Limitation of Infarct Size and No-Reflow by Intracoronary Adenosine Depends Critically on Dose and Duration

JACC: Cardiovascular Interventions

Volumn 8, Issue 15, 2015, Pages 1990-1999

  Yetgin, Tuncay ^a,b   Uitterdijk, André ^a   Te Lintel Hekkert, Maaike ^a   Merkus, Daphne ^a   Krabbendam Peters, Ilona ^a   Van Beusekom, Heleen M M ^a   Falotico, Robert ^c   Serruys, Patrick W ^a   Manintveld, Olivier C ^a   Van Geuns, Robert Jan M ^a   Zijlstra, Felix ^a,b   Duncker, Dirk J ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c Endovascular Division   (United States)

Author keywords

acute myocardial infarction; adenosine; no reflow; reperfusion injury

Indexed keywords

ADENOSINE; SODIUM CHLORIDE;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY OCCLUSION; CORONARY HEMODYNAMICS; CORONARY REPERFUSION; HEART INFARCTION SIZE; HEART PROTECTION; INTRACORONARY DRUG ADMINISTRATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; ADVERSE EFFECTS; ANIMAL; CARDIAC MUSCLE; CORONARY ARTERY BLOOD FLOW; CORONARY OCCLUSION; DISEASE MODEL; DRUG ADMINISTRATION; FEMALE; HEART MUSCLE REPERFUSION; HEMODYNAMICS; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NO-REFLOW PHENOMENON; PARENTERAL DRUG ADMINISTRATION; PATHOLOGY; PATHOPHYSIOLOGY; PIG; TIME FACTOR;

ADENOSINE; ANIMALS; CORONARY CIRCULATION; CORONARY OCCLUSION; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEMODYNAMICS; INFUSIONS, PARENTERAL; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NO-REFLOW PHENOMENON; SWINE; TIME FACTORS;

EID: 84951945018     PISSN: 19368798     EISSN: 18767605     Source Type: Journal    
DOI: 10.1016/j.jcin.2015.08.033     Document Type: Article

References (46)

1. P.G. Steg, S.K. James, D. Atar, et al. for the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation Eur Heart J 33 2012 2569 2619
2. E. Braunwald, and R.A. Kloner Myocardial reperfusion: a double-edged sword? J Clin Invest 76 1985 1713 1719
3. D.M. Yellon, and D.J. Hausenloy Myocardial reperfusion injury N Engl J Med 357 2007 1121 1135
4. R.A. Kloner, C.E. Ganote, and R.B. Jennings The "no-reflow" phenomenon after temporary coronary occlusion in the dog J Clin Invest 54 1974 1496 1508
5. G. Ndrepepa, K. Tiroch, M. Fusaro, and et al. 5-year prognostic value of no-reflow phenomenon after percutaneous coronary intervention in patients with acute myocardial infarction J Am Coll Cardiol 55 2010 2383 2389
6. M.B. Forman, G.W. Stone, and E.K. Jackson Role of adenosine as adjunctive therapy in acute myocardial infarction Cardiovasc Drug Rev 24 2006 116 147
7. D.J. Hausenloy, and D.M. Yellon Remote ischaemic preconditioning: underlying mechanisms and clinical application Cardiovasc Res 79 2008 377 386
8. M.V. Cohen, and J.M. Downey Adenosine: trigger and mediator of cardioprotection Basic Res Cardiol 103 2008 203 215
9. M.T. Dirksen, G.J. Laarman, M.L. Simoons, and D.J. Duncker Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies Cardiovasc Res 74 2007 343 355
10. W. Desmet, J. Bogaert, C. Dubois, and et al. High-dose intracoronary adenosine for myocardial salvage in patients with acute ST-segment elevation myocardial infarction Eur Heart J 32 2011 867 877
11. M.L. Fokkema, P.J. Vlaar, M. Vogelzang, and et al. Effect of high-dose intracoronary adenosine administration during primary percutaneous coronary intervention in acute myocardial infarction: a randomized controlled trial Circ Cardiovasc Interv 2 2009 323 329
12. C. Kilkenny, W.J. Browne, I.C. Cuthill, M. Emerson, and D.G. Altman Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research PLoS Biol 8 2010 e1000412
13. ATP channels Circulation 93 1996 178 186
14. M. Te Lintel Hekkert, G.P. Dubé, E. Regar, and et al. Preoxygenated hemoglobin-based oxygen carrier HBOC-201 annihilates myocardial ischemia during brief coronary artery occlusion in pigs Am J Physiol Heart Circ Physiol 298 2010 H1103 H1113
15. A. Uitterdijk, S. Sneep, R.W. van Duin, and et al. Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted? Am J Physiol Heart Circ Physiol 305 2013 H1104 H1110
16. M. Grygier, A. Araszkiewicz, M. Lesiak, and et al. New method of intracoronary adenosine injection to prevent microvascular reperfusion injury in patients with acute myocardial infarction undergoing percutaneous coronary intervention Am J Cardiol 107 2011 1131 1135
17. A. Hendler, A. Aronovich, E. Kaluski, and et al. Optimization of myocardial perfusion after primary coronary angioplasty following an acute myocardial infarction: beyond TIMI 3 flow J Invasive Cardiol 18 2006 32 36
18. K.E. Barletta, K. Ley, and B. Mehrad Regulation of neutrophil function by adenosine Arterioscler Thromb Vasc Biol 32 2012 856 864
19. D.A. Liem, P.D. Verdouw, H. Ploeg, S. Kazim, and D.J. Duncker Sites of action of adenosine in interorgan preconditioning of the heart Am J Physiol Heart Circ Physiol 283 2002 H29 H37
20. O.C. Manintveld, M. te Lintel Hekkert, E. Keijzer, P.D. Verdouw, and D.J. Duncker Intravenous adenosine protects the myocardium primarily by activation of a neurogenic pathway Br J Pharmacol 145 2005 703 711
21. K.W. Mahaffey, J.A. Puma, N.A. Barbagelata, and et al. Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial J Am Coll Cardiol 34 1999 1711 1720
22. A.M. Ross, R.J. Gibbons, G.W. Stone, et al. for the AMISTAD-II Investigators A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II) J Am Coll Cardiol 45 2005 1775 1780
23. R.A. Kloner, M.B. Forman, R.J. Gibbons, A.M. Ross, R.W. Alexander, and G.W. Stone Impact of time to therapy and reperfusion modality on the efficacy of adenosine in acute myocardial infarction: the AMISTAD-2 trial Eur Heart J 27 2006 2400 2405
24. M. Marzilli, E. Orsini, P. Marraccini, and R. Testa Beneficial effects of intracoronary adenosine as an adjunct to primary angioplasty in acute myocardial infarction Circulation 101 2000 2154 2159
25. M.G. Stoel, K.M. Marques, C.C. de Cock, J.G. Bronzwaer, C. von Birgelen, and F. Zijlstra High dose adenosine for suboptimal myocardial reperfusion after primary PCI: a randomized placebo-controlled pilot study Catheter Cardiovasc Interv 71 2008 283 289
26. G. Niccoli, S. Rigattieri, M.R. De Vita, and et al. Open-label, randomized, placebo-controlled evaluation of intracoronary adenosine or nitroprusside after thrombus aspiration during primary percutaneous coronary intervention for the prevention of microvascular obstruction in acute myocardial infarction: the REOPEN-AMI study (Intracoronary Nitroprusside Versus Adenosine in Acute Myocardial Infarction) J Am Coll Cardiol Intv 6 2013 580 589
27. G. Niccoli, C. Spaziani, F. Crea the REOPEN-AMI Investigators Left ventricular remodeling and 1-year clinical follow-up of the REOPEN-AMI trial J Am Coll Cardiol 63 2014 1454 1455
28. R. de Jong, J.H. Houtgraaf, S. Samiei, E. Boersma, and H.J. Duckers Intracoronary stem cell infusion after acute myocardial infarction: a meta-analysis and update on clinical trials Circ Cardiovasc Interv 7 2014 156 167
29. R.A. Kloner, S. Das, W.K. Poole, and et al. Seasonal variation of myocardial infarct size Am J Cardiol 88 2001 1021 1024
30. D.J. Durgan, T. Pulinilkunnil, C. Villegas-Montoya, and et al. Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock Circ Res 106 2010 546 550
31. A. Suarez-Barrientos, P. López-Romero, D. Vivas, and et al. Circadian variations of infarct size in acute myocardial infarction Heart 97 2011 970 976
32. R. Reiter, C. Swingen, L. Moore, T.D. Henry, and J.H. Traverse Circadian dependence of infarct size and left ventricular function after ST elevation myocardial infarction Circ Res 110 2012 105 110
33. Z.Q. Zhao, M. Nakamura, N.P. Wang, and et al. Administration of adenosine during reperfusion reduces injury of vascular endothelium and death of myocytes Coron Artery Dis 10 1999 617 628
34. M. Goto, T. Miura, E.K. Iliodoromitis, and et al. Adenosine infusion during early reperfusion failed to limit myocardial infarct size in a collateral deficient species Cardiovasc Res 25 1991 943 949
35. E.D. Norton, E.K. Jackson, R. Virmani, and M.B. Forman Effect of intravenous adenosine on myocardial reperfusion injury in a model with low myocardial collateral blood flow Am Heart J 122 1991 1283 1291
36. C.J. Pitarys 2nd, R. Virmani, H.D. Vildibill Jr., E.K. Jackson, and M.B. Forman Reduction of myocardial reperfusion injury by intravenous adenosine administered during the early reperfusion period Circulation 83 1991 237 247
37. E.D. Norton, E.K. Jackson, M.B. Turner, R. Virmani, and M.B. Forman The effects of intravenous infusions of selective adenosine A1-receptor and A2-receptor agonists on myocardial reperfusion injury Am Heart J 123 1992 332 338
38. R.S. Vander Heide, and K.A. Reimer Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs Cardiovasc Res 31 1996 711 718
39. J.M. Budde, D.A. Velez, Z. Zhao, and et al. Comparative study of AMP579 and adenosine in inhibition of neutrophil-mediated vascular and myocardial injury during 24 h of reperfusion Cardiovasc Res 47 2000 294 305
40. J.M. Budde, C.D. Morris, D.A. Velez, and et al. Reduction of infarct size and preservation of endothelial function by multidose intravenous adenosine during extended reperfusion J Surg Res 116 2004 104 115
41. B. Olafsson, M.B. Forman, D.W. Puett, and et al. Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon Circulation 76 1987 1135 1145
42. D.G. Babbitt, R. Virmani, H.D. Vildibill Jr., E.D. Norton, and M.B. Forman Intracoronary adenosine administration during reperfusion following 3 hours of ischemia: effects on infarct size, ventricular function, and regional myocardial blood flow Am Heart J 120 1990 808 818
43. J.W. Homeister, P.T. Hoff, D.D. Fletcher, and B.R. Lucchesi Combined adenosine and lidocaine administration limits myocardial reperfusion injury Circulation 82 1990 595 608
44. C.E. Velasco, M. Turner, M.A. Cobb, R. Virmani, and M.B. Forman Myocardial reperfusion injury in the canine model after 40 minutes of ischemia: effect of intracoronary adenosine Am Heart J 122 1991 1561 1570
45. M.B. Forman, C.E. Velasco, and E.K. Jackson Adenosine attenuates reperfusion injury following regional myocardial ischaemia Cardiovasc Res 27 1993 9 17
46. Garcia-Dorado D, Otaegui I, Rodriguez Palomares JF, et al. Primary results of the PROMISE trial: myocardial protection with intracoronary adenosine given before reperfusion in patients with STEMI. Paper presented at: Annual Congress of the European Society of Cardiology; September 2, 2013; Amsterdam, the Netherlands.