Novel physiological functions of branched-chain amino acids

Journal of Nutritional Science and Vitaminology

Volumn 61, Issue , 2015, Pages S112-S114

  Shimomura, Yoshiharu ^a   Kitaura, Yasuyuki ^a   Kadota, Yoshihiro ^a   Ishikawa, Takuya ^a   Kondo, Yusuke ^a   Xu, Minjun ^a   Ota, Miki ^a   Morishita, Yukako ^a   Bariuan, Jussiaea V ^a   Zhen, Hongmin ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

Brain function; Branched chain amino acid; Protein and glucose metabolism

Indexed keywords

BRANCHED CHAIN AMINO ACID; GLUTAMIC ACID; LEUCINE; ESSENTIAL AMINO ACID; GLUCOSE; PROTEIN;

AMINO ACID METABOLISM; BRAIN FUNCTION; ENZYME ACTIVITY; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HUMAN; INSULIN SENSITIVITY; METABOLIC REGULATION; OXIDATION; REVIEW; SIGNAL TRANSDUCTION; BRAIN; METABOLISM;

AMINO ACIDS, BRANCHED-CHAIN; AMINO ACIDS, ESSENTIAL; BRAIN; GLUCOSE; HUMANS; PROTEINS;

EID: 84950323382     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.61.S112     Document Type: Review

References (16)

1. WHO/FAO/UNU. 2007. Amino acid requirements of adults. Protein and Amino Acid Requirements in Human Nutrition. Technical Reports Series 935, p 135-159. WHO, Geneva.
2. Shimomura Y, Honda T, Shiraki M, Murakami T, Sato J, Kobayashi H, Mawatari K, Obayashi M, Harris RA. 2006. Branched-chain amino acid catabolism in exercise and liver disease. J Nutr 136: 250S-253S.
3. She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, Hutson SM. 2007. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab 6: 181-194.
4. Joshi MA, Jeoung NH, Obayashi M, Hattab EM, Brocken EG, Liechty EA, Kubek MJ, Vattem KM, Wek RC, Harris RA. 2006. Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. Biochem J 400: 153-162.
5. Kimball SR, Jefferson LS. 2010. Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. J Biol Chem 285: 29027-29032.
6. Mizushima N, Komatsu M. 2011. Autophagy: renovation of cells and tissues. Cell 147: 728-741.
7. Kawaguchi T, Izumi N, Charlton MR, Sata M. 2011. Branched-chain amino acids as pharmacological nutrients in chronic liver disease. Hepatol 54: 1063-1070.
8. Sako K, Imamura Y, Nishimata H, Tahara K, Kubozono O, Tsubouchi H. 2003. Branched-chain amino acids supplements in the late evening decrease the frequency of muscle cramps with advanced hepatic cirrhosis. Hepatol Res 26: 327-329.
9. Nishitani S, Ijichi C, Takehana K, Fujitani S, Sonaka I. 2004. Pharmacological activities of branched-chain amino acids: specificity of tissue and signal transduction. Biochem Biophys Res Commun 313: 387-389.
10. Doi M, Yamaoka I, Nakayama M, Sugahara K, Yoshizawa F. 2007. Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis. Am J Physiol Endocrinol Metab 292: E1683-E1693.
11. Nishitani S, Takehana K, Fujitani S, Sonaka I. 2005. Branched-chain amino acids improve glucose metabolism in rats with liver cirrhosis. Am J Physiol Gastrointest Liver Physiol 288: G1292-G300.
12. Kadota Y, Kazama S, Bajotto G, Kitaura Y, Shimomura Y. 2012. Clofibrate-induced reduction of plasma branchedchain amino acid concentrations impairs glucose tolerance in rats. JPEN J Parenter Enteral Nutr 36: 337-343.
13. Yudkoff M, Daikhin Y, Nissim I, Horyn O, Luhovyy B, Lazarow A, Nissim I. 2005. Brain amino acid requirements and toxicity: the example of leucine. J Nutr 135: 1531S-1538S.
14. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, Tanaka K. 2006. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884.
15. Novarino G, El-Fishawy P, Kayserili H, Meguid NA, Scott EM, Schroth J, Silhavy JL, Kara M, Khalil RO, Ben-Omran T, Ercan-Sencicek AG, Hashish AF, Sanders SJ, Gupta AR, Hashem HS, Matern D, Gabriel S, Sweetman L, Rahimi Y, Harris RA, State MW, Gleeson JG. 2012. Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. Science 338: 394-397.
16. García-Cazorla A, Oyarzabal A, Fort J, Robles C, Castejón E, Ruiz-Sala P, Bodoy S, Merinero B, Lopez-Sala A, Dopazo J, Nunes V, Ugarte M, Artuch R, Palacín M, Rodríguez-Pombo P, Alcaide P, Navarrete R, Sanz P, Font-Llitjós M, Vilaseca MA, Ormaizabal A, Pristoupilova A, Agulló SB. 2014. Two novel mutations in the BCKDK (branched-chain keto-acid dehydrogenase kinase) gene are responsible for a neurobehavioral deficit in two pediatric unrelated patients. Hum Mutat 35: 470-477.