TLR4 Up-regulation and reduced Foxp3 expression in mechanically ventilated smokers with obstructive chronic bronchitis

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 10, Issue 2, 2013, Pages 147-155

  Pace, Elisabetta ^a   Ferraro, Maria ^a   Giarratano, Antonino ^b   Cipollina, Chiara ^a,b,c   Gjomarkaj, Mark ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c RiMED Foundation   (Italy)

Author keywords

Chemokines; Foxp3; Respiratory failure; Smokers; Toll like receptors

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 8; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3;

AGED; ARTICLE; ARTIFICIAL VENTILATION; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOCYTOCHEMISTRY; LUNG LAVAGE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RESPIRATORY FAILURE; SMOKING;

AGED; AGED, 80 AND OVER; BRONCHITIS, CHRONIC; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL10; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-8; LEUKOCYTE COUNT; MALE; NEUTROPHILS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATION, ARTIFICIAL; SMOKING; STATISTICS, NONPARAMETRIC; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 84875851732     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.3109/15412555.2012.730565     Document Type: Article

References (30)

1. Garcia-Aymerich J, Serra Pons I, Mannino DM, Maas AK, Miller DP, Davis KJ. Lung function impairment, COPD hospitalisations and subsequent mortality. Thorax 2011; 66(7):585-590.
2. Vestbo J, Prescott E, Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Am J Respir Crit Care Med 1996; 153:1530-1535.
3. Mullen JB, Wright JL, Wiggs BR, Pare PD, Hogg JC. Structure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: Relationship to lung function; Thorax 1987;42: 843-848.
4. Zhang G, Ghosh S. Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J Endotoxin Res 2000; 6:453-457.
5. Cosio MG, Saetta M, Agusti A. Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med 2009; 360:2445-2454.
6. Pace E, Ferraro M, Siena L Melis M, Montalbano A, Johnson M, Bonsignore MR, Bonsignore G, Gjomarkaj M. Cigarette smoke increases TLR4 and modifies LPS mediated responses in airway epithelial cells. Immunology 2008; 124:401-411.
7. Pace E, Giarratano A, Ferraro M, Bruno A, Siena L, Mangione S, Johnson M, Gjomarkaj M. TLR4 upregulation underpins airway neutrophilia in smokers with chronic obstructive pulmonary disease and acute respiratory failure. Hum Immunol 2011; 72:54-62.
8. Isajevs S, Taivans I, Strazda G, Kopeika U, Bukovskis M, Gordjusina V, Kratovska A. Decreased FOXP3 expression in small airways of smokers with COPD. Eur Respir J 2009; 33(1):61-67.
9. Roos-Engstrand E, Pourazar J, Behndig AF, Bucht A, Blomberg A. Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD. Respir Res 2011; 12:74.
10. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/ WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary. Am J Respir Crit Care Med 2001; 163:1256-1276.
11. Pace E, Ferraro M, Uasuf CG, La Grutta S, Liotta G, Giarratano A, Johnson M, Gjomarkaj M. Cilomilast counteracts the effects of cigarette smoke in innate responses of airway epithelial cells. Cell Immunol 2011; 268:47-53.
12. Calverley PM, Walker P. Chronic obstructive pulmonary disease. Lancet 2003; 362:1053-1061.
13. Agustí A. Systemic effects of chronic obstructive pulmonary disease: What we know and what we don't know (but should). Proc Am Thorac Soc 2007; 4(7):522-525.
14. Reid L. Pathology of chronic bronchitis. Lancet 1954; i:275-279.
15. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004; 364:709-721.
16. von Scheele I, Larsson K, Dahlén B, Billing B, Skedinger M, Lantz AS, Palmberg L. Toll-like receptor expression in smokers with and without COPD. Respir Med 2011; 105:1222-1230.
17. Geraghty P, Dabo AJ, D'Armiento J. TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease. J Biol Chem 2011; 286:30211-30218.
18. Horvath KM, Brighton LE, Zhang W, Carson JL, Jaspers I. Epithelial cells from smokers modify dendritic cell responses in the context of influenza infection. Am J Respir Cell Mol Biol 2011; 45:237-245.
19. Boodoo S, Spannhake EW, Powell JD, Horton MR. Diff erential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2006; 291:L479-L486.
20. Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005; 6:331-337.
21. Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010; 10:490-500.
22. Hori S. Rethinking the molecular definition of regulatory T cells. Eur J Immunol 2008; 38:928-930.
23. Chu S, Zhong X, Zhang J, Lao Q, He Z, Bai J. The expression of Foxp3 and ROR gamma t in lung tissues from normal smokers and chronic obstructive pulmonary disease patients. Int Immunopharmcol 2011; 11(11):1780-1788. Epub 2011 Jul 23.
24. Yang L, Ma QL, Yao W, Zhang Q, Chen HP, Wang GS, Wang CZ. Relationship between the anti-inflammatory properties of salmeterol/fluticasone and the expression of CD4+CD25+Foxp3+ regulatory T cells in COPD. Respir Res 2011; 12:142.
25. Isajevs S, Taivans I, Strazda G, Kopeika U, Bukovskis M, Gordjusina V, Kratovska A. Decreased FOXP3 expression in small airways of smokers with COPD. Eur Respir J 2009; 33(1):61-67.
26. Le Gall Jr, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/ North American multicenter study. JAMA 1993; 270:2957-2963.
27. Tiruvoipati R, Ong K, Gangopadhyay H, Arora S, Carney I, Botha J. Hypothermia predicts mortality in critically ill elderly patients with sepsis. BMC Geriatr 2010; 10:70.
28. Vincent JL, de Mendonça A, Cantraine F, Moreno R, Takala J, Suter PM, Sprung CL, Colardyn F, Blecher S. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998; 26(11):1793-1800.
29. Zügel NP, Kox M, Lichtwark-Aschoff M, Gippner-Steppert C, Jochum M. Predictive relevance of clinical scores and inflammatory parameters in secondary peritonitis. Bull Soc Sci Med Grand Duche Luxemb 2011; 1:41-71.
30. Zilberberg MD, Shorr AF. Clin Infect Dis. Ventilatorassociated pneumonia: the clinical pulmonary infection score as a surrogate for diagnostics and outcome. Clin Infect Dis 2010; 51 Suppl 1: S131-135.