A palatability study of a flavored dexamethasone preparation versus prednisolone liquid in children with asthma exacerbation in a pediatric emergency department

Canadian Journal of Clinical Pharmacology

Volumn 15, Issue 1, 2008, Pages

  Hames, Heather ^b   Seabrook, Jamie A ^a   Matsui, Doreen ^a   Rieder, Michael J ^a,b   Joubert, Gary I ^a,b  

^a CHILDREN S HOSPITAL OF WESTERN ONTARIO   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Asthma; Children; Corticosteroids; Taste

Indexed keywords

DEXAMETHASONE; FLAVORING AGENT; GLUCOCORTICOID; PREDNISOLONE;

ARTICLE; ASTHMA; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG FORMULATION; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; PRESCHOOL CHILD; QUESTIONNAIRE; SEX DIFFERENCE; SINGLE BLIND PROCEDURE; SUSPENSION; TASTE;

ADMINISTRATION, ORAL; ASTHMA; CHILD; CHILD, PRESCHOOL; DEXAMETHASONE; DRUG COMPOUNDING; FEMALE; FLAVORING AGENTS; GLUCOCORTICOIDS; HUMANS; MALE; PATIENT COMPLIANCE; PREDNISOLONE; QUESTIONNAIRES; SEX FACTORS; SINGLE-BLIND METHOD; SUSPENSIONS; TASTE;

EID: 84877786156     PISSN: 1198581X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Health Canada. Centre for Chronic Disease Prevention and Control Chronic of Respiratory Diseases: Asthma. (2003) http://www.phacaspc.gc.ca/ccdpc-cpcmc/crd-mrc/asthmae.html (August 2, 2006).
2. Nowak RM, Tokarski G. Asthma. In: Marx JA, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. Philadelphia: Mosby Elsevier, 2006:72-79.
3. Katherine Barber, ed. Canadian Oxford Dictionary. Thumb Index Edition. Oxford University Press, 1998:1046.
4. Chou JW, Decarie D, Dumont RJ, Ensom MH. Stability of dexamethasone in extemporaneously prepared oral suspensions. Can J Hosp Pharm 2001;54:96-101.
5. Matsui D, Barron A, Rieder MJ. Assessment of the palatability of antistaphylococcal antibiotics in pediatric volunteers. Ann Pharmacother 1996;30:586-8.
6. Sjovall J, Fogh A, Huitfeldt B, Karlsson G, Nylen O. Methods for evaluating the taste of paediatric formulations in children: a comparison between the facial hedonic method and the patients' own spontaneous verbal judgement. Eur J Pediatr 1984;141:243-7.
7. Steele RW, Thomas MP, Begue RE. Compliance issues related to the selection of antibiotic suspensions for children. Pediatr Infect Dis J 2001;20:1-5.
8. Kim MK, Yen K, Redman RL, Nelson TJ, Brandos J, Hennes HM. Vomiting of liquid corticosteroids in children with asthma. Pediatr Emerg Care 2006;22:397-401.
9. Mitchell JC, Counselman FL. A taste comparison of three different liquid steroid preparations: prednisone, prednisolone, and dexamethasone. Acad EmergMed 2003;10:400-3.
10. Lucas-bouwman ME, Roorda RJ, Jansman FGA, Brand PLP. Crushed prednisone tablets or oral solution for acute asthma? Arch Dis Child 2001;84:347-8.
11. Hendeles L. Selecting a systemic corticosteroid for acute asthma in young children. J Pediatr 2003;142:S40-4.
12. Hutto CJ, Bratton TH. Palatability and cost comparison of five liquid corticosteroid formulations. J Pediatr Oncol Nurs 1999;16:74-7.
13. Isa JM, Wong GK, Teraoka SS, Sera MJ, Tsusuima MM, Yamamoto LG. Parental pediatric corticosteroid preferences. Am J Emerg Med 2001;19:29-31.
14. Qureshi F, Zaritsky A, Poirier MP. Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma. J Pediatr 2001;139:20-6.
15. Altamimi S, Robertson G, Jastaniah W, et al. Single-dose oral dexamethasone in the emergency management of children with exacerbations of mild to moderate asthma. Pediatr Emerg Care 2006;22:786-93.