메뉴 건너뛰기




Volumn 7, Issue 12, 2015, Pages 6716-6729

Mechanisms of hepatitis C viral resistance to direct acting antivirals

Author keywords

Breakthrough variants; Direct acting antivirals; Hepatitis C; Resistance

Indexed keywords

ASUNAPREVIR; BECLABUVIR; BETA INTERFERON; BOCEPREVIR; DACLATASVIR; LEDIPASVIR; NONSTRUCTURAL PROTEIN 5A; OMBITASVIR; PEGINTERFERON; POLYPROTEIN; RIBAVIRIN; RNA POLYMERASE; SOFOSBUVIR; TELAPREVIR; TOLL LIKE RECEPTOR; ANTIVIRUS AGENT;

EID: 84950995455     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v7122968     Document Type: Review
Times cited : (73)

References (83)
  • 1
    • 84876149257 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence
    • [CrossRef] [PubMed]
    • Mohd Hanafiah, K.; Groeger, J.; Flaxman, A.D.; Wiersma, S.T. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013, 57, 1333-1342. [CrossRef] [PubMed].
    • (2013) Hepatology , vol.57 , pp. 1333-1342
    • Mohd Hanafiah, K.1    Groeger, J.2    Flaxman, A.D.3    Wiersma, S.T.4
  • 3
    • 0004016899 scopus 로고    scopus 로고
    • (accessed on 29 September 2015)
    • World Health Organisation. Hepatitis C. Available online: http://www.who.int/mediacentre/factsheets/fs164/en/(accessed on 29 September 2015).
    • Hepatitis C
    • World Health Organisation1
  • 4
    • 0035811625 scopus 로고    scopus 로고
    • Hepatitis C virus infection
    • [CrossRef] [PubMed]
    • Lauer, G.M.;Walker, B.D. Hepatitis C virus infection. N. Engl. J. Med. 2001, 345, 41-52. [CrossRef] [PubMed].
    • (2001) N. Engl. J. Med , vol.345 , pp. 41-52
    • Lauer, G.M.1    Walker, B.D.2
  • 10
    • 84943558459 scopus 로고    scopus 로고
    • Efficacy of sofosbuvir plus ribavirin with or without peginterferon-α in patients with HCV genotype 3 infection and treatment-experienced patients with cirrhosis and HCV genotype 2 infection
    • [CrossRef] [PubMed]
    • Foster, G.R.; Pianko, S.; Brown, A.; Forton, D.; Nahass, R.G.; George, J.; Barnes, E.; Brainard, D.M.; Massetto, B.; Lin, M.; et al. Efficacy of sofosbuvir plus ribavirin with or without peginterferon-α in patients with HCV genotype 3 infection and treatment-experienced patients with cirrhosis and HCV genotype 2 infection. Gastroenterology 2015, 149, 1462-1470. [CrossRef] [PubMed].
    • (2015) Gastroenterology , vol.149 , pp. 1462-1470
    • Foster, G.R.1    Pianko, S.2    Brown, A.3    Forton, D.4    Nahass, R.G.5    George, J.6    Barnes, E.7    Brainard, D.M.8    Massetto, B.9    Lin, M.10
  • 11
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy
    • [CrossRef] [PubMed]
    • Neumann, A.U.; Lam, N.P.; Dahari, H.; Gretch, D.R.; Wiley, T.E.; Layden, T.J.; Perelson, A.S. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy. Science 1998, 282, 103-107. [CrossRef] [PubMed].
    • (1998) Science , vol.282 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3    Gretch, D.R.4    Wiley, T.E.5    Layden, T.J.6    Perelson, A.S.7
  • 12
    • 0026334457 scopus 로고
    • Nucleotide sequence and mutation rate of the H strain of hepatitis C virus
    • [CrossRef] [PubMed]
    • Ogata, N.; Alter, H.J.; Miller, R.H.; Purcell, R.H. Nucleotide sequence and mutation rate of the H strain of hepatitis C virus. Proc. Natl. Acad. Sci. USA 1991, 88, 3392-3396. [CrossRef] [PubMed].
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 3392-3396
    • Ogata, N.1    Alter, H.J.2    Miller, R.H.3    Purcell, R.H.4
  • 16
    • 0026538287 scopus 로고
    • Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
    • [PubMed]
    • Martell, M.; Esteban, J.I.; Quer, J.; Genesca, J.; Weiner, A.; Esteban, R.; Guardia, J.; Gomez, J. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution. J. Virol. 1992, 66, 3225-3229. [PubMed].
    • (1992) J. Virol , vol.66 , pp. 3225-3229
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Genesca, J.4    Weiner, A.5    Esteban, R.6    Guardia, J.7    Gomez, J.8
  • 17
    • 0033920795 scopus 로고    scopus 로고
    • Replication of hepatitis C virus
    • [CrossRef] [PubMed]
    • Bartenschlager, R.; Lohmann, V. Replication of hepatitis C virus. J. Gen. Virol. 2000, 81, 1631-1648. [CrossRef] [PubMed].
    • (2000) J. Gen. Virol , vol.81 , pp. 1631-1648
    • Bartenschlager, R.1    Lohmann, V.2
  • 19
    • 84870413046 scopus 로고    scopus 로고
    • The role of resistance in HCV treatment
    • [CrossRef] [PubMed]
    • Vermehren, J.; Sarrazin, C. The role of resistance in HCV treatment. Best Pract. Res. Clin. Gastroenterol. 2012, 26, 487-503. [CrossRef] [PubMed].
    • (2012) Best Pract. Res. Clin. Gastroenterol , vol.26 , pp. 487-503
    • Vermehren, J.1    Sarrazin, C.2
  • 20
    • 77956147218 scopus 로고    scopus 로고
    • Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation
    • [CrossRef] [PubMed]
    • Fafi-Kremer, S.; Fofana, I.; Soulier, E.; Carolla, P.; Meuleman, P.; Leroux-Roels, G.; Patel, A.H.; Cosset, F.L.; Pessaux, P.; Doffoel, M.; et al. Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation. J. Exp. Med. 2010, 207, 2019-2031. [CrossRef] [PubMed].
    • (2010) J. Exp. Med , vol.207 , pp. 2019-2031
    • Fafi-Kremer, S.1    Fofana, I.2    Soulier, E.3    Carolla, P.4    Meuleman, P.5    Leroux-Roels, G.6    Patel, A.H.7    Cosset, F.L.8    Pessaux, P.9    Doffoel, M.10
  • 21
    • 77950203857 scopus 로고    scopus 로고
    • Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs)
    • [CrossRef] [PubMed]
    • Kieffer, T.L.; Kwong, A.D.; Picchio, G.R. Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs). J. Antimicrob. Chemother. 2010, 65, 202-212. [CrossRef] [PubMed].
    • (2010) J. Antimicrob. Chemother , vol.65 , pp. 202-212
    • Kieffer, T.L.1    Kwong, A.D.2    Picchio, G.R.3
  • 22
    • 77953416889 scopus 로고    scopus 로고
    • New direct-acting antivirals in the development for hepatitis C virus infection
    • [CrossRef] [PubMed]
    • Pockros, P.J. New direct-acting antivirals in the development for hepatitis C virus infection. Ther. Adv. Gastroenterol. 2010, 3, 191-202. [CrossRef] [PubMed].
    • (2010) Ther. Adv. Gastroenterol , vol.3 , pp. 191-202
    • Pockros, P.J.1
  • 23
    • 0037687422 scopus 로고    scopus 로고
    • Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
    • [CrossRef] [PubMed]
    • Foy, E.; Li, K.; Wang, C.; Sumpter, R., Jr.; Ikeda, M.; Lemon, S.M.; Gale, M., Jr. Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science 2003, 300, 1145-1148. [CrossRef] [PubMed].
    • (2003) Science , vol.300 , pp. 1145-1148
    • Foy, E.1    Li, K.2    Wang, C.3    Sumpter, R.4    Ikeda, M.5    Lemon, S.M.6    Gale, M.7
  • 24
    • 14544280209 scopus 로고    scopus 로고
    • Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the toll-like receptor 3 adaptor protein TRIF
    • [CrossRef] [PubMed]
    • Li, K.; Foy, E.; Ferreon, J.C.; Nakamura, M.; Ferreon, A.C.; Ikeda, M.; Ray, S.C.; Gale, M., Jr.; Lemon, S.M. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the toll-like receptor 3 adaptor protein TRIF. Proc. Natl. Acad. Sci. USA 2005, 102, 2992-2997. [CrossRef] [PubMed].
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 2992-2997
    • Li, K.1    Foy, E.2    Ferreon, J.C.3    Nakamura, M.4    Ferreon, A.C.5    Ikeda, M.6    Ray, S.C.7    Gale, M.8    Lemon, S.M.9
  • 25
    • 33744828747 scopus 로고    scopus 로고
    • Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and-independent mechanisms
    • [CrossRef] [PubMed]
    • Cheng, G.; Zhong, J.; Chisari, F.V. Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and-independent mechanisms. Proc. Natl. Acad. Sci. USA 2006, 103, 8499-8504. [CrossRef] [PubMed].
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8499-8504
    • Cheng, G.1    Zhong, J.2    Chisari, F.V.3
  • 26
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • [CrossRef] [PubMed]
    • Sarrazin, C.; Zeuzem, S. Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology 2010, 138, 447-462. [CrossRef] [PubMed].
    • (2010) Gastroenterology , vol.138 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 27
    • 84863550914 scopus 로고    scopus 로고
    • Hepatitis C viral evolution in genotype 1 treatment-naive and treatment-experienced patients receiving telaprevir-based therapy in clinical trials
    • [CrossRef] [PubMed]
    • Kieffer, T.L.; de Meyer, S.; Bartels, D.J.; Sullivan, J.C.; Zhang, E.Z.; Tigges, A.; Dierynck, I.; Spanks, J.; Dorrian, J.; Jiang, M.; et al. Hepatitis C viral evolution in genotype 1 treatment-naive and treatment-experienced patients receiving telaprevir-based therapy in clinical trials. PLoS ONE 2012, 7, e34372. [CrossRef] [PubMed].
    • (2012) PLoS ONE , vol.7
    • Kieffer, T.L.1    de Meyer, S.2    Bartels, D.J.3    Sullivan, J.C.4    Zhang, E.Z.5    Tigges, A.6    Dierynck, I.7    Spanks, J.8    Dorrian, J.9    Jiang, M.10
  • 28
    • 84878036817 scopus 로고    scopus 로고
    • Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-α2b and ribavirin in patients with chronic hepatitis C in the sprint-1 trial
    • [CrossRef] [PubMed]
    • Ogert, R.A.; Howe, J.A.; Vierling, J.M.; Kwo, P.Y.; Lawitz, E.J.; McCone, J.; Schiff, E.R.; Pound, D.; Davis, M.N.; Gordon, S.C.; et al. Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-α2b and ribavirin in patients with chronic hepatitis C in the sprint-1 trial. Antivir. Ther. 2013, 18, 387-397. [CrossRef] [PubMed].
    • (2013) Antivir. Ther , vol.18 , pp. 387-397
    • Ogert, R.A.1    Howe, J.A.2    Vierling, J.M.3    Kwo, P.Y.4    Lawitz, E.J.5    McCone, J.6    Schiff, E.R.7    Pound, D.8    Davis, M.N.9    Gordon, S.C.10
  • 29
    • 79958830099 scopus 로고    scopus 로고
    • Hepatitis C virus resistance to protease inhibitors
    • [CrossRef] [PubMed]
    • Halfon, P.; Locarnini, S. Hepatitis C virus resistance to protease inhibitors. J. Hepatol. 2011, 55, 192-206. [CrossRef] [PubMed].
    • (2011) J. Hepatol , vol.55 , pp. 192-206
    • Halfon, P.1    Locarnini, S.2
  • 30
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients
    • [CrossRef] [PubMed]
    • Kuntzen, T.; Timm, J.; Berical, A.; Lennon, N.; Berlin, A.M.; Young, S.K.; Lee, B.; Heckerman, D.; Carlson, J.; Reyor, L.L.; et al. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naive patients. Hepatology 2008, 48, 1769-1778. [CrossRef] [PubMed].
    • (2008) Hepatology , vol.48 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3    Lennon, N.4    Berlin, A.M.5    Young, S.K.6    Lee, B.7    Heckerman, D.8    Carlson, J.9    Reyor, L.L.10
  • 31
    • 84910648788 scopus 로고    scopus 로고
    • Incidence of virological failure and emergence of resistance with twice-daily vs every 8-h administration of telaprevir in the optimize study
    • [CrossRef] [PubMed]
    • Dierynck, I.; Ghys, A.;Witek, J.; Luo, D.; Janssen, K.; Daems, B.; Picchio, G.; Buti, M.; De Meyer, S. Incidence of virological failure and emergence of resistance with twice-daily vs every 8-h administration of telaprevir in the optimize study. J. Viral Hepat. 2014, 21, 835-842. [CrossRef] [PubMed].
    • (2014) J. Viral Hepat , vol.21 , pp. 835-842
    • Dierynck, I.1    Ghys, A.2    Witek, J.3    Luo, D.4    Janssen, K.5    Daems, B.6    Picchio, G.7    Buti, M.8    De Meyer, S.9
  • 32
    • 84882876118 scopus 로고    scopus 로고
    • Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical studies
    • [CrossRef] [PubMed]
    • Barnard, R.J.; Howe, J.A.; Ogert, R.A.; Zeuzem, S.; Poordad, F.; Gordon, S.C.; Ralston, R.; Tong, X.; Sniukiene, V.; Strizki, J.; et al. Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical studies. Virology 2013, 444, 329-336. [CrossRef] [PubMed].
    • (2013) Virology , vol.444 , pp. 329-336
    • Barnard, R.J.1    Howe, J.A.2    Ogert, R.A.3    Zeuzem, S.4    Poordad, F.5    Gordon, S.C.6    Ralston, R.7    Tong, X.8    Sniukiene, V.9    Strizki, J.10
  • 33
    • 79951630741 scopus 로고    scopus 로고
    • Long-term follow-up of patients with chronic hepatitis C treated with telaprevir in combination with peginterferon alfa-2a and rabivirin: Interim analysis of extend study
    • Zeuzem, S.; Sulkowski, M.; Zoulim, F.; Sherman, K.; Alberti, A.; Wei, L.; van Baelen, B.; Sullivan, J.; Kieffer, T.; de Meyer, S.; et al. Long-term follow-up of patients with chronic hepatitis C treated with telaprevir in combination with peginterferon alfa-2a and rabivirin: Interim analysis of extend study. Hepatology 2010, 52, 436A.
    • (2010) Hepatology , vol.52 , pp. 436A
    • Zeuzem, S.1    Sulkowski, M.2    Zoulim, F.3    Sherman, K.4    Alberti, A.5    Wei, L.6    van Baelen, B.7    Sullivan, J.8    Kieffer, T.9    de Meyer, S.10
  • 34
  • 35
    • 84927798764 scopus 로고    scopus 로고
    • Virology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in phase IIb/III studies
    • [CrossRef] [PubMed]
    • Lenz, O.; Verbinnen, T.; Fevery, B.; Tambuyzer, L.; Vijgen, L.; Peeters, M.; Buelens, A.; Ceulemans, H.; Beumont, M.; Picchio, G.; et al. Virology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in phase IIb/III studies. J. Hepatol. 2015, 62, 1008-1014. [CrossRef] [PubMed].
    • (2015) J. Hepatol , vol.62 , pp. 1008-1014
    • Lenz, O.1    Verbinnen, T.2    Fevery, B.3    Tambuyzer, L.4    Vijgen, L.5    Peeters, M.6    Buelens, A.7    Ceulemans, H.8    Beumont, M.9    Picchio, G.10
  • 36
    • 78649644443 scopus 로고    scopus 로고
    • Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors
    • [CrossRef] [PubMed]
    • Bae, A.; Sun, S.C.; Qi, X.; Chen, X.; Ku, K.; Worth, A.; Wong, K.A.; Harris, J.; Miller, M.D.; Mo, H. Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors. Antimicrob. Agents Chemother. 2010, 54, 5288-5297. [CrossRef] [PubMed].
    • (2010) Antimicrob. Agents Chemother , vol.54 , pp. 5288-5297
    • Bae, A.1    Sun, S.C.2    Qi, X.3    Chen, X.4    Ku, K.5    Worth, A.6    Wong, K.A.7    Harris, J.8    Miller, M.D.9    Mo, H.10
  • 38
    • 84906059095 scopus 로고    scopus 로고
    • Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): A randomised, double-blind, placebo-controlled phase 3 trial
    • [CrossRef]
    • Manns, M.; Marcellin, P.; Poordad, F.; de Araujo, E.S.; Buti, M.; Horsmans, Y.; Janczewska, E.; Villamil, F.; Scott, J.; Peeters, M.; et al. Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): A randomised, double-blind, placebo-controlled phase 3 trial. Lancet (Lond. Engl.) 2014, 384, 414-426. [CrossRef].
    • (2014) Lancet (Lond. Engl.) , vol.384 , pp. 414-426
    • Manns, M.1    Marcellin, P.2    Poordad, F.3    de Araujo, E.S.4    Buti, M.5    Horsmans, Y.6    Janczewska, E.7    Villamil, F.8    Scott, J.9    Peeters, M.10
  • 39
    • 84950981068 scopus 로고    scopus 로고
    • SVR 12 results from the phase II, open-label impact study of simeprevir (SMV) in combination with daclatasvir (DCV) and sofosbuvir (SOF) in treatment naive and experienced patients with chronic HCV genotype 1/4 infection and decompensated liver disease
    • Lawitz, E.; Poordad, F.; Gutierrez, J.; Kakuda, T.; Picchio, G.; Beets, G.; Vandevoorde, A.; Peter, V.R.; Jaquesmyn, B.; Quinn, G.; et al. SVR 12 results from the phase II, open-label impact study of simeprevir (SMV) in combination with daclatasvir (DCV) and sofosbuvir (SOF) in treatment naive and experienced patients with chronic HCV genotype 1/4 infection and decompensated liver disease. Hepatology 2015, 62, 227A.
    • (2015) Hepatology , vol.62 , pp. 227A
    • Lawitz, E.1    Poordad, F.2    Gutierrez, J.3    Kakuda, T.4    Picchio, G.5    Beets, G.6    Vandevoorde, A.7    Peter, V.R.8    Jaquesmyn, B.9    Quinn, G.10
  • 40
    • 84880299420 scopus 로고    scopus 로고
    • NS5A inhibitors in the treatment of hepatitis C
    • [CrossRef] [PubMed]
    • Pawlotsky, J.M. NS5A inhibitors in the treatment of hepatitis C. J. Hepatol. 2013, 59, 375-382. [CrossRef] [PubMed].
    • (2013) J. Hepatol , vol.59 , pp. 375-382
    • Pawlotsky, J.M.1
  • 42
    • 84908295905 scopus 로고    scopus 로고
    • Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication
    • [CrossRef] [PubMed]
    • Berger, C.; Romero-Brey, I.; Radujkovic, D.; Terreux, R.; Zayas, M.; Paul, D.; Harak, C.; Hoppe, S.; Gao, M.; Penin, F.; et al. Daclatasvir-like inhibitors of NS5A block early biogenesis of hepatitis C virus-induced membranous replication factories, independent of RNA replication. Gastroenterology 2014, 147, 1094-1105. [CrossRef] [PubMed].
    • (2014) Gastroenterology , vol.147 , pp. 1094-1105
    • Berger, C.1    Romero-Brey, I.2    Radujkovic, D.3    Terreux, R.4    Zayas, M.5    Paul, D.6    Harak, C.7    Hoppe, S.8    Gao, M.9    Penin, F.10
  • 43
    • 10344221613 scopus 로고    scopus 로고
    • The NS5A protein of hepatitis C virus is a zinc metalloprotein
    • [CrossRef] [PubMed]
    • Tellinghuisen, T.L.; Marcotrigiano, J.; Gorbalenya, A.E.; Rice, C.M. The NS5A protein of hepatitis C virus is a zinc metalloprotein. J. Biol. Chem. 2004, 279, 48576-48587. [CrossRef] [PubMed].
    • (2004) J. Biol. Chem , vol.279 , pp. 48576-48587
    • Tellinghuisen, T.L.1    Marcotrigiano, J.2    Gorbalenya, A.E.3    Rice, C.M.4
  • 44
    • 84921317221 scopus 로고    scopus 로고
    • Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides
    • [CrossRef] [PubMed]
    • Chukkapalli, V.; Berger, K.L.; Kelly, S.M.; Thomas, M.; Deiters, A.; Randall, G. Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides. Virology 2015, 476, 168-179. [CrossRef] [PubMed].
    • (2015) Virology , vol.476 , pp. 168-179
    • Chukkapalli, V.1    Berger, K.L.2    Kelly, S.M.3    Thomas, M.4    Deiters, A.5    Randall, G.6
  • 45
    • 84912117710 scopus 로고    scopus 로고
    • NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase iiialpha complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes
    • [CrossRef] [PubMed]
    • Reghellin, V.; Donnici, L.; Fenu, S.; Berno, V.; Calabrese, V.; Pagani, M.; Abrignani, S.; Peri, F.; de Francesco, R.; Neddermann, P. NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase iiialpha complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes. Antimicrob. Agents Chemother. 2014, 58, 7128-7140. [CrossRef] [PubMed].
    • (2014) Antimicrob. Agents Chemother , vol.58 , pp. 7128-7140
    • Reghellin, V.1    Donnici, L.2    Fenu, S.3    Berno, V.4    Calabrese, V.5    Pagani, M.6    Abrignani, S.7    Peri, F.8    de Francesco, R.9    Neddermann, P.10
  • 47
    • 82455192239 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
    • [PubMed]
    • Fridell, R.A.; Wang, C.; Sun, J.H.; O'Boyle, D.R., 2nd; Nower, P.; Valera, L.; Qiu, D.; Roberts, S.; Huang, X.; Kienzle, B.; et al. Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations. Hepatology 2011, 54, 1924-1935. [PubMed].
    • (2011) Hepatology , vol.54 , pp. 1924-1935
    • Fridell, R.A.1    Wang, C.2    Sun, J.H.3    O'Boyle, D.R.4    Nower, P.5    Valera, L.6    Qiu, D.7    Roberts, S.8    Huang, X.9    Kienzle, B.10
  • 48
    • 84884223989 scopus 로고    scopus 로고
    • Daclatasvir combined with peginterferon alfa-2a and ribavirin for 12 or 16 weeks in patients with HCV genotype 1 or 3 infection: Command GT2/3 study
    • [CrossRef]
    • Dore, G.J.; Lawitz, E.; Hezode, C.; Shafran, S.; Ramji, A.; Tatum, H.; Taliani, G.; Tran, A.; Brunetto, M.; Zaltron, S.; et al. Daclatasvir combined with peginterferon alfa-2a and ribavirin for 12 or 16 weeks in patients with HCV genotype 1 or 3 infection: Command GT2/3 study. J. Hepatol. 2013, 58, S570-S571. [CrossRef].
    • (2013) J. Hepatol , vol.58 , pp. S570-S571
    • Dore, G.J.1    Lawitz, E.2    Hezode, C.3    Shafran, S.4    Ramji, A.5    Tatum, H.6    Taliani, G.7    Tran, A.8    Brunetto, M.9    Zaltron, S.10
  • 49
    • 84883219967 scopus 로고    scopus 로고
    • Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir
    • [CrossRef] [PubMed]
    • McPhee, F.; Hernandez, D.; Yu, F.; Ueland, J.; Monikowski, A.; Carifa, A.; Falk, P.; Wang, C.; Fridell, R.; Eley, T.; et al. Resistance analysis of hepatitis C virus genotype 1 prior treatment null responders receiving daclatasvir and asunaprevir. Hepatology 2013, 58, 902-911. [CrossRef] [PubMed].
    • (2013) Hepatology , vol.58 , pp. 902-911
    • McPhee, F.1    Hernandez, D.2    Yu, F.3    Ueland, J.4    Monikowski, A.5    Carifa, A.6    Falk, P.7    Wang, C.8    Fridell, R.9    Eley, T.10
  • 50
    • 84951192604 scopus 로고    scopus 로고
    • Prevalence of pre-treatment NS5A resistance associated variants in genotype 1 patients across different regions using deep sequencing and effect on treatment outcome with LDV/SOF
    • Zeuzem, S.; Mizokami, M.; Pianko, S.; Mangia, A.; Han, K.; Martin, R.; Svarovskaia, E.; Dvory-Sobol, H.; Doehle, B.; Pang, P.; et al. Prevalence of pre-treatment NS5A resistance associated variants in genotype 1 patients across different regions using deep sequencing and effect on treatment outcome with LDV/SOF. Hepatology 2015, 62, 254A.
    • (2015) Hepatology , vol.62 , pp. 254A
    • Zeuzem, S.1    Mizokami, M.2    Pianko, S.3    Mangia, A.4    Han, K.5    Martin, R.6    Svarovskaia, E.7    Dvory-Sobol, H.8    Doehle, B.9    Pang, P.10
  • 52
    • 84925364974 scopus 로고    scopus 로고
    • All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: Ally-3 phase III study
    • [CrossRef] [PubMed]
    • Nelson, D.R.; Cooper, J.N.; Lalezari, J.P.; Lawitz, E.; Pockros, P.J.; Gitlin, N.; Freilich, B.F.; Younes, Z.H.; Harlan, W.; Ghalib, R.; et al. All-oral 12-week treatment with daclatasvir plus sofosbuvir in patients with hepatitis C virus genotype 3 infection: Ally-3 phase III study. Hepatology 2015, 61, 1127-1135. [CrossRef] [PubMed].
    • (2015) Hepatology , vol.61 , pp. 1127-1135
    • Nelson, D.R.1    Cooper, J.N.2    Lalezari, J.P.3    Lawitz, E.4    Pockros, P.J.5    Gitlin, N.6    Freilich, B.F.7    Younes, Z.H.8    Harlan, W.9    Ghalib, R.10
  • 53
    • 84949089864 scopus 로고    scopus 로고
    • Therapy: Avoiding treatment failures associated with HCV resistance
    • [CrossRef] [PubMed]
    • Pawlotsky, J.M. Therapy: Avoiding treatment failures associated with HCV resistance. Nat. Rev. Gastroenterol. Hepatol. 2015, 12, 673-674. [CrossRef] [PubMed].
    • (2015) Nat. Rev. Gastroenterol. Hepatol , vol.12 , pp. 673-674
    • Pawlotsky, J.M.1
  • 58
    • 84921276609 scopus 로고    scopus 로고
    • Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials
    • [CrossRef] [PubMed]
    • Svarovskaia, E.S.; Dvory-Sobol, H.; Parkin, N.; Hebner, C.; Gontcharova, V.; Martin, R.; Ouyang, W.; Han, B.; Xu, S.; Ku, K.; et al. Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials. Clin. Infect. Dis. 2014, 59, 1666-1674. [CrossRef] [PubMed].
    • (2014) Clin. Infect. Dis , vol.59 , pp. 1666-1674
    • Svarovskaia, E.S.1    Dvory-Sobol, H.2    Parkin, N.3    Hebner, C.4    Gontcharova, V.5    Martin, R.6    Ouyang, W.7    Han, B.8    Xu, S.9    Ku, K.10
  • 63
    • 84923224881 scopus 로고    scopus 로고
    • In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor
    • [CrossRef] [PubMed]
    • Kati,W.; Koev, G.; Irvin, M.; Beyer, J.; Liu, Y.; Krishnan, P.; Reisch, T.; Mondal, R.;Wagner, R.; Molla, A.; et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob. Agents Chemother. 2015, 59, 1505-1511. [CrossRef] [PubMed].
    • (2015) Antimicrob. Agents Chemother , vol.59 , pp. 1505-1511
    • Kati, W.1    Koev, G.2    Irvin, M.3    Beyer, J.4    Liu, Y.5    Krishnan, P.6    Reisch, T.7    Mondal, R.8    Wagner, R.9    Molla, A.10
  • 68
    • 84904647749 scopus 로고    scopus 로고
    • ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection
    • [CrossRef] [PubMed]
    • Andreone, P.; Colombo, M.G.; Enejosa, J.V.; Koksal, I.; Ferenci, P.; Maieron, A.; Mullhaupt, B.; Horsmans, Y.; Weiland, O.; Reesink, H.W.; et al. ABT-450, ritonavir, ombitasvir, and dasabuvir achieves 97% and 100% sustained virologic response with or without ribavirin in treatment-experienced patients with HCV genotype 1b infection. Gastroenterology 2014, 147, 359-365. [CrossRef] [PubMed].
    • (2014) Gastroenterology , vol.147 , pp. 359-365
    • Andreone, P.1    Colombo, M.G.2    Enejosa, J.V.3    Koksal, I.4    Ferenci, P.5    Maieron, A.6    Mullhaupt, B.7    Horsmans, Y.8    Weiland, O.9    Reesink, H.W.10
  • 70
    • 34247594930 scopus 로고    scopus 로고
    • Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    • [CrossRef] [PubMed]
    • Sarrazin, C.; Kieffer, T.L.; Bartels, D.; Hanzelka, B.; Muh, U.; Welker, M.; Wincheringer, D.; Zhou, Y.; Chu, H.M.; Lin, C.; et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007, 132, 1767-1777. [CrossRef] [PubMed].
    • (2007) Gastroenterology , vol.132 , pp. 1767-1777
    • Sarrazin, C.1    Kieffer, T.L.2    Bartels, D.3    Hanzelka, B.4    Muh, U.5    Welker, M.6    Wincheringer, D.7    Zhou, Y.8    Chu, H.M.9    Lin, C.10
  • 71
    • 73149113353 scopus 로고    scopus 로고
    • Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    • [CrossRef] [PubMed]
    • Susser, S.; Welsch, C.; Wang, Y.; Zettler, M.; Domingues, F.S.; Karey, U.; Hughes, E.; Ralston, R.; Tong, X.; Herrmann, E.; et al. Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology 2009, 50, 1709-1718. [CrossRef] [PubMed].
    • (2009) Hepatology , vol.50 , pp. 1709-1718
    • Susser, S.1    Welsch, C.2    Wang, Y.3    Zettler, M.4    Domingues, F.S.5    Karey, U.6    Hughes, E.7    Ralston, R.8    Tong, X.9    Herrmann, E.10
  • 73
    • 84921021932 scopus 로고    scopus 로고
    • Next-generation sequencing sheds light on the natural history of hepatitis C infection in patients who fail treatment
    • [CrossRef] [PubMed]
    • Abdelrahman, T.; Hughes, J.; Main, J.; McLauchlan, J.; Thursz, M.; Thomson, E. Next-generation sequencing sheds light on the natural history of hepatitis C infection in patients who fail treatment. Hepatology 2015, 61, 88-97. [CrossRef] [PubMed].
    • (2015) Hepatology , vol.61 , pp. 88-97
    • Abdelrahman, T.1    Hughes, J.2    Main, J.3    McLauchlan, J.4    Thursz, M.5    Thomson, E.6
  • 74
    • 84924103954 scopus 로고    scopus 로고
    • Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: Comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan
    • [CrossRef] [PubMed]
    • Ogishi, M.; Yotsuyanagi, H.; Tsutsumi, T.; Gatanaga, H.; Ode, H.; Sugiura, W.; Moriya, K.; Oka, S.; Kimura, S.; Koike, K. Deconvoluting the composition of low-frequency hepatitis C viral quasispecies: Comparison of genotypes and NS3 resistance-associated variants between HCV/HIV coinfected hemophiliacs and HCV monoinfected patients in Japan. PLoS ONE 2015, 10, e0119145. [CrossRef] [PubMed].
    • (2015) PLoS ONE , vol.10
    • Ogishi, M.1    Yotsuyanagi, H.2    Tsutsumi, T.3    Gatanaga, H.4    Ode, H.5    Sugiura, W.6    Moriya, K.7    Oka, S.8    Kimura, S.9    Koike, K.10
  • 76
    • 84946949842 scopus 로고    scopus 로고
    • Naturally occurring mutations associated with resistance to HCV NS5B polymerase and ns3 protease inhibitors in treatment-naive patients with chronic hepatitis C
    • [CrossRef] [PubMed]
    • Costantino, A.; Spada, E.; Equestre, M.; Bruni, R.; Tritarelli, E.; Coppola, N.; Sagnelli, C.; Sagnelli, E.; Ciccaglione, A.R. Naturally occurring mutations associated with resistance to HCV NS5B polymerase and ns3 protease inhibitors in treatment-naive patients with chronic hepatitis C. Virol. J. 2015, 12. [CrossRef] [PubMed].
    • (2015) Virol. J , vol.12
    • Costantino, A.1    Spada, E.2    Equestre, M.3    Bruni, R.4    Tritarelli, E.5    Coppola, N.6    Sagnelli, C.7    Sagnelli, E.8    Ciccaglione, A.R.9
  • 77
    • 84921260778 scopus 로고    scopus 로고
    • Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing
    • [CrossRef] [PubMed]
    • Margeridon-Thermet, S.; le Pogam, S.; Li, L.; Liu, T.F.; Shulman, N.; Shafer, R.W.; Najera, I. Similar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencing. PLoS ONE 2014, 9, e105569. [CrossRef] [PubMed].
    • (2014) PLoS ONE , vol.9
    • Margeridon-Thermet, S.1    le Pogam, S.2    Li, L.3    Liu, T.F.4    Shulman, N.5    Shafer, R.W.6    Najera, I.7
  • 78
    • 84920945807 scopus 로고    scopus 로고
    • Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir
    • [CrossRef] [PubMed]
    • Donaldson, E.F.; Harrington, P.R.; O'Rear, J.J.; Naeger, L.K. Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir. Hepatology 2015, 61, 56-65. [CrossRef] [PubMed].
    • (2015) Hepatology , vol.61 , pp. 56-65
    • Donaldson, E.F.1    Harrington, P.R.2    O'Rear, J.J.3    Naeger, L.K.4
  • 79
    • 84954399628 scopus 로고    scopus 로고
    • The importance of resistance to direct antiviral drugs in HCV infection in clinical practice
    • [CrossRef] [PubMed]
    • Sarrazin, C. The importance of resistance to direct antiviral drugs in HCV infection in clinical practice. J. Hepatol. 2015. [CrossRef] [PubMed].
    • (2015) J. Hepatol
    • Sarrazin, C.1
  • 80
    • 84876246624 scopus 로고    scopus 로고
    • Persistence of resistant variants in hepatitis C virus-infected patients treated with the NS5A replication complex inhibitor daclatasvir
    • [CrossRef] [PubMed]
    • Wang, C.; Sun, J.H.; O'Boyle, D.R., 2nd; Nower, P.; Valera, L.; Roberts, S.; Fridell, R.A.; Gao, M. Persistence of resistant variants in hepatitis C virus-infected patients treated with the NS5A replication complex inhibitor daclatasvir. Antimicrob. Agents Chemother. 2013, 57, 2054-2065. [CrossRef] [PubMed].
    • (2013) Antimicrob. Agents Chemother , vol.57 , pp. 2054-2065
    • Wang, C.1    Sun, J.H.2    O'Boyle, D.R.3    Nower, P.4    Valera, L.5    Roberts, S.6    Fridell, R.A.7    Gao, M.8
  • 81
    • 84877580079 scopus 로고    scopus 로고
    • The presence of resistance mutations to protease and polymerase inhibitors in hepatitis C virus sequences from the Los Alamos databank
    • [CrossRef] [PubMed]
    • Alves, R.; Queiroz, A.T.; Pessoa, M.G.; da Silva, E.F.; Mazo, D.F.; Carrilho, F.J.; Carvalho-Filho, R.J.; de Carvalho, I.M. The presence of resistance mutations to protease and polymerase inhibitors in hepatitis C virus sequences from the Los Alamos databank. J. Viral Hepat. 2013, 20, 414-421. [CrossRef] [PubMed].
    • (2013) J. Viral Hepat , vol.20 , pp. 414-421
    • Alves, R.1    Queiroz, A.T.2    Pessoa, M.G.3    da Silva, E.F.4    Mazo, D.F.5    Carrilho, F.J.6    Carvalho-Filho, R.J.7    de Carvalho, I.M.8
  • 82
    • 84901318422 scopus 로고    scopus 로고
    • Resistance to hepatitis C virus protease inhibitors
    • [CrossRef] [PubMed]
    • Kieffer, T.L.; George, S. Resistance to hepatitis C virus protease inhibitors. Curr. Opin. Virol. 2014, 8, 16-21. [CrossRef] [PubMed].
    • (2014) Curr. Opin. Virol , vol.8 , pp. 16-21
    • Kieffer, T.L.1    George, S.2
  • 83
    • 84896520682 scopus 로고    scopus 로고
    • Antiviral therapy of hepatitis C in 2014: Do we need resistance testing?
    • [CrossRef] [PubMed]
    • Schneider, M.D.; Sarrazin, C. Antiviral therapy of hepatitis C in 2014: Do we need resistance testing? Antivir. Res. 2014, 105, 64-71. [CrossRef] [PubMed].
    • (2014) Antivir. Res , vol.105 , pp. 64-71
    • Schneider, M.D.1    Sarrazin, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.