Skeletal muscle-specific HMG-CoA reductase knockout mice exhibit rhabdomyolysis: A model for statin-induced myopathy

Biochemical and Biophysical Research Communications

Volumn 466, Issue 3, 2015, Pages 536-540

  Osaki, Yoshinori ^a   Nakagawa, Yoshimi ^a   Miyahara, Shoko ^a   Iwasaki, Hitoshi ^a   Ishii, Akiko ^a   Matsuzaka, Takashi ^a   Kobayashi, Kazuto ^a   Yatoh, Shigeru ^a   Takahashi, Akimitsu ^a   Yahagi, Naoya ^a   Suzuki, Hiroaki ^a   Sone, Hirohito ^b   Ohashi, Ken ^c   Ishibashi, Shun ^d   Yamada, Nobuhiro ^a   Shimano, Hitoshi ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL   (Japan)

^d JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

HMG CoA reductase; Knockout mice; Mevalonic acid; Necrosis; Rhabdomyolysis; Skeletal muscle

Indexed keywords

CRE RECOMBINASE; CREATINE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; MEVALONIC ACID;

ADVERSE DRUG REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DISEASE SEVERITY; DRUG MECHANISM; ENZYME ACTIVITY; EXERCISE TOLERANCE; GASTROCNEMIUS MUSCLE; GENE DELETION; GENE EXPRESSION; KNOCKOUT MOUSE; MALE; MOUSE; MUSCLE INJURY; MYOPATHY; NECROSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RHABDOMYOLYSIS; SKELETAL MUSCLE; STATIN INDUCED MYOPATHY; ANIMAL; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED; DEFICIENCY; DISEASE MODEL; ENZYMOLOGY; GENETICS; METABOLISM; MUSCLE DISEASE;

ANIMALS; CHOLESTEROL; CREATINE KINASE; DISEASE MODELS, ANIMAL; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MEVALONIC ACID; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; MUSCULAR DISEASES; RHABDOMYOLYSIS; RNA, MESSENGER;

EID: 84952637961     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.09.065     Document Type: Article

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