Preclinical safety of human embryonic stem cell-derived oligodendrocyte progenitors supporting clinical trials in spinal cord injury

Regenerative Medicine

Volumn 10, Issue 8, 2015, Pages 939-958

  Priest, Catherine A ^a,b   Manley, Nathan C ^c   Denham, Jerrod ^a,d   Wirth, Edward D ^a,c   Lebkowski, Jane S ^a,c  

^a GERON CORPORATION   (United States)

^b California Institute for Regenerative Medicine   (United States)

^c Asterias Biotherapeutics Inc   (United States)

^d Dark Horse Consulting   (United States)

Author keywords

biodistribution; clinical trial; human embryonic stem cells; oligodendrocyte progenitors; preclinical safety; thoracic spinal cord injury; toxicology; tumorigenicity

Indexed keywords

LIVER ENZYME; NITROGEN;

ADULT; ALLODYNIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BODY WEIGHT; CARCINOGENICITY; CAUSE OF DEATH; CONTROLLED STUDY; EMBRYONIC STEM CELL; FEMALE; FUNCTIONAL STATUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MORTALITY; MYELINATION; NERVE FIBER GROWTH; NONHUMAN; OLIGODENDROCYTE PROGENITOR CELL; OLIGODENDROGLIA; PHENOTYPE; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; TERATOMA; ADVERSE EFFECTS; ANIMAL; HUMAN EMBRYONIC STEM CELL; METABOLISM; MOUSE; NUDE MOUSE; PROCEDURES; SPINAL CORD INJURIES; TRANSPLANTATION; XENOGRAFT;

ANIMALS; HETEROGRAFTS; HUMAN EMBRYONIC STEM CELLS; HUMANS; MICE; MICE, NUDE; OLIGODENDROGLIA; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION;

EID: 84951265632     PISSN: 17460751     EISSN: 1746076X     Source Type: Journal    
DOI: 10.2217/rme.15.57     Document Type: Article

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