Common polygenic variation enhances risk prediction for Alzheimer's disease

Brain

Volumn 138, Issue 12, 2015, Pages 3673-3684

  Escott Price, Valentina ^a   Sims, Rebecca ^a   Bannister, Christian ^a   Harold, Denise ^b   Vronskaya, Maria ^a   Majounie, Elisa ^a   Badarinarayan, Nandini ^a   Morgan, Kevin ^c   Passmore, Peter ^d   Holmes, Clive ^e   Powell, John ^f   Brayne, Carol ^g   Gill, Michael ^h   Mead, Simon ⁱ   Goate, Alison ^j   Cruchaga, Carlos ^k   Lambert, Jean Charles ^l,m,n   Van Duijn, Cornelia ^o   Maier, Wolfgang ^p,q   Ramirez, Alfredo ^p   Holmans, Peter ^a   Jones, Lesley ^a   Hardy, John ^r   Seshadri, Sudha ^s   Schellenberg, Gerard D ^t   Amouyel, Philippe ^l,m,n   Williams, Julie ^a   more..

^a CARDIFF UNIVERSITY   (United Kingdom)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^f KING'S COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^h ST JAMES S HOSPITAL   (Ireland)

ⁱ UNIVERSITY COLLEGE LONDON   (United Kingdom)

^j MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^k WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l INSERM   (France)

^m UNIV LILLE   (France)

ⁿ INSTITUT PASTEUR DE LILLE   (France)

^o ERASMUS MEDICAL CENTER   (Netherlands)

^p UNIVERSITY OF BONN   (Germany)

^q GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^r UNIVERSITY COLLEGE LONDON   (United Kingdom)

^s BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^t UNIVERSITY OF PENNSYLVANIA   (United States)

more..

Author keywords

Alzheimer's disease; polygenic score; predictive model

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOMICS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MIDDLE AGED; PREDICTIVE VALUE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SENSITIVITY AND SPECIFICITY; VERY ELDERLY; CASE CONTROL STUDY; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MULTIFACTORIAL INHERITANCE; RISK; STATISTICAL MODEL;

ALLELES; ALZHEIMER DISEASE; APOLIPOPROTEINS E; CASE-CONTROL STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LOGISTIC MODELS; MULTIFACTORIAL INHERITANCE; RISK; ROC CURVE;

EID: 84951070268     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv268     Document Type: Article

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