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Volumn 157, Issue , 2016, Pages 120-124

Liquid biopsies for solid tumors: Understanding tumor heterogeneity and real time monitoring of early resistance to targeted therapies

Author keywords

Circulating tumor DNA; Disease monitoring; Early detection; Intra tumor heterogeneity; Liquid biopsy; Molecular resistance

Indexed keywords

B RAF KINASE; CA 15-3 ANTIGEN; CETUXIMAB; CHLOROPLAST DNA; ERLOTINIB; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; N RAS PROTEIN; PHOSPHOINOSITIDE 3 KINASE CATALYTIC ALPHA PROTEIN; PROTEIN; PROTEIN P53; TUMOR MARKER; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; ANTINEOPLASTIC AGENT; DNA;

EID: 84952638610     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2015.11.007     Document Type: Review
Times cited : (87)

References (38)
  • 2
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early- and late-stage human malignancies
    • C. Bettegowda, M. Sausen, R.J. Leary, I. Kinde, Y. Wang, N. Agrawal, and et al. Detection of circulating tumor DNA in early- and late-stage human malignancies Sci Transl Med 6 224 Feb 19, 2014 224ra24
    • (2014) Sci Transl Med , vol.6 , Issue.224 , pp. 224ra24
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3    Kinde, I.4    Wang, Y.5    Agrawal, N.6
  • 3
    • 84872020299 scopus 로고    scopus 로고
    • Cancer genome scanning in plasma: Detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing
    • K.C. Chan, P. Jiang, Y.W. Zheng, G.J. Liao, H. Sun, J. Wong, and et al. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing Clin Chem 59 2013 211 224
    • (2013) Clin Chem , vol.59 , pp. 211-224
    • Chan, K.C.1    Jiang, P.2    Zheng, Y.W.3    Liao, G.J.4    Sun, H.5    Wong, J.6
  • 4
    • 70349696342 scopus 로고    scopus 로고
    • Analysis of cancer mutation signatures in blood by a novel ultra-sensitive assay: Monitoring of therapy or recurrence in non metastatic breast cancer
    • Z. Chen, J. Feng, C.H. Buzin, Q. Liu, L. Weiss, K. Kernstine, and et al. Analysis of cancer mutation signatures in blood by a novel ultra-sensitive assay: monitoring of therapy or recurrence in non metastatic breast cancer PLoS One 4 9 Sep 28, 2009 e7220
    • (2009) PLoS One , vol.4 , Issue.9 , pp. e7220
    • Chen, Z.1    Feng, J.2    Buzin, C.H.3    Liu, Q.4    Weiss, L.5    Kernstine, K.6
  • 5
    • 84875520648 scopus 로고    scopus 로고
    • Analysis of circulating tumor DNA to monitor metastatic breast cancer
    • S.J. Dawson, D.W. Tsui, M. Murtaza, H. Biggs, O.M. Rueda, S.F. Chin, and et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer N Engl J Med 368 13 Mar 28, 2013 1199 1209
    • (2013) N Engl J Med , vol.368 , Issue.13 , pp. 1199-1209
    • Dawson, S.J.1    Tsui, D.W.2    Murtaza, M.3    Biggs, H.4    Rueda, O.M.5    Chin, S.F.6
  • 6
    • 84906890825 scopus 로고    scopus 로고
    • Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: A proof-of-principle
    • L. De Mattos-Arruda, B. Weigelt, J. Cortes, H.H. Won, C.K. Ng, P. Nuciforo, and et al. Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle Ann Oncol 25 9 Sep. 2014 1729 1735
    • (2014) Ann Oncol , vol.25 , Issue.9 , pp. 1729-1735
    • De Mattos-Arruda, L.1    Weigelt, B.2    Cortes, J.3    Won, H.H.4    Ng, C.K.5    Nuciforo, P.6
  • 7
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • W. De Roock, B. Claes, D. Bernasconi, J. De Schutter, B. Biesmans, G. Fountzilas, and et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis Lancet Oncol 11 2010 753 762
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5    Fountzilas, G.6
  • 8
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • L.A. Diaz Jr., R.T. Williams, J. Wu, I. Kinde, J.R. Hecht, J. Berlin, and et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers Nature 486 2012 537 540
    • (2012) Nature , vol.486 , pp. 537-540
    • Diaz, L.A.1    Williams, R.T.2    Wu, J.3    Kinde, I.4    Hecht, J.R.5    Berlin, J.6
  • 9
    • 33745379412 scopus 로고    scopus 로고
    • BEAMing: Single-molecule PCR on microparticles in water-in-oil emulsions
    • F. Diehl, He Y. LiM, Vogelstein B. KinzlerKW, and D. Dressman BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions Nat Methods 3 2006 551 559
    • (2006) Nat Methods , vol.3 , pp. 551-559
    • Diehl, F.1    Lim, H.Y.2    KinzlerKW, V.B.3    Dressman, D.4
  • 11
    • 84898458573 scopus 로고    scopus 로고
    • Monitoring tumor-derived cell-free DNA in patients with solid tumors: Clinical perspectives and research opportunities
    • A. Esposito, A. Bardelli, C. Criscitiello, N. Colombo, L. Gelao, L. Fumagalli, and et al. Monitoring tumor-derived cell-free DNA in patients with solid tumors: clinical perspectives and research opportunities Cancer Treat Rev. 40 5 Jun. 2014 648 655
    • (2014) Cancer Treat Rev. , vol.40 , Issue.5 , pp. 648-655
    • Esposito, A.1    Bardelli, A.2    Criscitiello, C.3    Colombo, N.4    Gelao, L.5    Fumagalli, L.6
  • 12
    • 84861746437 scopus 로고    scopus 로고
    • Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
    • T. Forshew, M. Murtaza, C. Parkinson, D. Gale, D.W. Tsui, F. Kaper, and et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA Sci Transl Med 4 136 May 30, 2012 136ra68
    • (2012) Sci Transl Med , vol.4 , Issue.136 , pp. 136ra68
    • Forshew, T.1    Murtaza, M.2    Parkinson, C.3    Gale, D.4    Tsui, D.W.5    Kaper, F.6
  • 13
    • 84940416459 scopus 로고    scopus 로고
    • Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer
    • I. Garcia-Murillas, G. Schiavon, B. Weigelt, C. Ng, S. Hrebien, R.J. Cutts, and et al. Mutation tracking in circulating tumor DNA predicts relapse in early breast cancer Sci Transl Med 7 302 Aug 26, 2015 302ra133
    • (2015) Sci Transl Med , vol.7 , Issue.302 , pp. 302ra133
    • Garcia-Murillas, I.1    Schiavon, G.2    Weigelt, B.3    Ng, C.4    Hrebien, S.5    Cutts, R.J.6
  • 15
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells
    • S. Jahr, H. Hentze, S. Englisch, D. Hardt, F.O. Fackelmayer, R.D. Hesch, and et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells Cancer Res 61 2001 1659 1665
    • (2001) Cancer Res , vol.61 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3    Hardt, D.4    Fackelmayer, F.O.5    Hesch, R.D.6
  • 19
    • 84870312106 scopus 로고    scopus 로고
    • Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing
    • R.J. Leary, M. Sausen, I. Kinde, N. Papadopoulos, J.D. Carpten, D. Craig, and et al. Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing Sci Transl Med 4 162 Nov 28, 2012 162ra154
    • (2012) Sci Transl Med , vol.4 , Issue.162 , pp. 162ra154
    • Leary, R.J.1    Sausen, M.2    Kinde, I.3    Papadopoulos, N.4    Carpten, J.D.5    Craig, D.6
  • 20
    • 84926416450 scopus 로고    scopus 로고
    • Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types
    • R. Lebofsky, C. Decraene, V. Bernard, M. Kamal, A. Blin, Q. Leroy, and et al. Circulating tumor DNA as a non-invasive substitute to metastasis biopsy for tumor genotyping and personalized medicine in a prospective trial across all tumor types Mol Oncol 9 4 Apr. 2015 783 790
    • (2015) Mol Oncol , vol.9 , Issue.4 , pp. 783-790
    • Lebofsky, R.1    Decraene, C.2    Bernard, V.3    Kamal, M.4    Blin, A.5    Leroy, Q.6
  • 21
    • 0017360626 scopus 로고
    • Free DNA in the serum of cancer patients and the effect of therapy
    • S.A. Leon, B. Shapiro, D.M. Sklaroff, and M.J. Yaros Free DNA in the serum of cancer patients and the effect of therapy Cancer Res 37 1977 646 650
    • (1977) Cancer Res , vol.37 , pp. 646-650
    • Leon, S.A.1    Shapiro, B.2    Sklaroff, D.M.3    Yaros, M.J.4
  • 22
    • 0033737004 scopus 로고    scopus 로고
    • Pyrophosphorolysisactivated polymerization (PAP): Application to allele specific amplification
    • (1078, 1080)
    • Q. Liu, and S.S. Sommer Pyrophosphorolysisactivated polymerization (PAP): application to allele specific amplification Biotechniques 29 2000 1072 1076 (1078, 1080)
    • (2000) Biotechniques , vol.29 , pp. 1072-1076
    • Liu, Q.1    Sommer, S.S.2
  • 23
    • 77957911880 scopus 로고    scopus 로고
    • Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors
    • D.J. McBride, A.K. Orpana, C. Sotiriou, H. Joensuu, P.J. Stephens, L.J. Mudie, and et al. Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors Genes Chromosomes Cancer 49 2010 1062 1069
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 1062-1069
    • McBride, D.J.1    Orpana, A.K.2    Sotiriou, C.3    Joensuu, H.4    Stephens, P.J.5    Mudie, L.J.6
  • 24
    • 84896078397 scopus 로고    scopus 로고
    • Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer
    • S. Misale, S. Arena, S. Lamba, G. Siravegna, A. Lallo, S. Hobor, and et al. Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer Sci Transl Med 6 2014 224ra26
    • (2014) Sci Transl Med , vol.6 , pp. 224ra26
    • Misale, S.1    Arena, S.2    Lamba, S.3    Siravegna, G.4    Lallo, A.5    Hobor, S.6
  • 25
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
    • S. Misale, R. Yaeger, S. Hobor, E. Scala, M. Janakiraman, D. Liska, and et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer Nature 486 7404 Jun 28, 2012 532 536
    • (2012) Nature , vol.486 , Issue.7404 , pp. 532-536
    • Misale, S.1    Yaeger, R.2    Hobor, S.3    Scala, E.4    Janakiraman, M.5    Liska, D.6
  • 26
    • 84877579861 scopus 로고    scopus 로고
    • Non invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
    • M. Murtaza, S.J. Dawson, D.W. Tsui, D. Gale, T. Forshew, A.M. Piskorz, and et al. Non invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA Nature 497 2013 108 112
    • (2013) Nature , vol.497 , pp. 108-112
    • Murtaza, M.1    Dawson, S.J.2    Tsui, D.W.3    Gale, D.4    Forshew, T.5    Piskorz, A.M.6
  • 27
    • 84896539307 scopus 로고    scopus 로고
    • Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA
    • G.R. Oxnard, C.P. Paweletz, Y. Kuang, S.L. Mach, A. O'Connell, M.M. Messineo, and et al. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA Clin Cancer Res 20 2014 1698 1705
    • (2014) Clin Cancer Res , vol.20 , pp. 1698-1705
    • Oxnard, G.R.1    Paweletz, C.P.2    Kuang, Y.3    MacH, S.L.4    O'Connell, A.5    Messineo, M.M.6
  • 28
    • 84868682387 scopus 로고    scopus 로고
    • Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers
    • G. Perkins, T.A. Yap, L. Pope, A.M. Cassidy, J.P. Dukes, R. Riisnaes, and et al. Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers PLoS One 7 11 2012 e47020
    • (2012) PLoS One , vol.7 , Issue.11 , pp. e47020
    • Perkins, G.1    Yap, T.A.2    Pope, L.3    Cassidy, A.M.4    Dukes, J.P.5    Riisnaes, R.6
  • 29
    • 84930038230 scopus 로고    scopus 로고
    • Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery
    • (pii: gutjnl-2014-308859 [Epub ahead of print])
    • T. Reinert, L.V. Schøler, R. Thomsen, H. Tobiasen, S. Vang, and Nordentoft Analysis of circulating tumour DNA to monitor disease burden following colorectal cancer surgery Gut Feb 4, 2015 10.1136/gutjnl-2014-308859 (pii: gutjnl-2014-308859 [Epub ahead of print])
    • (2015) Gut
    • Reinert, T.1    Schøler, L.V.2    Thomsen, R.3    Tobiasen, H.4    Vang, S.5    Nordentoft6
  • 30
    • 84867509213 scopus 로고    scopus 로고
    • Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression
    • H. Schwarzenbach, C. Eichelser, J. Kropidlowski, W. Janni, B. Rack, and K. Pantel Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression Clin Cancer Res 18 2012 5719 5730
    • (2012) Clin Cancer Res , vol.18 , pp. 5719-5730
    • Schwarzenbach, H.1    Eichelser, C.2    Kropidlowski, J.3    Janni, W.4    Rack, B.5    Pantel, K.6
  • 31
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • H. Schwarzenbach, D.S. Hoon, and K. Pantel Cell-free nucleic acids as biomarkers in cancer patients Nat Rev Cancer 11 6 2011 426 437
    • (2011) Nat Rev Cancer , vol.11 , Issue.6 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.S.2    Pantel, K.3
  • 32
    • 0020581141 scopus 로고
    • Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease
    • B. Shapiro, M. Chakrabarty, E.M. Cohn, and S.A. Leon Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease Cancer 51 1983 2116 2120
    • (1983) Cancer , vol.51 , pp. 2116-2120
    • Shapiro, B.1    Chakrabarty, M.2    Cohn, E.M.3    Leon, S.A.4
  • 33
    • 84936748494 scopus 로고    scopus 로고
    • Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
    • G. Siravegna, B. Mussolin, M. Buscarino, G. Corti, A. Cassingena, G. Crisafulli, and et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients Nat Med 21 7 Jul. 2015 795 801
    • (2015) Nat Med , vol.21 , Issue.7 , pp. 795-801
    • Siravegna, G.1    Mussolin, B.2    Buscarino, M.3    Corti, G.4    Cassingena, A.5    Crisafulli, G.6
  • 35
    • 84940434554 scopus 로고    scopus 로고
    • Does molecular monitoring matter in early-stage breast cancer?
    • T.K. Sundaresan, and D.A. Haber Does molecular monitoring matter in early-stage breast cancer? Sci Transl Med 7 302 Aug 26, 2015
    • (2015) Sci Transl Med , vol.7 , Issue.302
    • Sundaresan, T.K.1    Haber, D.A.2
  • 36
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time
    • C. Swanton Intratumor heterogeneity: evolution through space and time Cancer Res 72 2012 4875 4882
    • (2012) Cancer Res , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 37
    • 84863110761 scopus 로고    scopus 로고
    • Detecting biomarkers with microdroplet technology
    • V. Taly, D. Pekin, A.A. El, and P. Laurent-Puig Detecting biomarkers with microdroplet technology Trends Mol Med 18 2012 405 416
    • (2012) Trends Mol Med , vol.18 , pp. 405-416
    • Taly, V.1    Pekin, D.2    El, A.A.3    Laurent-Puig, P.4
  • 38
    • 84930755018 scopus 로고    scopus 로고
    • Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M
    • K.S. Thress, C.P. Paweletz, E. Felip, B.C. Cho, D. Stetson, B. Dougherty, and et al. Acquired EGFR C797S mutation mediates resistance to AZD9291 in non-small cell lung cancer harboring EGFR T790M Nat Med 21 6 Jun. 2015 560 562
    • (2015) Nat Med , vol.21 , Issue.6 , pp. 560-562
    • Thress, K.S.1    Paweletz, C.P.2    Felip, E.3    Cho, B.C.4    Stetson, D.5    Dougherty, B.6


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