Phenylalanine hydroxylation across the kidney in humans: Rapid communication

Kidney International

Volumn 56, Issue 6, 1999, Pages 2168-2172

  Tessari, Paolo ^a   Deferrari, Giacomo ^a   Robaudo, Cristina ^a   Vettore, Monica ^a   Pastorino, Nadia ^a   De Biasi, Luisa ^a   Garibotto, Giacomo ^a  

^a Dept of Clin and Exp Medicine ^*

Author keywords

Amino acids; Catheterization; Stable isotopes; Tyrosine; Uremia

Indexed keywords

PHENYLALANINE; PHENYLALANINE 4 MONOOXYGENASE; TYROSINE;

ADULT; AMINO ACID METABOLISM; ARTICLE; CLINICAL ARTICLE; ENZYME ACTIVITY; FEMALE; HUMAN; HYDROXYLATION; ISOTOPE LABELING; KIDNEY METABOLISM; MALE; MATHEMATICAL MODEL; PRIORITY JOURNAL; TRANSAMINATION; UREMIA; VEIN CATHETERIZATION;

EID: 0033460298     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.00802.x     Document Type: Article

References (19)

1. 1. Rosenberg LE, Scriver CR: Disorders of amino acid metabolism, in Metabolic Control and Disease, edited by Bondy PK, Rosenberg LE, Philadelphia, W.B. Saunders, 1980, pp 707-710
2. 2. Tourian A, Goddard J, Puck TT: Phenylalanine hydroxylase activity in mammalian cells. J Cell Physiol 73:159-165, 1969
3. 3. Hufton SE, Jennings JG, Cotton RGH: Structure and function of the aromatic amino acid hydroxylases. Biochem J 311:353-366, 1995
4. 13C]-tyrosine in the postabsorptive state. Metabolism 31:999-1005, 1982
5. 5]-phenylalanine model. Am J Physiol 256:E631-E639, 1989
6. 6. Guettler F: Hyperphenylalaninemia: Diagnosis and classification of the various phenotypes of phenylalanine hydroxylase deficiency in childhood. Acta Pediatr Scand 280(Suppl):1-80, 1980
7. 7. van Spronsen FJ, Reungoud DJ, Smit GP, Nagel GT, Stellaard F, Berger R, Haymans HS: Phenylketonuria: The in vivo hydroxylation rate of phenylalanine into lyrosine is decreased. J Clin Invest 101:2875-2880, 1998
8. 8. Tizianello A, Deferrari G, Garibotto G, Gurreri G, Robaudo C: Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 65:1162-1173, 1980
9. 9. Nair KS, Ford GC, Ekberg K, Fernqvist-Forbes E, Wahren J: Protein dynamics in whole body and in splanchnic and leg tissues in type 1 diabetic patients. J Clin Invest 95:2926-2937, 1995
10. 10. Meek SE, Persson M, Ford GC, Nair KS: Differential regulation of amino acid exchange and protein dynamics across splanchnic and skeletal muscle beds by insulin in healthy subjects. Diabetes 47:1824-1835, 1998
11. 11. Tessari P, Garibotto G, Inchiostro S, Robaudo C, Saffioti S, Vettore M, Zanetti M, Russo R, Deferrari G: Kidney, splanchnic and leg protein turnover in humans: Insight from leucine and phenylalanine kinetics. J Clin Invest 98:1481-1492, 1996
12. 12. Schwenk WF, Berg PJ, Beaufrere B, Miles JM, Haymond MW: Use of t-butyldimethylsilylation in the GC/MS analysis of physiologic compounds found in plasma using electron impact ionization. Anal Biochem 141:101-109, 1984
13. 13. Wolff JE, Bergman EN, Williams HH: Net metabolism of plasma amino acids by liver and portal-drained viscera. Am J Physiol 223:438-446, 1972
14. 14. Tessari P, Barazzoni R, Zanetti M, Vettore M, Normand S, Bruttomesso D, Beaufrere B: Protein degradation and synthesis measured with multiple amino acid tracers in post-absorptive and protein-anabolic conditions. Am J Physiol 271:E733-E741, 1996
15. 15. Alverstrand A, Fürst P, Bergström J: Plasma and muscle free amino acids in uremia: Influence of nutrition with amino acids. Clin Nephrol 18:297-305, 1982
16. 16. Tizianello A, Deferrari G, Garibotto G, Robaudo C: Amino acid metabolism and the liver in renal failure. Am J Clin Nutr 33:1354-1362, 1980
17. 17. Deferrari G, Garibotto G, Robaudo C, Sala M, Tizianello A: Splanchnic exchange of amino acids after amino acid ingestion in patients with chronic renal insufficiency. Am J Clin Nutr 48:72-83, 1988
18. 18. Mitch WE, Walser M, Steinman, TL, Hill S, Zeger S, Tungsanga K: The effect of a ketoacid/amino acid supplement to a restricted diet on the progression of chronic renal failure. N Engl J Med 311:623-629, 1984
19. 19. Kopple JD: Nitrogen metabolism, in Clinical Aspects of Uremia and Dialysis, edited by Massry SG, Sellers AL, Charles C. Thomas Publisher, Springfield, IL, 1976. p 246