Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Biological Psychiatry

Volumn 79, Issue 2, 2016, Pages 107-116

  Salvador, Raymond ^a,b   Vega, Daniel ^a,c   Pascual, Juan Carlos ^d,e   Marco, Josep ^f   Canales Rodríguez, Erick Jorge ^a,b   Aguilar, Salvatore ^g   Anguera, Maria ^a   Soto, Angel ^a,e,h   Ribas, Joan ^a   Soler, Joaquim ^b,d,e   Maristany, Teresa ^e   Rodríguez Fornells, Antoni ^f   Pomarol Clotet, Edith ^a,b  

^a Germanes Hospitalaries ^*  (Spain)

^b Benito Menni Complex Assistencial en Salut Mental   (Spain)

^c INSTITUT DE NEUROCIÈNCIES   (Spain)

^d HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f UNIVERSITY OF BARCELONA   (Spain)

^g Benito Menni Centre Assistencial en Salut Mental   (Spain)

^h Section of Gastroenterology   (Spain)

Author keywords

ALFF; Amygdala; BPD; Brain connectivity; Diffusion MRI; Resting state

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ANTERIOR CINGULATE; ARTICLE; BORDERLINE STATE; BRAIN MAPPING; CINGULATE GYRUS; CONTROLLED STUDY; CORPUS CALLOSUM; DIFFUSION WEIGHTED IMAGING; EMOTIONALITY; EXTERNAL CAPSULE; FEMALE; FOLLOW UP; FRACTIONAL ANISOTROPY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GRAY MATTER; HIPPOCAMPUS; HUMAN; IMPULSIVENESS; MAJOR CLINICAL STUDY; NEUROIMAGING; OCCIPITAL LOBE; PRIORITY JOURNAL; PUTAMEN; RESTING STATE NETWORK; TEMPORAL LOBE; UNCINATE FASCICULUS; WHITE MATTER; AMYGDALA; ANISOTROPY; CASE CONTROL STUDY; MIDDLE AGED; NERVE CELL NETWORK; PATHOPHYSIOLOGY; SPAIN; YOUNG ADULT;

ADULT; AMYGDALA; ANISOTROPY; BORDERLINE PERSONALITY DISORDER; CASE-CONTROL STUDIES; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; GYRUS CINGULI; HUMANS; IMPULSIVE BEHAVIOR; MIDDLE AGED; NERVE NET; SPAIN; YOUNG ADULT;

EID: 84951040302     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2014.08.026     Document Type: Article

References (70)

1. B.F. Grant, S.P. Chou, R.B. Goldstein, B. Huang, F.S. Stinson, T.D. Saha, and et al. Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: Results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions J Clin Psychiatry 69 2008 533 545
2. M.C. Zanarini, L. Yong, F.R. Frankenburg, J. Hennen, D.B. Reich, M.F. Marino, and et al. Severity of reported childhood sexual abuse and its relationship to severity of borderline psychopathology and psychosocial impairment among borderline inpatients J Nerv Ment Dis 190 2002 381 387
3. A.S. New, M. Goodman, J. Triebwasser, and L.J. Siever Recent advances in the biological study of personality disorders Psychiatr Clin North Am 31 2008 441 461
4. A.S. New, E.A. Hazlett, M.S. Buchsbaum, M. Goodman, S.A. Mitelman, R. Newmark, and et al. Amygdala-prefrontal disconnection in borderline personality disorder Neuropsychopharmacology 32 2007 1629 1640
5. A.C. Ruocco, S. Amirthavasagam, and K.K. Zakzanis Amygdala and hippocampal volume reductions as candidate endophenotypes for borderline personality disorder: A meta-analysis of magnetic resonance imaging studies Psychiatry Res 201 2012 245 252
6. R. Brunner, R. Henze, P. Parzer, J. Kramer, N. Feigl, K. Lutz, and et al. Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: Is it disorder specific? Neuroimage 49 2010 114 120
7. I. Niedtfeld, L. Schulze, A. Krause-Utz, T. Demirakca, M. Bohus, and C. Schmahl Voxel-based morphometry in women with borderline personality disorder with and without comorbid posttraumatic stress disorder PloS One 8 2013 e65824
8. K.R. Ridderinkhof, M. Ullsperger, E.A. Crone, and S. Nieuwenhuis The role of the medial frontal cortex in cognitive control Science 306 2004 443 447
9. J.M. De La Fuente, S. Goldman, E. Stanus, C. Vizuete, I. Morlan, J. Bobes, and et al. Brain glucose metabolism in borderline personality disorder J Psychiatr Res 31 1997 531 541
10. A.R. Prossin, T.M. Love, R.A. Koeppe, J.K. Zubieta, and K.R. Silk Dysregulation of regional endogenous opioid function in borderline personality disorder Am J Psychiatry 167 2010 925 933
11. J. Salavert, M. Gasol, E. Vieta, A. Cervantes, C. Trampal, and J.D. Gispert Fronto-limbic dysfunction in borderline personality disorder: A 18F-FDG positron emission tomography study J Affect Disord 131 2011 260 267
12. A.C. Ruocco, S. Amirthavasagam, L.W. Choi-Kain, and S.F. McMain Neural correlates of negative emotionality in borderline personality disorder: An activation-likelihood-estimation meta-analysis Biol Psychiatry 73 2013 153 160
13. P.M. Wall, and C. Messier The hippocampal formation - orbitomedial prefrontal cortex circuit in the attentional control of active memory Behav Brain Res 127 2001 99 117
14. R.G. Phillips, and J.E. LeDoux Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning Behav Neurosci 106 1992 274 285
15. K.R. Cullen, N. Vizueta, K.M. Thomas, G.J. Han, K.O. Lim, J. Camchong, and et al. Amygdala functional connectivity in young women with borderline personality disorder Brain Connect 1 2011 61 71
16. I. Niedtfeld, P. Kirsch, L. Schulze, S.C. Herpertz, M. Bohus, and C. Schmahl Functional connectivity of pain-mediated affect regulation in borderline personality disorder PloS One 7 2012 e33293
17. M.E. Raichle The restless brain Brain Connect 1 2011 3 12
18. R.C. Wolf, F. Sambataro, N. Vasic, M. Schmid, P.A. Thomann, S.D. Bienentreu, and et al. Aberrant connectivity of resting-state networks in borderline personality disorder J Psychiatry Neurosci 36 2011 402 411
19. A. Doll, C. Sorg, A. Manoliu, A. Woller, C. Meng, H. Forstl, and et al. Shifted intrinsic connectivity of central executive and salience network in borderline personality disorder Front Hum Neurosci 7 2013 727
20. M.W. Cole, S. Pathak, and W. Schneider Identifying the brain's most globally connected regions Neuroimage 49 2010 3132 3148
21. R.L. Buckner, J. Sepulcre, T. Talukdar, F.M. Krienen, H. Liu, T. Hedden, and et al. Cortical hubs revealed by intrinsic functional connectivity: Mapping, assessment of stability, and relation to Alzheimer's disease J Neurosci 29 2009 1860 1873
22. D. Tomasi, and N.D. Volkow Functional connectivity density mapping Proc Natl Acad Sci U S A 107 2010 9885 9890
23. R. Salvador, S. Sarro, J.J. Gomar, J. Ortiz-Gil, F. Vila, A. Capdevila, and et al. Overall brain connectivity maps show cortico-subcortical abnormalities in schizophrenia Hum Brain Mapp 31 2010 2003 2014
24. R. Salvador, M. Anguera, J.J. Gomar, E.T. Bullmore, and E. Pomarol-Clotet Conditional mutual information maps as descriptors of net connectivity levels in the brain Front Neuroinform 4 2010 115
25. J.L. Carrasco, K. Tajima-Pozo, M. Diaz-Marsa, A. Casado, J.J. Lopez-Ibor, J. Arrazola, and et al. Microstructural white matter damage at orbitofrontal areas in borderline personality disorder J Affect Disord 139 2012 149 153
26. J.E. Grant, S. Correia, T. Brennan-Krohn, P.F. Malloy, D.H. Laidlaw, and S.C. Schulz Frontal white matter integrity in borderline personality disorder with self-injurious behavior J Neuropsychiatry Clin Neurosci 19 2007 383 390
27. N. Rusch, T. Bracht, B.W. Kreher, S. Schnell, V. Glauche, K.A. Il'yasov, and et al. Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder Psychiatry Res 181 2010 151 154
28. Y.F. Zang, Y. He, C.Z. Zhu, Q.J. Cao, M.Q. Sui, M. Liang, and et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI Brain Dev 29 2007 83 91
29. H. Yang, X.Y. Long, Y. Yang, H. Yan, C.Z. Zhu, X.P. Zhou, and et al. Amplitude of low frequency fluctuation within visual areas revealed by resting-state functional MRI Neuroimage 36 2007 144 152
30. Z. Li, Y. Zhu, A.R. Childress, J.A. Detre, and Z. Wang Relations between BOLD fMRI-derived resting brain activity and cerebral blood flow PloS One 7 2012 e44556
31. C. Magri, U. Schridde, Y. Murayama, S. Panzeri, and N.K. Logothetis The amplitude and timing of the BOLD signal reflects the relationship between local field potential power at different frequencies J Neurosci 32 2012 1395 1407
32. J. Sacher, J. Neumann, H. Okon-Singer, S. Gotowiec, and A. Villringer Sexual dimorphism in the human brain: Evidence from neuroimaging Magn Reson Imaging 31 2013 366 375
33. M. Villar Garcia, J.F. Perez Prieto, M. Hernandez Viadel, M. Renovell Farre, C. Leal Cercos, and M. Gomez Beneyto Preparation of a SCID-II-based diagnostic tool for personality disorders [in Spanish] Actas Luso Esp Neurol Psiquiatr Cienc Afines 23 1995 178 183
34. J. Barrachina, J. Soler, M.J. Campins, A. Tejero, J.C. Pascual, E. Alvarez, and et al. Validation of a Spanish version of the Diagnostic Interview for Bordelines-Revised (DIB-R) [in Spanish] Actas Esp Psiquiatr 32 2004 293 298
35. M. Bohus, N. Kleindienst, M.F. Limberger, R.D. Stieglitz, M. Domsalla, A.L. Chapman, and et al. The short version of the Borderline Symptom List (BSL-23): Development and initial data on psychometric properties Psychopathology 42 2009 32 39
36. J. Soler, D. Vega, A. Feliu-Soler, J. Trujols, A. Soto, M. Elices, and et al. Validation of the Spanish version of the Borderline Symptom List, short form (BSL-23) BMC Psychiatry 13 2013 139
37. E. Pomarol-Clotet, E.J. Canales-Rodriguez, R. Salvador, S. Sarro, J.J. Gomar, F. Vila, and et al. Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging Mol Psychiatry 15 2010 823 830
38. S.M. Smith, M. Jenkinson, M.W. Woolrich, C.F. Beckmann, T.E. Behrens, H. Johansen-Berg, and et al. Advances in functional and structural MR image analysis and implementation as FSL Neuroimage 23 suppl 1 2004 S208 S219
39. S.M. Smith, M. Jenkinson, H. Johansen-Berg, D. Rueckert, T.E. Nichols, C.E. Mackay, and et al. Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data Neuroimage 31 2006 1487 1505
40. R Development Core Team R: A Language and Environment for Statistical Computing 2011 R Foundation for Statistical Computing Vienna
41. M. Beckmann, H. Johansen-Berg, and M.F. Rushworth Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization J Neurosci 29 2009 1175 1190
42. E.J. Canales-Rodriguez, E. Pomarol-Clotet, J. Radua, S. Sarro, S. Alonso-Lana, C. Del Mar Bonnin, and et al. Structural abnormalities in bipolar euthymia: A multicontrast molecular diffusion imaging study Biol Psychiatry 76 2014 329 348
43. R. Rossi, M. Pievani, M. Lorenzi, M. Boccardi, R. Beneduce, S. Bignotti, and et al. Structural brain features of borderline personality and bipolar disorders Psychiatry Res 213 2013 83 91
44. M.C. Craig, M. Catani, Q. Deeley, R. Latham, E. Daly, R. Kanaan, and et al. Altered connections on the road to psychopathy Mol Psychiatry 14 2009 946 953 907
45. E. Camara, A. Rodriguez-Fornells, and T.F. Munte Microstructural brain differences predict functional hemodynamic responses in a reward processing task J Neurosci 30 2010 11398 11402
46. D. Vega, A. Soto, J.L. Amengual, J. Ribas, R. Torrubia, A. Rodriguez-Fornells, and et al. Negative reward expectations in borderline personality disorder patients: Neurophysiological evidence Biol Psychol 94 2013 388 396
47. J. Joutsa, J. Saunavaara, R. Parkkola, S. Niemela, and V. Kaasinen Extensive abnormality of brain white matter integrity in pathological gambling Psychiatry Res 194 2011 340 346
48. L.G. Ungerleider, D. Gaffan, and V.S. Pelak Projections from inferior temporal cortex to prefrontal cortex via the uncinate fascicle in rhesus monkeys Exp Brain Res 76 1989 473 484
49. M. Catani, and M. Thiebaut de Schotten A diffusion tensor imaging tractography atlas for virtual in vivo dissections Cortex 44 2008 1105 1132
50. D. Gaffan, and C.R. Wilson Medial temporal and prefrontal function: Recent behavioural disconnection studies in the macaque monkey Cortex 44 2008 928 935
51. E.D. Ross Sensory-specific amnesia and hypoemotionality in humans and monkeys: Gateway for developing a hodology of memory Cortex 44 2008 1010 1022
52. N. Rusch, E. Luders, K. Lieb, R. Zahn, D. Ebert, P.M. Thompson, and et al. Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder J Psychiatry Neurosci 32 2007 417 422
53. M.V. Zanetti, P.H. Soloff, M.A. Nicoletti, J.P. Hatch, P. Brambilla, M.S. Keshavan, and et al. MRI study of corpus callosum in patients with borderline personality disorder: A pilot study Prog Neuropsychopharmacol Biol Psychiatry 31 2007 1519 1525
54. D. Pandya, and B. Seltzer The topography of commisural fibers F. Lepore, M. Ptito, H. Jasper, Two Hemispheres - One Brain: Functions of the Corpus Callosum 1986 Alan R. Liss, Inc New York
55. P. Brambilla, M.A. Nicoletti, R.B. Sassi, A.G. Mallinger, E. Frank, D.J. Kupfer, and et al. Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder Biol Psychiatry 54 2003 1294 1297
56. P. Brambilla, M. Nicoletti, R.B. Sassi, A.G. Mallinger, E. Frank, M.S. Keshavan, and et al. Corpus callosum signal intensity in patients with bipolar and unipolar disorder J Neurol Neurosurg Psychiatry 75 2004 221 225
57. M.D. De Bellis, M.S. Keshavan, D.B. Clark, B.J. Casey, J.N. Giedd, A.M. Boring, and et al. A.E. Bennett Research Award. Developmental traumatology. Part II: Brain development Biol Psychiatry 45 1999 1271 1284
58. M.H. Teicher, N.L. Dumont, Y. Ito, C. Vaituzis, J.N. Giedd, and S.L. Andersen Childhood neglect is associated with reduced corpus callosum area Biol Psychiatry 56 2004 80 85
59. M.J. Hoptman, X.N. Zuo, P.D. Butler, D.C. Javitt, D. D'Angelo, C.J. Mauro, and et al. Amplitude of low-frequency oscillations in schizophrenia: A resting state fMRI study Schizophr Res 117 2010 13 20
60. R. Yu, Y.L. Chien, H.L. Wang, C.M. Liu, C.C. Liu, T.J. Hwang, and et al. Frequency-specific alternations in the amplitude of low-frequency fluctuations in schizophrenia Hum Brain Mapp 35 2014 627 637
61. W.B. Guo, F. Liu, Z.M. Xue, X.J. Xu, R.R. Wu, C.Q. Ma, and et al. Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study Prog Neuropsychopharmacol Biol Psychiatry 37 2012 153 160
62. J. Hou, W. Wu, Y. Lin, J. Wang, D. Zhou, J. Guo, and et al. Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: A resting-state fMRI study J Affect Disord 138 2012 313 321
63. M.E. Raichle, A.M. MacLeod, A.Z. Snyder, W.J. Powers, D.A. Gusnard, and G.L. Shulman A default mode of brain function Proc Natl Acad Sci U S A 98 2001 676 682
64. G. Northoff, and F. Bermpohl Cortical midline structures and the self Trends Cogn Sci 8 2004 102 107
65. D.R. Vago, and D.A. Silbersweig Self-awareness, self-regulation, and self-transcendence (S-ART): A framework for understanding the neurobiological mechanisms of mindfulness Front Hum Neurosci 6 2012 296
66. J. Holtmann, M.C. Herbort, T. Wustenberg, J. Soch, S. Richter, H. Walter, and et al. Trait anxiety modulates fronto-limbic processing of emotional interference in borderline personality disorder Front Hum Neurosci 7 2013 54
67. G.A. Jacob, K. Zvonik, S. Kamphausen, A. Sebastian, S. Maier, A. Philipsen, and et al. Emotional modulation of motor response inhibition in women with borderline personality disorder: An fMRI study J Psychiatry Neurosci 38 2013 164 172
68. D. Silbersweig, J.F. Clarkin, M. Goldstein, O.F. Kernberg, O. Tuescher, K.N. Levy, and et al. Failure of frontolimbic inhibitory function in the context of negative emotion in borderline personality disorder Am J Psychiatry 164 2007 1832 1841
69. J.G. Gunderson, R.L. Stout, T.H. McGlashan, M.T. Shea, L.C. Morey, C.M. Grilo, and et al. Ten-year course of borderline personality disorder: psychopathology and function from the Collaborative Longitudinal Personality Disorders study Arch Gen Psychiatry 68 2011 827 837
70. M.C. Zanarini, F.R. Frankenburg, D.B. Reich, and G. Fitzmaurice Attainment and stability of sustained symptomatic remission and recovery among patients with borderline personality disorder and axis II comparison subjects: A 16-year prospective follow-up study Am J Psychiatry 169 2012 476 483