Human virus-specific effector-type T cells accumulate in blood but not in lymph nodes

Blood

Volumn 119, Issue 7, 2012, Pages 1702-1712

  Remmerswaal, Ester B M ^a   Havenith, Simone H C ^a   Idu, Mirza M ^a   Van Leeuwen, Ester M M ^a   Van Donselaar, Karlijn A M I ^a   Ten Brinke, Anja ^b   Van Der Bom Baylon, Nelly ^a   Bemelman, Fréderike J ^a   Van Lier, René A W ^a,b   Ten Berge, Ineke J M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b SANQUIN RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1;

ARTICLE; BLOOD; BLOOD LEVEL; CD8+ T LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN VIRUS SPECIFIC EFFECTOR TYPE T LYMPHOCYTE; IMMUNE RESPONSE; INFLUENZA VIRUS; LYMPH NODE; MEMORY T LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL;

EID: 84857476244     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-09-381574     Document Type: Article

References (38)

1. Shaw AC, Joshi S, Greenwood H, et al. Aging of the innate immune system. Curr Opin Immunol. 2010;22(4):507-513.
2. Ademokun A, Wu YC, Dunn-Walters D. The ageing B cell population: composition and function. Biogerontology. 2010;11(2):125-137.
3. Henson SM, Akbar AN. Memory T-cell homeostasis and senescence during aging. Adv Exp Med Biol. 2010;684:189-197.
4. Wikby A, Mansson IA, Johansson B, et al. The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age. Biogerontology. 2008;9(5):299-308.
5. Kuijpers TW, Vossen MT, Gent MR, et al. Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV. J Immunol. 2003;170(8):4342-4348. (Pubitemid 36428204)
6. Looney RJ, Falsey A, Campbell D, et al. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol. 1999;90(2):213- 219.
7. Olsson J, Wikby A, Johansson B, et al. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev. 2000;121(1-3):187-201. (Pubitemid 32115413)
8. Moss P. The emerging role of cytomegalovirus in driving immune senescence: a novel therapeutic opportunity for improving health in the elderly. Curr Opin Immunol. 2010;22(4):529-534.
9. Welsh RM, Bahl K, Wang XZ. Apoptosis and loss of virus-specific CD8+ T-cell memory. Curr Opin Immunol. 2004;16(3):271-276. (Pubitemid 38595364)
10. Vezys V, Yates A, Casey KA, et al. Memory CD8 T-cell compartment grows in size with immunological experience. Nature. 2009;457(7226):196-199.
11. van Leeuwen EM, Koning JJ, Remmerswaal EB, et al. Differential usage of cellular niches by cytomegalovirus versus EBV- and influenza virusspecific CD8+ T cells. J Immunol. 2006;177(8):4998-5005. (Pubitemid 44527569)
12. van Lier RA, ten Berge IJ, Gamadia LE. Human CD8+ T-cell differentiation in response to viruses. Nat Rev Immunol. 2003;3(12):931-939.
13. Appay V, Dunbar PR, Callan M, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002;8(4):379-385. (Pubitemid 34407033)
14. Wills MR, Okecha G, Weekes MP, et al. Identification of naive or antigen-experienced human CD8+ T cells by expression of costimulation and chemokine receptors: analysis of the human cytomegalovirus- specific CD8() T cell response. J Immunol. 2002;168(11):5455-5464. (Pubitemid 34556123)
15. Hertoghs KM, Moerland PD, van SA, et al. Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation. J Clin Invest. 2010;120(11):4077-4090.
16. Bolovan-Fritts CA, Spector SA. Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction. Blood. 2008; 111(1):175-182.
17. Umehara H, Bloom ET, Okazaki T, et al. Fractalkine in vascular biology: from basic research to clinical disease. Arterioscler Thromb Vasc Biol. 2004;24(1):34-40. (Pubitemid 38082409)
18. Lamoreaux L, Roederer M, Koup R. Intracellular cytokine optimization and standard operating procedure. Nat Protoc. 2006;1(3):1507-1516.
19. Guarda G, Hons M, Soriano SF, et al. L-selectin-negative CCR7-negative and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat Immunol. 2007;8(7):743-752. (Pubitemid 46965350)
20. Gratama JW, Naipal AM, Oosterveer MA, et al. Effects of herpes virus carrier status on peripheral T lymphocyte subsets. Blood. 1987;70(2):516-523. (Pubitemid 17142938)
21. Förster R, Davalos-Misslitz AC, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol. 2008;8(5):362-371. (Pubitemid 351595218)
22. Bardi G, Lipp M, Baggiolini M, et al. The T cell chemokine receptor CCR7 is internalized on stimulation with ELC, but not with SLC. Eur J Immunol. 2001;31(11):3291-3297. (Pubitemid 33100521)
23. Byers MA, Calloway PA, Shannon L, et al. Arrestin 3 mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. J Immunol. 2008;181(7):4723-4732.
24. Betts MR, Nason MC, West SM, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood. 2006;107(12):4781-4789. (Pubitemid 43882629)
25. Hamann D, Baars PA, Rep MH, et al. Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med. 1997;186(9):1407-1418. (Pubitemid 27479800)
26. Bratke K, Kuepper M, Bade B, et al. Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral blood. Eur J Immunol. 2005;35(9):2608-2616. (Pubitemid 41404044)
27. Grefte JM, van der Giessen M, Blom N, et al. Circulating cytomegalovirus-infected endothelial cells after renal transplantation: possible clue to pathophysiology? Transplant Proc. 1995;27(1): 939-942.
28. Sinzger C, Grefte A, Plachter B, et al. Fibroblasts, epithelial cells, endothelial cells and smooth muscle cells are major targets of human cytomegalovirus infection in lung and gastrointestinal tissues. J Gen Virol. 1995;76(4):741-750.
29. Crough T, Khanna R. Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev. 2009;22(1):76-98.
30. van Leeuwen EM, de Bree GJ, Remmerswaal EB, et al. IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. Blood. 2005;106(6):2091-2098. (Pubitemid 41291724)
31. Lynch HE, Goldberg GL, Chidgey A, et al. Thymic involution and immune reconstitution. Trends Immunol. 2009;30(7):366-373.
32. Wikby A, Johansson B, Olsson J, et al. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol. 2002;37(2-3):445-453. (Pubitemid 34073563)
33. van de Berg PJ, Heutinck KM, Raabe R, et al. Human cytomegalovirus induces systemic immune activation characterized by a type 1 cytokine signature. J Infect Dis. 2010;202(5):690-699.
34. Balashov KE, Khoury SJ, Hafler DA, et al. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest. 1995;95(6):2711-2719.
35. Arens R, Tesselaar K, Baars PA, et al. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion. Immunity. 2001;15(5):801-812. (Pubitemid 34008507)
36. Lockridge KM, Zhou SS, Kravitz RH, et al. Primate cytomegaloviruses encode and express an IL-10-like protein. Virology. 2000;268(2):272-280. (Pubitemid 30159977)
37. Jones BC, Logsdon NJ, Josephson K, et al. Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. Proc Natl Acad Sci U S A. 2002;99(14):9404-9409. (Pubitemid 34764626)
38. Chang WL, Barry PA. Attenuation of innate immunity by cytomegalovirus IL-10 establishes a longterm deficit of adaptive antiviral immunity. Proc Natl Acad Sci U S A. 2010;107(52):22647-22652.