Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme a reductase causes hepatic steatosis and death

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 32, Issue 8, 2012, Pages 1824-1831

  Nagashima, Shuichi ^a   Yagyu, Hiroaki ^a   Ohashi, Ken ^b   Tazoe, Fumiko ^a   Takahashi, Manabu ^b   Ohshiro, Taichi ^a   Bayasgalan, Tumenbayar ^a   Okada, Kenta ^a   Sekiya, Motohiro ^a   Osuga, Jun Ichi ^a   Ishibashi, Shun ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A; cholesterol; fatty acids; knockout mouse; liver

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; CHOLESTEROL ESTER; FATTY ACID; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MESSENGER RNA; MEVALONIC ACID; PHOSPHOLIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHOLESTEROL LIVER LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DEATH; FATTY ACID SYNTHESIS; FATTY LIVER; FEMALE; GENE; GENE DELETION; GENE DISRUPTION; GENE INACTIVATION; HOMOZYGOTE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE GENE; HYPERCHOLESTEROLEMIA; HYPOGLYCEMIA; IN VIVO STUDY; JAUNDICE; LIPID LIVER LEVEL; LIVER CELL; LIVER FAILURE; LIVER FUNCTION; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PRENYLATION; SURVIVAL; TRANSGENE;

ANIMALS; FATTY LIVER; FEMALE; HYDROXYMETHYLGLUTARYL-COA-REDUCTASES, NADP-DEPENDENT; LIVER; MALE; MICE; MICE, KNOCKOUT; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84864279081     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.240754     Document Type: Article

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