Platelet-activating factor receptor (PAFr) is upregulated in small airways and alveoli of smokers and COPD patients

Respirology

Volumn 21, Issue 3, 2016, Pages 504-510

  Shukla, Shakti Dhar ^a   Muller, Hans Konrad ^a   Latham, Roger ^a   Sohal, Sukhwinder Singh ^a   Walters, Eugene Haydn ^a  

^a UNIVERSITY OF TASMANIA   (Australia)

Author keywords

'Respiratory' bacteria adhesion; Airway epithelium; Chronic obstructive pulmonary disease; Inhaled corticosteroid; Platelet activating factor receptor

Indexed keywords

THROMBOCYTE ACTIVATING FACTOR RECEPTOR; FIBRINOGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; RNA;

ADULT; AGED; AIRWAY; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INFECTION RISK; LUNG ALVEOLUS; LUNG INFECTION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; RESPIRATORY EPITHELIUM; SMALL AIRWAY DISEASE; SMOKING; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; LUNG; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; RESPIRATORY MUCOSA; THROMBOCYTE; TRANSCRIPTION INITIATION; UPREGULATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BLOOD PLATELETS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LUNG; MALE; MIDDLE AGED; PLATELET MEMBRANE GLYCOPROTEINS; PULMONARY ALVEOLI; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, G-PROTEIN-COUPLED; RESPIRATORY MUCOSA; RNA; SMOKING; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84952359835     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/resp.12709     Document Type: Article

References (41)

1. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD). News & events from around the world, 2015. [Accessed 23 Mar 2015.] Available from http://www.goldcopd.org/
2. Buist AS, McBurnie MA, Vollmer WM, Gillespie S, Burney P, Mannino DM, Menezes AM, Sullivan SD, Lee TA, Weiss KB, et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 2007; 370: 741-750.
3. Mathers CD, Loncar D,. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006; 3: e442.
4. Toelle BG, Xuan W, Bird TE, Abramson MJ, Atkinson DN, Burton DL, James AL, Jenkins CR, Johns DP, Maguire GP, et al. Respiratory symptoms and illness in older Australians: the Burden of Obstructive Lung Disease (BOLD) study. Med. J. Aust. 2013; 198: 144-148.
5. Banerjee D, Khair OA, Honeybourne D,. Impact of sputum bacteria on airway inflammation and health status in clinical stable COPD. Eur. Respir. J. 2004; 23: 685-691.
6. Cabello H, Torres A, Celis R, El-Ebiary M, Puig de la Bellacasa J, Xaubet A, Gonzalez J, Agusti C, Soler N,. Bacterial colonization of distal airways in healthy subjects and chronic lung disease: a bronchoscopic study. Eur. Respir. J. 1997; 10: 1137-1144.
7. Garcha DS, Thurston SJ, Patel AR, Mackay AJ, Goldring JJ, Donaldson GC, McHugh TD, Wedzicha JA,. Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD. Thorax 2012; 67: 1075-1080.
8. Beasley V, Joshi PV, Singanayagam A, Molyneaux PL, Johnston SL, Mallia P,. Lung microbiology and exacerbations in COPD. Int. J. Chron. Obstruct. Pulmon. Dis. 2012; 7: 555-569.
9. Miravitlles M, Espinosa C, Fernandez-Laso E, Martos JA, Maldonado JA, Gallego M,. Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD. Study Group of Bacterial Infection in COPD. Chest 1999; 116: 40-46.
10. Rosell A, Monsó E, Soler N, Torres F, Angrill J, Riise G, Zalacaín R, Morera J, Torres A,. MIcrobiologic determinants of exacerbation in chronic obstructive pulmonary disease. Arch. Intern. Med. 2005; 165: 891-897.
11. Sapey E, Stockley RA,. COPD exacerbations.2: aetiology. Thorax 2006; 61: 250-258.
12. Wilkinson TM, Patel IS, Wilks M, Donaldson GC, Wedzicha JA,. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2003; 167: 1090-1095.
13. Patel IS, Seemungal TA, Wilks M, Lloyd-Owen SJ, Donaldson GC, Wedzicha JA,. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax 2002; 57: 759-764.
14. Papi A, Bellettato CM, Braccioni F, Romagnoli M, Casolari P, Caramori G, Fabbri LM, Johnston SL,. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. Am. J. Respir. Crit. Care Med. 2006; 173: 1114-1121.
15. Osman IM, Godden DJ, Friend JA, Legge JS, Douglas JG,. Quality of life and hospital re-admission in patients with chronic obstructive pulmonary disease. Thorax 1997; 52: 67-71.
16. Pizarro-Cerda J, Cossart P,. Bacterial adhesion and entry into host cells. Cell 2006; 124: 715-727.
17. Cundell DR, Gerard NP, Gerard C, Idanpaan-Heikkila I, Tuomanen EI,. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 1995; 377: 435-438.
18. Swords WE, Buscher BA, Ver Steeg Ii K, Preston A, Nichols WA, Weiser JN, Gibson BW, Apicella MA,. Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor. Mol. Microbiol. 2000; 37: 13-27.
19. Grigg J,. The platelet activating factor receptor: a new anti-infective target in respiratory disease? Thorax 2012; 67: 840-841.
20. Grigg J, Walters H, Sohal SS, Wood-Baker R, Reid DW, Xu CB, Edvinsson L, Morissette MC, Stampfli MR, Kirwan M, et al. Cigarette smoke and platelet-activating factor receptor dependent adhesion of Streptococcus pneumoniae to lower airway cells. Thorax 2012; 67: 908-913.
21. Suri R, Mallia P, Martin JE, Footitt J, Zhu J, Trujillo-Torralbo MB, Johnston SL, Grigg J,. Bronchial platelet-activating factor receptor in chronic obstructive pulmonary disease. Respir. Med. 2014; 108: 898-904.
22. Shukla SD, Sohal SS, Mahmood MQ, Reid D, Muller HK, Walters EH,. Airway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis. 2014; 9: 853-861.
23. Burgel PR,. The role of small airways in obstructive airway diseases. Eur. Respir. Rev. 2011; 20: 23-33.
24. Cosio MG, Saetta M, Agusti A,. Immunologic aspects of chronic obstructive pulmonary disease. N. Engl. J. Med. 2009; 360: 2445-2454.
25. Sohal SS, Soltani A, Reid D, Ward C, Wills KE, Muller HK, Walters EH,. A randomized controlled trial of inhaled corticosteroids (ICS) on markers of epithelial-mesenchymal transition (EMT) in large airway samples in COPD: an exploratory proof of concept study. Int. J. Chron. Obstruct. Pulmon. Dis. 2014; 9: 533-542.
26. Sohal SS, Reid D, Soltani A, Ward C, Weston S, Muller HK, Wood-Baker R, Walters EH,. Reticular basement membrane fragmentation and potential epithelial mesenchymal transition is exaggerated in the airways of smokers with chronic obstructive pulmonary disease. Respirology 2010; 15: 930-938.
27. Sohal SS, Mahmood MQ, Walters EH,. Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer. Clin. Transl. Med. 2014; 3: 1-4.
28. Mushtaq N, Ezzati M, Hall L, Dickson I, Kirwan M, Png KM, Mudway IS, Grigg J,. Adhesion of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate matter. J. Allergy Clin. Immunol. 2011; 127: 1236-1242.e1232.
29. Ishizuka S, Yamaya M, Suzuki T, Nakayama K, Kamanaka M, Ida S, Sekizawa K, Sasaki H,. Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. Am. J. Respir. Cell Mol. Biol. 2001; 24: 459-468.
30. Ishizuka S, Yamaya M, Suzuki T, Nakayama K, Kamanaka M, Ida S, Sekizawa K, Sasaki H,. Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. J. Infect. Dis. 2003; 188: 1928-1939.
31. Sohal SS, Eapen MS, Shukla SD, Courtney JM, Mahmood MQ, Walters EH,. Novel insights into chronic obstructive pulmonary disease (COPD): an overview. EMJ Respir 2014; 2: 81-87.
32. Iovino F, Brouwer MC, van de Beek D, Molema G, Bijlsma JJ,. Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease. Cell. Microbiol. 2013; 15: 870-881.
33. Weiser JN, Shchepetov M, Chong ST,. Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae. Infect. Immun. 1997; 65: 943-950.
34. Clementi C, Murphy T,. Nontypeable Haemophilus influenzae invasion and persistence in the human respiratory tract. Front. Cell. Infect. Microbiol. 1: 1-9. doi: 10.3389/fcimb.2011.00001
35. Hackler PC, Reuss S, Konger RL, Travers JB, Sahu RP,. Systemic platelet-activating factor receptor activation augments experimental lung tumor growth and metastasis. Cancer Growth Metastasis 2014; 7: 27-32.
36. Nuorti JP, Butler JC, Farley MM, Harrison LH, McGeer A, Kolczak MS, Breiman RF,. Cigarette smoking and invasive pneumococcal disease. Active Bacterial Core Surveillance Team. N. Engl. J. Med. 2000; 342: 681-689.
37. Calverley PM, Anderson JA, Celli B, Ferguson GT, Jenkins C, Jones PW, Yates JC, Vestbo J,. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N. Engl. J. Med. 2007; 356: 775-789.
38. Cates C,. Inhaled corticosteroids in COPD: quantifying risks and benefits. Thorax 2013; 68: 499-500.
39. Singh S, Amin AV, Loke YK,. Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis. Arch. Intern. Med. 2009; 169: 219-229.
40. Barnes PJ,. Immunology of asthma and chronic obstructive pulmonary disease. Nat. Rev. Immunol. 2008; 8: 183-192.
41. Sukhwinder SS, Mathew SE, Daniel T, Hans KM, Eugene HW,. Is central airway inflammation really a feature of mild-moderate chronic obstructive pulmonary disease (COPD)? In:, Wedzicha JA, (ed.) B37 Tell Me Why: Copd Pathogenesis. American Thoracic Society, New York, 2015; A2870. [American Thoracic Society International Conference Abstracts].