Divergence of angiogenic and vascular permeability signaling by VEGF: Inhibition of protein kinase C suppresses VEGF-induced angiogenesis, but promotes VEGF-induced, NO-dependent vascular permeability

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 6, 2002, Pages 901-906

  Spyridopoulos, Ioakim ^a   Luedemann, Corinne ^a   Chen, Donghui ^a   Kearney, Marianne ^a   Chen, Dongfen ^a   Murohara, Toyoaki ^a   Principe, Nicole ^a   Isner, Jeffrey M ^a   Losordo, Douglas W ^a  

^a ST ELIZABETH'S MEDICAL CENTER   (United States)

Author keywords

Angiogenesis; Nitric oxide; Programmed cell death; Protein kinase C inhibitor; Vascular endothelial growth factor; Vascular permeability

Indexed keywords

CALPHOSTIN C; ISOENZYME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CATTLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOGENESIS; MYRISTYLATION; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; AORTA; BRAIN; CAPILLARY PERMEABILITY; CATTLE; CELL DIVISION; CELLS, CULTURED; CORNEA; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; LYMPHOKINES; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C; RATS; SIGNAL TRANSDUCTION; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036072098     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000020006.89055.11     Document Type: Article

References (40)

1. Molecular basis of angiogenesis: Role of VEGF and VE-cadherin
2. Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: Balance between growth and death signals
3. Endothelial cell apoptosis in angiogenesis and vessel regression
4. High affinity VEGF binding and developmental expression suggest Flk-l as a major regulator of vasculogenesis and angiogenesis
5. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
6. Different signal transduction properties of KDR and Fltl, two receptors for vascular endothelial growth factor
7. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains: Association with endothelial cell proliferation
8. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
9. Protein kinase C contains a pseudosubstrate prototype in its regulatory domain
10. Enhancement of migration by protein kinase Cα and inhibition of proliferation and cell cycle progression by protein kinase Cδ in capillary endothelial cells
11. Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cδ activity
12. Tumor-promoting phorbol esters induce angiogenesis in vitro
13. Protein kinase C modulates microvascular permeability through nitric oxide synthase
14. Role of protein kinase C in bradykinin-induced increases in microvascular permeability
15. Protein kinase Cβ overexpression augments phorbol ester-induced increase in endothelial permeability
16. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin
17. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia
18. Use of protein (serine/threonine) kinase activators and inhibitors to study protein phosphorylation in intact cells
19. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C
20. Requirement for protein kinase C activation in basic fibroblast growth factor-induced human endothelial cell proliferation
21. Regulation of endothelial constitutive nitric oxide synthase by protein kinase C
22. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor
23. Inhibition of protein kinase C by N-myristoylated peptide substrate analogs
24. Estrogen receptor mediated inhibition of human endothelial cell apoptosis: Estradiol as a survival factor
25. A model of angiogenesis in the mouse cornea
26. Phosphorylation of nitric oxide synthase by protein kinase
27. Vascular reactions to histamine, histamine liberators or leukotoxins in the skin of the guinea pig
28. Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) augments nitric oxide release from quiescent rabbit and human vascular endothelium
29. Angiogenesis
30. Nitric oxide synthase regulatory sites
31. 2+/calmodulin-dependent endothelial nitric oxide synthase activity
32. Regulation of biosynthesis of nitric oxide
33. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity
34. Reciprocal relationship between VEGF and NO in the regulation of endothelial integrity
35. Role of nitric oxide in tumor microcirculation
36. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not fibroblast growth factor-induced angiogenesis
37. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
38. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis
39. During angiogenesis, vascular endothelial growth factor and fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
40. 2 gradients in solid tumors in vivo: High resolution measurements reveal a lack of correlation