Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system

Biomaterials

Volumn 63, Issue , 2015, Pages 177-188

  Yang, Kisuk ^a   Park, Hyun Ji ^a   Han, Sewoon ^b   Lee, Joan ^a   Ko, Eunkyung ^a   Kim, Jin ^a   Lee, Jong Seung ^a   Yu, Ji Hea ^c   Song, Ki Yeong ^a   Cheong, Eunji ^a   Cho, Sung Rae ^c   Chung, Seok ^b   Cho, Seung Woo ^a,c  

^a Yonsei University   (South Korea)

^b Korea University   (South Korea)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

Glial cell derived neurotrophic factor; Human mesenchymal stem cell; Human neural stem cell; Microfluidic array; Neuronal differentiation; Paracrine signal

Indexed keywords

CELL CULTURE; CELL SIGNALING; CELLS; CYTOLOGY; ELECTROPHYSIOLOGY; FLUIDIC DEVICES; GENETIC ENGINEERING; MICROFLUIDICS; NEURONS; SIGNALING; TISSUE REGENERATION;

HUMAN MESENCHYMAL STEM CELLS; MICROFLUIDIC ARRAY; NEURAL STEM CELL; NEURONAL DIFFERENTIATION; NEUROTROPHIC FACTORS; PARACRINE;

STEM CELLS;

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NANOPARTICLE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; COCULTURE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HYDROGEL; IN VIVO STUDY; MESENCHYMAL STEM CELL; MICROENVIRONMENT; MICROFLUIDICS; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE REGENERATION; ANIMAL; BRAIN INJURIES; CULTURE TECHNIQUE; CYTOLOGY; DEVICES; EQUIPMENT DESIGN; GENETICS; LAB ON A CHIP; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; PARACRINE SIGNALING; UPREGULATION;

ANIMALS; BRAIN INJURIES; CELL CULTURE TECHNIQUES; EQUIPMENT DESIGN; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; LAB-ON-A-CHIP DEVICES; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; PARACRINE COMMUNICATION; UP-REGULATION;

EID: 84952670324     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.06.011     Document Type: Article

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