Extracorporeal shock wave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis

Annals of Surgery

Volumn 253, Issue 5, 2011, Pages 1024-1032

  Mittermayr, Rainer ^a,b,g   Hartinger, Joachim ^a   Antonic, Vlado ^c,d   Meinl, Alexandra ^a,e   Pfeifer, Sabine ^a   Stojadinovic, Alexander ^c,d,f   Schaden, Wolfgang ^b   Redl, Heinz ^a  

^a LUDWIG BOLTZMANN INSTITUTE FOR EXPERIMENTAL AND CLINICAL TRAUMATOLOGY   (Austria)

^b AUVA Soziale Unfallversicherung   (Austria)

^c Bernhard Gottlieb University Clinic of Dentistry   (Austria)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

^e UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^f ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^g NONE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

SMOOTH MUSCLE ACTIN; VASCULOTROPIN RECEPTOR 2; VON WILLEBRAND FACTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXTRACORPOREAL LITHOTRIPSY; GRAFT NECROSIS; GRAFT SURVIVAL; IMMUNOHISTOCHEMISTRY; ISCHEMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THERAPY EFFECT; TISSUE NECROSIS; UPREGULATION;

ANIMALS; BIOPSY, NEEDLE; DISEASE MODELS, ANIMAL; EPIGASTRIC ARTERIES; GRAFT REJECTION; GRAFT SURVIVAL; HIGH-ENERGY SHOCK WAVES; IMMUNOHISTOCHEMISTRY; ISCHEMIA; ISCHEMIC PRECONDITIONING; MALE; NECROSIS; NEOVASCULARIZATION, PHYSIOLOGIC; POSTOPERATIVE CARE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; SKIN TRANSPLANTATION; SURGICAL FLAPS; TREATMENT OUTCOME;

EID: 79954629313     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e3182121d6e     Document Type: Article

References (36)

1. Michlits W, Mittermayr R, Schafer R, et al. Fibrin-embedded administration of VEGF plasmid enhances skin flap survival. Wound Repair Regen. 2007;15:360-367. (Pubitemid 46817412)
2. Mittermayr R, Morton T, Hofmann M, et al. Sustained (rh)VEGF(165) release from a sprayed fibrin biomatrix induces angiogenesis, up-regulation of endogenous VEGF-R2, and reduces ischemic flap necrosis. Wound Repair Regen. 2008;16:542-550. (Pubitemid 352000310)
3. Davis RE, Wachholz JH, Jassir D, et al. Comparison of topical anti-ischemic agents in the salvage of failing random-pattern skin flaps in rats. Arch Facial Plast Surg. 1999;1:27-32.
4. Zhang Q, Chang Q, Cox RA, et al. Hyperbaric oxygen attenuates apoptosis and decreases inflammation in an ischemic wound model. J Invest Dermatol. 2008;128:2102-2112. (Pubitemid 352001230)
5. Korompilias AV, Chen LE, Seaber AV, et al. Actions of glucocorticosteroids on ischemic-reperfused muscle and cutaneous tissue. Microsurgery. 1996;17:495-502. (Pubitemid 27491970)
6. Shalom A, Friedman T,Westreich M. Effect of aspirin and heparin on random skin flap survival in rats. Dermatol Surg. 2008;34:785-790. (Pubitemid 351792291)
7. Knight KR. Review of postoperative pharmacological infusions in ischemic skin flaps. Microsurgery. 1994;15:675-684.
8. Qi Z, Hiura A, Nakagawa N, et al. Oral administration of nicorandil enhances the survival of ischemic skin flaps in rats. Eur J Pharmacol. 2006;550: 127-133. (Pubitemid 44572260)
9. Knight KR, Kawabata H, Coe SA, et al. Prostacyclin and prostanoidmodifiers aid ischemic skin flap survival. J Surg Res. 1991;50:119-123.
10. Gurunluoglu R, Meirer R, Shafighi M, et al. Gene therapy with adenovirus-mediated VEGF enhances skin flap prefabrication. Microsurgery. 2005;25:433-441. (Pubitemid 41098674)
11. Giacca M. Virus-mediated gene transfer to induce therapeutic angiogenesis: where do we stand? Int J Nanomedicine. 2007;2:527-540.
12. Korpisalo P, Karvinen H, Rissanen TT, et al. Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels. Circ Res. 2008;103:1092-1099.
13. Huemer GM, Shafighi M, Meirer R, et al. Adenovirus-mediated transforming growth factor-beta ameliorates ischemic necrosis of epigastric skin flaps in a rat model. J Surg Res. 2004;121:101-107. (Pubitemid 39094102)
14. Benest AV, Salmon AH, Wang W, et al. VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue. Microcirculation. 2006;13:423-437. (Pubitemid 44322159)
15. Rinsch C, Quinodoz P, Pittet B, et al. Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia. Gene Ther. 2001;8: 523-533. (Pubitemid 32409527)
16. Ikeda Y, Fukuda N, Wada M, et al. Development of angiogenic cell and gene therapy by transplantation of umbilical cord blood with vascular endothelial growth factor gene. Hypertens Res. 2004;27:119-128. (Pubitemid 38325182)
17. Yan X, Zeng B, Chai Y, et al. Improvement of blood flow, expression of nitric oxide, and vascular endothelial growth factor by low-energy shockwave therapy in random-pattern skin flap model. Ann Plast Surg. 2008;61:646-653.
18. Nishida T, Shimokawa H, Oi K, et al. Extracorporeal cardiac shock wave therapymarkedly ameliorates ischemia-inducedmyocardial dysfunction in pigs in vivo. Circulation. 2004;110:3055-3061. (Pubitemid 39491998)
19. Stojadinovic A, Elster EA, Anam K, et al. Angiogenic response to extracorporeal shock wave treatment in murine skin isografts. Angiogenesis. 2008;11:369-380.
20. Meirer R, Brunner A, Deibl M, et al. Shock wave therapy reduces necrotic flap zones and induces VEGF expression in animal epigastric skin flap model. J Reconstr Microsurg. 2007;23:231-236.
21. Mariotto S, Cavalieri E, Amelio E, et al. Extracorporeal shock waves: from lithotripsy to anti-inflammatory action by NO production. Nitric Oxide. 2005;12:89-96. (Pubitemid 40312450)
22. Kuo YR, Wang CT, Wang FS, et al. Extracorporeal shock wave treatment modulates skin fibroblast recruitment and leukocyte infiltration for enhancing extended skin-flap survival. Wound Repair Regen. 2009;17:80-87.
23. Davis TA, Stojadinovic A, Anam K, et al. Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury. Int Wound J. 2009;6:11-21.
24. Ciampa AR, de Prati AC, Amelio E, et al. Nitric oxide mediates antiinflammatory action of extracorporeal shock waves. FEBS Lett. 2005; 579:6839-6845. (Pubitemid 41773696)
25. Meirer R, Kamelger FS, Huemer GM, et al. Extracorporal shock wave may enhance skin flap survival in an animal model. Br J Plast Surg. 2005;58: 53-57. (Pubitemid 40089681)
26. Finseth F, Cutting C. An experimental neurovascular island skin flap for the study of the delay phenomenon. Plast Reconstr Surg. 1978;61:412-420. (Pubitemid 8332869)
27. Padubidri AN, Browne E, Jr.Modification in flap design of the epigastric artery flap in rats - a new experimental flap model. Ann Plast Surg. 1997;39:500-504.
28. Komorowska-Timek E, Newlin L, Zhang F, et al. Shortening of rat teeth prevents autocannibalization of surgical flaps. J Reconstr Microsurg. 1999;15:303-306. (Pubitemid 29247271)
29. Zhang N, Fang Z, Contag PR, et al. Tracking angiogenesis induced by skin wounding and contact hypersensitivity using a Vegfr2-luciferase transgenic mouse. Blood. 2004;103:617-626. (Pubitemid 38140096)
30. Kuo YR, Wu WS, Hsieh YL, et al. Extracorporeal shock wave enhanced extended skin flap tissue survival via increase of topical blood perfusion and associated with suppression of tissue pro-inflammation. J Surg Res. 2007;143:385-392.
31. Schaden W, Thiele R, Kolpl C, et al. Shock wave therapy for acute and chronic soft tissue wounds: a feasibility study. J Surg Res. 2007;143:1-12. (Pubitemid 47570044)
32. Huemer GM, Meirer R, Gurunluoglu R, et al. Comparison of the effectiveness of gene therapy with transforming growth factor-beta or extracorporal shock wave therapy to reduce ischemic necrosis in an epigastric skin flap model in rats. Wound Repair Regen. 2005;13:262-268. (Pubitemid 40848019)
33. Reichenberger MA, Germann G, Roth HJ, et al. Preoperative shock wave therapy reduces ischemic necrosis in an epigastric skin flap model. Ann Plast Surg. 2009;63:682-684.
34. Kuo YR, Wang CT, Wang FS, et al. Extracorporeal shock wave therapy enhanced wound healing via increasing topical blood perfusion and tissue regeneration in a rat model of STZ-induced diabetes.Wound Repair Regen. 2009;17: 522-530.
35. Zimpfer D, Aharinejad S, Holfeld J, et al. Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure. J Thorac Cardiovasc Surg. 2009;137:963-970.
36. Aicher A, Heeschen C, Sasaki K, et al. Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia. Circulation. 2006;114:2823-2830. (Pubitemid 46018285)