A Randomized Trial of Single-Dose Oral Dexamethasone Versus Multidose Prednisolone for Acute Exacerbations of Asthma in Children Who Attend the Emergency Department

Annals of Emergency Medicine

Volumn 67, Issue 5, 2016, Pages 593-601.e3

  Cronin, John J ^a,b   McCoy, Siobhan ^a,b   Kennedy, Una ^c   An Fhailí, Sinéad Nic ^a   Wakai, Abel ^d   Hayden, John ^a   Crispino, Gloria ^e   Barrett, Michael J ^a,b,f   Walsh, Sean ^a,b   O'Sullivan, Ronan ^a,b,f,g  

^a NATIONAL CHILDREN S RESEARCH CENTRE   (Ireland)

^b OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^c ST JAMES S HOSPITAL   (Ireland)

^d ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^e StatisticaMedica   (Ireland)

^f UNIVERSITY COLLEGE DUBLIN   (Ireland)

^g UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CORTICOSTEROID; DEXAMETHASONE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PREDNISOLONE; SALBUTAMOL; ANTIASTHMATIC AGENT; ANTIINFLAMMATORY AGENT;

ARTICLE; ASTHMA; CHILD; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE EXACERBATION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG SAFETY; EMERGENCY WARD; FEMALE; HEALTH CARE PERSONNEL; HOSPITAL ADMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; OUTCOME ASSESSMENT; PEDIATRIC RESPIRATORY ASSESSMENT MEASURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SINGLE DRUG DOSE; VOMITING; WHEEZING; ACUTE DISEASE; ADOLESCENT; CLINICAL PATHWAY; DOSE RESPONSE; DRUG ADMINISTRATION; EMERGENCY HEALTH SERVICE; HOSPITALIZED CHILD; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PRESCHOOL CHILD; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ACUTE DISEASE; ADMINISTRATION, ORAL; ADOLESCENT; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; CHILD; CHILD, HOSPITALIZED; CHILD, PRESCHOOL; CRITICAL PATHWAYS; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EMERGENCY MEDICAL SERVICES; FEMALE; HUMANS; MALE; PREDNISOLONE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84951827655     PISSN: 01960644     EISSN: 10976760     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2015.08.001     Document Type: Article

References (26)

1. J. Choi, and G.L. Lee Common pediatric respiratory emergencies Emerg Med Clin North Am 30 2012 529 563
2. American Lung Association. Trends in Asthma Morbidity and Mortality. 2012.
3. B.H. Rowe, C.H. Spooner, F.M. Ducharme, and et al. Corticosteroids for preventing relapse following acute exacerbations of asthma Cochrane Database Syst Rev 3 2007 CD000195
4. British Thoracic Society and Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Available at: https://www.brit-thoracic.org.uk/document-library/clinical-information/asthma/btssign-asthma-guideline-2014/. Accessed September 17, 2015.
5. Schimmer BP, Parker KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman & Gilman's the pharmacological basis of therapeutics. 11th ed. New York: McGraw-Hill; 2007. p. 1587-612.
6. M.E. Lucas-Bouwman, R.J. Roorda, F.G. Jansman, and et al. Crushed prednisolone tablets or oral solution for acute asthma? Arch Dis Child 84 2001 347 348
7. K. Butler, and W.O. Cooper Adherence of pediatric asthma patients with oral corticosteroid prescriptions following pediatric emergency department visit or hospitalization Pediatr Emerg Care 20 2004 730 735
8. K.F. Russell, Y. Liang, K. O'Gorman, and et al. Glucocorticoids for croup Cochrane Database Syst Rev 1 2011 CD001955
9. X. Saez-Llorens, and G.H. McCracken Jr. Bacterial meningitis in children Lancet 361 2003 2139 2148
10. S. Altamimi, G. Robertson, W. Jastaniah, and et al. Single-dose oral dexamethasone in the emergency management of children with exacerbations of mild to moderate asthma Pediatr Emerg Care 22 2006 786 793
11. S. Gordon, T. Tompkins, and P.S. Dayan Randomized trial of single-dose intramuscular dexamethasone compared with prednisolone for children with acute asthma Pediatr Emerg Care 23 2007 521 527
12. D.M. Gries, D.R. Moffitt, E. Pulos, and et al. A single dose of intramuscularly administered dexamethasone acetate is as effective as oral prednisone to treat asthma exacerbations in young children J Pediatr 136 2000 298 303
13. G.E. Keeney, M.P. Gray, A.K. Morrison, and et al. Dexamethasone for acute asthma exacerbations in children: a meta-analysis Pediatrics 133 2014 493 499
14. J.E. Klig, D. Hodge 3rd, and M.W. Rutherford Symptomatic improvement following emergency department management of asthma: a pilot study of intramuscular dexamethasone versus oral prednisone J Asthma 34 1997 419 425
15. F. Qureshi, A. Zaritsky, and M.P. Poirier Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma J Pediatr 139 2001 20 26
16. R.J. Scarfone, J.M. Loiselle, J.F. Wiley 2nd, and et al. Nebulized dexamethasone versus oral prednisone in the emergency treatment of asthmatic children Ann Emerg Med 26 1995 480 486
17. R.A. Greenberg, G. Kerby, and G.E. Roosevelt A comparison of oral dexamethasone with oral prednisone in pediatric asthma exacerbations treated in the emergency department Clin Pediatr 47 2008 817 823
18. F.M. Ducharme, D. Chalut, L. Plotnick, and et al. The Pediatric Respiratory Assessment Measure: a valid clinical score for assessing acute asthma severity from toddlers to teenagers J Pediatr 152 2008 476 480 80.e1
19. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use ICH Harmonized Tripartite Guideline: guideline for good clinical practice J Postgrad Med 47 2001 45 50
20. C.S. Birken, P.C. Parkin, and C. Macarthur Asthma severity scores for preschoolers displayed weaknesses in reliability, validity, and responsiveness J Clin Epidemiol 57 2004 1177 1181
21. J. Panickar, M. Lakhanpaul, P.C. Lambert, and et al. Oral prednisolone for preschool children with acute virus-induced wheezing N Engl J Med 360 2009 329 338
22. J. Cronin, U. Kennedy, S. McCoy, and et al. Single dose oral dexamethasone versus multi-dose prednisolone in the treatment of acute exacerbations of asthma in children who attend the emergency department: study protocol for a randomized controlled trial Trials 13 2012 141
23. F.E. Babl, N. Sheriff, M. Borland, and et al. Paediatric acute asthma management in Australia and New Zealand: practice patterns in the context of clinical practice guidelines Arch Dis Child 93 2008 307 312
24. A.B. Chang, R. Clark, T.P. Sloots, and et al. A 5- versus 3-day course of oral corticosteroids for children with asthma exacerbations who are not hospitalised: a randomised controlled trial Med J Aust 189 2008 306 310
25. H. Hames, J.A. Seabrook, D. Matsui, and et al. A palatability study of a flavored dexamethasone preparation versus prednisolone liquid in children Can J Clin Pharmacol 15 2008 e95 e98
26. G. Piaggio, D.R. Elbourne, S.J. Pocock, and et al. Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement JAMA 308 2012 2594 2604