Role of Foxp3/Treg and ROR γ t/Thl7 cell imbalance in rat model of chronic obstructive pulmonary disease

Chinese Critical Care Medicine

Volumn 26, Issue 12, 2014, Pages 860-864

  Wang, Chengyang ^a   Liu, Xiangguo ^a   Peng, Qinghe ^a   Fang, Li ^a   Wang, Chuanbo ^a   Li, Zegeng ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Chronic obstructive pulmonary disease; Fork head like transcription factor p3; Helper T cell 17; Regulatory T cell; Retinoid related orphan receptor gamma

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, RAT; CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; LUNG ALVEOLUS; LUNG FUNCTION; LUNG PARENCHYMA; NONHUMAN; PEAK EXPIRATORY FLOW; RAT; REGULATORY T LYMPHOCYTE; SMOKE; TH17 CELL; WESTERN BLOTTING; ANIMAL; INFLAMMATION; LUNG; SPRAGUE DAWLEY RAT; DOWN REGULATION; INFLAMMATORY INFILTRATE; LUNG ALVEOLUS WALL; LUNG HEMORRHAGE; LUNG INTERSTITIUM; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; FORKHEAD TRANSCRIPTION FACTORS; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LUNG; MODELS, ANIMAL; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84952317581     PISSN: 10030603     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.2095-4352.2014.12.003     Document Type: Article

References (15)

1. Malerba M, Clini E, Malagola M, et al. Platelet activation as a novel mechanism of atherothrombotic risk in chronic obstructive pulmonary disease [J]. Expert Rev Hematol, 2013, 6(4):475-483.
2. Faner R, Cruz T, Agusti A. Immune response in chronic obstructive pulmonary disease [J]. Expert Rev Clin Immunol, 2013, 9(9):821-833.
3. Wang H, Peng W, Weng Y, et al. Imbalance of Thl7/Treg cells in mice with chronic cigarette smoke exposure [J]. Int Immunopharmacol, 2012, 14(4):504-512.
4. Pace E, Ferraro M, Giarratano A, et al. TLR4 up-regulation and reduced Foxp3 expression in mechanically ventilated smokers with obstructive chronic bronchitis [J]. COPD, 2013, 10(2):147-155.
5. Eppert BL, Wortham BW, Flury JL, et al. Functional characterization of T cell populations in a mouse model of chronic obstructive pulmonary disease [J]. J Immunol, 2013, 190(3):1331-1340.
6. Pion M, Jaramillo-Ruiz D, Martinez A, et al. HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene [J]. AIDS, 2013, 27(13):2019-2029.
7. + cells during pregnancy [J]. Am J Clin Exp Immunol, 2013, 2(3):222-233.
8. Lim H, Kim YU, Yun K, et al. Distinct regulation of Th2 and Th17 responses to allergens by pulmonary antigen presenting cells in vivo [J]. Immunol Lett, 2013, 156(1-2):140-148.
9. Li J, Zhang B. Apigenin protects ovalbumin-induced asthma through the regulation of Thl7 cells [J]. Fitoterapia, 2013, 91:298-304.
10. Vargas-Rojas MI, Ramirez-Venegas A, Limón-Camacho L, et al. Increase of Thl7 cells in peripheral blood of patients with chronic obstructive pulmonary disease [J]. Respir Med, 2011, 105(11):1648-1654.
11. Chen S, Wu H, Klebe D, et al. Regulatory T cell in stroke: a new paradigm for immune regulation [J]. Clin Dev Immunol, 2013, 2013:689827.
12. Limón-Camacho L, Solleiro-Villavicencio H, Pupko-Sissa I, et al. Regulatory T cells in chronic obstructive pulmonary disease [J]. Arch Cardiol Mex, 2013, 83(1):45-54.
13. Usher AK, Stockley RA. The link between chronic periodontitis and COPD: a common role for the neutrophil? [J]. BMC Med, 2013, 11:241.
14. + regulatory cells support plasticity between Thl7 and regulatory T cells in inflammatory bowel disease patients [J]. Inflamm Bowel Dis, 2013, 19(12):2522-2534.
15. Blatner NR, Mulcahy MF, Dennis KL, et al. Expression of ROR γ t marks a pathogenic regulatory T cell subset in human colon cancer [J]. Sci Transl Med, 2012, 4(164):164ra159.