NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

Oncotarget

Volumn 6, Issue 40, 2015, Pages 42717-42732

  Galvani, Elena ^a,g   Sun, Jing ^b,g   Leon, Leticia G ^c,g   Sciarrillo, Rocco ^a,g   Narayan, Ravi S ^a,g   Sjin, Robert Tjin Tham ^d,g   Lee, Kwangho ^d,g   Ohashi, Kadoaki ^b,g   Heideman, Daniëlle A M ^a,g   Alfieri, Roberta R ^e,g   Heynen, Guus J ^f,g   Bernards, René ^f,g   Smit, Egbert F ^a,g   Pao, William ^b,g   Peters, Godefridus J ^a,g   Giovannetti, Elisa ^a,g  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSIDAD DE LA LAGUNA   (Spain)

^d Celgene Avilomics Research   (United States)

^e UNIVERSITY OF PARMA   (Italy)

^f NETHERLANDS CANCER INSTITUTE   (Netherlands)

^g UNIVERSITY OF PISA   (Italy)

Author keywords

Drug resistance; EGFR T790M; EMT; NF B; NSCLC

Indexed keywords

CNX 2006; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ROCILETINIB; UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; AZETIDINE DERIVATIVE; CNX-2006; EGFR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER RESISTANCE; CELL VIABILITY; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SELECTIVITY; DRUG STRUCTURE; GENE MUTATION; GI50; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NON SMALL CELL LUNG CANCER; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG RESISTANCE; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSFECTION; LUNG TUMOR; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ACRYLAMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; AZETIDINES; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LUNG NEOPLASMS; MICE; NF-KAPPA B; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, SMALL INTERFERING; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84952333891     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3956     Document Type: Article

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