LDL-lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: Mitigation by statin intervention

Clinical Science

Volumn 129, Issue 12, 2015, Pages 1195-1206

  Dias, H K Irundika ^a   Brown, Caroline L R ^a   Polidori, M Cristina ^b   Lip, Gregory Y H ^c   Griffiths, Helen R ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c CITY HOSPITAL   (United Kingdom)

Author keywords

Alzheimer's disease; Blood brain barrier; Endothelium; Lipids; Statins

Indexed keywords

CARBONYL DERIVATIVE; CHOLESTEROL; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN; SIMVASTATIN; AUTACOID; BIOLOGICAL MARKER; OXIDIZED LOW DENSITY LIPOPROTEIN;

ADULT; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CAPILLARY ENDOTHELIAL CELL; CELL STRESS; CELL VIABILITY; CHOLESTEROL BLOOD LEVEL; COGNITION; CONTROLLED STUDY; CYTOKINE RELEASE; ELECTROPHORETIC MOBILITY; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; IN VIVO STUDY; INFLAMMATION; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID OXIDATION; MALE; METABOLIC INHIBITION; MIDDLE AGED; MULTIINFARCT DEMENTIA; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIGHT JUNCTION; AGED; BLOOD; CAPILLARY PERMEABILITY; CELL CULTURE; CLINICAL TRIAL; DRUG EFFECTS; ENDOTHELIUM CELL; GERMANY; LIPID PEROXIDATION; METABOLISM; MICROVASCULATURE; MULTICENTER STUDY; PROTEIN CARBONYLATION; TIME; TREATMENT OUTCOME; UNITED KINGDOM; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BIOMARKERS; CAPILLARY PERMEABILITY; CELLS, CULTURED; ENDOTHELIAL CELLS; ENGLAND; GERMANY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; INFLAMMATION MEDIATORS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALE; MICROVESSELS; MIDDLE AGED; PROTEIN CARBONYLATION; SIMVASTATIN; TIME FACTORS; TREATMENT OUTCOME;

EID: 84951926026     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20150351     Document Type: Article

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