Accumulation Mechanisms of CD4 + CD25 + FOXP3 + Regulatory T Cells in EBV-associated Gastric Carcinoma

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Zhang, Na Na ^a   Chen, Jian Ning ^a   Xiao, Lin ^a,b   Tang, Fang ^a,b   Zhang, Zhi Gang ^a   Zhang, Yi Wang ^a   Feng, Zhi Ying ^a   Jiang, Ye ^a   Shao, Chun Kui ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CCR7 PROTEIN, HUMAN; CHEMOKINE RECEPTOR CCR7; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA; MACROPHAGE DERIVED CHEMOKINE;

ADULT; APOPTOSIS; CELL CULTURE; CELL PROLIFERATION; COCULTURE; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; FEMALE; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LYMPHOCYTE COUNT; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY; REGULATORY T LYMPHOCYTE; STOMACH TUMOR; TUMOR CELL LINE; VIROLOGY; WESTERN BLOTTING;

ADULT; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINE CCL22; COCULTURE TECHNIQUES; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HERPESVIRUS 4, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; RECEPTORS, CCR7; STOMACH NEOPLASMS; T-LYMPHOCYTES, REGULATORY;

EID: 84950260967     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep18057     Document Type: Article

References (34)

1. Young, L. S. & Rickinson, A. B. Epstein-Barr virus: 40 years on. Nat Rev Cancer 4, 757-768 (2004).
2. Chen, J. N., He, D., Tang, F. & Shao, C. K. Epstein-Barr virus-associated gastric carcinoma: a newly defined entity. J Clin Gastroenterol 46, 262-271 (2012).
3. Saiki, Y., Ohtani, H., Naito, Y., Miyazawa, M. & Nagura, H. Immunophenotypic characterization of Epstein-Barr virus-associated gastric carcinoma: massive infiltration by proliferating CD8+ T-lymphocytes. Lab Invest 75, 67-76 (1996).
4. Kuzushima, K. et al. Increased frequency of antigen-specific CD8(+ ) cytotoxic T lymphocytes infiltrating an Epstein-Barr virusassociated gastric carcinoma. J Clin Invest 104, 163-171 (1999).
5. Taylor, G. S. T cell-based therapies for EBV-associated malignancies. Expert Opin Biol Ther 4, 11-21.
6. Li, J., Qian, C. N. & Zeng, Y. X. Regulatory T cells and EBV associated malignancies. Int Immunopharmacol 9, 590-592 (2009).
7. Gershon, R. K. & Kondo, K. Infectious immunological tolerance. Immunology 21, 903-914 (1971).
8. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155, 1151-1164 (1995).
9. O'Garra, A. & Vieira, P. Twenty-first century Foxp3. Nat Immunol 4, 304-306 (2003).
10. Banham, A. H. Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+ ) regulatory T cells. Trends Immunol 27, 541-544 (2006).
11. Sonawane, S. B. et al. GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation 88, 1169-1177 (2009).
12. Sojka, D. K., Hughson, A. & Fowell, D. J. CTLA-4 is required by CD4+ CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation. Eur J Immunol 39, 1544-1551 (2009).
13. Ghourbani Gazar, S., Andalib, A., Hashemi, M. & Rezaei, A. CD4Foxp3 Treg and its ICOS Subsets in Patients with Myocardial Infarction. Iran J Immunol 9, 53-60 (2012).
14. Miyara, M. & Sakaguchi, S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med 13, 108-116 (2007).
15. Assis, M. C. et al. Increased expression of CD4(+) CD25(+) FOXP3(+) regulatory T cells correlates with Epstein-Barr virus and has no impact on survival in patients with classical Hodgkin lymphoma in Brazil. Med Oncol 29, 3614-3619 (2012).
16. Gandhi, M. K. et al. Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. Blood 108, 2280-2289 (2006).
17. Baumforth, K. R. et al. Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells. Am J Pathol 173, 195-204 (2008).
18. Lau, K. M. et al. Increase in circulating Foxp3+ CD4+ CD25(high) regulatory T cells in nasopharyngeal carcinoma patients. Br J Cancer 96, 617-622 (2007).
19. Haas, M. et al. Inflammation in gastric adenocarcinoma of the cardia: how do EBV infection, Her2 amplification and cancer progression influence tumor-infiltrating lymphocytes? Virchows Arch 458, 403-411 (2011).
20. Iellem, A. et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+) CD25(+) regulatory T cells. J Exp Med 194, 847-853 (2001).
21. Mizukami, Y. et al. CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer. Int J Cancer 122, 2286-2293 (2008).
22. Shaknovich, R. et al. Identification of rare Epstein-Barr virus infected memory B cells and plasma cells in non-monomorphic posttransplant lymphoproliferative disorders and the signature of viral signaling. Haematologica 91, 1313-1320 (2006).
23. Nakayama, T. et al. Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein-Barr virus. J Virol 78, 1665-1674 (2004).
24. Remmerswaal, E. B. et al. Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes. Blood 119, 1702-1712 (2012).
25. Lin, Y. C. et al. Activated but not resting regulatory T cells accumulated in tumor microenvironment and correlated with tumor progression in patients with colorectal cancer. Int J Cancer (2012).
26. Strauss, L. et al. A unique subset of CD4+ CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment. Clin Cancer Res 13, 4345-4354 (2007).
27. Schaefer, C. et al. Characteristics of CD4+ CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer. Br J Cancer 92, 913-920 (2005).
28. Takahashi, T. et al. Immunologic self-tolerance maintained by CD25+ CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol 10, 1969-1980 (1998).
29. Oberg, H. H., Juricke, M., Kabelitz, D. & Wesch, D. Regulation of T cell activation by TLR ligands. Eur J Cell Biol 90, 582-592 (2011).
30. Nocentini, G. et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 94, 6216-6221 (1997).
31. Ronchetti, S., Nocentini, G., Riccardi, C. & Pandolfi, P. P. Role of GITR in activation response of T lymphocytes. Blood 100, 350-352 (2002).
32. Chen, J. N. et al. Association of distinctive Epstein-Barr virus variants with gastric carcinoma in Guangzhou, southern China. J Med Virol 82, 658-667 (2010).
33. Zhang, Y. L. et al. Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways. Mol Cancer 9, 4 (2010).
34. Ding, Y. et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin Cancer Res 9, 3406-3412 (2003).