BDNF as a biomarker in the course and treatment of schizophrenia;BDNF jako biomarker w przebiegu i leczeniu schizofrenii

Psychiatria Polska

Volumn 49, Issue 6, 2015, Pages 1149-1158

  Libman Sokołowska, Małgorzata ^a   Drozdowicz, Ewa ^a   Nasierowski, Tadeusz ^a  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

Author keywords

BDNF; Biomarkers; Schizophrenia

Indexed keywords

BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

ARTICLE; AUTOPSY; CLINICAL ASSESSMENT; DISEASE COURSE; DNA METHYLATION; DNA POLYMORPHISM; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; HUMAN; NERVOUS SYSTEM DEVELOPMENT; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSYCHOPHARMACOTHERAPY; SCHIZOPHRENIA; SYNAPTOGENESIS; BLOOD; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE;

BIOMARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DNA METHYLATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; PROMOTER REGIONS, GENETIC; SCHIZOPHRENIA;

EID: 84950971336     PISSN: 00332674     EISSN: 23915854     Source Type: Journal    
DOI: 10.12740/PP/37705     Document Type: Article

References (55)

1. Hanson IM, Seawright A, van Heyningen V. The human BDNF gene maps between FSHB and HVBS1 at the boundary of 11p13-p14. Genomics 1992; 13: 1331-1333.
2. Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T. Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters. Genomics 2007; 90: 397-406.
3. Greenberg ME, Xu B, Lu B, Hempstead BL. New insights in the biology of BDNF synthesis and release: implications in CNS function. J. Neurosci. 2009; 29: 12764-12767.
4. Patapoutian A, Reichardt LF. Trk receptors: mediators of neurotrophin action. Curr. Opin. Neurobiol. 2001; 11: 272-280.
5. Barbacid M. Neurotrophic factors and their receptors. Curr. Opin. Cell Biol. 1995; 7: 148-155.
6. Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD. i wsp. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J. Neurosci. 2005; 25: 5455-5463.
7. Djalali S, Höltje M, Grosse G, Rothe T, Stroh T, Grosse J. i wsp. Effects of brain-derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development. J. Neurochem. 2005; 92: 616-627.
8. Huang EJ1, Reichardt LF. Neurotrophins: roles in neuronal development and function. Ann. Rev. Neurosci. 2001; 24: 677-736.
9. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A. i wsp. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112: 257-269.
10. Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth Factors 2004; 22: 123-131.
11. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA. i wsp. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat. Neurosci. 2005; 8: 1069-1077.
12. Mowla SJ, Pareek S, Farhadi HF, Petrecca K, Fawcett JP, Seidah NG. i wsp. Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons. J. Neurosci. 1999; 19: 2069-2080.
13. Paredes D, Granholm AC, Bickford PC. Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat. Brain Res. 2007; 1141: 56-64.
14. Xing B, Guo J, Meng X, Wei SG, Li SB. The dopamine D1 but not D3 receptor plays a fundamental role in spatial working memory and BDNF expression in prefrontal cortex of mice. Behav. Brain Res. 2012; 235: 36-41.
15. Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998; 37: 1553-1561.
16. Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci. Lett. 2002; 328: 261-264.
17. Nakahashi T, Fujimura H, Altar CA, Li J, Kambayashi J, Tandon NN. i wsp. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett. 2000; 470: 113-117.
18. Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi J. i wsp. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb. Haemost. 2002; 87: 728-734.
19. Neves-Pereira M, Cheung JK, Pasdar A, Zhang F, Breen G, Yates P. i wsp. BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol. Psychiatry 2005; 10: 208-212.
20. Rosa A, Cuesta MJ, Fatjó-Vilas M, Peralta V, Zarzuela A, Fañanás L. The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006; 141B: 135-138.
21. Smith GN, Thornton AE, Lang DJ, MacEwan GW, Ehmann TS, Kopala LC. i wsp. Hippocampal volume and the brain-derived neurotrophic factor Val66Met polymorphism in first episode psychosis. Schizophr. Res. 2012; 134: 253-259.
22. Gratacòs M, González JR, Mercader JM, de Cid R, Urretavizcaya M, Estivill X. Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol. Psychiatry 2007; 61: 911-922.
23. Zhou DH, Yan QZ, Yan XM, Li CB, Fang H, Zheng YL. i wsp. The study of BDNF Val66Met polymorphism in Chinese schizophrenic patients. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010; 34: 930-933.
24. Golimbet VE, Korovaitseva GI, Abramova LI, Kasparov SV, Uvarova LG. Association between the Val66Met polymorphism of brain-derived neurotrophic factor gene and schizophrenia in Russians. Mol. Biol. (Mosk.) 2008; 42: 599-603.
25. Hawi Z, Straub RE, O'Neill A, Kendler KS, Walsh D, Gill M. No linkage or linkage disequilibrium between brain-derived neurotrophic factor (BDNF) dinucleotide repeat polymorphism and schizophrenia in Irish families. Psychiatry Res. 1998; 81: 111-116.
26. Sotiropoulou M, Mantas C, Bozidis P, Marselos M, Mavreas V, Hyphantis T. i wsp. BDNF serum concentrations in first psychotic episode drug-näive schizophrenic patients: Associations with personality and BDNF Val66Met polymorphism. Life Sci. 2013; 92: 305-310.
27. Kawashima K, Ikeda M, Kishi T, Kitajima T, Yamanouchi Y, Kinoshita Y. i wsp. BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysis. Schizophr. Res. 2009; 112: 72-79.
28. Baig BJ, Whalley HC, Hall J, McIntosh AM, Job DE, Cunningham-Owens DG. i wsp. Functional magnetic resonance imaging of BDNF val66met polymorphism in unmedicated subjects at high genetic risk of schizophrenia performing a verbal memory task. Psychiatry Res. 2010; 183: 195-201.
29. Kayahan B, Kaymaz BT, Altintoprak AE, Aktan Ç, Veznedaroʇlu B, Kosova B. The lack of association between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms and schizophrenia in a group of Turkish population. Neurol. Psychiatry Brain Res. 2013; 19: 102-108.
30. Chen SL, Lee SY, Chang YH, Chen SH, Chu CH, Wang TY. i wsp. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2014; 51: 99-104.
31. Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Ohta K. i wsp. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms. Neurosci. Lett. 2006; 401: 1-5.
32. Chao HM, Kao HT, Porton B. BDNF Val66Met variant and age of onset in schizophrenia. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008; 147B: 505-506.
33. Szekeres G, Juhász A, Rimanóczy A, Kéri S, Janka Z. The C270T polymorphism of the brain - derived neurotrophic factor gene is associated with schizophrenia. Schizophr. Res. 2003; 6: 15-18.
34. Xiu MH, Hui L, Dang YF, Hou TD, Zhang CX, Zheng YL. i wsp. Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009; 33: 1508-1512.
35. Kordi-Tamandani DM, Sahranavard R, Torkamanzehi A. DNA methylation and expression profiles of the brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in patients with schizophrenia. Mol. Biol. Rep. 2012; 39: 10889-10893.
36. Ikegame T, Bundo M, Sunaga F, Asai T, Nishimura F, Yoshikawa A. i wsp. DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients. Neurosci. Res. 2013; 77: 208-214.
37. Issa G, Wilson C, Terry AV Jr, Pillai A. An inverse relationship between cortisol and BDNF level in schizophrenia: Data from human postmortem and animal studies. Neurobiol. Dis. 2010; 39: 327-333.
38. Durany N, Michel T, Zöchling R, Boissl KW, Cruz-Sánchez FF, Riederer P. i wsp. Brain-derived neurotrophic factor and neurotrophin 3 in schizophrenic psychoses. Schizophr. Res. 2001; 52: 79-86.
39. Pirildar S, Gönül AS, Taneli F, Akdeniz F. Low serum levels of brain-derived neurotrophic factor in patients with schizophrenia do not elevate after antipsychotic treatment. Prog. Neuropsychopharmacol. Biol. Psychiatry 2004; 28: 709-713.
40. Rizos EN, Rontos I, Laskos E, Arsenis G, Michalopoulou PG, Vasilopoulos D. i wsp. Investigation of serum BDNF levels in drug-naive patients with schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008; 32: 1308-1311.
41. Jindal RD, Pillai AK, Mahadik SP, Eklund K, Montrose DM, Keshavan MS. Decreased BDNF in patients with antipsychotic naïve first episode schizophrenia. Schizophr. Res. 2010; 119: 47-51.
42. Toyooka K, Asama K, Watanabe Y, Muratake T, Takahashi M, Someya T. i wsp. Decreased levels of barin-derived neurotrophic factor in serum of chronic schizophrenic patients. Psychiatry Res. 2002; 110: 249-257.
43. Grillo RW, Ottoni GL, Leke R, Souza DO, Portela LV, Lara DR. Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics. J. Psychiatr. Res. 2007; 41: 31-35.
44. Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Xu Q. i wsp. Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. J. Psychiatr. Res. 2007; 41: 997-1004.
45. Kernie SG, Liebl DJ, Parada LF. BDNF regulates eating behavior and locomotor activity in mice. EMBO J. 2000; 19: 1290-1300.
46. Nurjono M, Tay YH, Lee J. The relationship between serum brain-derived neurotrophic factor (BDNF) and cardiometabolic indices in schizophrenia. Schizophr. Res. 2014; 157: 244-248.
47. Yamamori H, Hashimoto R, Ishima T, Kishi F, Yasuda Y, Ohi K. i wsp. Plasma levels of mature brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) in treatment-resistant schizophrenia treated with clozapine. Neurosci. Lett. 2013; 556: 37-41.
48. Carlino D, Leone E, Di Cola F, Baj G, Marin R, Dinelli G. i wsp. Low serum truncated-BDNF isoform correlates with higher cognitive impairment in schizophrenia. J. Psychiatr. Res. 2011; 45: 273-279.
49. Chen SL, Lee SY, Chang YH, Chen SH, Chu CH, Tzeng NS. i wsp. Inflammation in patients with schizophrenia: the therapeutic benefits of risperidone plus add-on dextromethorphan. J. Neuroimmune Pharmacol. 2012; 7: 656-664.
50. Asevedo E, Gadelha A, Noto C, Mansur RB, Zugman A, Belangero SI. i wsp. Impact of peripheral levels of chemokines, BDNF and oxidative markers on cognition in individuals with schizophrenia. J. Psychiatr. Res. 2013; 47: 1376-1382.
51. Domenici E, Wille DR, Tozzi F, Prokopenko I, Miller S, McKeown A. i wsp. Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections. PLoS ONE 2010; 5: e9166.
52. Chen CC, Huang TL. Effects of antipsychotics on the serum BDNF levels in schizophrenia. Psychiatry Res. 2011; 189(3): 327-330.
53. Lin PY. Increase in brain-derived factor in patients with schizophrenia treated with olanazapine: a systemic review and meta-analysis. J. Exp. Clin. Med. 2012; 4(2): 119-124.
54. Zhang XY, Xiu MH, Chen DC, Yang FD, Wu GY, Lu L. i wsp. Nicotine dependence and serum BDNF levels in male patients with schizophrenia. Psychopharmacology 2010; 212: 302-307.
55. Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH. Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biol. Psychiatry 2009; 66: 549-553.