miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

Clinical Science

Volumn 129, Issue 12, 2015, Pages 1237-1249

  McClelland, Aaron D ^a,b   Herman Edelstein, Michal ^c,d   Komers, Radko ^e   Jha, Jay C ^b   Winbanks, Catherine E ^a   Hagiwara, Shinji ^b   Gregorevic, Paul ^a   Kantharidis, Phillip ^a   Cooper, Mark E ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c RABIN MEDICAL CENTER   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Biopsy; Diabetic nephropathy; Fibrosis; Micro ribonucleic acid (RNA); Signalling; Transforming growth factor (TGF) 1

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE; MICRORNA 21; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; AKT1 PROTEIN, RAT; APOLIPOPROTEIN E; COLLAGEN; MICRORNA; MIRN21 MICRORNA, HUMAN; MIRN21 MICRORNA, MOUSE; MIRN21 MICRORNA, RAT; PTEN PROTEIN, RAT; SMAD7 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE SEVERITY; ECTOPIC EXPRESSION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; REGULATORY MECHANISM; RENAL CORTICAL TISSUE; RENAL PROTECTION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CASE CONTROL STUDY; CELL LINE; CHEMICALLY INDUCED; COMPLICATION; DEFICIENCY; DIABETIC NEPHROPATHIES; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; FIBROSIS; GENETIC TRANSFECTION; GENETICS; KIDNEY PROXIMAL TUBULE; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PROGNOSIS; RNA INTERFERENCE; SEVERITY OF ILLNESS INDEX; SPRAGUE DAWLEY RAT;

ANIMALS; APOLIPOPROTEINS E; CASE-CONTROL STUDIES; CELL LINE; COLLAGEN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FIBROSIS; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY TUBULES, PROXIMAL; MICE, KNOCKOUT; MICRORNAS; PHOSPHORYLATION; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84952031873     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150427     Document Type: Article

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