Cerebral injury in perinatally HIV-infected children compared to matched healthy controls

Neurology

Volumn 86, Issue 1, 2016, Pages 19-27

  Cohen, Sophie ^a   Caan, Matthan W A ^b   Mutsaerts, Henk Jan ^b   Scherpbier, Henriette J ^a   Kuijpers, Taco W ^a   Reiss, Peter ^b,c   Majoie, Charles B L M ^b   Pajkrt, Dasja ^a  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c STICHTING HIV MONITORING   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

ADOLESCENT; ADOPTION; AFRICA SOUTH OF THE SAHARA; AGE; ARTICLE; ATTENTION; BLACK PERSON; BRAIN FUNCTION; BRAIN INJURY; BRAIN SIZE; CAUCASIAN; CD4 LYMPHOCYTE COUNT; CHILD; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; DIFFUSION WEIGHTED IMAGING; DIVORCED PARENT; EDUCATION; EMPLOYMENT; ETHNICITY; EXECUTIVE FUNCTION; FEMALE; FOSTER CARE; FRACTIONAL ANISOTROPY; GENDER; GRAY MATTER; HIGH SCHOOL; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTELLIGENCE TEST; MALE; MARRIAGE; MEMORY; MONOTHERAPY; NERVOUS SYSTEM PARAMETERS; NETHERLANDS; NEUROIMAGING; NEUROLOGIC DISEASE; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PATHOGENESIS; PERINATAL INFECTION; PRIMARY SCHOOL; PRIORITY JOURNAL; SOCIAL STATUS; SURINAME; THREE DIMENSIONAL FLUID ATTENUATED INVERSION RECOVERY; THREE DIMENSIONAL IMAGING; VIRUS LOAD; VISUOMOTOR COORDINATION; WHITE MATTER HYPERINTENSITY; WHITE MATTER LESION; BRAIN; BRAIN INJURIES; COMPLICATION; HIV INFECTIONS; ORGAN SIZE; PATHOLOGY; VIROLOGY;

ADOLESCENT; BRAIN; BRAIN INJURIES; CHILD; FEMALE; HIV INFECTIONS; HUMANS; MALE; ORGAN SIZE; VIRAL LOAD;

EID: 84952360964     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000002209     Document Type: Article

References (40)

1. Laughton B, Cornell M, Boivin M, Van Rie A. Neurodevelopment in perinatally HIV-infected children: a concern for adolescence. J Int AIDS Soc 2013; 16: 18603
2. Cardenas V, Meyerhoff DJ, Studholme C, et al. Evidence for ongoing brain injury in human immunodeficiency virus-positive patients treated with antiretroviral therapy. J Neurovirol 2009; 15: 324-333
3. Ragin AB, Du H, Ochs R, et al. Structural brain alterations can be detected early in HIV infection. Neurology 2012; 79: 2328-2334
4. Hoare J, Ransford GL, Philipps N, Amos T, Donald KA, Stein DJ. Systematic review of neuroimaging studies in vertically transmitted HIV positive children and adolescents. Metab Brain Dis 2014; 29: 221-229
5. Johann-Liang R, Lin K, Cervia J, Stavola J, Noel G. Neuroimaging findings in children perinatally infected with the human immunodeficiency virus. Pediatr Infect Dis J 1998; 17: 753-754
6. Sarma MK, Nagarajan R, Keller MA, et al. Regional brain gray and white matter changes in perinatally HIV-infected adolescents. Neuroimage Clin 2013; 4: 29-34
7. Ackermann C, Andronikou S, Laughton B, et al. White matter signal abnormalities in children with suspected HIV-related neurologic disease on early combination antiretroviral therapy. Pediatr Infect Dis J 2014; 66: 207-212
8. Hoare J, Fouche JP, Spottiswoode B, et al. A diffusion tensor imaging and neurocognitive study of HIV-positive children who are HAART-naïve slow progressors. J Neurovirol 2012; 18: 205-212
9. González-Scarano F, Martín-García J. The neuropathogenesis of AIDS. Nat Rev Immunol 2005; 5: 69-81
10. Cohen S, ter Stege JA, Geurtsen GJ, et al. Poorer cognitive performance in perinatally HIV-infected children as compared to healthy socioeconomically matched controls. Clin Infect Dis 2015; 1: 1111-1119
11. Christensen DL, Schieve LA, Devine O, Drews-Botsch C. Socioeconomic status, child enrichment factors, and cognitive performance among preschool-age children: results from the Follow-Up of Growth and Development Experiences study. Res Dev Disabil 2014; 35: 1789-1801
12. Shahand S, Benabdelkader A, Jaghoori MM, et al. A datacentric neuroscience gateway: design, implementation, and experiences. Concurr Comput Pract Exp 2015; 27: 489-506
13. Fischl B, Salat DH, Busa E, et al. Whole brain segmentation: neurotechnique automated labeling of neuroanatomical structures in the human brain. Neuron 2002; 33: 341-355
14. Caan MWA, Khedoe G, Poot D, et al. Adaptive noise filtering for accurate and precise diffusion estimation in fiber crossings. Med Image Comput Comput Assist Interv 2010; 13: 167-174
15. Smith SM, Jenkinson M, Johansen-Berg H, et al. Tractbased spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006; 31: 1487-1505
16. Rueckert D, Sonoda LI, Hayes C, Hill DL, Leach MO, Hawkes DJ. Nonrigid registration using free-form deformations: application to breast MR images. IEEE Trans Med Imaging 1999; 18: 712-721
17. Nichols TE, Holmes AP. Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 2002; 15: 1-25
18. Mori S, Wakana S, Nagae-Poetscher LM, van Zijl PCM. MRI Atlas of Human White Matter. Amsterdam: Elsevier; 2005
19. Fujishima M, Maikusa N, Nakamura K, Nakatsuka M, Matsuda H, Meguro K. Mild cognitive impairment, poor episodic memory, and late-life depression are associated with cerebral cortical thinning and increased white matter hyperintensities. Front Aging Neurosci 2014; 6: 306
20. Iverson GL, Hakulinen U, Wäljas M, et al. To exclude or not to exclude: white matter hyperintensities in diffusion tensor imaging research. Brain Inj 2011; 25: 1325-1332
21. Di Perri C, Dwyer MG, Bergsland N, et al. White matter hyperintensities on 1.5 and 3 tesla brain MRI in healthy individuals. J Biomed Graph Comput 2013; 3: 53-62
22. Schiffmann R, van Der Knaap MS. Invited article: an MRIbased approach to the diagnosis of white matter disorders. Neurology 2009; 72: 750-759
23. Nelson F, Datta S, Garcia N, et al. Intracortical lesions by 3T magnetic resonance imaging and correlation with cognitive impairment in multiple sclerosis. Mult Scler 2011; 17: 1122-1129
24. Lazeron RH, Langdon DW, Filippi M, et al. Neuropsychological impairment in multiple sclerosis patients: the role of (juxta)cortical lesion on FLAIR. Mult Scler 2000; 6: 280-285
25. Kim KW, MacFall JR, Payne ME. Classification of white matter lesions on magnetic resonance imaging in elderly persons. Biol Psychiatry 2008; 64: 273-280
26. Hopkins RO, Beck CJ, Burnett DL, Weaver LK, Victoroff J, Bigler ED. Prevalence of white matter hyperintensities in a young healthy population. J Neuroimaging 2006; 16: 243-251
27. Pillai JJ, Friedman L, Stuve TA, et al. Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder. Psychiatry Res 2002; 114: 51-56
28. Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002; 17: 1429-1436
29. Leite SCB, Corrêa DG, Doring TM, et al. Diffusion tensor MRI evaluation of the corona radiata, cingulate gyri, and corpus callosum in HIV patients. J Magn Reson Imaging 2013; 38: 1488-1493
30. Hoare J, Jacqueline H, Westgarth-Taylor J, et al. A diffusion tensor imaging and neuropsychological study of prospective memory impairment in South African HIV positive individuals. Metab Brain Dis 2012; 27: 289-297
31. Wright PW, Heaps JM, Shimony JS, Thomas JB, Ances BM. The effects of HIV and combination antiretroviral therapy on white matter integrity. AIDS 2012; 26: 1501-1508
32. Crowell CS, Malee KM, Yogev R, Muller WJ. Neurologic disease in HIV-infected children and the impact of combination antiretroviral therapy. Rev Med Virol 2014; 24: 316-331
33. Hoare J, Fouche J, Phillips N, et al. Clinical associations of white matter damage in cART-treated HIV-positive children in South Africa. J Neurovirol 2015; 21: 120-128
34. Robertson K, Liner J, Meeker RB. Antiretroviral neurotoxicity. J Neurovirol 2013; 18: 388-399
35. Mollan KR, Smurzynski M, Eron JJ, et al. Association between efavirenz as initial therapy for HIV-1 infection and increased risk for suicidal ideation or attempted or completed suicide: an analysis of trial data. Ann Intern Med 2014; 161: 1-10
36. Potchen MJ, Kampondeni SD, Mallewa M, Taylor TE, Birbeck GL. Brain imaging in normal kids: a communitybased MRI study in Malawian children. Trop Med Int Health 2013; 18: 398-402
37. Ortega M, Heaps JM, Joska J, et al. HIV clades B and C are associated with reduced brain volumetrics. J Neurovirol 2013; 19: 479-487
38. Rao VR, Sas AR, Eugenin EA, et al. HIV-1 clade-specific differences in the induction of neuropathogenesis. J Neurosci 2008; 28: 10010-10016
39. Behnke M, Smith VC. Prenatal substance abuse: shortand long-term effects on the exposed fetus. Pediatrics 2013; 131: 1009-1024
40. Van Harmelen AL, van Tol MJ, van Der Wee NJA, et al. Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment. Biol Psychiatry 2010; 68: 832-838