White matter signal abnormalities in children with suspected HIV-related neurologic disease on early combination antiretroviral therapy

Pediatric Infectious Disease Journal

Volumn 33, Issue 8, 2014, Pages

  Ackermann, Christelle ^a   Andronikou, Savvas ^b   Laughton, Barbara ^a,c   Kidd, Martin ^d   Dobbels, Els ^a,c   Innes, Steve ^a,c   Van Toorn, Ronald ^a   Cotton, Mark ^a,c  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c STELLENBOSCH UNIVERSITY   (South Africa)

^d Centre for Statistical Consultation   (South Africa)

Author keywords

Developmental score; Early antiretroviral therapy; HIV encephalopathy; HIV related brain disease; MRI; White matter signal abnormality

Indexed keywords

ANTIRETROVIRUS AGENT;

AIDS DEMENTIA COMPLEX; BRAIN; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; HUMAN; INFANT; LEUKOENCEPHALOPATHY; MALE; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRESCHOOL CHILD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SOUTH AFRICA; VIROLOGY;

AIDS DEMENTIA COMPLEX; ANTI-RETROVIRAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BRAIN; CHILD, PRESCHOOL; FEMALE; HIV INFECTIONS; HUMANS; INFANT; LEUKOENCEPHALOPATHIES; MAGNETIC RESONANCE IMAGING; MALE; PROSPECTIVE STUDIES; SOUTH AFRICA;

EID: 84905921031     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000000288     Document Type: Article

References (34)

1. Gavin P, Yogev R. Central nervous system abnormalities in pediatric human immunodeficiency virus infection. Pediatr Neurosurg. 1999;31:115-123.
2. Fowler MG. Pediatric HIV infection: neurologic and neuropsychologic findings. Acta Paediatr Suppl. 1994;400:59-62.
3. Sánchez-Ramón S, Bellón JM, Resino S, et al. Low blood CD8+ T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children. Pediatrics. 2003;111:E168-E175.
4. Schmitt B, Seeger J, Kreuz W, et al. Central nervous system involvement of children with HIV infection. Dev Med Child Neurol. 1991;33:535-540.
5. Mitchell W. Neurological and developmental effects of HIV and AIDS in children and adolescents. Ment Retard Dev Disabil Res Rev. 2001;7: 211-216.
6. Nagamitsu S, Okabayashi S, Dai S, et al. Neuroimaging and neuropathologic findings in AIDS patient with cytomegalovirus infection. Intern Med. 1994;33:158-162.
7. Wilkinson ID, Chinn RJ, Hall-Craggs MA, et al. Sub-cortical white-grey matter contrast on MRI as a quantitative marker of diffuse HIV-related parenchymal abnormality. Clin Radiol. 1996;51:475-479.
8. Thurnher MM, Schindler EG, Thurnher SA, et al. Highly active antiretroviral therapy for patients with AIDS dementia complex: effect on MR imaging findings and clinical course. AJNR Am J Neuroradiol. 2000;21:670-678.
9. Spreer J, Enenkel-Stoodt S, Funk M, et al. [Neuroradiological findings in perinatally HIV-infected children]. Rofo. 1994;161:106-112.
10. Violari A, Cotton MF, Gibb DM, et al.; CHER Study Team. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med. 2008;359:2233-2244.
11. Cotton MF, Violari A, Otwombe K, et al.; CHER Study Team. Early time-limited antiretroviral therapy versus deferred therapy in South African infants infected with HIV: results from the children with HIV early antiretroviral (CHER) randomised trial. Lancet. 2013;382:1555-1563.
12. Griffiths R. The Griffiths Mental Development Scales, from birth to 2 years. The 1996 Revision by Michael Huntley. Association for research in infant and child development. Oxford: The Test Agency; 1996.
13. Luiz D, Faragher B, Barnard A, et al. Griffiths mental development Scales-extended revised, two to eight years. Analysis manual, Association for research in infant and child development. Oxford: The Test Agency; 2006.
14. Laughton B, Springer P, Grove D, et al. Longitudinal developmental profile of children from low socio-economic circumstances in Cape Town, using the 1996 Griffiths Mental Development Scales. SAJCH. 2010;4: 106-111.
15. Ammassari A, Cingolani A, Pezzotti P, et al. AIDS-related focal brain lesions in the era of highly active antiretroviral therapy. Neurology. 2000;55: 1194-1200.
16. Johann-Liang R, Lin K, Cervia J, et al. Neuroimaging findings in children perinatally infected with the human immunodeficiency virus. Pediatr Infect Dis J. 1998;17:753-754.
17. Kauffman WM, Sivit CJ, Fitz CR, et al. CT and MR evaluation of intracranial involvement in pediatric HIV infection: a clinical-imaging correlation. AJNR Am J Neuroradiol. 1992;13:949-957.
18. Luiz DM, Foxcroft CD, Stewart R. The construct validity of the Griffiths Scales of Mental Development. Child Care Health Dev. 2001;27:73-83.
19. Lowick S, Sawry S, Meyers T. Neurodevelopmental delay among HIV-infected preschool children receiving antiretroviral therapy and healthy preschool children in Soweto, South Africa. Psychol Health Med. 2012;17:599-610.
20. Amod Z, Cockcroft K, Soellaart B. Use of the 1996 Griffiths Mental Development Scales for infants: a pilot study with a Black, South African sample. J Child Adolescent Mental Health. 2007;19:123-130.
21. Springer P, Laughton B, Tomlinson M, et al. Neurodevelopmental status of HIV-exposed but uninfected children: A pilot study. SAJCH. 2012; 6:51-55.
22. Perez EM, Hendricks MK, Beard JL, et al. Mother-infant interactions and infant development are altered by maternal iron deficiency anemia. J Nutr. 2005;135:850-855.
23. Lallemant M, Chang S, Cohen R, et al. Pediatric HIV-A neglected disease? N Engl J Med. 2011;365:581-583.
24. Ciccarelli N, Fabbiani M, Di Giambenedetto S, et al. Efavirenz associated with cognitive disorders in otherwise asymptomatic HIV-infected patients. Neurology. 2011;76:1403-1409.
25. Cohen RA, Harezlak J, Schifitto G et al. Effects of nadir CD4 and duration of HIV infection on brain volumes in the HAART era. J Neurovirol. 2010;16:25-32.
26. Schiffmann R, van der Knaap MS. Invited article: an MRI-based approach to the diagnosis of white matter disorders. Neurology. 2009;72:750-759.
27. Gray F, Scaravilli F, Everall I, et al. Neuropathology of early HIV-1 infection. Brain Pathol. 1996;6:1-15.
28. Morriss MC, Rutstein RM, Rudy B, et al. Progressive multifocal leukoencephalopathy in an HIV-infected child. Neuroradiology. 1997;39:142-144.
29. Berger JR, Aksamit AJ, Clifford DB, et al. PML diagnostic criteria: consensus statement from the AAN Neuroinfectious Disease Section. Neurology. 2013;80:1430-1438.
30. Parazzini C, Baldoli C, Scotti G, et al. Terminal zones of myelination: MR evaluation of children aged 20-40 months. AJNR Am J Neuroradiol. 2002;23:1669-1673.
31. Keller MA, Venkatraman TN, Thomas MA, et al. Cerebral metabolites in HIV-infected children followed for 10 months with 1H-MRS. Neurology. 2006;66:874-879.
32. Puthanakit T, Ananworanich J, Vonthanak S, et al.; PREDICT Study Group. Cognitive function and neurodevelopmental outcomes in HIV-infected Children older than 1 year of age randomized to early versus deferred antiretroviral therapy: the PREDICT neurodevelopmental study. Pediatr Infect Dis J. 2013;32:501-508.
33. Prado PT, Escorsi-Rosset S, Cervi MC, et al. Image evaluation of HIV encephalopathy: a multimodal approach using quantitative MR techniques. Neuroradiology. 2011;53:899-908.
34. Gongvatana A, Schweinsburg BC, Taylor MJ, et al.; Charter Group. White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals. J Neurovirol. 2009;15:187-195.