L.; Zhao, B.S.; Luo. F. Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain. Eur. J. Pharmacol. 2009, 612, 54-60.
38. Schmittgen, T.D.; Zakrajsek, B.A.; Mills, A.G.; Gorn, V.; Singer, M.J.; Reed, M.W. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: Comparison of endpoint and real-time methods. Anal. Biochem. 2000, 285, 194-204.
39. Lou, J.S.; Li, C.Y.; Yang, X.C.; Fang, J.; Yang, Y.X.; Guo, J.Y. Protective effect of gan mai da zao decoction in unpredictable chronic mild stress-induced behavioral and biochemical alterations. Pharm. Biol. 2010, 48, 1328-1336.